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TG Tor F 160 Tablet 10'S
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Introduction About TG TOR F TABLET
TG TOR F TABLET is a combination medication used to manage cholesterol levels and reduce the risk of cardiovascular diseases. It reduces the levels of bad cholesterol (VLDL and LDL) and triglycerides in the body by modulating the actions of certain enzymes that are involved in lipid metabolism (such as HMG-CoA reductase and lipoprotein lipase). Additionally, it can also reduce the amount of cholesterol absorbed in the body.
Take the tablet at the same time each day to maintain consistent blood levels of the medication. Avoid drinking large amounts of alcohol while taking this cholesterol medicine. If you are diabetic, work on your blood sugar levels and keep them under control. Before using TG TOR F TABLET, inform your doctor if you have liver or kidney problems, are pregnant or breastfeeding, are taking other medications that may interact with Atorvastatin or Fenofibrate.
It is also not suitable for use in patients who had recently taken an antibiotic called Fusidic acid to manage bacterial infections. Women of childbearing potential must use a suitable contraceptive method to avoid pregnancy while undergoing therapy with this medicine.
The most common side effects of taking TG TOR F TABLET are muscle pain or weakness, headache, abdominal discomfort and elevated liver enzymes. Consult your doctor if they bother you. You must also inform your doctor if you experience severe unexplained muscle pain or weakness with fever, weakness or reddish-brown urine after taking TG TOR F TABLET.
Uses Of TG TOR F TABLET
- Reduces bad cholesterol (LDL) and triglycerides
- Increases good cholesterol (HDL)
- Reduces the risk of cardiovascular complications like heart attacks and strokes
Benefits of TG TOR F TABLET:
For Hyperlipidemia:
TG TOR F TABLET reduces low-density lipoprotein (LDL) cholesterol, a primary factor in the development of atherosclerosis and plaque buildup in arteries. Lowering LDL cholesterol helps reduce the risk of heart attacks and strokes. It increases levels of high-density lipoprotein (HDL) cholesterol, which helps remove excess LDL cholesterol from the bloodstream.
Benefits of TG TOR F TABLET:
To reduce the risk of cardiovascular diseases:
TG TOR F TABLET helps to reduce plaque buildup, it helps lower the risk of atherosclerosis, a leading cause of heart attacks and strokes. It reduces triglycerides to protect heart health and increases HDL cholesterol, higher HDL levels are associated with a lower risk of heart disease and improved vascular health.
How TG TOR F TABLET Works
TG TOR F TABLET is a lipid-lowering medicine. It reduces the levels of bad cholesterol (VLDL and LDL) and triglycerides in the body by modulating the actions of certain enzymes that are involved in lipid metabolism. Additionally, it can also reduce the amount of cholesterol absorbed in the body. By lowering the blood lipid levels, TG TOR F TABLET manages fat deposition within the blood vessels and reduces the chances of heart attack, stroke, atherosclerosis or other circulatory problems.
How to use TG TOR F TABLET
Take TG TOR F TABLET preferably after meals. Swallow the medicine with a glass of water. Do not crush or chew the medicine.
Dosage and Administration:
- Take one Tablet daily at the same time every day to maintain consistent blood levels of the medication or as prescribed by your healthcare provider
- Dosage may vary based on individual health conditions such as liver function, age, or other medical factors. Always follow your doctor’s instructions.
Missed dose instructions for TG TOR F TABLET:
- If you forgot a dose, take as soon as you remember
- If it’s almost time for your next dose, skip the forgotten dose
- Do not take an extra dose to compensate for the missed one, as this may increase the risk of side effects
Overdosage instructions for TG TOR F TABLET:
- Overdosing may cause symptoms such as severe muscle pain, weakness, nausea, liver damage, or gastrointestinal distress
- In case of overdose, seek immediate medical attention or contact a poison control center.
- Bring the medication packaging or a written record of the dose consumed for reference during emergencies
Side Effects Of TG TOR F TABLET
Like all medicines, TG TOR F TABLET may cause certain side effects, although not everybody gets them.
Most common side effects of TG TOR F TABLET are:
- muscle pain or weakness
- headache
- abdominal discomfort
- elevated liver enzymes
When to consult your doctor?
- severe allergic skin reactions (such as skin rash, itching, skin redness with blisters or peeling of the skin, swelling in the mouth, which may be associated with high fever and joint pains)
- unexplained muscle pain or weakness, especially if accompanied by fever, weakness or reddish-brown urine
- severe stomach pain due to inflammation of the pancreas
- signs of blood clots in the body (such as chest pain, shortness of breath, pain, redness and swelling in the legs)
How To Manage Side Effects
Headache
Drink plenty of water throughout the day. Herbal teas like chamomile or peppermint can also help soothe the headache. Lie down in a comfortable, dark, and quiet room. Use an eye mask or a cool compress on your forehead for additional relief.
Muscle Cramps
Drink at least 8-10 glasses of water daily. Include electrolyte-rich drinks if you experience severe weakness or cramping. Give your body time to rest. Avoid heavy lifting or intense physical activities until symptoms improve. Apply a warm towel or heating pad for 15-20 minutes or use a cold pack wrapped in a cloth to numb the affected area.
Stomach Discomfort
Stick to a low-fat, bland diet while experiencing abdominal discomfort. Avoid caffeine, alcohol, and carbonated beverages. Take a short walk after meals to help food move through your digestive tract. Avoid lying down immediately after eating.
Warning & Precautions
Pregnancy
ContraindicatedStudies in animal and human study shows that Atorvastatin and Fenofibrate can cause significant harm to the growing baby when exposed to pregnant women. Therefore it can be considered as not safe for use in pregnant women. To know more, consult your gynaecologist for advice.
Breastfeeding
ContraindicatedAnimal studies shows that Atorvastatin and Fenofibrate cause significant harm to the nursing infants when exposed to breastfeeding women. Therefore, TG TOR F TABLET should not be used if you are breastfeeding. Consult your doctor for advice.
Driving and Using Machines
Use with CautionDo not drive or operate any heavy tools or machines if your ability is affected by TG TOR F TABLET.
Alcohol
Consult your doctorAvoid consumption of alcohol while taking TG TOR F TABLET as it may reduce the effectiveness of this medicine.
Kidney
Consult your doctorTG TOR F TABLET is not recommended for use in patients with moderate to severe kidney problems. It should be used with caution in patients with other mild kidney problems. Dosage adjustment and careful monitoring are required in such patients. Therefore, consult your doctor before taking it.
Liver
Consult your doctorTG TOR F TABLET is not recommended for use in patients with severe liver or gall bladder problems. It should be used with caution in patients with other liver problems. Regular medical check-ups and blood tests are required in such patients. Therefore, consult your doctor before taking it.
Allergy
ContraindicatedIt is not recommended if you are allergic to Atorvastatin or Fenofibrate or any other ingredients of this medicine.
Lungs
Use with CautionTG TOR F TABLET should be used with caution in patients with respiratory failure. Therefore, consult your doctor before taking it.
Use In Pediatrics
ContraindicatedTG TOR F TABLET is not recommended for use in children and adolescents (aged below 18 years). Therefore, consult your doctor for advice.
Use In Geriatrics
Use with CautionTG TOR F TABLET should be used with caution in elderly patients (aged 70 years or above). Therefore, consult your doctor before taking it.
Others
TG TOR F TABLET is not recommended for use if you:
- have inflammation of the pancreas
Before taking TG TOR F TABLET, inform your doctor if you:
- have diabetes (type I or type II)
- are obese
- have high blood pressure
- have blood problems
- have a previous history of stroke or bleeding in the brain
- have underactive thyroid
- have repeated or unexplainable muscle cramps or pain
- have a family history of muscular disorder
- previously had any muscle problems while taking similar types of lipid-lowering medicines
Safety Advice
Quick Tips:
- Follow Prescribed Dosage: Always take the medicine exactly as prescribed by your doctor. Do not alter the dosage without consulting a healthcare professional.
- Take at the Same Time Daily: Establish a routine by taking the tablet at the same time each day, with or without food, for maximum effectiveness.
- Monitor Liver Function: Regular liver function tests are essential during treatment to ensure safety and avoid potential side effects.
- Stay Hydrated: Drink plenty of water to support kidney function and reduce the risk of muscle-related side effects.
- Avoid Alcohol: Limit or avoid alcohol consumption, as it can increase the risk of liver damage when combined with the medicine.
- Inform About Other Medications: Let your doctor know about all other medications, supplements, or herbal remedies you’re taking to avoid harmful interactions.
- Report Muscle Symptoms: Notify your doctor immediately if you experience unexplained muscle pain, weakness, or tenderness, as these could indicate serious side effects.
- Contraceptive Use: Women should consult their doctor if they are using hormonal contraceptives, as the medication may alter its effectiveness.
- Avoid During Pregnancy and Breastfeeding: Not recommended for use during pregnancy or breastfeeding due to potential risks to the baby.
- Be Cautious with Grapefruit: Avoid grapefruit or grapefruit juice, as it may interfere with the metabolism of atorvastatin in the tablet.
- Monitor Blood Sugar: Diabetic patients should regularly check their blood sugar levels, as it may influence glucose metabolism.
- Exercise and Diet: Combine the medication with a healthy diet and regular exercise to enhance its lipid-lowering effects.
- Missed Dose: If you forgot a dose, take it as soon as you remember, but skip it if it’s almost time for your next dose. Never double the dose to make up for the missed one.
Always consult your healthcare provider for personalized advice to ensure safe and effective use
Interactions
A. Drug-Drug interactions:
Before taking TG TOR F TABLET inform to your doctor, if you are taking any of these medicines:
Anticoagulants (e.g., Warfarin)
- Interaction: Atorvastatin and fenofibrate can enhance Warfarin’s anticoagulant effect by displacing it from plasma proteins or inhibiting its metabolism. This increases the risk of excessive bleeding
- Effect: Prolonged clotting times, increased risk of bruising, nosebleeds, or internal bleeding
Antibiotics (e.g., Erythromycin)
- Interaction: Erythromycin, a macrolide antibiotic, inhibits the cytochrome P450 3A4 (CYP3A4) enzyme, which is responsible for metabolizing atorvastatin. This can lead to increased levels of atorvastatin in the bloodstream, raising the risk of adverse effects.
- Effect: Elevated atorvastatin levels can cause severe muscle-related side effects, including myopathy (muscle pain or weakness) and, in rare cases, rhabdomyolysis (muscle breakdown leading to kidney damage).
Contraceptives (e.g., Ethinylestradiol)
- Interaction: Atorvastatin influence the metabolism of ethinylestradiol by inducing or inhibiting liver enzymes such as cytochrome P450. Fenofibrate’s lipid-modifying action may alter how ethinylestradiol affects cholesterol and triglyceride levels, potentially impacting cardiovascular health.
- Effect: The combination may increase liver enzyme levels, leading to a higher risk of hepatotoxicity. Atorvastatin might reduce the effectiveness of oral contraceptives by influencing their metabolism, potentially increasing the risk of unintended pregnancy.
Antidiabetics (e.g., Rosiglitazone)
- Interaction: Both atorvastatin and rosiglitazone are metabolized by the liver via cytochrome P450 enzymes (CYP3A4 and CYP2C8, respectively). Co-administration may alter drug metabolism, affecting efficacy and side effects. Fenofibrate’s lipid-lowering effects and rosiglitazone’s impact on glucose metabolism may interact, leading to imbalances in lipid and glucose homeostasis.
- Effect: It may elevate liver enzyme levels, increasing the risk of liver damage
B. Drug- Food Interactions:
Avoid drinking grapefruit juice while taking TG TOR F TABLET as it may increase the risk of side effects.
Synopsis
| Drug | : | Atorvastatin, Fenofibrate |
| Pharmacological Category | : | HMG-CoA reductase inhibitors, Lipoprotein Lipase Activators |
| Therapeutic Indication | : | Used to Manage Cholesterol levels, To reduce the risk of cardiovascular diseases |
| Dosage Forms | : | Tablet, Capsule |
More Information
Duration of Action: TG TOR F TABLET provides effective, 24-hour coverage for lipid management due to the sustained actions of both atorvastatin and fenofibrate. Single Daily Dose: Both components of TG TOR F TABLET work together to provide continuous benefits with just one tablet per day.
Onset of Action: The combined onset of action of TG TOR F TABLET occurs relatively quickly, with initial effects on lipid levels starting within 2 to 4 days. However, the maximum therapeutic benefit is typically observed after 2 to 4 weeks of consistent use.
FAQs About TG TOR F TABLET
Q: What is TG TOR F TABLET used for?
A: It combines atorvastatin (a statin) and fenofibrate (a fibrate), and is primarily used to manage high cholesterol and high triglycerides. It helps lower LDL (bad cholesterol), total cholesterol, and triglyceride levels while increasing HDL (good cholesterol). This dual-action formulation is effective for reducing the risk of cardiovascular events, such as heart attack and stroke, particularly in individuals with dyslipidemia or metabolic syndrome.
Q: How should I take TG TOR F TABLET?
A: It should be taken once daily, preferably at the same time each day, with or without food. Swallow the tablet whole with a glass of water. Do not crush or chew the tablet, as this may interfere with its effectiveness. Always follow the dosage prescribed by your healthcare provider. If you forgot a dose, take it as soon as you remember, but skip it if it is almost time for your next dose. Do not double the dose.
Q: What are the common side effects of TG TOR F TABLET?
A: Common side effects may include Muscle pain or weakness (myopathy), Headache, Abdominal discomfort or nausea and Elevated liver enzymes (in rare cases, liver function may be affected).
Q: Are there any drug interactions with TG TOR F TABLET?
A: Yes, TG TOR F TABLET can interact with several other medications, including Warfarin (an anticoagulant), which may increase the risk of bleeding, Erythromycin (an antibiotic), which can raise atorvastatin levels in the blood, Cyclosporine (immunosuppressant), which may increase the risk of muscle problems. Other statins or fibrates, which may increase the risk of side effects
Q: Can I take TG TOR F TABLET while pregnant or breastfeeding?
A: It is not recommended during pregnancy or while breastfeeding. The active ingredients in the tablet may pose risks to the fetus or infant. If you are pregnant, planning to become pregnant, or breastfeeding, inform your healthcare provider. They will recommend alternative treatments that are safer for you and your baby.
Q: What should I do if I forgot a dose of TG TOR F TABLET?
A: If you forgot a dose, take it as soon as you remember unless it is almost time for your next dose. In that case, skip the missed dose and continue with your regular dosing schedule. Do not take two doses at once to make up for a missed dose, as this may increase the risk of side effects.
Q: How long will it take to see the effects of TG TOR F TABLET?
A: You may begin to notice some improvements in cholesterol and triglyceride levels within 2 to 4 weeks of starting TG TOR F TABLET. However, the full benefits of the medication can take several weeks to be realized. Regular follow-ups with your healthcare provider are important to monitor your progress and make any necessary adjustments to your treatment.
Q: Can I consume alcohol while taking TG TOR F TABLET?
A: It is advisable to limit alcohol consumption while taking TG TOR F TABLET, as alcohol can increase the risk of liver damage, especially when combined with atorvastatin. Discuss with your doctor how much alcohol, if any, is safe for you while on this medication.
Q: What precautions should I take while using TG TOR F TABLET?
A: When using TG TOR F TABLET, consider the following precautions like Liver function: Regular liver tests are necessary to monitor liver health. Muscle pain: Report any muscle pain, tenderness, or weakness immediately, as these could be signs of serious conditions like rhabdomyolysis. Kidney function: If you have kidney issues, your doctor may adjust the dose to avoid complications. Drug interactions: Always inform your doctor about all medications you are taking, including over-the-counter drugs. Diet and exercise: Follow a healthy diet and engage in regular physical activity to support the medication’s lipid-lowering effects.
Q: How should I store TG TOR F TABLET?
A: Store TG TOR F TABLET at room temperature (20°C to 25°C or 68°F to 77°F) in a dry place away from direct sunlight and moisture. Keep the medication in its original blister pack or container, tightly sealed, and out of reach of children. Do not store the medication in the bathroom or near sources of heat, such as a stove or radiator.
References
1. KD. Tripathi. Hypolipidemic Drugs and Plasma Expanders. Essentials of medical pharmacology. Seventh edition. Page - 637 & 639.
2. Gursharan Sidhu; Jayson Tripp. Fenofibrate. StatPearls [Internet]. NIH. National Library of Medicine. National Center for Biotechnology Information. March 2022. [Accessed on 14th October 2022]. click here
3. Md. Tanjir Islam, A.F.M. Towheedur Rahman, Md. Shahid Sarwar, Md. Asaduzzaman, Yusuf Ali, Shaheda Zannah and Mamunur Rashid. Fenofibrate Potentiates the Antihyperglycemic, Antidyslipidemic and Hepatoprotective Activity of Pioglitazone on Alloxan-Induced Diabetic Rats. ResearchGate.com. December 2015. [Accessed on 14th October 2022]. click here
4. Shinichi Oikawa, Shizuya Yamashita, Noriaki Nakaya, Jun Sasaki, Suminori Kono. Efficacy and Safety of Long-term Coadministration of Fenofibrate and Ezetimibe in Patients with Combined Hyperlipidemia: Results of the EFECTL Study. NIH. National Library of Medicine. National Center for Biotechnology Information. January 2017. [Accessed on 14th October 2022]. click here
5. Upjohn UK Limited. Electronic Medicines Compendium (EMC). [Revised in May 2020] [Accessed on 14th October 2022]. click here
6. Sun Pharmaceutical Industries Europe B.V. Electronic Medicines Compendium (EMC). [Revised in April 2022] [Accessed on 14th October 2022]. click here
7. Genus Pharmaceuticals. Electronic Medicines Compendium (EMC). [Revised in October 2020] [Accessed on 13th October 2022]. click here
8. Accord. Electronic Medicines Compendium (EMC). [Revised in April 2021] [Accessed on 13th October 2022]. click here
9. Accord. Electronic Medicines Compendium (EMC). [Revised in April 2021] [Accessed on 13th October 2022]. click here
10. Cipla Ltd. Atorlip-F Tablets (Atorvastatin + Fenofibrate). Ciplamed.com. [Revised in July 2022]. [Accessed on 14th October 2022]. click here
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