Game takes place in its own universe separated from the MCU and the Marvel Comics timeline. That said, Marvel did release several #1 comic books for five of the game's main characters under the Marvel GamerVerse label which do cross over with the game's story. The comics are meant to be a prequel to the game and tell the backstory of each Avenger before the events of A-Day.
This game will have an ever growing story and gameplay including super heroes and regions.
Game was released with six playable characters. However, new playable Avengers will be added over time with new storylines for free. The first new hero revealed for the game's post-release was Hawkeye, both Clint Barton and Kate Bishop. Afterwards was Black Panther and Spider-Man, with more to follow.
Laura Bailey (Black Widow) and Travis Willingham (Thor) are married in real life.
Following the release of the game on PS5 and Xbox Series X/S Black Panther was announced as the third post-release playable hero, with Spider-Man scheduled to follow.