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New Progress in Extracellular Vesicles
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New Progress in Extracellular Vesicles

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".

Deadline for manuscript submissions: 20 March 2025 | Viewed by 2478

Special Issue Editor

Dr. Jorge Sanz-Ros

E-Mail Website
Guest Editor
1. Freshage Research Group, Department of Physiology, Faculty of Medicine, University of Valencia, 46010 Valencia, Spain
2. Centro de Investigación Biomédica en Red Fragilidad y Envejecimiento Saludable-Instituto de Salud Carlos III (CIBERFES-ISCIII), INCLIVA, 28029 Madrid, Spain
3. Department of Cardiology, Hospital Universitari i Politècnic La Fe, 46026 Valencia, Spain
Interests: aging; intercellular communication; extracellular vesicles; stem cells; regenerative medicine

Special Issue Information

Dear Colleagues,

The aim of the Special Issue "New Progress in Extracellular Vesicles" is to provide an up-to-date overview of the latest advances in the field of extracellular vesicles (EVs). EVs are small, membrane-bound structures that are released by cells and carry a wide range of biological molecules, including proteins, lipids and nucleic acids. In recent years, there has been a growing interest in understanding the roles of EVs in several biological processes, such as intercellular communication, immunity, or specific diseases such as cancer.

This Special Issue will cover a broad range of topics related to EV research, including the isolation and characterization of EVs, the mechanisms of EV biogenesis and uptake, and the functional roles of EVs in disease pathogenesis and therapeutic applications, with a focus on regenerative medicine. Articles that highlight new techniques and technologies for studying EVs, such as single-particle analysis and high-throughput sequencing, are also welcome.

Overall, the Special Issue provides a comprehensive and timely overview of the rapidly evolving field of EV research and will be of interest to researchers from different fields, including cell biology, immunology, oncology and drug discovery.

Dr. Jorge Sanz-Ros
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • extracellular vesicles
  • intercellular communication
  • biogenesis
  • uptake
  • disease pathogenesis
  • regenerative medicine
  • immunology
  • single-particle analysis

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Published Papers (2 papers)

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23 pages, 5513 KiB  
Article
Exosomal Preconditioning of Human iPSC-Derived Cardiomyocytes Beneficially Alters Cardiac Electrophysiology and Micro RNA Expression
by Øystein Røsand, Jianxiang Wang, Nathan Scrimgeour, Gurdeep Marwarha and Morten Andre Høydal
Int. J. Mol. Sci. 2024, 25(15), 8460; https://doi.org/10.3390/ijms25158460 - 2 Aug 2024
Viewed by 1158
Abstract
Experimental evidence, both in vitro and in vivo, has indicated cardioprotective effects of extracellular vesicles (EVs) derived from various cell types, including induced pluripotent stem cell-derived cardiomyocytes. The biological effects of EV secretion, particularly in the context of ischemia and cardiac electrophysiology, remain [...] Read more.
Experimental evidence, both in vitro and in vivo, has indicated cardioprotective effects of extracellular vesicles (EVs) derived from various cell types, including induced pluripotent stem cell-derived cardiomyocytes. The biological effects of EV secretion, particularly in the context of ischemia and cardiac electrophysiology, remain to be fully explored. Therefore, the goal of this study was to unveil the effects of exosome (EXO)-mediated cell–cell signaling during hypoxia by employing a simulated preconditioning approach on human-induced pluripotent stem cell-derived cardiomyocytes (hIPSC-CMs). Electrophysiological activity of hIPSC-CMs was measured using a multielectrode array (MEA) system. A total of 16 h of hypoxic stress drastically increased the beat period. Moreover, hIPSC-CMs preconditioned with EXOs displayed significantly longer beat periods compared with non-treated cells after 16 h of hypoxia (+15.7%, p < 0.05). Furthermore, preconditioning with hypoxic EXOs resulted in faster excitation–contraction (EC) coupling compared with non-treated hIPSC-CMs after 16 h of hypoxia (−25.3%, p < 0.05). Additionally, microRNA (miR) sequencing and gene target prediction analysis of the non-treated and pre-conditioned hIPSC-CMs identified 10 differentially regulated miRs and 44 gene targets. These results shed light on the intricate involvement of miRs, emphasizing gene targets associated with cell survival, contraction, apoptosis, reactive oxygen species (ROS) regulation, and ion channel modulation. Overall, this study demonstrates that EXOs secreted by hIPSC-CM during hypoxia beneficially alter electrophysiological properties in recipient cells exposed to hypoxic stress, which could play a crucial role in the development of targeted interventions to improve outcomes in ischemic heart conditions. Full article
(This article belongs to the Special Issue New Progress in Extracellular Vesicles)
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19 pages, 5547 KiB  
Article
Small and Large Extracellular Vesicles of Porcine Seminal Plasma Differ in Lipid Profile
by Pablo Martínez-Díaz, Ana Parra, Christian M. Sanchez-López, Josefina Casas, Xiomara Lucas, Antonio Marcilla, Jordi Roca and Isabel Barranco
Int. J. Mol. Sci. 2024, 25(13), 7492; https://doi.org/10.3390/ijms25137492 - 8 Jul 2024
Viewed by 883
Abstract
Seminal plasma contains a heterogeneous population of extracellular vesicles (sEVs) that remains poorly characterized. This study aimed to characterize the lipidomic profile of two subsets of differently sized sEVs, small (S-) and large (L-), isolated from porcine seminal plasma by size-exclusion chromatography and [...] Read more.
Seminal plasma contains a heterogeneous population of extracellular vesicles (sEVs) that remains poorly characterized. This study aimed to characterize the lipidomic profile of two subsets of differently sized sEVs, small (S-) and large (L-), isolated from porcine seminal plasma by size-exclusion chromatography and characterized by an orthogonal approach. High-performance liquid chromatography–high-resolution mass spectrometry was used for lipidomic analysis. A total of 157 lipid species from 14 lipid classes of 4 major categories (sphingolipids, glycerophospholipids, glycerolipids, and sterols) were identified. Qualitative differences were limited to two cholesteryl ester species present only in S-sEVs. L-sEVs had higher levels of all quantified lipid classes due to their larger membrane surface area. The distribution pattern was different, especially for sphingomyelins (more in S-sEVs) and ceramides (more in L-sEVs). In conclusion, this study reveals differences in the lipidomic profile of two subsets of porcine sEVs, suggesting that they differ in biogenesis and functionality. Full article
(This article belongs to the Special Issue New Progress in Extracellular Vesicles)
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