Everything, usually with hilarious results. In this series, a take off of Jack Kerouac's On The Road, 'nice normal' Gary gets hooked up with Mike 'the friend from hell' on a cross country odyssey to find themselves. Mike talks Gary into abandoning the traditional roadtrip following Lewis and Clark's expedition in favor of a new trip, while Mike himself is just trying to escape the father of a girl he 'made friends' with on the morning of her wedding to another boy. With a start like this, it's no surprise that they usually find trouble rather than enlightenment, especially since Officer Dick (the girl's father) is following along to claim a large portion of Mike's hide.
On the way they meet everything from pyromaniac hippies to Klingon speaking hookers to Mole People to Mike's brother. Each story seems crazier than the last with no end in sight. Gary wants to lose his virginity to 'the right woman' while Mike is willing to take whoever's next, ideally 'fixing' Gary's condition at the same time. They go on television, jump from planes, run from Rabbis, and eat food stored in their glove box. And they never ever look back to home.
