In some episodes, stock footage of Bo & Luke driving in the General Lee was used. Sometimes they would use the wrong footage and show Bo driving the General, when Luke was behind the drivers seat. It would then switch back to Luke driving.
In several episodes, during pursuit scenes, footage would show makes and models of the Sheriff's Department cars that would differ from cut to cut, and be different than the ones shown driven by Rosco, Enos and Cletus at that time.
Throughout the series, Hugie Hogg (Jeff Altman) always appeared with a duo of henchmen. Even though played by the same actors in every appearance, they constantly switched names. Actor Roger Torrey's character had the names Wayne and Norris, while actor Pat Studstill's character switched names between Floyd and Barclay.
Throughout the show, Jesse has a shotgun in the house, and he is occasionally seen using it. However, a gun is not allowed in a house that has a convicted felon in it.
In one episode, Roscoe steals the General Lee and is forced to make his first jump over someone's camping trailer, but ends up clipping it with the rear wheels of the General and destroying the trailer. The inside of the trailer is visible in the destruction and is clearly shown to be an empty prop trailer.
Oftentimes, in several episodes, interior shots of Uncle Jesse's truck, while being driven, show the gearshift lever to be in the "park" position no matter who's driving it.
Despite being lifelong residents of Hazzard County, Georgia, neither Bo, nor Luke Duke, could consistently speak with a Southern accent, much less a Georgian one. This becomes even more apparent after John Schneider and Tom Wopat return from their Season 5 salary holdout.
Crashing into a hay stack often stops a criminal's speeding car and causes them to surrender.
Very few, if any, vehicles have rear view mirrors.
Strangers often know to climb in through the windows of General Lee without being told or seeing the Dukes climb in.
It is clear from the plant life and the terrain that the series is set, but not filmed, in the state of Georgia. This becomes even more apparent in later seasons when the budget is reduced and the number of exterior shots show vegetation that doesn't grow in the southern US at all.
In the early episodes Uncle Jesse refers to Boss Hogg as "Mr. Hogg" instead of calling him "J.D." As the series progresses it's revealed that Uncle Jesse and Boss Hogg are enemies/friends but still have great respect for each other. However early in the series they hardly know each other as Rosco was the main antagonist against the Dukes. His character was later changed to more of a bumbling buffoon as James Best didn't want children to think of police officers as corrupt.
A main plot point of the series was Bo and Luke's probation, which restricted them from legally leaving Hazzard County. However, when actors Tom Wopat and John Schneider walked off set over salary disputes at the start of Season 5, the characters of Bo and Luke were temporally written off the show and replaced by look-alike cousins Coy Duke (Byron Cherry) and Vance Duke (Christopher Mayer). This move was explained by informing viewers that Bo and Luke had left Hazzard County to race as professional NASCAR drivers. But how could Bo and Luke travel around the country if they were still on probation?
The story-line is also often how Sheriff Little of neighboring Chickasaw County would never allow the Duke boys into his county. That may be the case, but often he is shown standing all alone at the county line on one road waiting for the Dukes to try to cross, which would be an unlikely thing for a Sheriff to do, considering there is only one actual "sheriff" in a county, and especially when it is very unlikely there is only one road in or out of a county, even rural Southern counties like Hazzard and Chickasaw. If Sheriff Little was really that obsessed with blocking the Dukes from coming into his county, he would likely assign deputies to man every road coming in and out of Chickasaw and they would report back to him.
Sherriff Coltrane's first name, in written or printed form, appears variously as either Rosco (the correct spelling) or Roscoe, throughout the series. This may be a deliberate portrayal of the supposed general illiteracy of "Deep Southern" people.