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    Atlas of Diagnostically Challenging Melanocytic Neoplasms
    Atlas of Diagnostically Challenging Melanocytic Neoplasms
    Atlas of Diagnostically Challenging Melanocytic Neoplasms
    Ebook235 pages1 hour

    Atlas of Diagnostically Challenging Melanocytic Neoplasms

    By Caterina Longo, Giuseppe Argenziano, Aimilios Lallas and

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    This atlas provides a clear, concise overview of the most challenging circumstances faced by clinicians and pathologists when dealing with melanocytic neoplasms. The book is structured as a case series; for each case, the clinical and dermoscopic appearances are presented, accompanied by a brief but comprehensive description and compelling histopathologic images. When available, in vivo confocal microscopy images are also included to highlight additional diagnostic clues. Identification of key messages and selected references will further guide the reader in the diagnosis and management of the neoplasm under consideration.

    It is well known that melanocytic lesions can be difficult to interpret. Some lesions show an ambiguous combination of morphologic criteria, and in these cases interpretation entails a high degree of subjectivity that results in low interobserver agreement even among expert pathologists. This atlas demonstrates how the addition of clinical information, including that provided by dermoscopy, can assist in reaching a more confident diagnosis.

    LanguageEnglish
    PublisherSpringer
    Release dateDec 18, 2017
    ISBN9783319486536
    Atlas of Diagnostically Challenging Melanocytic Neoplasms
    Author

    Caterina Longo

    Caterina Longo is Associate Professor at the University of Modena and Reggio Emilia, Italy. Although providing the best care possible for patients remains her primary goal, she also committed to education and clinical research. She is actively involved in clinical research and she has published numerous papers on topics related to skin cancer with an emphasis on melanoma, atypical nevi, Spitz/Reed nevi and non-melanoma skin cancer. Her research interests are focused on the use of imaging instruments such as dermoscopy, and confocal laser microscopy to recognize skin cancer early in its development. She pioneered the use of ex vivo fluorescence confocal microscopy for micrographic Mohs surgery applied for basal cell carcinoma and other visceral tumors. She frequently lectures on these topics both nationally and internationally being the second Author publishing on this topic (source Scopus, December 2016) for a total of 250 papers (H-Index 28; citations 2702).

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      Book preview

      Atlas of Diagnostically Challenging Melanocytic Neoplasms - Caterina Longo

      © Springer International Publishing AG 2018

      Caterina Longo, Giuseppe Argenziano, Aimilios Lallas, Elvira Moscarella and Simonetta PianaAtlas of Diagnostically Challenging Melanocytic Neoplasmshttps://doi.org/10.1007/978-3-319-48653-6_1

      1. Flat Solitary Pigmented Lesions in the Elderly

      Caterina Longo¹ , Giuseppe Argenziano², Aimilios Lallas³, Elvira Moscarella⁴ and Simonetta Piana⁵

      (1)

      Dermatology and Skin Cancer Unit, Arcispedale Santa Maria Nuova-IRCCS, Department of Dermatology, University of Modena and Reggio Emilia, Reggio Emilia, Italy

      (2)

      Dermatology Unit, University of Campania, Naples, Italy

      (3)

      First Department of Dermatology, Aristotle University, Thessaloniki, Greece

      (4)

      Dermatology and Skin Cancer Unit, Arcispedale Santa Maria Nuova-IRCCS, Reggio Emilia, Italy

      (5)

      Pathology Unit, Arcispedale Santa Maria Nuova-IRCCS, Reggio Emilia, Italy

      The sentence we are born and we will die without nevi summarizes one of the key components of the diagnosis of atypical lesions in the elderly. Epidemiologic data demonstrate that the nevus count and prevailing nevus patterns are strongly influenced by age. Notably, nevus count increases from childhood to midlife and decreases thereafter. In light of these findings, if evolving nevi in adolescence are an expected finding and therefore do not require further interventions, a melanocytic skin lesion showing signs of growth in the elderly should raise the index for malignancy. Furthermore, any flat acquired melanocytic lesion in this age should be considered with caution since the majority of lesions in the elderly are persistent intradermal nevi (congenital type). Firstly termed as atypical lentiginous junctional melanocytic proliferations, indeed they are regarded nowadays as melanomas.

      Clinically, these atypical lentiginous junctional melanocytic proliferations of the elderly are commonly located on the upper back, shoulders, or extremities. They are solitary, often large (>8 mm), ill-defined macules with different shades of black, brown, and gray. Dermoscopically, these lesions are typified by a more or less atypical pigmented network, diffuse structureless brown pigmentation, and areas of regression. Studies employing digital dermoscopic follow-up suggest that these melanomas belong to a group of slow-growing tumors, which may grow in situ for several years. Their histologic diagnosis can be very difficult as they are cytologically bland and show scant epidermotropism and very little atypia. In the early phases, only a numerical increase of the melanocytes, scattered along the basal epidermis, can be noted. The alternation of single cells and irregular nests, with skip areas, usually within a sun-damaged skin, is an important histological clue for a diagnosis of early in situ melanoma.

      What is a common finding in this age group is the presence of several benign non-melanocytic skin lesions such as seborrheic keratosis, angiomas, or solar lentigos. Thus, the clues to identify flat melanomas are the following: solitary flat pigmented lesions, large size, with network and regression on dermoscopy. Conversely, the presence of rough surface, comedo-like openings, fingerprinting, and red lacunae should be regarded as benign clues. However, the recognition of incipient melanomas should always be based on clinical data, patient’s phenotype, and history.

      This section depicts the clinical and dermoscopic features of common and problematic melanocytic tumors in the elderly while trying to provide clues and rules for the correct diagnosis.

      Case 1

      Patient: Female, 62 years old

      Anatomic site of the lesion: Right leg

      History of the lesion: Acquired lesion, present since a few years

      Management: Although the dermoscopic aspect revealed the presence of few criteria for melanoma diagnosis, the lesion was excised to rule out melanoma diagnosis since it was a larger and darker lesion in the context of the patient’s other nevi.

      First histopathologic diagnosis: Junctional nevus

      Second histopathologic diagnosis after clinicopathologic consultation: Junctional nevus versus early melanoma in situ. The latter hypothesis seemed the most likely.

      Key message: Slow-growing melanomas can show very bland cytological features. The correlation among clinical data (in this case, patient’s age), dermoscopic characteristics, and histological features is mandatory.

      ../images/340418_1_En_1_Chapter/340418_1_En_1_Fig1_HTML.gif

      Fig. 1.1

      Flat pigmented lesion in the context of a patient with multiple small-sized moles

      ../images/340418_1_En_1_Chapter/340418_1_En_1_Fig2_HTML.gif

      Fig. 1.2

      Flat pigmented macule and darker compared to the surrounding lesions with irregular borders

      ../images/340418_1_En_1_Chapter/340418_1_En_1_Fig3_HTML.gif

      Fig. 1.3

      Dermoscopically the lesion was typified by the presence of atypical pigmented network, with the presence of wider skin markings

      ../images/340418_1_En_1_Chapter/340418_1_En_1_Fig4_HTML.gif

      Fig. 1.4

      On histology, the lesion was a very bland junctional melanocytic proliferation, mainly arranged in single cells or forming little nests. Neither marked cellular atypia nor epidermotropism was present

      ../images/340418_1_En_1_Chapter/340418_1_En_1_Fig5_HTML.gif

      Fig. 1.5

      The melanocytic proliferation was limited to the basal epidermal layer but it was continuous

      Case 2

      Patient: Male, 67 years old

      Anatomic site of the lesion: Upper back

      History of the lesion: Appeared several years earlier

      Management: The dermoscopic findings were interpreted as suggestive of regression, and, therefore, the lesion was excised to rule out melanoma.

      First histopathologic diagnosis: Junctional nevus

      Second histopathologic diagnosis after clinicopathologic consultation: Early in situ melanoma

      Key message: The well-known melanoma-specific dermoscopic criteria were investigated mainly in the context of invasive melanoma. Melanoma in situ usually does not display fully developed melanoma-specific criteria, but is characterized by only subtle dermoscopic features. The most frequent dermoscopic criteria of melanoma in situ are atypical network and regression. Consequently, a lesion displaying the latter features should be excised, especially in elderly patients in which reticular nevi are rarely seen.

      ../images/340418_1_En_1_Chapter/340418_1_En_1_Fig6_HTML.gif

      Fig. 1.6

      A flat pigmented lesion on the upper back, characterized by light-brown color, relatively irregular border, and a maximum diameter of 6 mm

      ../images/340418_1_En_1_Chapter/340418_1_En_1_Fig7_HTML.gif

      Fig. 1.7

      Dermoscopically, the lesion displayed a reticular pattern. However, the network was not distributed symmetrically all over the surface of the lesion, a large part of which was hypopigmented. A few white lines and gray dots were also present

      ../images/340418_1_En_1_Chapter/340418_1_En_1_Fig8_HTML.gif

      Fig. 1.8

      Histologically, the lesion was constituted by a basally located, continuous proliferation of melanocytes. The epidermis was hyperplastic with fusion of the rete ridges

      ../images/340418_1_En_1_Chapter/340418_1_En_1_Fig9_HTML.gif

      Figs. 1.9 and 1.10

      The overall appearance was of a dysplastic nevus. Some hyperchromatic atypical melanocytes were seen in the

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