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INTRODUCTION ABOUT ETOGESIC 400MG TABLET
ETOGESIC 400MG TABLET contains Etodolac which belongs to the group of medicines called Non-steroidal Anti-inflammatory Drugs (NSAIDs). ETOGESIC 400MG TABLET is used in adults for acute pain management, for relieving pain, stiffness and reducing inflammation associated with conditions such as osteoarthritis and rheumatoid arthritis.
Rheumatoid arthritis is a chronic condition affecting hands, feet and wrists joints and causing pain, swelling and stiffness of joints. Osteoarthritis is a progressive bone disorder affecting joints and causing pain and joint stiffness.
During long term management with ETOGESIC 400MG TABLET, your doctor might order some investigations such as complete hemogram, liver function tests, kidney function tests to ensure better management outcomes.
Avoid consuming alcohol and smoking while taking ETOGESIC 400MG TABLET as it may increase the risk of stomach ulcers and bleeding.
ETOGESIC 400MG TABLET is not recommended for use in patients who experienced allergic reaction, gastrointestinal bleeding, perforation after taking any other NSAID’s such as ibuprofen, aspirin, suffering from stomach ulcers, stomach bleeding or perforation, severe heart failure, liver failure, kidney failure or those who are in setting of coronary artery bypass graft surgery. Consult your doctor before taking.
ETOGESIC 400MG TABLET should be used with caution in patients suffering from high blood pressure, heart disorders (such as myocardial infarction, stroke), patients at risk of developing ulcerative colitis, Crohn’s disease, pre-existing kidney disease, asthma, blood disorders, diabetes, high cholesterol, mixed connective tissue disorder such as lupus and fluid retention (swelling of legs, ankles, feet).
ETOGESIC 400MG TABLET is not recommended for use in pregnant and breastfeeding women unless clearly necessary, therefore, consult your doctor before taking.
ETOGESIC 400MG TABLET is not recommended for use in children and adolescents less than 18 years of age as its safety and effectiveness is not yet established.
The most common side effects after taking ETOGESIC 400MG TABLET are abdominal pain, diarrhoea, dyspepsia, flatulence, bloating, vomiting. Consult your doctor immediately in case any of the side effects worsens or you experience allergic reaction after taking ETOGESIC 400MG TABLET.
USES OF ETOGESIC 400MG TABLET
- Used to relieve pain and inflammation in patients with rheumatoid arthritis and osteoarthritis
HOW ETOGESIC 400MG TABLET WORKS
ETOGESIC 400MG TABLET helps in reducing pain and inflammation by managing the formation of prostaglandins and other mediators of inflammation and pain.
DIRECTIONS FOR USE
Take ETOGESIC 400MG TABLET as advised by your physician. Swallow the medicine as whole with a glass of water and do not crush or chew the medicine. Your doctor will decide the exact dosage and management duration depending upon your age, body weight and disease condition.
SIDE EFFECTS OF ETOGESIC 400MG TABLET
COMMON
- stomach ulcer
- bleeding and pain
- diarrhoea
- constipation
- indigestion, flatulence
- chills and fever
- nausea, vomiting, bloating
- itching, rashes
- blurred vision, tingling in ears
- infrequent urination
- joint pain
- dizziness, fatigue, nervousness, malaise
- heart burn
UNCOMMON
- high blood pressure
- thirst, dry mouth, mouth ulcers
- sleeping problems
- asthma and breathing problems
- swelling in ankles (oedema)
- elevated liver enzymes, hepatitis
- visual disturbances
RARE
- allergic reaction
- inflammation of blood vessels
- jaundice, liver failure, pancreatitis
- blood disorders such as aplastic anaemia, leukopenia, neutropenia, pancytopenia
- increased blood sugar (diabetic patients)
Stop taking ETOGESIC 400MG TABLET and consult your doctor immediately in case you experience:
- allergic reaction which causes difficulty breathing, swelling of the face or throat
- cardiovascular problems-symptoms include chest pain, shortness of breath, weakness or slurred speech
- gastrointestinal bleeding and ulcerations symptoms include upper abdominal pain, dyspepsia, melena (black stools due to gastrointestinal bleeding) and hematemesis (vomiting blood)
- liver problems- symptoms include nausea, fatigue, lethargy, pruritus (severe itching), jaundice, right upper quadrant tenderness and flu-like symptoms
- congestive heart failure- symptoms include shortness of breath, unexplained weight gain or oedema (swelling in arms, legs, hands and feet)
- serious skin reactions such as erythema multiforme, steven-Johnson syndrome, drug reaction with eosinophilia and systemic symptoms (dress) symptoms include fever, rashes, swollen lymph nodes, blisters
- aseptic meningitis- symptoms include headache, neck stiffness, fever, disorientation, feeling sick
HOW TO MANAGE SIDE EFFECTS
Stomach pain:
Try to rest and relax. Eat small meals but take frequently. Avoid consuming caffeinated drinks, tea and coffee. Keep a heat pad on your stomach. Contact your doctor in case the stomach pain did not improve.
Diarrhoea:
Drink plenty of water or fruit juices to keep yourself hydrated. Don’t take any medicine on your own for managing diarrhoea however contact your doctor if diarrhoea worsen.
Headache:
Rest and relax. Drink plenty of water and electrolytes. Apply a pain-relieving balm on the head if required and do not consume alcohol however, contact your doctor if your headache did not improve.
Nausea or Vomiting:
Take the medicine with meals or after meals and stick to simple meals. Avoid eating oily or spicy food however, contact your doctor if nausea and vomiting worsen.
Flatulence:
Eat smaller meals but take frequently. Eat and drink slowly and exercise regularly. Contact your doctor if the flatulence did not improve.
Constipation:
Eat plenty of fibre rich foods such as fresh fruits, vegetables and cereals. Drink water and exercise regularly. Contact your doctor if constipation persists.
Skin rash:
Avoid hot showers because hot water can irritate the skin and do not scratch the affected area. Apply moisturizing cream and sunscreen regularly. Contact your doctor in case itching persists.
WARNING & PRECAUTIONS
PREGNANCY
ETOGESIC 400MG TABLET is not recommended for use in pregnant women unless clearly necessary, therefore, consult your doctor before taking.
BREASTFEEDING
ETOGESIC 400MG TABLET is not recommended for use in breastfeeding women unless clearly necessary as it may pass through breastmilk, therefore, consult your doctor before taking.
DRIVING AND USING MACHINES
Do not drive or operate machines after taking ETOGESIC 400MG TABLET as it may cause dizziness and vision problems.
ALCOHOL
Avoid consuming alcohol while taking ETOGESIC 400MG TABLET as it might as it may increase the risk of stomach ulcers and bleeding.
KIDNEY
ETOGESIC 400MG TABLET is not recommended for use in patients suffering from kidney failure. Consult your doctor before taking.
LIVER
ETOGESIC 400MG TABLET is not recommended for use in patients suffering from liver failure. Consult your doctor before taking.
ALLERGY
Do not take ETOGESIC 400MG TABLET if you are allergic to Etodolac or any other ingredients of this medicine.
LUNGS
ETOGESIC 400MG TABLET should be used with caution in patients suffering from asthma or breathing problems, therefore consult your doctor before taking.
HEART DISEASE
ETOGESIC 400MG TABLET is not recommended for use in patients suffering from severe heart failure, therefore, inform your doctor if you are suffering from heart disorders (such as myocardial infarction, recent stroke) before taking ETOGESIC 400MG TABLET.
OTHERS
ETOGESIC 400MG TABLET is not recommended for use if you:
- have experienced allergic reaction, gastrointestinal bleeding, perforation after taking any other NSAIDs such as ibuprofen, aspirin
- are suffering from stomach ulcers, stomach bleeding or perforation
- have been planned for setting of coronary artery bypass graft surgery
Before taking ETOGESIC 400MG TABLET inform your doctor if you have:
- high blood pressure
- urine investigation for urinary bilirubin or ketone bodies
- ulcerative colitis, Crohn’s Disease
- blood disorders
- diabetes
- high cholesterol
- mixed connective tissue diseases such as lupus
- fluid retention (swelling of legs, ankles, feet)
Use in pediatrics:
Safety and effectiveness in pediatric patients below the age of 18 years have not been established. Consult your doctor before giving it to your child.
Use in geriatrics:
[GBNKYWORD] should be used with caution in elderly patients aged more than 65 years, therefore consult your doctor before taking.
INTERACTIONS
A. Drug-Drug interactions:
Before taking ETOGESIC 400MG TABLET, inform your doctor if you are taking any of the following medicine:
- ACE inhibitors such as captopril, enalapril (medicines used for management of high blood pressure)
- antacids such as magnesium carbonate, magnesium hydroxide (medicines used for management of acidity)
- aspirin, dipyridamole, clopidogrel (medicines used for managing blood thinning in cardiovascular patients)
- cyclosporine, tacrolimus (medicines used to manage transplant rejection)
- digoxin (a medicine used for management of irregular heartbeat)
- methotrexate (a medicine used for management of rheumatoid arthritis, psoriasis, Crohn's disease)
- frusemide, hydrochlorothiazide (medicine used for management of high blood pressure, oedema, kidney problems)
- lithium (a medicine used for management of mood disorders)
- phenylbutazone (a medicine used to manage arthritis and inflammatory musculoskeletal disorders)
- warfarin (a medicine used for managing blood from clotting)
- phenytoin (a medicine used to manage seizures/fits)
- propranolol (a medicine used for management of high blood pressure)
- zidovudine (a medicine used for management of HIV infection)
- mifepristone (a medicine used for medical termination of pregnancy)
- ciprofloxacin, levofloxacin, ofloxacin (medicines used for management bacterial infections)
- corticosteroids such as prednisolone (medicines used for management of various inflammatory conditions)
Overdosage
In case you or anybody else accidently takes too much of ETOGESIC 400MG TABLET then consult your doctor immediately or visit the nearby hospital. Symptoms of ETOGESIC 400MG TABLET include lethargy, drowsiness, nausea, vomiting, epigastric pain, gastrointestinal bleeding.
SYNOPSIS
| Drug | : | Etodolac |
| Pharmacological Category | : | Non-steroidal Anti-inflammatory Drugs (NSAID’s) |
| Therapeutic Indication | : | Relieve pain and inflammation in patients with rheumatoid arthritis and osteoarthritis |
| Dosage Forms | : | Tablet, Gel, Injection |
MORE INFORMATION
- Keep ETOGESIC 400MG TABLET out of reach of children
- Store ETOGESIC 400MG TABLET at room temperature
FAQs ABOUT ETOGESIC 400MG TABLET
What is ETOGESIC 400MG TABLET used for?
ETOGESIC 400MG TABLET is used in adults for acute pain management, for relieving pain, stiffness and reducing inflammation associated with conditions such as osteoarthritis and rheumatoid arthritis.
How ETOGESIC 400MG TABLET works?
ETOGESIC 400MG TABLET contains Etodolac which helps in reducing pain and inflammation by inhibiting the formation of Prostaglandins and other mediators of inflammation and pain.
What precautions I should take while taking ETOGESIC 400MG TABLET?
Avoid consuming alcohol and smoking while taking ETOGESIC 400MG TABLET as it may increase the risk of stomach ulcers and gastrointestinal bleeding. ETOGESIC 400MG TABLET may affect cause dizziness and vision problems, therefore, avoid driving or operating machines after taking ETOGESIC 400MG TABLET.
Can I give ETOGESIC 400MG TABLET to my child?
Safety and effectiveness in pediatric patients below the age of 18 years have not been established. Consult your doctor before giving it to your child.
What are common side effects after taking ETOGESIC 400MG TABLET?
The most common side effects after taking ETOGESIC 400MG TABLET are abdominal pain, diarrhoea, dyspepsia, flatulence, bloating, vomiting, heartburn. Consult your doctor immediately in case any of the side effects worsens or you experience allergic reaction after taking this medicine.
Can I take my regular antacids for managing acidity while taking ETOGESIC 400MG TABLET?
No, avoid taking antacids such as magnesium carbonate, magnesium hydroxide (medicines used for management of acidity) while taking ETOGESIC 400MG TABLET and consult your doctor for management of acidity.
REFERENCES
1. KD Tripathi. Non-steroidal Anti-inflammatory Drugs and Antipyretic-Analgesics. Essentials of Medical Pharmacology, 7th edition 2013. Page-204.
2. Shravan Kumar Tirunagri, Sheena Derry, R Andrew Moore, Henry J McQuay. Single dose oral etoloac for acute postoperative pain in adults. NIH National Library of Medicine, National center for biotechnology information. Cochrane Library. July 2009. [Accessed 21st November 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4164827/
3. Sun Pharmaceutical Industries Europe B.V. Electronic Medicines Compendium (EMC). [Revised in February 2018] [Accessed on 21st November] https://www.medicines.org.uk/emc/files/pil.3020.pdf
4. Wyeth Pharmaceuticals Inc. U.S Food and Drug Administration (FDA). [Revised in March 2021] [Accessed on 21st November] https://www.accessdata.fda.gov/drugsatfda_docs/label/2006/018922s022,020584s009lbl.pdf
5. Taro Pharmaceutical Industries Ltd. Etodolac. [Revised in March 2021] [Accessed on 21st November] https://www.taro.com/sites/default/files/USA-Products-Rx/Etodolac%20Capsules%20and%20Tablets%20Prescribing%20Information%20-%20March%202021_2.pdf
6. Taro Pharmaceutical Industries Ltd. Etodolac. Dailymed. [Revised in March 2021] [Accessed on 21st November] https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=ec82b108-6a6f-4d1b-82cb-831d4ed36c80
7. AA Pharma Inc. Etodolac. [Revised in January 2018] [Accessed on 21st November] https://www.aapharma.ca/downloads/en/PIL/2019/Etodolac_EN_PM.pdf
USEFUL DIAGNOSTIC TESTS
- Complete blood count
- Liver function test
- Kidney function test
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