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On Sulphonfluoresceïn and Some of Its Derivatives
On Sulphonfluoresceïn and Some of Its Derivatives
On Sulphonfluoresceïn and Some of Its Derivatives
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On Sulphonfluoresceïn and Some of Its Derivatives

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This work discusses Sulphonfluorescein and the various compounds derived from it through different chemical reactions. The chief aim of this work is to overcome the difficulty in obtaining the o-sulpho-benzoic acid. This text is a PhD thesis submitted by C. W. Hayes at Johns Hopkins University in 1887.
LanguageEnglish
PublisherGood Press
Release dateMay 19, 2021
ISBN4064066125509
On Sulphonfluoresceïn and Some of Its Derivatives

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    On Sulphonfluoresceïn and Some of Its Derivatives - C. W. Hayes

    C. W. Hayes

    On Sulphonfluoresceïn and Some of Its Derivatives

    Published by Good Press, 2022

    [email protected]

    EAN 4064066125509

    Table of Contents

    Introduction.

    Ortho-sulpho-benzoic acid: Methods for its preparation.

    1. From toluene and H 2 SO 4 .

    2. From p-nitro-toluene and H 2 SO 4 .

    Oxidation of toluene-o-sodium sulphonate.

    Formation of Sulphinide from toluene-o-sodium sulphonate.

    Formation of Sulphinide from Toluene by means of the chlorsulphonic acid reaction.

    Formation of Orthosulphobenzoic acid from Sulphinide.

    Sulphonfluoresceïn.

    Preparation of Sulphonfluoresceïn.

    Properties of S.fluoresceïn.

    Salts of sulphonfluoresceïn.

    Acetyl derivative of S.fluoresceïn.

    Bromine substitution products of S-fluoresceïn.

    Action of H 2 SO 4 on S.fluoresceïn.

    Action of HCl on S.fluoresceïn.

    Reduction of S.fluoresceïn.

    Conclusion.

    Introduction.

    Table of Contents

    The close analogy in composition and structure between phthalic acid and ortho-sulpho-benzoic acid suggests the possibility of obtaining from the latter, by its action on phenols, substances analogous to the phthaleïns. If such compounds could be made they would afford a favorable opportunity of studying the effects produced in the properties of a compound by the replacement of CO by SO2. It was with a view to such study that the following discussed work was undertaken at the suggestion of Prof. Remsen and carried on under his constant guidance.

    Some experiments previously performed by Remsen and Palmer (A.G.) indicated the possibility of the formation of a fluorescent substance by the action of ortho-sulpho-benzoic acid on resorcin but they did not succeed in obtaining any definite crystallized compound from the reaction.

    The chief obstacle to be overcome in the work is the difficulty in obtaining the o-sulpho-benzoic acid and a large proportion of the work here described was applied in that direction.

    Ortho-sulpho-benzoic acid: Methods for its preparation.

    Table of Contents

    1. From toluene and H2SO4.

    Table of Contents

    A method employed by Remsen and Fahlberg (Am. Ch. Jour. Vol. 1. p __ ) for getting the sulphonic acid group

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