Pantosec DSR Capsule 10'S (N)

INTRODUCTION ABOUT PANTOSEC DSR CAPSULE

PANTOSEC DSR CAPSULE is used to manage peptic ulcers, gastroesophageal reflux disease (GERD) and reflux esophagitis. It is a combination of Domperidone and Pantoprazole which belongs to the group of medicines called Prokinetic Drugs and Proton pump inhibitors respectively. PANTOSEC DSR CAPSULE acts by reducing the production of gastric acid. It also speeds up the movement of food from the stomach to the intestines, thereby reducing the signs of nausea, vomiting and acid reflux. Due to these actions, it can also reduce the unpleasant signs of GI tract such as nausea, vomiting, indigestion, burping, bloating, acidity or heartburn.

It should be taken at least 15-30 minutes before meals. During management with PANTOSEC DSR CAPSULE your doctor will closely monitor your kidney functions, liver functions and blood magnesium levels to avoid the risk of unwanted side effects. Before taking PANTOSEC DSR CAPSULE inform your doctor if you have any liver, kidney or heart problems. You must also inform your doctor if you have any blockage or tears in the gut or have weak bones.

PANTOSEC DSR CAPSULE is not recommended for use in patients bleeding from the gut. Consult your doctor before taking PANTOSEC DSR CAPSULE if you are pregnant or breastfeeding. The most common side effects are dryness of mouth, constipation and flatulence. Consult your doctor if any of these side effect bothers you. You must also inform your doctor immediately if you experience any signs of low magnesium levels in blood (such as tiredness, abnormal muscle movements, dizziness, confusion, disorientation, irregular heartbeat).

USES OF PANTOSEC DSR CAPSULE

It is used to manage:

• Peptic ulcer
• Gastrointestinal Reflux disease (GERD)
• Reflux esophagitis (inflammation of the esophagus)
• Nausea and Vomiting
• Acidity, Heartburn
• Signs of indigestion (such as burping, bloating)

HOW PANTOSEC DSR CAPSULE WORKS

PANTOSEC DSR CAPSULE contains Domperidone and Pantoprazole. Domperidone is a prokinetic medicine with anti-emetic properties which works by blocking the actions of a chemical messenger called dopamine in the gut and across the brain and spinal cord. This action stimulates the gut, reduces acid reflux and speeds up the movements of food from the stomach into the intestines. It also blocks the transmission of nerve signals between the vomiting centers and brain which reduces the onset of nausea and vomiting. Pantoprazole reduces gastric acid secretion by the blocking the actions of a protein membrane called H+K+Atpase (proton pump) present in the lining of the stomach. By reducing stomach acid production, PANTOSEC DSR CAPSULE it manages the worsening of ulcers, heals the existing ulcers and esophageal lesions and provides relief from the unpleasant symptoms of GI tract (such as acidity, bloating, burping and indigestion).

DIRECTIONS FOR USE

• Take PANTOSEC DSR CAPSULE 15-30 minutes before meals or as advised by your physician
• Swallow the medicine with a glass of water. Do not crush or chew the medicine
• Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition
• Do not stop taking PANTOSEC DSR CAPSULE unless your doctor advice you to stop

SIDE EFFECTS OF PANTOSEC DSR CAPSULE

Common side effects of PANTOSEC DSR CAPSULE:

• benign polyps in the stomach
• dry mouth
• headache, dizziness, drowsiness
• diarrhea, constipation, stomach pain, flatulence

Stop taking PANTOSEC DSR CAPSULE and inform your doctor immediately if you experience any of the following side effects such as:

• severe allergic reactions (such as skin rash, itching, swelling of the lips, face or body and difficulty in breathing or swallowing)
• signs of liver problems (yellowing of the skin and eyes, dark urine and tiredness)
• severe skin reactions (such as redness, blistering, peeling of skin and bleeding in the lips, eyes, mouth, nose and genitals with fever)
• signs of kidney problem (such as lower back pain, painful urination)
• signs of low magnesium levels in blood (such as tiredness, abnormal muscle movements, dizziness, confusion, disorientation, irregular heartbeat)
• severe, persistent diarrhea
• fast or irregular heartbeat, difficulty in breathing, feeling faint
• fits
• uncontrollable body movements (including eye and tongue), twisted neck and abnormal body posture

WARNING & PRECAUTIONS

PREGNANCY

Monitoring required

PANTOSEC DSR CAPSULE should be used in pregnant women only if it is considered necessary by the physician.  

BREASTFEEDING

Monitoring required

PANTOSEC DSR CAPSULE may pass through breast milk. Therefore, it should be used in breastfeeding women only if it is considered necessary by the physician.  

DRIVING AND USING MACHINES

Use with Caution

PANTOSEC DSR CAPSULE does not affect your ability in driving or handling heavy tools or machines. However, do not drive or handle heavy tools or machines if your ability is affected by the medicine.

ALCOHOL

Consult your doctor

Avoid consumption of alcohol while taking PANTOSEC DSR CAPSULE, as it could aggravate your existing condition.

KIDNEY

Use with Caution

PANTOSEC DSR CAPSULE should be used with caution in patients with kidney problems.  

LIVER

Consult your doctor

PANTOSEC DSR CAPSULE is not recommended for use in patients with moderate or severe liver impairment. It should be used with caution in patients with other mild liver problems.

ALLERGY

Contraindicated

Do not take PANTOSEC DSR CAPSULE if you are allergic to Domperidone, Pantoprazole or to any other ingredients of this medicine.

HEART DISEASE

Contraindicated

PANTOSEC DSR CAPSULE is not recommended for use in patients with heart problems such as prolongation of QT interval or congestive heart failure.  

USE IN PEDIATRICS

Contraindicated

PANTOSEC DSR CAPSULE is not recommended for use in children and adolescents (aged below 18 years).  

USE IN GERIATRICS

Use with Caution

PANTOSEC DSR CAPSULE should be used with caution in elderly patients (aged 65 years and above).

INTERACTIONS

A. Drug-Drug interactions:

Before taking PANTOSEC DSR CAPSULE inform your doctor if you are taking any of the following medicines such as:

• Aminobenzamides (Ex. cisapride, dolasetron, prucalopride, diphemanil)
• Cardiac glycosides (Ex. digoxin, apomorphine, disopyramide, hydroquinidine, quinidine, amiodarone, dofetilide, dronedarone, ibutilide, sotalol, diltiazem or verapamil)
• Anti-viral agents (Ex. atazanavir, nelfinavir, saquinavir, telaprevir)
• Antifungal (Ex. ketoconazole, itraconazole, posaconazole)
• Anti-coagulants (Ex. warfarin, phenprocoumon)
• Antipsychotics (Ex. haloperidol, pimozide, sertindole)
• Antidepressants (Ex. escitalopram or citalopram, fluvoxamine, St John’s wort)
• Antibiotics (Ex. moxifloxacin, erythromycin, levofloxacin, clarithromycin, telithromycin or amoxicillin)
• Phenanthrene class (Ex. halofantrine, lumefantrine)
• Antihistamines (Ex. mizolastine, mequitazine)
• Anti-cancer agents (Ex. toremifene, vandetanib, vincamine, erlotinib, dasatinib, nilotinib)
• Antimetabolites (Ex. methotrexate)
• Anti-arrhythmic  (Ex. bepridil)
• Opiate (narcotic) analgesics (Ex. methadone)
• Iron salts
• Immunosupressants (Ex. tacrolimus or mycophenolate mofetil)
• Anti-infective (Ex. pentamidine)
• Anti-TB agents (Ex. rifampicin)

Overdosage:

If you or anyone else accidentally took more PANTOSEC DSR CAPSULE, contact your doctor immediately or go to a hospital straight away. Symptoms of overdosage might include sleepiness, confusion, uncontrollable body movements (including eye and tongue), twisted neck and abnormal body posture.

SYNOPSIS

MORE INFORMATION

FAQs ABOUT PANTOSEC DSR CAPSULE

REFERENCES

1. KD. Tripathi. Antiemetic, Prokinetic and Digestant drugs & Drugs for Peptic Ulcer and Gastroesophageal Reflux Disease. Essentials of medical pharmacology. Seventh edition. 2013. Page – 666 & 653.

2. Nur Fathurah Zamani, Afifah Sjamun Sjahid, Tuan Hairulnizam Tuan Kamauzaman, Yeong Yeh Lee and Md Asiful Islam. Efficacy and Safety of Domperidone in Combination with Proton Pump Inhibitors in Gastroesophageal Reflux Disease: A Systematic Review and Meta-Analysis of Randomised Controlled Trials. Journal of Clinical Medicine. August 2022. [Accessed on 21st October 2022] click here

3. Cipla Ltd. NEW PANTOSEC D SR Capsules (Pantoprazole Gastro-resistant + Domperidone Prolonged Release Capsules IP). Ciplamed.com. [Revised in April 2020] [Accessed on 21st October 2022] click here

4. Panacea Biotec Limited. OD-PEP-D CAPSULES. [Revised in July 2019]. [Accessed on 21st October 2022] click here

5. Milpharm Limited. Electronic Medicines Compendium (EMC). [Revised in March 2021]. [Accessed on 21st October 2022] click here

6. Takeda GmbH. Electronic Medicines Compendium (EMC). [Revised in April 2022]. [Accessed on 21st October 2022] click here

7. Milpharm Limited. Electronic Medicines Compendium (EMC). [Revised in November 2021]. [Accessed on 21st October 2022] click here

8. Leeford Healthcare Ltd. Pantafol-D. [Accessed on 21st October 2022] click here

9. Hetero Healthcare Ltd. Pantin RD Tablet. [Accessed on 21st October 2022] click here

10. Central Drugs Standard Control Organization. Pantoprazole+Domperidone SR. [Revised in December 2004] [Accessed on 21st October 2022] click here

USEFUL DIAGNOSTIC TESTS

• Complete Blood Count (CBC)
• Stool Complete Analysis

AUTHOR DETAILS

Written By Srilekha. R - B.Pharm

Reviewed By Dr. Sankara Babu Gorle - MBBS, MD(Pharmacology) View profile

Last updated on 20 Nov 2024 | 09:50 AM(IST)