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INTRODUCTION ABOUT RELENT COLD SYRUP
RELENT COLD SYRUP is a combination of Phenylephrine and Chlorpheniramine which belongs to the group of medicines called Nasal decongestants and Antihistamines respectively. It is used to relieve nasal and sinus congestion, allergic symptoms of the nose or throat due to upper respiratory tract allergies, sinus pain and headache. Also, it is used adjunctly with antibacterials to manage sinusitis (inflammation of the tissue lining the sinuses), tonsillitis (inflammation of the tonsils) and otitis media (middle ear infection).
Before giving RELENT COLD SYRUP to your child, inform child’s doctor if your child has kidney, liver or heart problems, diabetes, fits or severely raised blood pressure. RELENT COLD SYRUP is not recommended for use in pregnant or breast-feeding women and elderly patients as it is used only in children.
The most common side effects of RELENT COLD SYRUP are nausea, vomiting, dry mouth, dizziness and tiredness. Consult your child’s doctor if any of the side effects worsen.
USES OF RELENT COLD SYRUP
It is used to:
- relieve nasal and sinus congestion
- relieves allergic symptoms of the nose or throat due to upper respiratory tract allergies
- relieves sinus pain and headache
- adjunctly with antibacterials to manage sinusitis, tonsillitis and otitis media
HOW RELENT COLD SYRUP WORKS
RELENT COLD SYRUP relieves cold symptoms where Phenylephrine decreases nasal congestion by acting on α1-adrenergic receptors in the small vessels of the nasal mucosa to produce constriction, resulting in decreased swelling and increased drainage of the sinus cavities and Chlorpheniramine binds to the histamine H1 receptor and blocks its action, resulting in temporary relief of the negative symptoms (runny nose, sneezing, watery and itchy eyes) brought on by histamine.
DIRECTIONS FOR USE
Give RELENT COLD SYRUP to your child as advised by the physician. Shake well before use. Use a measuring cup to properly measure the dose. Your child’s doctor will decide the correct dose and duration of RELENT COLD SYRUP for your child depending upon child’s age, body weight and disease condition.
SIDE EFFECTS OF RELENT COLD SYRUP
COMMON
- drowsiness
- sedation
- disturbance in concentrating, un-coordination, dizziness, headache
- blurred vision
- nausea or vomiting
- dry mouth
- tiredness
RARE
- fear, anxiety, restlessness
- tremor, weakness
- painful urination
Stop giving RELENT COLD SYRUP to your child and contact doctor immediately if your child experiences any of the following side effects:
- develop rash, hives, itching, red or swollen or blistered or peeling skin; wheezing, tightness in the chest or throat, trouble breathing, swallowing or talking, unusual hoarseness or swelling of the mouth, face lips, tongue or throat
HOW TO MANAGE SIDE EFFECTS
Dry Mouth
Tell your child to sip water regularly and other sugar free liquids. Tell your child not to use mouthwashes that contain alcohol because they can make your mouth dry, use mouthwash that is used only for dry mouth. Limit your caffeine intake. Consult child’s doctor if the symptom does not improve.
Headache
Apply hot or cold-water bag on your child’s head. Advise your child to take rest in a quiet room. Massage child’s scalp or head with mild pressure for relieving effect. Consult child’s doctor if the symptom does not improve.
Nausea And Vomiting
Follow simple meal plan for your child while administering RELENT COLD SYRUP. Avoid giving foods that are oily, fried or spicy foods. Do not let your child to lie down or sleep immediately after eating. Consult child’s doctor if the symptom does not improve.
WARNING & PRECAUTIONS
PREGNANCY
ContraindicatedRELENT COLD SYRUP is not recommended for use in pregnant women as it is used only in children. Consult your doctor for advice.
BREASTFEEDING
ContraindicatedRELENT COLD SYRUP is not recommended for use in breast-feeding women as it is used only in children. Consult your doctor for advice.
DRIVING AND USING MACHINES
Use with CautionDo not let your child ride bicycles or drive other vehicles or operate any tools if your child experiences dizziness, drowsiness and sedation after taking RELENT COLD SYRUP.
KIDNEY
Use with CautionRELENT COLD SYRUP should be used with caution in children with kidney failure. Consult your child’s doctor for advice before administration of RELENT COLD SYRUP to your child.
LIVER
Use with CautionRELENT COLD SYRUP should be used with caution in children with liver impairment. Consult your child’s doctor for advice before administration of RELENT COLD SYRUP to your child.
ALLERGY
ContraindicatedTalk to your child’s doctor if your child is allergic to Phenylephrine, Chlorpheniramine or any other ingredients of this medicine.
HEART DISEASE
Consult your doctorRELENT COLD SYRUP is not recommended for use in children with severely high blood pressure. RELENT COLD SYRUP should be used with caution in patients with any other cardiovascular problems. Consult your child’s doctor for advice before administration of RELENT COLD SYRUP to your child.
USE IN PEDIATRICS
Use with CautionRELENT COLD SYRUP should be used with caution in children from 1 month to 12 years of age. Consult your child’s doctor for advice before administration of RELENT COLD SYRUP.
USE IN GERIATRICS
ContraindicatedRELENT COLD SYRUP is not recommended for use in elderly patients as it is used only in children. Consult your doctor for advice.
OTHERS
RELENT COLD SYRUP is not recommended for use if your child:
- has phaeochromocytoma (rare tumours that start in the inner part of the adrenal gland)
- has peripheral or mesenteric vascular thrombosis (blood clots usually in legs or major veins (one or more) that drain blood from the intestine
Before giving RELENT COLD SYRUP to your child, inform your physician if your child:
- has diabetes
- has overactive thyroid
- has closed angle glaucoma
- has history of fits
INTERACTIONS
A. Drug-Drug interactions:
Before giving RELENT COLD SYRUP to your child, inform to child’s doctor if your child is taking or receiving any of the following medicines:
- ephedrine (used to manage low blood pressure)
- phenytoin (used to manage epilepsy)
- digoxin (used to manage irregular heartbeat)
Overdosage:
If your child accidentally takes too much of RELENT COLD SYRUP, contact your doctor immediately or visit a nearby hospital. Overdosage symptoms of RELENT COLD SYRUP includes extreme sleepiness, confusion, weakness, ringing in the ears, blurred vision, large pupils, dry mouth, flushing, fever or possibly seizures.
SYNOPSIS
| Drug | : | Phenylephrine, Chlorpheniramine |
| Pharmacological Category | : | Nasal decongestant, Antihistamines |
| Therapeutic Indication | : | Relieves nasal and sinus congestion, Allergic symptoms, sinus pain, sinusitis, tonsillitis and otitis media |
| Dosage Forms | : | Capsule, Tablet, Syrup, Oral drops |
MORE INFORMATION
STORAGE
- Keep RELENT COLD SYRUP out of reach of children
- Store at room temperature
FAQs ABOUT RELENT COLD SYRUP
Q: What if I forget to give a dose of RELENT COLD SYRUP to my child?
A: If you forget to give a dose of RELENT COLD SYRUP to your child, give it as soon as you remember. However, omit the missed dose if it is almost time for the next one. Do not give the medicine two times to make up for the forgotten dose.
Q: Can I stop giving RELENT COLD SYRUP to my child if the symptoms subside?
A: Continue giving RELENT COLD SYRUP to your child until your child’s doctor tells you to stop, unless your experience child’s any unwanted effects, worsening of the condition or any new symptoms. In such cases, contact your child’s doctor right away.
Q: What precautions do I need to follow while giving RELENT COLD SYRUP to my child?
A: Before giving RELENT COLD SYRUP to your child, you must inform child’s doctor about their pre-existing conditions like any kidney, liver, heart or thyroid problems, diabetes, fits or severely raised blood pressure and any other allergies. Consult your child’s doctor if your child experiences anything different.
Q: Can I give other medicines to my child along with RELENT COLD SYRUP?
A: Before giving RELENT COLD SYRUP to your child, inform your child’s doctor if your child is taking, have taken or might take any other medicine, including prescription, non-prescription or any herbal medicines, as these might interact with each other and cause serious side effects.
Q: Can RELENT COLD SYRUP be used in children with liver problems?
A: RELENT COLD SYRUP should be used with caution in children with liver impairment. Child’s doctor may monitor your child’s liver function before and during management with this medicine to manage the risk of any unusual effects. Consult your child’s doctor for advice before administration of RELENT COLD SYRUP to your child.
REFERENCES
1. Barbara G. Wells, Joseph T. DiPiro, Terry L. Shwinghammer, Cecily V. DiPiro. Allergic Rhinitis. Pharmacotherapy Handbook. Ninth edition. Page-813.
2. KD. Tripathi. Adrenergic System and Drugs. Essentials of Medical Pharmacology. Seventh edition. 2013. Page-135.
3. Mayuresh Kiran and Lalit Pawaskar. Study of Safety and Efficacy for the Combination of Chlorpheniramine maleate and Phenylephrine in Infants suffering from Allergic Rhinitis and Associated Symptoms. International Research of Contemporary Medical Research. March 2019. [Accessed on 20th July 2022] https://www.ijcmr.com/uploads/7/7/4/6/77464738/ijcmr_2406_v1.pdf
4. PubChem Compound Summary for CID 2725, Chlorpheniramine. National Center for Biotechnology Information. June 2022. [Accessed on 20th July 2022] https://pubchem.ncbi.nlm.nih.gov/compound/Chlorpheniramine#section=Mechanism-of-Action
5. Centaur Pharmaceuticals Pvt. Ltd. and Lab Daffodil. Sinarest AF Drops (Phenylephrine + Chlorpheniramine). [Revised in January 2022] [Accessed on 20th July 2022] https://www.centaurpharma.com/downloads/2022/pediatrics/cold/Sinarest%20AF%20oral%20drops.pdf
6. Centaur Pharmaceuticals Pvt. Ltd. and Lab Daffodil. Sinarest AF Drops/Syrups [Accessed on 20th July 2022] https://www.centaurpharma.com/downloads/Sinarest-AF-Syr-Drops2018.pdf
7. Zuventus Healthcare Limited. Maxtra Syrup (Phenylephrine + Chlorpheniramine maleate). [Accessed on 20th July 2022] http://www.zuventus.co.in/doctor_wise_products_selected.aspx?Medi_Id=149
8. GlaxoSmithKline Consumer Healthcare. Electronic Medicines Compendium (EMC). [Revised in March 2022] [Accessed on 20th July 2022] https://www.medicines.org.uk/emc/files/pil.3928.pdf
USEFUL DIAGNOSTIC TESTS
- Nasal cytology
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