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INTRODUCTION ABOUT REMETOR CV 20 CAPSULE
REMETOR CV 20 CAPSULE is used to reduce elevated cholesterol and triglyceride levels in patients when a low-fat diet and lifestyle changes alone have failed. It is a combination of Atorvastatin and Clopidogrel which belongs to the group of medicines called HMG-CoA reductase inhibitors and Antiplatelet medicines respectively. It can also be used to reduce the risk of heart problems such as myocardial infarction, angina (chest pain), heart failure including stroke or revascularization procedures in adult patients with or without a clinically evident chronic heart disease.
Along with management with REMETOR CV 20 CAPSULE, patient should follow an appropriate lipid-lowering diet as advised by their doctor to enhance recovery. Before using the medicine, inform your doctor if you have any liver or kidney disease. Patients with active liver disease should discontinue the use of REMETOR CV 20 CAPSULE as it may cause serious side effects in them.
It is not recommended for use in pregnant or breastfeeding women and in patients with bleeding disorders. It is not suitable for use in children and adolescents (aged below 18 years). Avoid consumption of grapefruit juice or alcohol while taking REMETOR CV 20 CAPSULE as it may lead to unwanted interactions. The most common side effects are muscle pain, joint pain, diarrhoea, nausea, headache or stomach pain. Consult your doctor if any of the side effects worsen.
USES OF REMETOR CV 20 CAPSULE
It is used to reduce:
- elevated cholesterol and triglyceride levels in patients when a low-fat diet and lifestyle changes alone have failed
- the risk of heart problems such as myocardial infarction (MI), angina, heart failure including stroke or revascularization procedures in adult patients with or without clinically evident of chronic heart disease
HOW REMETOR CV 20 CAPSULE WORKS
REMETOR CV 20 CAPSULE reduces elevated cholesterol and risk of heart disease, where Atorvastatin acts by inhibiting the action of an enzyme called HMG-CoA reductase, which is required to catalyze the formation of cholesterol and Clopidogrel acts by inhibiting platelet aggregation, which is believed to be an important factor resulting in heart problems.
DIRECTIONS FOR USE
- Take REMETOR CV 20 CAPSULE as advised by your physician
- Swallow the medicine with a glass of water. Do not crush or chew the medicine
- Your doctor will decide the correct dose and duration for you depending on your age, body weight and disease condition
SIDE EFFECTS OF REMETOR CV 20 CAPSULE
Common side effects of REMETOR CV 20 CAPSULE:
- diarrhoea
- stomach pain
- indigestion or heartburn
- constipation, flatulence, indigestion
- joint pain, muscle and back pain
Stop taking REMETOR CV 20 CAPSULE and contact your doctor immediately if you experience any of the following side effects:
- unexpected or unusual bleeding or bruising, hematoma
- signs of liver problems such as yellowing of the skin and/or the eyes (jaundice), whether associated with bleeding which appears under the skin as red pinpoint dots
- signs of infection or extreme tiredness (due to decrease of some blood cells)
WARNING & PRECAUTIONS
PREGNANCY
ContraindicatedREMETOR CV 20 CAPSULE is not recommended for use in pregnant women.
BREASTFEEDING
ContraindicatedREMETOR CV 20 CAPSULE is not recommended for use in breast-feeding women.
DRIVING AND USING MACHINES
Use with CautionDo not drive or operate any machines if your ability is affected after taking REMETOR CV 20 CAPSULE.
ALCOHOL
Consult your doctorAvoid consumption of alcohol while taking REMETOR CV 20 CAPSULE.
KIDNEY
Use with CautionREMETOR CV 20 CAPSULE should be used with caution in patients with kidney disease.
LIVER
ContraindicatedREMETOR CV 20 CAPSULE is not recommended for use in patients with active liver disease, including unexplained persistent elevations in hepatic transaminase levels.
ALLERGY
ContraindicatedDo not take REMETOR CV 20 CAPSULE if you are allergic to Atorvastatin or Clopidogrel.
LUNGS
Use with CautionREMETOR CV 20 CAPSULE should be used with caution in patients with severe respiratory failure.
USE IN PEDIATRICS
ContraindicatedREMETOR CV 20 CAPSULE is not recommended for use in children and adolescents (aged below 18 years) due to lack of safety and effectiveness.
USE IN GERIATRICS
Use with CautionREMETOR CV 20 CAPSULE should be used with caution in elderly patients (65 years of age or above). During prolonged management with the medicine, your doctor will monitor you regularly.
OTHERS
REMETOR CV 20 CAPSULE is not recommended for use if you have:
- bleeding disorders
Before taking REMETOR CV 20 CAPSULE, inform your physician if you have:
- hypothyroidism, diabetes
- repeated or unexplained muscle aches or pains
- personal history or family history of muscle problems
- previous muscular problems during management with other lipid-lowering medicines
- blood disorder that makes you prone to internal bleeding (bleeding inside any tissues, organs or joints of your body)
- recent serious injury
- recent surgery (including dental surgery)
- any planned surgeries
INTERACTIONS
A. Drug-Drug interactions:
Before taking REMETOR CV 20 CAPSULE inform your doctor, if you are taking any of these medicines:
- Anti-lipidemic agents (Ex. cholestyramine, colestipol, gemfibrozil, ezetimibe)
- Thienopyridine (Ex. ticlopidine)
- Anti-depressants (Ex. fluoxetine, fluvoxamine, citalopram, sertraline, venlafaxine, duloxetine, desvenlafaxine)
- Vitamins (Ex. niacin)
- Immunosuppressants (Ex. cyclosporin)
- Antibiotics (Ex. telithromycin, clarithromycin, fusidic acid)
- HIV protease inhibitors (ritonavir or lopinavir)
- Anti-fungal (Ex. itraconazole)
- proton pump inhibitors (Ex. omeprazole and esomeprazole)
- Ant-diabetic agents (Ex. repaglinide)
- Antimicrotubule agents (Ex. Paclitaxel)
- Anti-TB agents (Ex. rifampin)
- Cardiac glycosides (Ex. digoxin)
- Oral contraceptives (Ex. norethindrone, ethinyl estradiol)
- Anti-gout agents (Ex. colchicine)
- non-steroidal anti-inflammatory agents (Ex. aspirin)
- Anti-coagulants (Ex. heparin and warfarin)
- St. john’s wort
B. Drug-Food interaction:
While taking REMETOR CV 20 CAPSULE, avoid taking large quantities (not more than one or two small glasses) of grapefruit juice as it can alter the effects of this medicine resulting in undesired therapeutic outcomes.
Overdosage:
If you or anyone else accidentally takes too much of REMETOR CV 20 CAPSULE, contact your doctor immediately or go to a hospital straight away because of increased risk of bleeding.
SYNOPSIS
| Drug | : | Atorvastatin, Clopidogrel |
| Pharmacological Category | : | HMG-CoA reductase inhibitors, Anti-platelet medication |
| Therapeutic Indication | : | Controls blood cholesterol levels, Reduces the risk of heart diseases |
| Dosage Forms | : | Tablet, Capsule |
MORE INFORMATION
FAQs ABOUT REMETOR CV 20 CAPSULE
Q: What is REMETOR CV 20 CAPSULE used for?
A: REMETOR CV 20 CAPSULE, a combination of atorvastatin and clopidogrel, is used to reduce the risk of heart attacks, strokes, and other cardiovascular events. Atorvastatin lowers "bad" cholesterol (LDL) and triglycerides while increasing "good" cholesterol (HDL). Clopidogrel prevents platelets from clumping together, reducing the risk of blood clots. Together, they protect against complications related to high cholesterol and blood clots.
Q: How REMETOR CV 20 CAPSULE works for heart attack?
A: REMETOR CV 20 CAPSULE reduces the risk of heart attacks by targeting two main factors: high cholesterol and blood clots. Atorvastatin inhibits an enzyme in the liver responsible for cholesterol production, reducing plaque buildup in blood vessels. Clopidogrel prevents platelets from sticking together, maintaining smooth blood flow and minimizing clot formation. These actions ensure that blood vessels remain open, reducing strain on the heart.
Q: What high cholesterol levels can lead to?
A: High cholesterol can lead to the formation of fatty deposits (plaques) in blood vessels, narrowing them and restricting blood flow. This condition, known as atherosclerosis, increases the risk of heart attacks, strokes, and peripheral artery disease. Untreated high cholesterol can also lead to hypertension and other complications like kidney disease or chest pain (angina).
Q: Can REMETOR CV 20 CAPSULE be used in obese individuals?
A: Yes, REMETOR CV 20 CAPSULE is often prescribed for obese individuals who are at higher risk of cardiovascular diseases due to elevated cholesterol levels and a greater likelihood of blood clots. However, it should be combined with lifestyle changes like a healthy diet, regular exercise, and weight management for optimal results. Make sure to take this medicine under medical supervision only if you are obese and having blood tests indication high cholesterol or triglyceride levels.
Q: Can REMETOR CV 20 CAPSULE reduces body weight?
A: No, REMETOR CV 20 CAPSULE is not designed for weight loss. While atorvastatin helps manage cholesterol levels, and clopidogrel reduces clotting risk, neither directly affects body weight. Weight loss in patients taking this medication often results from lifestyle modifications, such as a healthy diet and increased physical activity.
Q: Can REMETOR CV 20 CAPSULE be used during pregnancy?
A: No, REMETOR CV 20 CAPSULE is not recommended during pregnancy. Atorvastatin may harm the developing fetus, and clopidogrel should only be used if absolutely necessary, as its safety during pregnancy is not well established. If you are pregnant or planning to conceive, consult your doctor for alternative treatments.
Q: What diet and lifestyle changes should be adopted for high cholesterol?
A: To manage high cholesterol, adopt a heart-healthy diet rich in fruits, vegetables, whole grains, and lean proteins like fish and chicken. Limit saturated fats, trans fats, and added sugars. Regular physical activity, maintaining a healthy weight, avoiding smoking, and limiting alcohol intake are also essential. These habits enhance the effectiveness of REMETOR CV 20 CAPSULE.
Q: What foods should be avoided if you are having high cholesterol?
A: Avoid foods high in saturated and trans fats, such as fried foods, full-fat dairy products, processed meats, and baked goods made with hydrogenated oils. Minimize consumption of red meat, butter, and fast foods. Instead, choose heart-healthy fats from nuts, seeds, avocados, and olive oil.
Q: Are there any medicines that should be avoided while taking REMETOR CV 20 CAPSULE?
A: Yes, some medications can interact with REMETOR CV 20 CAPSULE, including, blood thinners like warfarin (increased bleeding risk), certain antibiotics or antifungals (e.g., clarithromycin, ketoconazole), immunosuppressants (e.g., cyclosporine), anti-seizure medications (e.g., phenytoin). Always inform your doctor about all the medicines and supplements you are taking.
Q: What precautions must be followed while taking REMETOR CV 20 CAPSULE?
A: Avoid alcohol, as it can increase the risk of liver damage. Take the medication exactly as prescribed. Monitor your cholesterol and liver function tests regularly. Report any unusual bruising, bleeding, or muscle pain to your doctor. Avoid grapefruit or its juice, as it may interfere with atorvastatin's metabolism.
Q: Is REMETOR CV 20 CAPSULE safe?
A: REMETOR CV 20 CAPSULE is generally safe when taken as prescribed. However, like all medicines, it may cause side effects in some individuals. Regular follow-ups and monitoring are crucial to ensure safety and effectiveness. Speak to your doctor if you have concerns or pre-existing conditions.
Q: How long should REMETOR CV 20 CAPSULE be used?
A: The duration of REMETOR CV 20 CAPSULE therapy depends on your condition and response to therapy. In many cases, it is used as a long-term medication to prevent recurring cardiovascular events. Regular check-ups will help your doctor decide the appropriate duration for you.
Q: Can I stop using REMETOR CV 20 CAPSULE once after I feel better?
A: No, do not stop taking REMETOR CV 20 CAPSULE without consulting your doctor. Discontinuing the medication can increase your risk of a heart attack, stroke, or other complications. Always follow your doctor’s instructions regarding dose adjustments or discontinuation.
Q: What are the common side effects of using REMETOR CV 20 CAPSULE?
A: Common side effects of REMETOR CV 20 CAPSULE include headache, dizziness, nausea, muscle pain, and upset stomach. Rarely, it can cause severe side effects like liver damage, severe bleeding, or allergic reactions. Inform your doctor if you experience any unusual symptoms.
REFERENCES
1. KD. Tripathi. Hypolipidemic Drugs and Plasma Expanders & Drugs Affecting Coagulation, Bleeding and Thrombosis. Essentials of medical pharmacology. Seventh edition. 2013. Page – 636 & 630.
2. Thomas P. Bersot. Drug therapy for hypercholesterolemia and dyslipidemia. Goodman & Gilman’s: The Pharmacological basics of Therapeutics. 12th Edition. New York McGraw Hill Medical 2011. Page – 894-898.
3. Gerald G. Briggs and Roger K. Freeman. A reference guide to fetal and neonatal risk: Drugs in Pregnancy and Lactation. Tenth Edition. 2015. Page – 321-2775.
4. Ospedale Misericordia e Dolce. Atorvastatin and Clopidogrel High Dose in Stable Patients with Residual High Platelet Activity (ACHIDO). NIH U.S. National Library of Medicine ClinicalTrials.gov. [Revised in January 2012] [Accessed on 29th October 2022] click here
5. Goeng Bae Kim, Jeong Kyung Kim, Sul Park, Jae Jin Jeong, Hyung Sik Yoon, Sang Hun Ko, Jae Ee Ko, Soo Jin Park, Seon Woo Nam, Jae Hwan Lee, and Min Soo Hyon. Effect of Atorvastatin and Clopidogrel Co-Administration After Coronary Stenting in Korean Patients with Stable Angina. NCBI; PMC US National Library of Medicine, National Institute of Health. January 2011. [Accessed on 29th October 2022] click here
6. Cipla Ltd. Atorlip CV Capsules (Atorvastatin calcium + Clopidogrel). Ciplamed. [Revised in October 2016]. [Accessed on 29th October 2022] click here
7. CP Pharmaceuticals Ltd. Electronic Medicines Compendium (EMC). [Revised in March 2020] [Accessed on 29th October 2022] click here
8. APL Swift Services (Malta) Limited or Milpharm Limited. Electronic Medicines Compendium (EMC). [Revised in March 2021] [Accessed on 29th October 2022] click here
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