Derinide 400mcg Respicap 30'S

INTRODUCTION

DERINIDE 400MCG contains Budesonide which belongs to the group of medicines called Corticosteroids. It is used to prevent the symptoms of asthma. Asthma is a respiratory disease in which the airways become inflamed, swollen, and narrowed. It also causes excessive mucous secretion in the airways which makes it difficult for the air to pass through leading to unpleasant symptoms like wheezing, difficulty in breathing, chest pain or cough.

Budesonide is a steroid medication. It works on the airways and prevents the cells present in the airways from releasing certain chemicals that causes inflammation and swelling of the airways. DERINIDE 400MCG can only prevent you from getting an asthmatic attack. It will not stop an asthma attack that has been started already. Therefore, always carry a fast-acting ‘rescue’ inhaler containing a beta-2 agonist (Ex. salbutamol) with you to subside the symptoms. Your doctor may monitor your disease condition periodically and adjust the dose accordingly. It is important to tell your doctor if you are already taking any oral corticosteroids to manage your asthma. If so, your doctor would gradually reduce the number of doses taken before switching to DERINIDE 400MCG.

Before using DERINIDE 400MCG inform your doctor if you have any unmanageed infections, lung, or liver problems. Do not stop using DERINIDE 400MCG once your symptoms subside without consulting your doctor. Make sure to rinse your mouth with water after inhaling the medicine to avoid the risk of fungal infections in the oral cavity. DERINIDE 400MCG should be used in pregnant and breastfeeding women only if it is considered necessary by the physician. It is generally not recommended for use in children aged below 6 years. The most common side effects of using DERINIDE 400MCG are oral thrush (fungal infection in the mouth), throat irritation, swallowing difficulties and cough. Consult your doctor if any of the symptom worsens.

USES OF DERINIDE 400MCG

• Prevents the symptoms of asthma

HOW DERINIDE 400MCG WORKS

DERINIDE 400MCG controls the symptoms of asthma, where budesonide works on the airways and prevents the cells present in the airways from releasing certain chemicals that causes inflammation and swelling of the airways. As a result, it reduces airway inflammation, prevents airways from becoming narrow and improves breathing.

DIRECTIONS FOR USE

Use DERINIDE 400MCG every day until your doctor tells you to stop. It is meant for inhalation use only. Inhale the medicine only through your mouth into the lungs and not via nose.

If you are using an inhaler: Place the mouthpiece between your teeth and close your mouth tightly. Take a deep breathe through your mouth while simultaneously pressing the top of the canister firmly to release a puff of medicine. Your doctor will decide the number of puffs to be taken depending upon your medical condition. Wait at least for about 30 seconds between each inhalation.

If you are using other respiratory devices (such as rotacaps, respicaps or transcaps): Insert the capsule into the capsule chamber or into the hole present in the device. Release the medicine from the capsule, by adjusting the device (either rotate the base of the device or press the button meant for piercing the capsule) according to information given in the enclosed leaflet. Place the mouthpiece between your teeth and close your mouth tightly. Breath in through your mouth deeply and rapidly. Your doctor will decide the number of capsules to be taken depending upon your medical condition.

With both inhaler and other devices, after each inhalation remove the device from your mouth and hold your breath for about 10 seconds or for as long as is comfortable. Gently breathe out. If the emptied medicine is not completely inhaled, once again breath in through your mouthpiece.

After inhalation, wipe the mouthpiece with a dry tissue and close the device after use. Once inhalation is over, rinse your mouth with water and spit it out or brush your teeth. Do not start using this medicine unless your doctor or health care provider has taught you how to use or you understood how to use it correctly.

SIDE EFFECTS OF DERINIDE 400MCG

HOW TO MANAGE SIDE EFFECTS

Oral thrush (fungal infection of the mouth):

Rinse your mouth with water after inhaling the medicine to avoid the risk of fungal infections in the oral cavity. Spit out the rinse water rather than swallowing it. Consult your doctor if the symptom worsens.

Skin rash:

Hot showers should be avoided because it can irritate your skin even more. Scratching the affected area is not a good idea. Always wear protective clothing, while going outdoors. Moisturize your skin on a regular basis. Consult your doctor if the symptom worsens.

WARNING & PRECAUTIONS

INTERACTIONS

A. Drug-Drug interactions:

Before using DERINIDE 400MCG, inform your doctor if you are using any of the following:

• medicines used to manage viral infections (Ex. ritonavir, nelfinavir, cobicistat-containing dose regimen)
• medicines used to manage fungal infections (Ex. ketoconazole or itraconazole)
• other oral or inhaled corticosteroid medications (used to manage inflammation or allergies) such as prednisolone, salmeterol, dexamethasone

Overdosage:

If you or anyone else accidentally inhaled more of DERINIDE 400MCG, contact your doctor immediately or go to the nearest hospital straight away.

SYNOPSIS

MORE INFORMATION

• Keep DERINIDE 400MCG out of reach from children
• Store at room temperature

FAQs ABOUT DERINIDE 400MCG

How long will it take for DERINIDE 400MCG to show the results?

The effect of DERINIDE 400MCG are noticeable only after a few days of therapy, and it may take up to several weeks to notice its maximum benefits. Consult your doctor if you do not see any improvement in your disease condition even after using this medicine for a prolonged period.

Can DERINIDE 400MCG be used in children?

DERINIDE 400MCG is not recommended for use in children aged below 6 years. It can be used in children aged between 6-12 years only if prescribed by the physician. Consult your doctor before using. Because DERINIDE 400MCG can cause growth retardation, your doctor may want to keep an eye on your children's developmental milestones and growth.

Can DERINIDE 400MCG stop growth in children?

Yes. DERINIDE 400MCG can cause growth retardation in children. To avoid this, your doctor will carefully monitor your children's growth on a regular basis. To lessen the effect of DERINIDE 400MCG on growth, your doctor may reduce the dose of budesonide.

How long should I use DERINIDE 400MCG?

Use DERINIDE 400MCG as prescribed by your doctor. The effect of DERINIDE 400MCG are noticeable only after a few days of therapy and it may take several weeks to show its maximum benefits. Continue to use DERINIDE 400MCG as instructed by your doctor, even if you don’t have any symptoms. Do not stop using DERINIDE 400MCG without consulting your doctor as it may cause the symptoms to reappear.

Can DERINIDE 400MCG cause infection in the mouth?

Yes. [GBNKKEYWORD] can cause fungal infections of the mouth (oral thrush). To avoid this, make sure to rinse your mouth with water after inhaling the medicine. However, if an infection develops, consult your doctor.

Can DERINIDE 400MCG be used on an asthma attack?

No. DERINIDE 400MCG is only used to prevent or manage the symptoms of asthma. If your asthma or breathing gets worse suddenly, contact your doctor immediately or go to the hospital straight away to avoid further exacerbation of the attack. Meanwhile use a fast-acting rescue inhaler containing beta-2 agonists (such as salbutamol) along with DERINIDE 400MCG.

Can I stop using DERINIDE 400MCG once my symptoms subside?

No. Always use DERINIDE 400MCG as advised by your physician. Continue to use DERINIDE 400MCG as long as your doctor prescribes it to you. Do not stop using this medicine or reduce the dose suddenly without consulting your doctor as it may make it less effective.

Will using a higher dose of DERINIDE 400MCG be more effective?

Always consume the dose prescribed for you by your physician. Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and severity of the disease. Do not use a higher dose of DERINIDE 400MCG without consulting your doctor as it could lead to unwanted side effects. It your symptoms are not relieved by the prescribed dose, consult your doctor so that he might adjust the dose according to your health condition or can suggest an alternative therapy.

Can DERINIDE 400MCG cause bone loss?

DERINIDE 400MCG can affect your bones, but it happens very rarely. It is more common while taken as an oral therapy. Use DERINIDE 400MCG as advised by your physician to avoid unwanted bone related side effects.

What happens when you forget to use DERINIDE 400MCG?

If you forget to use DERINIDE 400MCG, use it as soon as you remember. However, if it's time for the next dose, skip the missed dose and take the next dose. Do not use a double dose to compensate the missed dose.

Can DERINIDE 400MCG be used if you have an infection?

Inform your doctor if you have any bacterial, fungal, or viral infection before using DERINIDE 400MCG. Your doctor will evaluate your existing health condition and advise changes in management accordingly. Also, inform your doctor if have exposure to an infectious environment or with a person with infectious diseases, as DERINIDE 400MCG may mask your symptoms of the infection.

REFERENCES

1. KD. Tripathi. Drugs for cough and bronchial asthma. Essentials of medical pharmacology. 8th Edition. 2019. Page – 250-251.

2. Norihide Murayama, Kei Asai, Kikuno Murayama, Satoru Doi, and Makoto Kameda. Dry Powder and Budesonide Inhalation Suspension Deposition Rates in Asthmatic Airway-Obstruction Regions. NIH National Library of Medicine, National center for biotechnology information. [Revised in November 2018] [Accessed on 31st May 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6885778/

3. Orion Pharma (UK) Limited. Electronic Medicines Compendium (EMC). [Revised in July 2021] [Accessed on 31st May 2022] https://www.medicines.org.uk/emc/files/pil.242.pdf

4. Ciplamed. Budecort Inhaler. [Revised in February 2019] [Accessed on 31st May 2022] https://www.ciplamed.com/content/budecort-rotacaps#storage%20and%20handling%20instructions

USEFUL DIAGNOSTIC TESTS

• Absolute Eosinophil Count
• Complete Blood Count