Goofs

When Gru is laying down the rules for the girls after being adopted, the clock on the stove goes from 12:10 to 12:11 and back to 12:10 again.

During the roller coaster scene, the cart which Gru rides in has a safety bar before he gets on, but it's missing when he gets off.

When Phil the Minion is drinking the soda in the Supermarket, he shakes the bottle making liquid fly out the top, but it never comes back down.

When the pyramid is falling down, the tourists that were standing in front of it disappear.

During the slo-mo scene of the ping pong ball leaving Agnes' gun, Edith's gun is still shooting and recoiling, but no balls are leaving the gun.

When the Times Square JumboTron is scrolling its message, the lettering appears damaged as it scrolls and maintains the same damaged/inconsistent state throughout the screen width. As a JumboTron is composed of stationary lights, a burnt bulb will cause the characters to be whole/correct as they clear the burnt area. The damage should be stationary and not scroll with the letter.

When Gru arrives at the moon he stops near it and then exits his spacecraft. In reality he would have to enter orbit around the moon otherwise the gravity of the Moon would cause Gru to accelerate towards it.

When Vector is seen on the moon he is visibly wearing a helmet presumably to provide oxygen. However, in the vacuum of space he would also need a pressure suit to prevent his blood from boiling and lungs exploding.

When Gru is returning to Earth from the Moon he is seen accelerating towards the Earth. If this were to happen he would skip right off Earth's atmosphere. In fact he should be slowing down to return to Earth.

Gru is shown arriving at the moon in only a few minutes time after taking off, and again taking only a few minutes to return to earth. In reality it takes about 3-4 days to reach the moon.

When Gru is reading the story about the Three Little Kitties, he turns the pages while keeping his fingers inside of the puppets. This would be impossible because of the way the holes in the other pages line up with his fingers as he turns them.

When the minions form a chain to save Gru and Margo from falling, they obviously wouldn't have fallen fast enough to reach them in time given their lower mass.

Gru states that he believes Saturday, May 26, is a bad day to steal the moon, but if the movie took place in the year it was released, which is 2010, May 26 is a Wednesday. Otherwise, it means the movie took place in 2007, or possibly the futures of 2012 or 2018.

When Gru grabs Edith while trying to get the girls to sleep, Agnes is shown hopping on her bed while she laughs out loud, the sound of her laughter continues to play briefly even after she stops laughing.

The lab where the shrink-ray is being tested takes place in East Asia. However, the elephant they are testing it on is an African elephant.

There are boys seen living in Miss Hattie's Home For Girls.

It is never explained how Vector knew about the girls' dance recital.

When Mr. Perkins of the Evil Bank shows Victor Perkins (Vector) the screen capture from his video conference with Gru, the shot that he displays never happened. It displays the Shrink Ray and all three girls at the bottom of the image with Gru. During the actual scene, the only person in the screen with the Shrink Ray present is Gru. Additionally Edith is the only daughter whom we ever see come into view on Mr. Perkins' screen.

When Gru observes the girls for the first time, the Cookie Order Form says "All Cookies $6", and the prices for the first three to four orders noted sum up accordingly. (e. g. "Christina" orders 2+3+10=15 cookies and will be billed $90)

When the girls deliver Vectors cookies, who boasts having ordered the most (in fact 4+2+2+15=23) boxes of cookies, Margo sums them up to only $52 instead of the expected $138.

After Vector steals the Shrink Ray from Gru while the two are flying in their aircraft, Gru launches approximately 42 missiles (presumably heat seeking) straight at Vector's aircraft, knowing that the Shrink Ray is on board. Had any of the missiles actually hit Vector's aircraft, it would've also destroyed the Shrink Ray.