The spatial and temporal evolution of parametrically excited geodesic acoustic mode (GAM) initial pulse is investigated both analytically and numerically. Our results show that the nonlinearly excited GAM propagates at a group velocity which is, typically, much larger than that due to finite ion Larmor radius as predicted by the linear theory. The nonlinear dispersion relation of GAM driven by a finite amplitude drift wave pump is also derived, showing a nonlinear frequency increment of GAM. Further implications of these findings for interpreting experimental observations are also discussed.

Generation of zonal flow (ZF) by energetic particle (EP) driven toroidal Alfvén eigenmode (TAE) is investigated using nonlinear gyrokinetic theory. It is found that nonlinear resonant EP contribution dominates over the usual Reynolds and Maxwell stresses due to thermal plasma nonlinear response. ZF can be forced driven in the linear growth stage of TAE, with the growth rate being twice the TAE growth rate. The ZF generation mechanism is shown to be related to polarization induced by resonant EP nonlinearity. The generated ZF has both the usual meso-scale and micro-scale radial structures. Possible consequences of this forced driven ZF on the nonlinear dynamics of TAE are also discussed.

Nonlinear excitation of low frequency zonal structure (LFZS) by beta-induced Alfvén eigenmode (BAE) is investigated using nonlinear gyrokinetic theory. It is found that electrostatic zonal flow (ZF), rather than zonal current, is preferentially excited by finite amplitude BAE. In addition to the well-known meso-scale radial envelope structure, ZF is also found to exhibit fine radial structure due to the localization of BAE with respect to mode rational surfaces. Specifically, the zonal electric field has an even mode structure at the rational surface where radial envelope peaks.

Destriping is a well-established technique for removing low-frequency correlated noise from Cosmic Microwave Background (CMB) survey data. In this paper we present a destriping algorithm tailored to data from a polarimeter, i.e.an instrument where each channel independently measures the polarization of the input signal. We also describe a fully parallel implementation in Python released as Open Source software and analyze its results and performance on simulated datasets, both the design case of signal and correlated noise, and also with the addition of other systematic effects.Finally we apply the algorithm to 30 days of 37.5 GHz polarized microwave data gathered from the B-Machine experiment, developed at UCSB. The B-Machine data and destriped maps are publicly available. The purpose is the development of a scalable software tool to be applied to the upcoming 12 months of temperature and polarization data from LATTE (Low frequency All sky TemperaTure Experiment) at 8GHz and to even larger datasets. © 2013 Elsevier B.V.

Nonlinear wave-particle interaction during chorus wave generation was assumed to be in the adiabatic regime in previous studies, i.e., the particle phase-space trapping timescale (τtr) is considered to be much smaller than the nonlinear dynamics timescale τNL. In this work, we use particle-in-cell simulations to demonstrate that τtr∼τNL, i.e., the interaction regime during chorus generation is in the nonadiabatic regime. The timescale for nonlinear evolution of resonant particle phase-space structures is determined by making the time-averaged power exchange plot, which clearly demonstrates that particles with pitch angle near 80° make the most significant contribution to wave growth. The phase-space trapping timescale is also comparable to the amplitude modulation timescale of chorus, suggesting that chorus subpackets are formed because of the self-consistent evolution of resonant particle phase-space structures and spatiotemporal features of the fluctuation spectrum.

Chorus waves are naturally occurring electromagnetic emissions in space and are known to produce highly energetic electrons in the hazardous radiation belt. The characteristic feature of chorus is its fast frequency chirping, whose mechanism remains a long-standing problem. While many theories agree on its nonlinear nature, they differ on whether or how the background magnetic field inhomogeneity plays a key role. Here, using observations of chorus at Mars and Earth, we report direct evidence showing that the chorus chirping rate is consistently related to the background magnetic field inhomogeneity, despite orders of magnitude difference in a key parameter quantifying the inhomogeneity at the two planets. Our results show an extreme test of a recently proposed chorus generation model and confirm the connection between the chirping rate and magnetic field inhomogeneity, opening the door to controlled plasma wave excitation in the laboratory and space.

The mutual nonlinear interactions of shear Alfvén modes and alpha particles can enhance their transport in burning plasmas. Theoretical and numerical works have shown that rapid transport of energetic ions can take place because of fast growing Alfvén modes (e.g. energetic particle driven modes, EPMs). This kind of transport has been observed in experiments as well as in numerical simulations. Hybrid MHD-gyrokinetic codes can investigate linear and nonlinear dynamics of energetic particle (EP) driven modes, retaining the mutual interaction between waves and EPs self-consistently. Self-consistent nonlinear wave-particle interactions (both in configuration and velocity space) are crucial for a correct description of the mode dynamics in the case of strongly driven modes; thus, a non-perturbative approach is mandatory. The knowledge of the threshold characterizing the transition from weakly to strongly driven regimes is of primary importance for burning plasma operations (e.g. for ITER), in order to avoid EPM enhanced EP transport regimes. The hybrid MHD-gyrokinetic code (HMGC) has been applied to the interpretation of phenomena observed in present experiments with neutral beam (NB) heating. In reversed-shear beam-heated DIII-D discharges, a large discrepancy between the expected and measured EP radial density profiles has been observed in the presence of large Alfvénic activity. HMGC simulations with EP radial profiles expected from classical NB deposition as input give rise to strong EPM activity, resulting in relaxed EP radial profiles at saturation level close to experimental measurements. The frequency spectra obtained from several simulations with different toroidal mode numbers, as calculated during the saturated phase when the strong EPMs transform in weak reversed-shear Alfvén modes, are quite close to experimental observations both in absolute frequency and in radial localization. In this work, we discuss in particular the effects of nonlinear coupling between different toroidal mode numbers. © 2009 IAEA, Vienna.

The biological mechanisms underlying the onset of major depressive disorder (MDD) have predominantly been studied in adult populations from high-income countries, despite the onset of depression typically occurring in adolescence and the majority of the world's adolescents living in low- and middle-income countries (LMIC). Taking advantage of a unique adolescent sample in an LMIC (Brazil), this study aimed to identify biological pathways characterizing the presence and increased risk of depression in adolescence, and sex-specific differences in such biological signatures. We collected blood samples from a risk-stratified cohort of 150 Brazilian adolescents (aged 14-16 years old) comprising 50 adolescents with MDD, 50 adolescents at high risk of developing MDD but without current MDD, and 50 adolescents at low risk of developing MDD and without MDD (25 females and 25 males in each group). We conducted RNA-Seq and pathway analysis on whole blood. Inflammatory-related biological pathways, such as role of hypercytokinemia/hyperchemokinemia in the pathogenesis of influenza (z-score = 3.464, p < 0.001), interferon signaling (z-score = 2.464, p < 0.001), interferon alpha/beta signaling (z-score = 3.873, p < 0.001), and complement signaling (z-score = 2, p = 0.002) were upregulated in adolescents with MDD compared with adolescents without MDD independently from their level of risk. The up-regulation of such inflammation-related pathways was observed in females but not in males. Inflammatory-related pathways involved in the production of cytokines and in interferon and complement signaling were identified as key indicators of adolescent depression, and this effect was present only in females.

This chapter reviews the progress accomplished since the redaction of the first ITER Physics Basis (1999 Nucl. Fusion 39 2137-664) in the field of energetic ion physics and its possible impact on burning plasma regimes. New schemes to create energetic ions simulating the fusion-produced alphas are introduced, accessing experimental conditions of direct relevance for burning plasmas, in terms of the Alfvénic Mach number and of the normalised pressure gradient of the energetic ions, though orbit characteristics and size cannot always match those of ITER. Based on the experimental and theoretical knowledge of the effects of the toroidal magnetic field ripple on direct fast ion losses, ferritic inserts in ITER are expected to provide a significant reduction of ripple alpha losses in reversed shear configurations. The nonlinear fast ion interaction with kink and tearing modes is qualitatively understood, but quantitative predictions are missing, particularly for the stabilisation of sawteeth by fast particles that can trigger neoclassical tearing modes. A large database on the linear stability properties of the modes interacting with energetic ions, such as the Alfvén eigenmode has been constructed. Comparisons between theoretical predictions and experimental measurements of mode structures and drive/damping rates approach a satisfactory degree of consistency, though systematic measurements and theory comparisons of damping and drive of intermediate and high mode numbers, the most relevant for ITER, still need to be performed. The nonlinear behaviour of Alfvén eigenmodes close to marginal stability is well characterized theoretically and experimentally, which gives the opportunity to extract some information on the particle phase space distribution from the measured instability spectral features. Much less data exists for strongly unstable scenarios, characterised by nonlinear dynamical processes leading to energetic ion redistribution and losses, and identified in nonlinear numerical simulations of Alfvén eigenmodes and energetic particle modes. Comparisons with theoretical and numerical analyses are needed to assess the potential implications of these regimes on burning plasma scenarios, including in the presence of a large number of modes simultaneously driven unstable by the fast ions. © 2007 IAEA, Vienna.