Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Recommendations for the Clinical Approach to Primary Immune Thrombocytopenia

Version 1 : Received: 5 September 2023 / Approved: 5 September 2023 / Online: 6 September 2023 (09:38:18 CEST)

A peer-reviewed article of this Preprint also exists.

Mingot-Castellano, M.E.; Canaro Hirnyk, M.; Sánchez-González, B.; Álvarez-Román, M.T.; Bárez-García, A.; Bernardo-Gutiérrez, Á.; Bernat-Pablo, S.; Bolaños-Calderón, E.; Butta-Coll, N.; Caballero-Navarro, G.; Caparrós-Miranda, I.S.; Entrena-Ureña, L.; Fernández-Fuertes, L.F.; García-Frade, L.J.; Gómez del Castillo, M.C.; González-López, T.J.; Grande-García, C.; Guinea de Castro, J.M.; Jarque-Ramos, I.; Jiménez-Bárcenas, R.; López-Ansoar, E.; Martínez-Carballeira, D.; Martínez-Robles, V.; Monteagudo-Montesinos, E.; Páramo-Fernández, J.A.; Perera-Álvarez, M.M.; Soto-Ortega, I.; Valcárcel-Ferreiras, D.; Pascual-Izquierdo, C. Recommendations for the Clinical Approach to Immune Thrombocytopenia: Spanish ITP Working Group (GEPTI). J. Clin. Med. 2023, 12, 6422. Mingot-Castellano, M.E.; Canaro Hirnyk, M.; Sánchez-González, B.; Álvarez-Román, M.T.; Bárez-García, A.; Bernardo-Gutiérrez, Á.; Bernat-Pablo, S.; Bolaños-Calderón, E.; Butta-Coll, N.; Caballero-Navarro, G.; Caparrós-Miranda, I.S.; Entrena-Ureña, L.; Fernández-Fuertes, L.F.; García-Frade, L.J.; Gómez del Castillo, M.C.; González-López, T.J.; Grande-García, C.; Guinea de Castro, J.M.; Jarque-Ramos, I.; Jiménez-Bárcenas, R.; López-Ansoar, E.; Martínez-Carballeira, D.; Martínez-Robles, V.; Monteagudo-Montesinos, E.; Páramo-Fernández, J.A.; Perera-Álvarez, M.M.; Soto-Ortega, I.; Valcárcel-Ferreiras, D.; Pascual-Izquierdo, C. Recommendations for the Clinical Approach to Immune Thrombocytopenia: Spanish ITP Working Group (GEPTI). J. Clin. Med. 2023, 12, 6422.

Abstract

Primary immune thrombocytopenia (ITP) is a complex autoimmune disease whose hallmark is a deregulation of cellular and humoral immunity leading to an increased destruction and a reduced production of platelets. The heterogeneity of presentation and clinical course hampers personalized approaches for diagnosis and management. In 2021, the Spanish ITP Group (GEPTI) of the Spanish Society of Hematology and Hemotherapy (SEHH) updated a consensus document which had been launched in 2011. The updated guidelines have been the reference for diagnosis and management of primary ITP in Spain ever since. Nevertheless, the emergence of new tools and strategies makes it advisable to review them again. For this reason, we have properly updated the main recommendations. Our aim is to provide a practical tool to enable the integral management of all the aspects concerning primary ITP management.

Keywords

Primary immune thrombocytopenia; Glucocorticoids; Intravenous immunoglobulins; Fostamatinib; Rituximab; Recommendations

Subject

Medicine and Pharmacology, Hematology

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