Search Results (11,614)

Background/Objectives: Vaccination of pregnant and postpartum women for pertussis, influenza and COVID-19 not only protects themselves but also offspring. Despite the benefits of this approach, vaccination uptake remains suboptimal in pregnancy. Where the opportunity to be vaccinated in pregnancy is missed, the offer of vaccination in the post-partum period may be an alternative strategy. The aim of this systematic review is to assess the impact of interventions to increase vaccination uptake in the postpartum period on vaccination uptake. Methods: A literature search was performed in MEDLINE, including interventional studies promoting vaccination uptake in postpartum women published between 2009 and 2024. The search was conducted according to PRISMA guidelines and registered with PROSPERO. Results: We finally included 16 studies in the review, and the primary outcome was vaccination uptake in the postpartum period. The most significant factors for increasing uptake were recommendation from healthcare providers, type of interventions used, and delivery of vaccines in the maternity wards or the community. Conclusions: In conclusion, maternal vaccination rates in the postpartum period may increase with targeted education by healthcare professionals and positive reinforcement. The interventions described in these studies could be applied in the healthcare systems worldwide. Full article

Sustainable digital transformation in SMEs not only simplifies operations and increases efficiency but also fosters innovation, facilitates data-driven decision-making, and minimizes negative environmental and social impacts, paving the way for a sustainable competitive advantage in the digital age. However, SMEs still face significant barriers to implementing this transformation. In addition to limited financial resources, a critical obstacle is the lack of specific and comprehensible roadmaps. Thus, this paper aims to analyze existing roadmaps for sustainable digital transformation in SMEs. A systematic literature review was conducted using the PRISMA and Methodi Ordinatio methods, with data collection and analysis performed using the NVivo 12 and VOSviewer software (version 1.6.20). Content analysis was used to assess how these papers align with the study’s context. The analysis identified whether the roadmaps address aspects related to the triple bottom line (TBL), their specificity to SMEs, the principles of digital transformation they incorporate, and the aspect of digital maturity. The findings indicate that none of the current literature provides a fully developed roadmap for sustainable digital transformation in SMEs. Consequently, future studies are suggested to develop a comprehensive roadmap that addresses these issues. Finally, this study highlights the main gaps and opportunities in each studied roadmap and formulates 14 research questions divided into six categories for future investigation. Addressing these questions can help close the current gaps in the literature and provide SMEs with robust, adaptable, and sustainable digital transformation strategies. Full article

Doll therapy is a psychosocial intervention that has been commonly used within dementia care for many decades. The practice of doll therapy involves supporting people with dementia to engage with a therapeutic doll and this has been associated with positive changes in a person’s wellbeing and behavior. While there have been several systematic reviews that have focused on behavioral outcomes, limited reviews have explored the broader psychosocial outcomes associated with doll therapy in care home settings. A scoping review of the literature was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analysis Extension for Scoping Reviews (PRISMA-ScR). Four electronic databases were searched systematically (CINAHL Plus, Medline, PsycINFO, and PubMed). Twelve primary research studies from the past ten years (2013–2023) were included in this review. Primary data were synthesized using a narrative synthesis methodology. The three main themes from this review relate to a reduction in levels of behavioral and psychological symptoms of dementia (BPSD), increased communication skills, and a reduction in caregiver distress. Doll therapy has the potential to be an effective person-centered intervention that can enhance quality of life for people living with dementia in care home settings. Full article

Government agencies, energy consumers, and other societal groups have all shown concern and attention for the energy management of buildings. Relevant statistical data, however, indicate that most public buildings continue to consume large amounts of energy overall and that the issues of low energy usage and energy waste have not materially improved. As a result, this study reviewed the state of progress and potential directions for future research in the field of building energy management in public buildings using a data-driven approach. Relevant studies were obtained from three databases—Web of Science, Scopus, and China National Knowledge Infrastructure—based on certain search phrases. The text mining program VOS viewer was then used to examine the material. We provide a thorough examination of the study techniques and material, as well as a visual representation of the keywords and current state of the field. According to this study, the range of data processing outcomes; the flexibility of research system standards; and the availability of a comprehensive, unified assessment system are the main factors contributing to the practical issues facing building energy management today. Based on the geographic distribution and state of energy development, this study is the first to examine possible research avenues for building energy management in public buildings through cross-fusion research on passive energy-saving design and subjective behavioral energy-saving. It offers a foundation for developing the building energy management system best practice model in the future. Full article

Heat stress has been one of the key research areas for researchers due to the wide-ranging effects and complex mechanisms of action of its stress product reactive oxygen species (ROS). The aim of this paper is to comprehensively review and summarize the effects of heat stress on ovarian granulosa cells and their mechanism of action. We systematically reviewed the effects of heat stress on ovarian granulosa cells, including intracellular steroid hormone changes, oxidative stress, apoptosis, and mitochondrial function. Meanwhile, this paper discusses in detail several major mechanisms by which heat stress induces apoptosis in ovarian granulosa cells, such as through the activation of apoptosis-related genes, induction of endoplasmic reticulum stress, and the mitochondrial pathway. In addition, we analyzed the mechanism of ferroptosis in ovarian granulosa cells under heat stress conditions, summarized the potential association between heat stress and ferroptosis in light of the existing literature, and explored the key factors in the mechanism of action of heat stress, such as the signaling pathways of Nrf2/Keap1, HSPs, and JNK, and analyzed their possible roles in the process of ferroptosis. Finally, this paper provides an outlook on the future research direction, describing the possible interaction between heat stress and ferroptosis, with a view to providing a theoretical basis for further understanding and revealing the complex mechanism of ferroptosis occurrence in ovarian granulosa cells under heat stress. Full article

Background: The hub-and-spoke model (HSM) offers a framework for efficient healthcare service delivery. This scoping review seeks to explore the implementation and effectiveness of the HSM in antimicrobial stewardship (AMS) programmes. Methods: The Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews (PRISMA-ScR) reporting guideline was followed. A systematic search was conducted in four electronic databases (PubMed, Medline, Cochrane Library, and Google Scholar) from inception until January 2024. Studies where the HSM was used for delivering any AMS activity, intervention, or action, were included. No study-specific filters were applied and all populations, study designs, and health settings were included. Data screening and selection were achieved using Rayyan. Three authors independently screened studies, with conflicts resolved by a fourth author. Data were narratively synthesised. Standard appraisal tools were impractical; however, critical evaluation of data collection and outcome reporting was ensured. Results: Out of 1438 articles, three were included in the scoping review. The primary interventions utilising the HSM in AMS involved reducing antibiotic misuse, training healthcare professionals, case-based learning, establishing AMS programmes, developing antibiograms, and formulating policies or guidelines pertinent to AMS. The studies demonstrated significant clinical improvements in AMS. Clinical outcomes from the studies include a significant reduction in antimicrobial usage and improved antibiotic management, with a notable decrease in days on antimicrobial therapy and increased antibiotic de-escalation. Key facilitators for AMS programme success were tailored education, collaborative learning, strong leadership, strategic practices, and data-driven decisions. Key barriers were leadership challenges, change resistance, knowledge gaps, inadequate data systems, resource limitations, and technological constraints. Conclusions: The review identified a literature gap in HSM use in AMS programmes. Further studies are needed to assess HSM’s effectiveness, feasibility, and cost-effectiveness in AMS contexts. Full article

Agriculture plays a significant role in global water consumption, accounting for approximately 70% of the world’s freshwater usage. This makes this sector a critical factor in the depletion of water resources. Accordingly, this paper explores potential mitigatory impacts of climate-smart water management (CSWM) technologies in sub-Saharan Africa. About 70% of the population in sub-Saharan Africa is dependent on agriculture for sustaining their livelihoods. This is despite the low agricultural output in smallholder farming systems (SFS) due to water scarcity. This has spurred several attempts to promote the adoption of climate-smart agriculture (CSA) to raise agricultural outputs and improve smallholder farmers’ livelihoods. However, there has not been a comprehensive analysis of data categorised by various aspects of climate-smart water management technologies. In this systematic literature review, climate-smart water management technologies in sub-Saharan Africa’s agricultural sector were identified and analysed to determine strategies that could enhance their adoption and impact. To this end, academic articles reporting on the adoption of climate-smart water management technologies in databases were reviewed. Four significant literature databases were used. These were limited to Springer Link, ScienceDirect, MDPI, Wiley Online, and Google Scholar. The findings demonstrate that rainwater harvesting and micro-irrigation are the primary climate-smart water management technologies used by smallholder farmers. The literature review shows that adoption of CSWM practices is constrained by inadequate technological infrastructure, financial implications, unsuitable policies, and low user skills, particularly. It is therefore recommended that government agricultural departments and relevant advocates of CSA should incentivise and subsidise smallholder farmers to encourage CSWM technology adoption. This can be achieved through the implementation of suitable policies directed at technological infrastructure development, financial support for adoption, and technical skills training. Full article

Background/Objectives: Mindfulness-based interventions (MBIs) have emerged in recent years as a strong candidate for the treatment of a range of difficulties faced by individuals with autism spectrum disorder (ASD), including cognitive, emotional, and social aspects. Therefore, we aimed to conduct a review that systematically examined the efficacy of MBIs for individuals with ASD and their caregivers. Methods: This systematic review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Our literature search was conducted within the MEDLINE database. We included in the review only longitudinal or intervention studies focusing mainly on mindfulness principles, while we excluded mixed intervention studies. We only included studies that explicitly utilized quantitative methodologies for evaluating the outcomes of the interventions, including mental health indices (e.g., stress, anxiety, depression) and assessments of cognitive and social skills (e.g., attention, prosociality). We conducted also a risk of bias assessment through the method of the Cochrane risk of bias tool for intervention studies ROBINS-I. Results: Thirty-seven studies were included in the review, and we grouped the studies by the targets of the interventions, i.e., adults (n = 12), children and adolescents (n = 9), caregivers and medical staff (n = 13), and combined intervention for both children/adolescents and their parents/caregivers (n 5). The reviewed papers seem to support the feasibility and utility of mindfulness interventions for persons with ASD and their caregivers, but any recommendations based on this body of evidence should be made with caution due to the overall low quality of the studies conducted so far. Conclusions: The review reveals a positive outcome, including the alleviation of psychological distress, reduced behavioral problems, and enhanced cognitive and social skills in individuals with ASD. Despite such promising results, the review notes a limitation in the scarcity of MBIs for young patients, emphasizing caution in universally endorsing the existing literature. Moreover, the results underline the urgency of the exploration of tailored interventions for different ASD subgroups, considering varying levels of autism, and expanding support to teachers in educational settings. Full article

As we transition into the era of Web 3.0, where decentralized information and user privacy are paramount, emerging technologies are reshaping the way in which personal data are managed. This paper focuses on decentralized identity management (DID) in the metaverse, particularly within the education sector, which has rapidly embraced digital tools for e-learning, especially since the COVID-19 pandemic. Technologies such as blockchain, artificial intelligence (AI), and virtual and augmented reality (VR/AR) are increasingly integrated into educational platforms, raising questions about privacy, security, and interoperability. This literature review examines the current landscape of DID in metaverse-based educational applications. Through a systematic methodology, relevant academic papers were identified, filtered, and analyzed based on four key criteria: standardization, interoperability, application scalability, and security/privacy considerations. The paper provides a comparative analysis of these papers to assess the maturity of DID implementations, highlight existing challenges, and suggest future research directions in the intersection of decentralized identity and educational metaverse applications. Full article

Background: With the increasing prevalence of pregnant women adhering to a vegan diet, gaining insight into their nutritional intake and its association with maternal and fetal outcomes is essential to providing recommendations and developing guidelines for general practice. Methods: Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, a systematic review of the available scientific literature in Medline, Embase, and Cochrane was conducted in January 2024. Results: The titles and abstracts of 2211 unique articles were screened. Only six studies were eligible for inclusion and assessed for methodological quality using the (National Institutes of Health Study Quality (NIHSQ) Assessment Tool. The intake of protein and various micronutrients was significantly lower among vegan pregnant women compared to omnivorous women. Vitamin B12 supplements seemed sufficient in optimizing maternal and umbilical cord vitamin B12 levels amongst vegan mothers. Further, women on a vegan diet less often showed excessive pregnancy weight gain. However, children from women on a vegan diet had a significantly lower birth weight than those from women on an omnivorous diet. Conclusion: So far, only a few studies, with a large diversity of (assessment of) outcomes and insufficient power, have been published on this topic, limiting our ability to make firm conclusions about the effects of a vegan diet during pregnancy on maternal and fetal outcomes. Full article

The objective was to review the existing literature reporting on spontaneous abortion (SA) and intrauterine fetal demise (IUFD) associated with cytomegalovirus (CMV) infection. A review using standardized terminology such as ‘intrauterine fetal death’, ‘congenital cytomegalovirus’ and ‘CMV’ was performed using PubMed and Embase (Medline) using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) methodology. Twenty-one studies met inclusion criteria. CMV was identified as a potential or likely factor in a median of 7.1% of SA or IUFD in study cohorts. Of the studies, 11 used fetal remains, 18 used placenta, 6 used serum, and 1 used post-mortem dried blood spot as specimens for testing for CMV. Features commonly observed were fetal thrombotic vasculopathy, hydrops fetalis and chronic villitis. CMV is frequently noted in studies evaluating viral etiologies of SA or IUFD. Large population-based studies are needed to estimate the incidence of CMV-associated SA or IUFD. CMV and congenital CMV should be included on the differential diagnosis in all cases of SA or IUFD of unknown etiology. Full article

As technology advances, virtual reality (VR) is increasingly being integrated into healthcare education to enhance learning outcomes. This systematic literature review and meta-analysis examined the effectiveness of virtual reality-based healthcare education. Randomized controlled trials (RCTs) published over the past 10 years were retrieved from 10 databases using VR, healthcare, and education as the primary keywords. Following the inclusion and exclusion criteria, 45 studies were included in the final analysis. A meta-analysis was performed to analyze the effects of VR in terms of knowledge, skill, and attitude. The results revealed that the use of VR significantly improved the knowledge (SMD: 0.28, 95% CI: 0.18–0.39, p < 0.001) and skill scores (SMD: 0.23, 95% CI: 0.11–0.34, p < 0.001), shortened the skill performance time (SMD: −0.59, 95% CI: −0.82 to −0.35, p < 0.001), and improved the satisfaction (SMD: 0.65, 95% CI: 0.48–0.81, p < 0.001) and confidence levels (SMD: 0.60, 95% CI: 0.41–0.80, p < 0.001). The in-depth analysis highlighted the significant potential of VR and provided practical implications in educational settings. In conclusion, effectively integrating VR with traditional educational methods is necessary to enhance both the quality of learning and the overall competence of healthcare professionals. Full article

Gingival crevicular fluid (GCF) and oral fluid have emerged as promising diagnostic tools for detecting biomarkers. This review aimed to evaluate the existing literature on using oral fluids as a source of biomarkers for bone turnover diseases affecting the jawbone. A comprehensive search strategy was executed between August 2014 and August 2024 across five major databases (Web of Science, EBSCOhost Dentistry & Oral Sciences Source, Cochrane Library, Scopus, and PubMed) and grey literature sources. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR) was applied. The screening was facilitated using Rayyan at rayyan.ai and Endnote X20 software tools, culminating in the evaluation of 14,965 citations from databases and 34 from grey literature. Following rigorous scrutiny, 37 articles were selected for inclusion in this review, encompassing diseases such as periodontitis, medication-related osteonecrosis of the jaw (MRONJ), and osteoporosis. The quality of the included observational studies was assessed using the Revised Risk of Bias Assessment Tool for Non-Randomized Studies (RoBANS 2). Interleukin-1 beta (IL-1β), sclerostin, osteoprotegerin (OPG), and interleukin-34 (IL-34) emerged as significant biomarkers in GCF, and they were mainly from periodontitis and osteoporosis. Osteocalcin (OC), IL-1β, tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), OPG, and matrix metalloproteinase-9 (MMP-9) were significant in oral fluid or saliva, and they were from periodontitis, MRONJ, and osteoporosis. These findings underscore the potential use of oral fluids, which are regarded as non-invasive tools for biomarker identification in bone turnover. Many biomarkers overlap, and it is important to identify other specific biomarkers to enable accurate diagnosis of these conditions. Full article

This paper presents a systematic review that examines the influence of human resource management (HRM) on financial performance in cooperative enterprises, utilizing the PRISMA approach. To gather relevant resources, we formulated a search strategy using predefined keywords such as “HRM”, “Financial Performance”, and “Cooperative”. After applying the inclusion criteria (full articles, online accessibility, English language, and relevance to the topic), 26 articles were selected for review. The findings of this analysis reveal a positive relationship between HRM practices and financial performance, with HRM driving both efficiency and profitability. High-performing HRM functions enhance employee productivity while ensuring personnel welfare and improving the organizational climate. Modern HRM practices are crucial in increasing employee engagement, fostering innovative cultures, and improving operational efficiency. These practices directly affect financial performance by linking employee engagement with product quality, profitability, and retention. Based on the studies reviewed, this paper contributes significantly to the existing literature and offers key conclusions that can be drawn from the findings. Full article

LED light technology has been used in recent years in plant breeding due to its proven energy efficiency, low cost, and high quality for the enhancement of crops, including some aromatic medicinal plants (AMPs). Nonetheless, although several studies have shown that specific wavelengths can increase the content of bioactive compounds used by pharmaceutical, medical, and perfumery industries, there is limited information on this topic and the possible implications for plant stress in AMPs. The current systematic review focused on the effects of LED light on the physiological response, metabolite synthesis, and flowering induction in three important AMP genera: Lavandula, Salvia, and Thymus, belonging to the Lamiaceae family. A literature search was performed in the Web of Science and Scopus databases. This review is reported in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. The bibliographic analysis highlights the significant variation in physiological responses to different light spectra between species, even within the same genera, implying a need to optimize light conditions in each species to achieve the best results. Finally, this review provides essential information for laying the groundwork for future research focused on enhancing AMPs using LED light to overcome various types of stress. Full article