530-62-1Relevant articles and documents
CARBONATE DERIVATIVE PRODUCTION METHOD
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Paragraph 0174-0175, (2020/04/09)
The objective of the present invention is to provide a method for producing a carbonate derivative in a safe and efficient manner. The method for producing a carbonate derivative according to the present invention is characterized in comprising irradiating light on a composition containing a C1-4 halogenated hydrocarbon having one or more kinds of halogen atoms selected from the group consisting of a chlorine atom, a bromine atom and an iodine atom, a nucleophilic functional group-containing compound and the specific base in the presence of oxygen.
Preparation method of carbonyl diimidazole
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Paragraph 0015; 0017; 0019; 0021; 0023; 0025; 0027-0032, (2019/02/03)
The invention discloses a preparation method of carbonyl diimidazole in the technical field of carbonyl diimidazole synthesis. The preparation method comprises the steps of taking imidazole and hexamethyl disilazane as starting materials, obtaining N-trimethylsilyl imidazole through condensation, absorbing a single byproduct, namely ammonia through a sodium hydroxide solution, allowing N-trimethylsilyl imidazole to react with triphosgene to prepare carbonyl diimidazole, and filtering the principal product, namely carbonyl diimidazole, from liquid trimethylchlorosilane for vacuum drying. A removal step is simpler; the byproduct is gaseous and does not influence purity of the product, namely N-trimethylsilyl imidazole; a reactor with higher purity is provided for a subsequent reaction; in areaction process of N-trimethylsilyl imidazole and triphosgene, no catalyst is required to be added; the method is simple to operate; a byproduct of the reaction of N-trimethylsilyl imidazole and triphosgene is liquid trimethylchlorosilane; and carbonyl diimidazole prepared by the method is higher in purity and good in quality.
Green synthesis of 1,1-Carbonyldiimidazole using copper oxide nanofiber as a heterogeneous catalyst
Sukumar, Thenmozhi,Nallasamy, Dharmaraj
, p. 234 - 241 (2017/12/12)
Poly(vinyl pyrrolidone) (PVP)/copper oxide composite nanofibers were prepared by electrospinning technique using PVP and copper acetate as precursors and calcinated at high temperature to yield polymer free, phase pure copper oxide nanofibers (CuO NFs). T
Ionic liquids/ZnO nanoparticles as recyclable catalyst for polycarbonate depolymerization
Iannone, Francesco,Casiello, Michele,Monopoli, Antonio,Cotugno, Pietro,Sportelli, Maria Chiara,Picca, Rosaria Anna,Cioffi, Nicola,Dell'Anna, Maria M.,Nacci, Angelo
, p. 107 - 116 (2016/12/09)
A useful protocol for waste bis-phenol A-polycarbonates (BPA-PC) chemical recycling is proposed based on a bifunctional acid/basic catalyst composed by nanostructured zinc oxide and tetrabutylammonium chloride (ZnO-NPs/NBu4Cl) in quality of Lewis acid and base, respectively. Retro-polymerization reaction proved to be of general application for several nucleophiles, including water, alcohols, amines, polyols, aminols and polyamines, leading to the complete recovery of BPA monomer and enabling the PC polymer to function as a green carbonylating agent (green phosgene alternative) for preparing carbonates, urethanes and ureas. A complete depolymerization can be obtained in seven hours at 100 °C and ZnO nanocatalyst can be recycled several times without sensible loss of activity. Remarkably, when polycarbonate is reacted with glycerol, it is possible to realize in a single process the conversion of two industrial wastes (BPA-PC and glycerol) into two valuable chemicals like BPA monomer and glycerol carbonate (the latter being a useful industrial solvent and fuel additive).
THE LITTLE MOLECULE COMPOUND WHICH USED FOR PROMOTING THE STEM CELLS HYPERPLASIA AND THE USE THEREOF
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Page/Page column 9, (2012/03/12)
The invention provides small molecule compounds capable of accelerating proliferation of stem cells and uses thereof. The compounds play an important role in the research of stem cell proliferation mechanism. The invention further relates to the uses of the compounds and relevant compounds thereof in the preparation of stem cell proliferation accelerators and the preparation of medicines accelerating stem cell proliferation. The invention also relates to the uses of the compounds in the preparation of medicines for the treatment of various diseases arising from functional cells loss or damage. The diseases arising from stem cell trauma comprise diseases related to the degeneration or damage of nervous system cells, blood system diseases, diseases related to the loss or damage of cardiovascular cells, skin burn and the like.
Copolymerization of ethylene with 1-hexene promoted by novel multi-chelated non-metallocene complexes with imine bridged imidazole ligand
Ma, Lifu,Wang, Hongli,Yi, Jianjun,Huang, Qigu,Gao, Kejing,Yang, Wantai
experimental part, p. 417 - 424 (2010/11/04)
A series of novel bridged multi-chelated non-metallocene catalysts is synthesized by the treatment of N,N-imidazole, N,N-dimethylimidazole, and N,N-benzimidazole with n- BuLi, 2,6-dimethylaniline, and MCl4 (M = Ti, Zr) in THF. These catalysts are used for copolymerization of ethylene with 1-hexene after activated by methylaluminoxane (MAO). The effects of polymerization temperature, Al/M molar ratio, and pressure of monomer on ethylene copolymerization behaviors are investigated in detail. These results reveal that these catalysts are favorable for copolymerization of ethylene with 1-hexene featured high catalytic activity and high comonomer incorporation. The copolymer is characterized by 13C NMR, WAXD, GPC, and DSC. The results confirm that the obtained copolymer features broad molecular weight distribution (MWD) about 33-35 and high 1-hexene incorporation up to 9.2 mol %, melting temperature of the copolymer depends on the content of 1-hexene incorporation within the copolymer chain and 1-hexene unit in the copolymer chain isolates by ethylene units. The homopolymer of ethylene has broader MWD with 42-46.
IMPLANT COMPRISING A SURFACE OF REDUCED THROMBOGENICITY
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, (2009/12/02)
An implant for a human or animal body, comprising a surface having reduced thrombogenic properties, whose surface has a wetting angle of Θ, where Θ≦80°. Also disclosed is a method for producing an implant and the use an implant to reduce the dose or concentration in administration of a concomitant systemic medication with one or more anticoagulant active ingredients before, during or after implantation of the implant in a human or animal body.
PROCESS FOR PRODUCING N,N'-CARBONYLDIIMIDAZOLE
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Page/Page column 5, (2008/06/13)
The present invention provides a process for producing N,N'-carbonyldiimidazole, comprising: reacting phosgene, diphosgene, or triphosgene with imidazole in an inert solvent to produce N,N'-carbonyldiimidazole; to imidazole hydrochloride yielded as a by-product in the above step, adding a gaseous or liquid basic compound represented by the below-shown general formula (1) in an inert solvent to conduct neutralization reaction; and circulating the imidazole thus generated to use it as a starting material for N,N'-carbonyldiimidazole production. In the general formula (1), R 1 , R 2 , and R 3 each independently represents a hydrogen atom, a methyl group, or an ethyl group. The CDI produced by the production process of the invention is a compound useful in the fields of synthesis of pharmaceutical agents, synthesis of agricultural chemicals, peptide synthesis, and the like, e.g., intermolecular condensation reactions, intramolecular condensation reactions for synthesizing N-carboxylic anhydrides, production of activated esters, and the like. The compound is especially suitable for use in applications where colorlessness is required.
METHOD FOR THE PRODUCTION OF N,N -CARBONYLDIAZOLES
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Page/Page column 8-9, (2008/06/13)
Disclosed is a method for producing N,N'-carbonyldiazoles by reacting azoles with phosgene in polar solvents from the group comprising ethers, ketones, and chlorinated aliphatic solvents. According to the inventive method, the azole and the phosgene are dosed such that 0.17 to 0.37 mole of phosgene are dosed during the time one mole of azole is dosed.
Process for the preparation of N,N'-Carbonyldiazoles
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Page/Page column 6, (2008/06/13)
Preparation of N,N'-carbonyldiazole compounds (I) comprises reacting azole compounds (II) with phosgene, where a halogenated aliphatic solvent (chlorinated, brominated or mixed chlorinated/brominated aliphatic hydrocarbon) is used and total quantity of (II) is added, followed by the addition of phosgene. Preparation of N,N'-carbonyldiazole compounds of formula (I) comprises reacting azole compounds of formula (II) with phosgene, where a halogenated aliphatic solvent (chlorinated, brominated or mixed chlorinated/brominated aliphatic hydrocarbon) is used and total quantity of (II) is added, followed by the addition of phosgene. R 1>H or 1-6C alkyl; either R 2>H; and X 1>-X 3>CR 1>or N; or X 3>+R 2>forms -CH=CH-CH=CH- bridge; X 1>CR 1>; and (MK#5) X 2>= CR 1>or N. [Image].
