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Molecular Research on Cardiac Regenerative Medicine

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".

Deadline for manuscript submissions: 20 November 2024 | Viewed by 1836

Special Issue Editor


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Guest Editor
Department of Cardiovascular Physiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama 700-8558, Japan
Interests: cardiovascular regenerative medicine; ischemia-reperfusion injury; space medicine/biology

Special Issue Information

Dear Colleagues,

Heart failure poses a significant threat to human health. However, with the advancement of cell culture technologies, such as human induced pluripotent stem cells (hiPSCs) and 3D bioprinting, the field of cardiac regenerative medicine is thriving. For this Special Issue, we are inviting a wide range of molecular scientific research papers and review articles related to cardiac regenerative medicine. While we anticipate contributions in areas such as cell biology, stem cells, biotechnology, extracellular matrix, mechanobiology, bioprinting, tissue transplantation, etc., we are not limiting invited works to these fields. We look forward to receiving research findings that significantly contribute to the advancement of cardiac regenerative medicine.

Dr. Ken Takahashi
Guest Editor

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Keywords

  • heart failure
  • human induced pluripotent stem cells
  • hiPSCs
  • 3D bioprinting
  • regenerative medicine
  • tissue engineering

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Published Papers (1 paper)

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Research

17 pages, 14797 KiB  
Article
Serum Induces the Subunit-Specific Activation of NF-κB in Proliferating Human Cardiac Stem Cells
by Kazuko E. Schmidt, Anna L. Höving, Katja Nowak, Nike an Mey, Sina Kiani Zahrani, Britta Nemeita, Lena Riedel, Agnes Majewski, Barbara Kaltschmidt, Cornelius Knabbe and Christian Kaltschmidt
Int. J. Mol. Sci. 2024, 25(7), 3593; https://doi.org/10.3390/ijms25073593 - 22 Mar 2024
Viewed by 1441
Abstract
Cardiovascular diseases (CVDs) are often linked to ageing and are the major cause of death worldwide. The declined proliferation of adult stem cells in the heart often impedes its regenerative potential. Thus, an investigation of the proliferative potential of adult human cardiac stem [...] Read more.
Cardiovascular diseases (CVDs) are often linked to ageing and are the major cause of death worldwide. The declined proliferation of adult stem cells in the heart often impedes its regenerative potential. Thus, an investigation of the proliferative potential of adult human cardiac stem cells (hCSCs) might be of great interest for improving cell-based treatments of cardiovascular diseases. The application of human blood serum was already shown to enhance hCSC proliferation and reduce senescence. Here, the underlying signalling pathways of serum-mediated hCSC proliferation were studied. We are the first to demonstrate the involvement of the transcription factor NF-κB in the serum-mediated proliferative response of hCSCs by utilizing the NF-κB inhibitor pyrrolidine dithiocarbamate (PDTC). RNA-Sequencing (RNA-Seq) revealed ATF6B, COX5B, and TNFRSF14 as potential targets of NF-κB that are involved in serum-induced hCSC proliferation. Full article
(This article belongs to the Special Issue Molecular Research on Cardiac Regenerative Medicine)
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