On Sulphonfluoresceïn and Some of Its Derivatives
By C. W. Hayes
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On Sulphonfluoresceïn and Some of Its Derivatives - C. W. Hayes
C. W. Hayes
On Sulphonfluoresceïn and Some of Its Derivatives
Published by Good Press, 2022
EAN 4064066125509
Table of Contents
Introduction.
Ortho-sulpho-benzoic acid: Methods for its preparation.
1. From toluene and H 2 SO 4 .
2. From p-nitro-toluene and H 2 SO 4 .
Oxidation of toluene-o-sodium sulphonate.
Formation of Sulphinide from toluene-o-sodium sulphonate.
Formation of Sulphinide from Toluene by means of the chlorsulphonic acid reaction.
Formation of Orthosulphobenzoic acid from Sulphinide.
Sulphonfluoresceïn.
Preparation of Sulphonfluoresceïn.
Properties of S.fluoresceïn.
Salts of sulphonfluoresceïn.
Acetyl derivative of S.fluoresceïn.
Bromine substitution products of S-fluoresceïn.
Action of H 2 SO 4 on S.fluoresceïn.
Action of HCl on S.fluoresceïn.
Reduction of S.fluoresceïn.
Conclusion.
Introduction.
Table of Contents
The close analogy in composition and structure between phthalic acid and ortho-sulpho-benzoic acid suggests the possibility of obtaining from the latter, by its action on phenols, substances analogous to the phthaleïns. If such compounds could be made they would afford a favorable opportunity of studying the effects produced in the properties of a compound by the replacement of CO by SO2. It was with a view to such study that the following discussed work was undertaken at the suggestion of Prof. Remsen and carried on under his constant guidance.
Some experiments previously performed by Remsen and Palmer (A.G.) indicated the possibility of the formation of a fluorescent substance by the action of ortho-sulpho-benzoic acid on resorcin but they did not succeed in obtaining any definite crystallized compound from the reaction.
The chief obstacle to be overcome in the work is the difficulty in obtaining the o-sulpho-benzoic acid and a large proportion of the work here described was applied in that direction.
Ortho-sulpho-benzoic acid: Methods for its preparation.
Table of Contents
1. From toluene and H2SO4.
Table of Contents
A method employed by Remsen and Fahlberg (Am. Ch. Jour. Vol. 1. p __ ) for getting the sulphonic acid group