Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Synthesis, Antibacterial Activity and Cytotoxicity of Azido-Propargyloxy 1,3,5-Triazine Derivatives and Hyperbranched Polymers

Version 1 : Received: 27 November 2023 / Approved: 28 November 2023 / Online: 29 November 2023 (08:10:21 CET)

A peer-reviewed article of this Preprint also exists.

Tsyganova, A.V.; Petrov, A.O.; Shastin, A.V.; Filatova, N.V.; Mumyatova, V.A.; Tarasov, A.E.; Lolaeva, A.V.; Malkov, G.V. Synthesis, Antibacterial Activity, and Cytotoxicity of Azido-Propargyloxy 1,3,5-Triazine Derivatives and Hyperbranched Polymers. Chemistry 2024, 6, 1-12. Tsyganova, A.V.; Petrov, A.O.; Shastin, A.V.; Filatova, N.V.; Mumyatova, V.A.; Tarasov, A.E.; Lolaeva, A.V.; Malkov, G.V. Synthesis, Antibacterial Activity, and Cytotoxicity of Azido-Propargyloxy 1,3,5-Triazine Derivatives and Hyperbranched Polymers. Chemistry 2024, 6, 1-12.

Abstract

A new method for the synthesis of azido-propargyloxy derivatives of 1,3,5-triazine has been developed. The antibacterial activity against E. coli bacteria of propargyloxy substituted 1,3,5-triazines - 2,4,6-trispropargyloxy-1,3,5-triazine, 2-azido-4,6-bispropargyloxy-1,3,5-triazine and 2,4-diazido-6-propargyloxy-1,3,5-triazine and their hyperbranched polymers. It has been shown that the presence of an azide group in the compound directly affects the antibacterial activity. The cytotoxicity of these compounds against the M-HeLa, FetMSC and Vero cell lines was studied. The IC50 value was determined for low molecular weight compounds. It has been shown that hyperbranched polymers without azide groups don’t exhibit pronounced cytotoxicity and can be used in biomedical applications.

Keywords

1,3,5-triazine; nucleophilic substitution; nitrosation reaction; azido-acetylene cycloaddition; 1,2,3-triazole; hyperbranched polymers; antibacterial activity; cytotoxicity; M-HeLa; Vero

Subject

Chemistry and Materials Science, Medicinal Chemistry

Comments (0)

We encourage comments and feedback from a broad range of readers. See criteria for comments and our Diversity statement.

Leave a public comment
Send a private comment to the author(s)
* All users must log in before leaving a comment
Views 0
Downloads 0
Comments 0


×
Alerts
Notify me about updates to this article or when a peer-reviewed version is published.
We use cookies on our website to ensure you get the best experience.
Read more about our cookies here.