GEORG OELTZSCHNER, PHD - INSTRUCTOR OF RADIOLOGY AND RADIOLOGICAL SCIENCE RUSSELL H. MORGAN DEPARTMENT OF RADIOLOGY AND RADIOLOGICAL SCIENCE JOHNS ...
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September 30th, 2020
Georg Oeltzschner, PhD
Instructor of Radiology and Radiological Science
Russell H. Morgan Department of Radiology and Radiological Science
Johns Hopkins University School of Medicine
I am an Instructor of Radiology, specializing in magnetic resonance spectroscopy (MRS) in the human
brain. Over the course of my career, my research has been dedicated to advanced MRS methods for
the detection of low-concentration metabolites, like the primary inhibitory neurotransmitter g-
aminobutyric acid (GABA), and the major antioxidant glutathione (GSH). More than eight years of
experience in the field have provided me with a strong methodological background in MR physics
data analysis, enabling me to develop accelerated MRS methods with increased precision for research
and clinical purposes.
I have extensive experience working with clinical populations with neurological and psychiatric
conditions such as hepatic encephalopathy, autism spectrum disorder, Tourette’s, tuberous sclerosis,
and glioblastoma. Recently, I acquired independent funding to study brain metabolism in mild
cognitive impairment with advanced MRS and PET methods.
Collaborative science is a deep passion of mine, and I maintain a strong focus on developing and
disseminating free, open-source, peer-reviewed data analysis methods to advance the comparability,
reproducibility, and robustness of MRS.
APPOINTMENTS
2020 – present Instructor of Radiology and Radiological Science
The Russell H. Morgan Department of Radiology and Radiological Science
The Johns Hopkins University School of Medicine, Baltimore, MD, USA
EDUCATION / TRAINING
2016 – 2020 Postdoctoral Research Fellow
The Russell H. Morgan Department of Radiology and Radiological Science
The Johns Hopkins University School of Medicine, Baltimore, MD, USA
Supervision: Prof. Richard A.E. Edden
2012 – 2015 PhD (magna cum laude)
Institute of Clinical Neuroscience and Medical Psychology
Department of Diagnostic and Interventional Radiology
Universitätsklinikum Düsseldorf
Heinrich-Heine-Universität, Düsseldorf, Germany
Supervision: Prof. Dr. Alfons Schnitzler
2003 – 2010 Physics
Heinrich-Heine-Universität, Düsseldorf, Germany
Lund University, Lund, Sweden (2009)
Degree: Very good (1.0) with honors
Georg Oeltzschner, PhD
[email protected]September 30th, 2020
RESEARCH ACTIVITIES
Peer-reviewed original publications
1. HJ Zöllner, G Oeltzschner, A Schnitzler, HJ Wittsack. In silico GABA+ MEGA-PRESS:
Effects of signal-to-noise ratio and linewidth on modeling the 3 ppm GABA+ resonance. NMR
Biomed (2020), in press.
2. S Tapper, M Mikkelsen, BE Dewey, HJ Zöllner, SCN Hui, G Oeltzschner, RAE Edden.
Frequency and phase correction of J-difference edited MR spectra using deep learning. Magn
Reson Med (2020), in press.
3. G Oeltzschner, HJ Zöllner, SCN Hui, M Mikkelsen, MG Saleh, S Tapper, RAE Edden. Osprey:
Open-Source Processing, Reconstruction & Estimation of Magnetic Resonance Spectroscopy
Data. J Neurosci Methods 343:108827 (2020).
4. Puts NAJ, Ryan M, Oeltzschner G, Horska A, Edden RAE, Mahone EM. Reduced striatal
GABA in unmedicated children with ADHD at 7T. Psychiatry Res Neuroimaging 301:111082
(2020).
5. MG Saleh, A Papantoni, M Mikkelsen, SCN Hui, G Oeltzschner, NA Puts, RAE Edden, S
Carnell. Effect of Age on GABA+ and Glutathione in a Pediatric Sample. ANJR Am J
Neuroradiol 41:1099-1104 (2020).
6. M Považan, M Mikkelsen, A Berrington, PK Bhattacharyya, MK Brix, PF Buur, KM Cecil, KL
Chan, DYT Chen, AR Craven, K Cuypers, M Dacko, NW Duncan, U Dydak, DA Edmondson,
G Ende, L Ersland, MA Forbes, F Gao, I Greenhouse, AD Harris, N He, S Heba, N Hoggard,
TW Hsu, JFA Jansen, A Kangarlu, T Lange, RM Lebel, Y Li, CE Lin, JK Liou, JF Lirng, F Liu,
JR Long, R Ma, C Maes, M Moreno-Ortega, SO Murray, S Noah, R Noeske, MD Noseworthy,
G Oeltzschner, EC Porges, JJ Prisciandaro, NAJ Puts, TPL Roberts, M Sack, N Sailasuta, MG
Saleh, MP Schallmo, N Simard, D Stoffers, SP Swinnen, M Tegenthoff, P Truong, G Wang, ID
Wilkinson, HJ Wittsack, AJ Woods, H Xu, F Yan, C Zhang, V Zipunnikov, HJ Zöllner, RAE
Edden, PB Barker. Comparison of Multivendor Single-Voxel MR Spectroscopy Data Acquired
in Healthy Brain at 26 Sites. Radiology 295:171-180 (2020).
7. MG Saleh, M Wang, M Mikkelsen, SCN Hui, G Oeltzschner, J Boissoneault, B Stennett, RAE
Edden, EC Porges. Simultaneous edited MRS of GABA, glutathione, and ethanol. NMR Biomed
33:e4227 (2020).
8. M Mikkelsen, DL Rimbault, PB Barker, PK Bhattacharyya, MK Brix, PF Buur, KM Cecil, KL
Chan, DYT Chen, AR Craven, K Cuypers, M Dacko, NW Duncan, U Dydak, DA Edmondson,
G Ende, L Ersland, MA Forbes, F Gao, I Greenhouse, AD Harris, N He, S Heba, N Hoggard,
TW Hsu, JFA Jansen, A Kangarlu, T Lange, RM Lebel, Y Li, CYE Lin, JK Liou, JF Lirng, F Liu,
JR Long, R Ma, C Maes, M Moreno-Ortega, SO Murray, S Noah, R Noeske, MD Noseworthy,
G Oeltzschner, EC Porges, JJ Prisciandaro, NAJ Puts, TPL Roberts, M Sack, N Sailasuta, MG
Saleh, MP Schallmo, N Simard, D Stoffers, SP Swinnen, M Tegenthoff, P Truong, G Wang, ID
Wilkinson, HJ Wittsack, AJ Woods, H Xu, F Yan, C Zhang, V Zipunnikov, HJ Zöllner, RAE
Georg Oeltzschner, PhD
[email protected]September 30th, 2020
Edden. Big GABA II: Water-referenced edited MR spectroscopy at 25 research sites. NeuroImage
191:537-548 (2019).
9. KL Chan, G Oeltzschner, MG Saleh, RAE Edden, PB Barker. Simultaneous editing of GABA
and GSH with Hadamard-encoded MR spectroscopic imaging. Magn Reson Med 82:21-23 (2019).
10. MG Saleh, D Rimbault, M Mikkelsen, G Oeltzschner, AM Wang, D Jiang, A Alhamud, J Near,
M Schär, R Noeske, JB Murdoch, L Ersland, AR Craven, GE Dwyer, ER Grüner, L Pan, S Ahn,
RAE Edden. Multi-vendor standardized sequence for edited magnetic resonance spectroscopy.
NeuroImage 189:425-431 (2019).
11. SA Wijtenburg, LM Rowland, G Oeltzschner, PB Barker, CI Workman, GS Smith.
Reproducibility of brain MRS in older healthy adults at 7T. NMR Biomed 32:e4040 (2019).
12. G Oeltzschner, MG Saleh, D Rimbault, M Mikkelsen, KL Chan, NAJ Puts, RAE Edden.
Advanced Hadamard-encoded editing of seven low-concentration brain metabolites: Principles
of HERCULES. NeuroImage 185:181-190 (2019).
13. G Oeltzschner, SA Wijtenburg, M Mikkelsen, RAE Edden, PB Barker, JH Joo, JMS
Leoutsakos, LM Rowland, CI Workman, GS Smith. Neurometabolites and associations with
cognitive deficits in mild cognitive impairment: A magnetic resonance spectroscopy study at 7
Tesla. Neurobiol Aging 73:211-218 (2019).
14. K Kurcyus, E Annac, NM Hanning, AD Harris, G Oeltzschner, RAE Edden, V Riedl.
Opposite dynamics of GABA and glutamate levels in the occipital cortex during visual
processing. J Neurosci 38:9967-9976 (2018).
15. TJ Baumgarten, J Neugebauer, G Oeltzschner, ND Füllenbach, G Kircheis, D Häussinger, J
Lange, HJ Wittsack, M Butz, A Schnitzler. Connecting occipital alpha band frequency, visual
temporal resolution, and occipital GABA levels in healthy participants and hepatic
encephalopathy patients. Neuroimage Clin 20:347-356 (2018).
16. G Oeltzschner, HJ Zöllner, M Jonuscheit, RS Lanzman, A Schnitzler, HJ Wittsack. J-
difference-edited MRS measures of g-aminobutyric acid before and after acute caffeine
administration. Magn Reson Med 80:2356-2365 (2018).
17. MG Saleh, M Mikkelsen, G Oeltzschner, KL Chan, A Berrington, PB Barker, RAE Edden.
Simultaneous editing of GABA and glutathione at 7T using semi-LASER localization. Magn
Reson Med 80:474-479 (2018).
18. M Mikkelsen, MG Saleh, J Near, KL Chan, T Gong, AD Harris, G Oeltzschner, NAJ Puts, KM
Cecil, ID Wilkinson, RAE Edden. Frequency and Phase Correction for Multiplexed Edited MRS
of GABA and Glutathione. Magn Reson Med 80:21-28 (2018).
19. G Oeltzschner, KL Chan, MG Saleh, M Mikkelsen, NA Puts, RAE Edden. Hadamard editing
of glutathione and macromolecule-suppressed GABA. NMR Biomed 31:e3844 (2018).
Georg Oeltzschner, PhD
[email protected]September 30th, 2020
20. G Oeltzschner, K Snoussi, NA Puts, M Mikkelsen, AD Harris, S Pradhan, K Tsapkini, M
Schär, PB Barker, RAE Edden. Effects of eddy currents on selective spectral editing
experiments at 3T. J Magn Reson Imaging 47:673-681 (2018).
21. M Mikkelsen, PB Barker, PK Bhattacharyya, MK Brix, PF Buur, KM Cecil, KL Chan, DYT
Chen, AR Craven, K Cuypers, M Dacko, NW Duncan, U Dydak, DA Edmondson, G Ende, L
Ersland, F Gao, I Greenhouse, AD Harris, N He, S Heba, N Hoggard, TW Hsu, JFA Jansen, A
Kangarlu, T Lange, RM Lebel, Y Li, CYE Lin, JK Liou, JF Lirng, F Liu, R Ma, C Maes, M
Moreno-Ortega, SO Murray, S Noah, R Noeske, MD Noseworthy, G Oeltzschner, JJ
Prisciandaro, NAJ Puts, TPL Roberts, M Sack, N Sailasuta, MG Saleh, MP Schallmo, N Simard,
SP Swinnen, M Tegenthoff, P Truong, G Wang, ID Wilkinson, HJ Wittsack, H Xu, F Yan, C
Zhang, V Zipunnikov, HJ Zöllner, RAE Edden. Big GABA: Edited MR spectroscopy at 24
research sites. NeuroImage 159:32-45 (2017).
22. KL Chan, MG Saleh, G Oeltzschner, PB Barker, RAE Edden. Simultaneous measurement of
Aspartate, NAA, and NAAG using HERMES spectral editing at 3 Tesla. NeuroImage 155:587-593
(2017).
23. KL Chan, G Oeltzschner, M Schär, PB Barker, RAE Edden. Spatial Hadamard encoding of J-
edited spectroscopy using slice-selective editing pulses. NMR Biomed 30:e3688 (2017).
24. G Oeltzschner, NAJ Puts, KL Chan, VO Boer, PB Barker, RAE Edden. Dual-Volume
Excitation and Parallel Reconstruction for J-Difference-Edited MR Spectroscopy. Magn Reson
Med 77:16-22 (2017).
25. MG Saleh, G Oeltzschner, KL Chan, NAJ Puts, M Mikkelsen, M Schär, AD Harris, RAE
Edden. Simultaneous edited MRS of GABA and glutathione. NeuroImage 142:576-582 (2016).
26. G Oeltzschner, A Schnitzler, F Wickrath, HJ Zöllner, HJ Wittsack. Use of quantitative brain
water imaging as concentration reference for J-edited MR spectroscopy of GABA. Magn Reson
Imaging 34:1057-1063 (2016)
27. TJ Baumgarten, G Oeltzschner, N Hoogenboom, HJ Wittsack, A Schnitzler, J Lange. Beta Peak
Frequencies at Rest Correlate with Endogenous GABA+/Cr Concentrations in Sensorimotor
Cortex Areas. PLoS One 11:e0156829 (2016)
28. RAE Edden, G Oeltzschner, AD Harris, NAJ Puts, KL Chan, VO Boer, M Schär, PB Barker.
Prospective frequency correction for macromolecule-suppressed GABA editing at 3T. J Magn
Reson Imaging 44:1474-1482 (2016).
29. G Oeltzschner, M Butz, F Wickrath, HJ Wittsack, A Schnitzler. Covert hepatic encephalopathy:
elevated total glutathione and absence of brain water content changes. Metab Brain Dis 31:517-
527 (2016).
30. G Oeltzschner, M Butz, TJ Baumgarten, N Hoogenboom, HJ Wittsack, A Schnitzler. Low
visual cortex GABA levels in hepatic encephalopathy: links to blood ammonia, critical flicker
frequency, and brain osmolytes. Metab Brain Dis 30:1429-1438 (2015)
Georg Oeltzschner, PhD
[email protected]September 30th, 2020
31. A Müller-Lutz, N Khalil, B Schmitt, V Jellus, G Pentang, G Oeltzschner, G Antoch, RS
Lanzman, HJ Wittsack. Pilot study of Iopamidol-based quantitative pH imaging on a clinical 3T
MR scanner. MAGMA 27:477-485 (2014)
32. G Oeltzschner, N Hoogenboom, T Baumgarten, HJ Wittsack, A Schnitzler. Absolute GABA
spectroscopy with MEGA-PRESS and watermapping in sensorimotor and visual cortex and
correlation to handedness. Eur J Med Res 19 (Suppl 1):S28 (2014)
33. RS Lanzman, HJ Wittsack, N Khalil, B Schmitt, P Heusch, G Oeltzschner, G Antoch, A
Müller-Lutz. Chemical exchange saturation transfer (CEST) MRT mit Iopamidol zur pH-
Messungen bei 3T: Phantommessungen und erste in-vivo Messung. RöFo-Fortschritte auf dem
Gebiet der Röntgenstrahlen und der bildgebenden Verfahren 185:VO105_II_3 (2013)
Named contributions to consensus efforts
34. R Kreis, V Boer, IY Choi, C Cudalbu, RA de Graaf, C Gasparovic, A Heerschap, M Krssak, B
Lanz, AA Maudsley, M Meyerspeer, J Near, G Öz, S Posse, J Slotboom, M Terpstra, I Tkac, M
Wilson, W Bogner, Experts’ Working Group on Terminology for MR Spectroscopy.
Terminology and concepts for the characterization of in vivo MR spectroscopy methods and
MR spectra: Background and experts' consensus recommendations. NMR Biomed e4347 (2020)
Conference contributions
Oral presentations (speaker in italics)
1. G Oeltzschner. Osprey – Open-source processing, reconstruction & estimation of MRS data.
5th International Symposium on GABA and Advanced MRS 2019, Park City, United States.
2. G Oeltzschner, G Zupan, RAE Edden. Simultaneous linear-combination modeling of MEGA-
PRESS sum and difference spectra without soft constraints. 27th Annual Meeting of the
International Society for Magnetic Resonance in Medicine (ISMRM) 2019, Montréal, Canada.
3. NAJ Puts, G Oeltzschner, AD Harris, M Mikkelsen, SH Mostofsky, RAE Edden. GABA levels
in children with autism and typically developing children differentially relate to social gesture
performance. 26th Annual Meeting of the International Society for Magnetic Resonance in
Medicine (ISMRM) 2018, Paris, France.
4. G Oeltzschner. Multi-voxel editing: PRIAM and SHERPA. 4th International Symposium on
MRS of GABA 2017, Leuven, Belgium.
5. HJ Zöllner, M Jonuscheit, RS Lanzman, HJ Wittsack, G Oeltzschner. Caffeine effects on human
brain metabolites measured by J-edited in vivo MR spectroscopy. 33rd Annual Meeting of the
European Society for Magnetic Resonance in Medicine and Biology (ESMRMB) 2016, Vienna,
Austria.
Georg Oeltzschner, PhD
[email protected]September 30th, 2020
6. G Oeltzschner. Absolute GABA spectroscopy with MEGA-PRESS and watermapping in
sensorimotor and visual cortex and correlation with handedness. 2nd International Symposium
on MRS of GABA 2013, Cardiff, UK.
7. G Oeltzschner, E Cankaya, G Antoch, HJ Wittsack. In-vitro-Detektion von 2HG mit VeSPA-
Simulationen. 44th Annual Meeting of the Deutsche Gesellschaft für Medizinische Physik
(DGMP) 2013, Cologne, Germany.
8. G Pentang, R Bastkowski, RS Lanzman, P Heusch, A Müller-Lutz, G Oeltzschner, D Blondin,
G Antoch, HJ Wittsack. MR Whole Brain Atlas on the Basis of Diffusion Tensor and Diffusion
Kurtosis Data at 3T. 29th Annual Meeting of the European Society for Magnetic Resonance in
Medicine and Biology (ESMRMB) 2012, Lisbon, Portugal.
Poster presentations (selection)
1. G Oeltzschner, HJ Zöllner, RAE Edden. Osprey – Open-source processing, reconstruction &
estimation of MRS data. 28th Annual Meeting of the International Society for Magnetic
Resonance in Medicine (ISMRM) 2020, virtual meeting.
2. G Oeltzschner, HJ Zöllner, RAE Edden. Osprey – Open-source processing, reconstruction &
estimation of MRS data. 26th Annual Meeting of the Organization for Human Brain Mapping
OHBM) 2020, virtual meeting.
3. G Oeltzschner, MG Saleh, D Rimbault, M Mikkelsen, NAJ Puts, RAE Edden. Simultaneous
spectral editing of seven low-concentration brain metabolites at 3T with HERCULES. 25th
Annual Meeting of the Organization for Human Brain Mapping (OHBM) 2019, Rome, Italy.
4. MG Saleh, AM Wang, M Mikkelsen, G Oeltzschner, J Boissoneault, EC Porges, RAE Edden.
Dynamic MRS measurements of GABA, glutathione and ethanol. 25th Annual Meeting of the
Organization for Human Brain Mapping (OHBM) 2019, Rome, Italy.
5. B Papazov, B Rauchmann, D Keeser, S Gürsel, S Milani, M Brendel, C Palleis, J Levin, G
Höglinger, C Haass, G Oeltzschner, B Ertl-Wagner, S Stöcklein, R Perneczky. GABA and Glx
levels in patients with early-stage AD and CBS: Initial results from the ActiGLIA study. 25th
Annual Meeting of the Organization for Human Brain Mapping (OHBM) 2019, Rome, Italy.
6. 7T MRS of neurometabolites and associations with cognitive deficits in mild cognitive
impairment. G Oeltzschner, SA Wijtenburg, M Mikkelsen, RAE Edden, PB Barker, JH Joo,
JMS Leoutsakos, LM Rowland, CI Workman, GS Smith. 27th Annual Meeting of the
International Society for Magnetic Resonance in Medicine (ISMRM) 2019, Montreal, Canada.
7. A Universal Edited MRS Sequence for 4 Vendors. MG Saleh, D Rimbault, M Mikkelsen, G
Oeltzschner, AM Wang, D Jiang, A Alhamud, J Near, M Schär, R Noeske, JB Murdoch, L
Ersland, AR Craven, GE Dwyer, ER Grüner, L Pan, S Ahn, RAE Edden. 27th Annual Meeting
of the International Society for Magnetic Resonance in Medicine (ISMRM) 2019, Montreal,
Canada.
Georg Oeltzschner, PhD
[email protected]September 30th, 2020
8. Analyzing Big GABA: Comparison of Five Software Packages for GABA-Edited MRS. M
Mikkelsen, PK Bhattacharyya, PK Mandal, D Shukla, AM Wang, M Wilson, U Dydak, JB
Murdoch, J Near, G Oeltzschner, RAE Edden. 27th Annual Meeting of the International
Society for Magnetic Resonance in Medicine (ISMRM) 2019, Montreal, Canada.
9. J-edited Cerebral MR spectroscopy in Patients with Hepatic Encephalopathy. HJ Zöllner, G
Oeltzschner, M Butz, M Jördens, ND Füllenbach, D Häussinger, HJ Wittsack, A Schnitzler.
27th Annual Meeting of the International Society for Magnetic Resonance in Medicine (ISMRM)
2019, Montreal, Canada.
10. MG Saleh, AM Wang, M Mikkelsen, G Oeltzschner, EC Porges, RAE Edden. Simultaneous
edited detection of GABA, glutathione and ethanol using HERMES. 27th Annual Meeting of the
International Society for Magnetic Resonance in Medicine (ISMRM) 2019, Montreal, Canada.
11. D Rotaru, G Oeltzschner, RAE Edden, D Lythgoe. Simultaneous modelling of Hadamard
encoded spectra for GABA and GSH using LCModel. 27th Annual Meeting of the International
Society for Magnetic Resonance in Medicine (ISMRM) 2019, Montreal, Canada.
12. G Oeltzschner, D Rimbault, M Mikkelsen, MG Saleh, NAJ Puts, RAE Edden. Editing
everything with HERCULES: Hadamard-encoded editing of seven low-concentration
metabolites. 26th Annual Meeting of the International Society for Magnetic Resonance in
Medicine (ISMRM) 2018, Paris, France.
13. G Oeltzschner, KL Chan, MG Saleh, M Mikkelsen, NAJ Puts, RAE Edden. Simultaneous
edited MR spectroscopy of glutathione and macromolecule-suppressed GABA. 26th Annual
Meeting of the International Society for Magnetic Resonance in Medicine (ISMRM) 2018, Paris,
France.
14. M Mikkelsen, MG Saleh, J Near, KL Chan, T Gong, AD Harris, G Oeltzschner, NAJ Puts, KM
Cecil, ID Wilkinson, RAE Edden. Multi-step frequency-and-phase correction for multiplexed
edited MRS data. 26th Annual Meeting of the International Society for Magnetic Resonance in
Medicine (ISMRM) 2018, Paris, France.
15. MG Saleh, M Mikkelsen, G Oeltzschner, KL Chan, A Berrington, PB Barker, RAE Edden.
Simultaneous editing of GABA and glutathione at 7T. 26th Annual Meeting of the International
Society for Magnetic Resonance in Medicine (ISMRM) 2018, Paris, France.
16. MG Saleh, M Mikkelsen, G Oeltzschner, KL Chan, A Berrington, PB Barker, RAE Edden.
Spectral simulations of glutathione at 7T: Comparison of two different spin system parameter
sets. 26th Annual Meeting of the International Society for Magnetic Resonance in Medicine
(ISMRM) 2018, Paris, France.
17. D Rimbault, G Oeltzschner, A Alhamud, E Meintjes, RAE Edden. Simultaneous modeling of
sum and difference spectra improves quantitative outcomes for edited MRS. 26th Annual
Meeting of the International Society for Magnetic Resonance in Medicine (ISMRM) 2018, Paris,
France.
Georg Oeltzschner, PhD
[email protected]September 30th, 2020
18. KL Chan, RAE Edden, G Oeltzschner, MG Saleh, PB Barker. Simultaneous MRSI of GABA
and glutathione using HERMES spectral editing at 3T. 26th Annual Meeting of the International
Society for Magnetic Resonance in Medicine (ISMRM) 2018, Paris, France.
19. G Oeltzschner, KL Chan, MG Saleh, NAJ Puts, M Mikkelsen, RAE Edden. Simultaneous
edited MR spectroscopy of glutathione and macromolecule-suppressed GABA. 23rd Annual
Meeting of the Organization for Human Brain Mapping (OHBM) 2017, Vancouver, Canada.
20. G Oeltzschner, NAJ Puts, KL Chan, VO Boer, PB Barker, RAE Edden. MEGA-PRIAM:
Dual-volume excitation and parallel reconstruction for J-difference-edited MR spectroscopy. 25th
Annual Meeting of the International Society for Magnetic Resonance in Medicine (ISMRM)
2017, Honolulu, USA.
21. G Oeltzschner, K Snoussi, NAJ Puts, M Mikkelsen, AD Harris, S Pradhan, K Tsapkini, M
Schär, PB Barker, RAE Edden. Measuring and minimizing effects of eddy currents on selective
spectral editing experiments at 3T. 25th Annual Meeting of the International Society for Magnetic
Resonance in Medicine (ISMRM) 2017, Honolulu, USA.
22. KL Chan, MG Saleh, G Oeltzschner, PB Barker, RAE Edden. Simultaneous measurement of
Aspartate, NAA, and NAAG using HERMES spectral editing at 3 Tesla. 25th Annual Meeting of
the International Society for Magnetic Resonance in Medicine (ISMRM) 2017, Honolulu, USA.
23. KL Chan, G Oeltzschner, M Schär, PB Barker, RAE Edden. Spatial Hadamard encoding of J-
edited spectroscopy using slice-selective editing pulses. 25th Annual Meeting of the International
Society for Magnetic Resonance in Medicine (ISMRM) 2017, Honolulu, USA.
24. M Mikkelsen, …, G Oeltzschner, … RAE Edden. Integrative analysis of GABA-edited MRS
data acquired at 19 research sites. 25th Annual Meeting of the International Society for Magnetic
Resonance in Medicine (ISMRM) 2017, Honolulu, USA.
25. MG Saleh, G Oeltzschner, KL Chan, NAJ Puts, M Mikkelsen, RAE Edden. Gannet 3.0:
Developing post-processing tools for accelerated editing. 25th Annual Meeting of the
International Society for Magnetic Resonance in Medicine (ISMRM) 2017, Honolulu, USA.
26. MG Saleh, G Oeltzschner, KL Chan, NAJ Puts, M Mikkelsen, M Schär, AD Harris, RAE
Edden. Simultaneous Hadamard editing of GABA and glutathione. 25th Annual Meeting of the
International Society for Magnetic Resonance in Medicine (ISMRM) 2017, Honolulu, USA.
27. TJ Baumgarten, M Butz, G Oeltzschner, N Hoogenboom, HJ Wittsack, A Schnitzler.
Corticomuscular Coherence Correlates with Critical Flicker Frequency but not with GABA+/Cr
Levels in Patients with Hepatic Encephalopathy. 20th International Conference on
Biomagnetism (Biomag) 2016, Seoul, Korea.
28. HJ Zöllner, G Oeltzschner, F Wickrath, HJ Wittsack, A Schnitzler. Wassergehaltskartierung des
menschlichen Gehirns – Vergleich quantitativer magnetresonanztomographischer Methoden.
47th Annual Meeting of the Deutsche Gesellschaft für Medizinische Physik (DGMP) 2013,
Würzburg, Germany.
Georg Oeltzschner, PhD
[email protected]September 30th, 2020
29. G Oeltzschner, N Hoogenboom, TJ Baumgarten, M Butz, F Wickrath, G Antoch, HJ Wittsack,
A Schnitzler. GABA in hepatic encephalopathy – Links to blood ammonia, CFF, brain
osmolytes, and cerebral water. 21st Annual Meeting of the Organization for Human Brain
Mapping (OHBM) 2015, Honolulu, USA.
30. G Oeltzschner, PK Bhattacharyya. Editing efficiency for macromolecule-suppressed and
unsuppressed J-edited GABA spectroscopy. 23rd Annual Meeting of the International Society for
Magnetic Resonance in Medicine (ISMRM) 2015, Toronto, Canada.
31. G Oeltzschner, N Hoogenboom, T Baumgarten, K Heberlein, HJ Wittsack, A Schnitzler.
Absolut quantitative GABA-Spektroskopie mit Watermapping im motorischen und visuellen
Kortex. 44th Annual Meeting of the Deutsche Gesellschaft für Medizinische Physik (DGMP)
2013, Cologne, Germany.
32. HJ Wittsack, J Weller, A Müller-Lutz, P Heusch, G Oeltzschner, G Pentang, G Antoch, RS
Lanzman. Zeitaufgelöste Bestimmung der Diffusionskoeffizienten der menschlichen Niere mit
EKG-getriggerter diffusionsgewichteter MRT. 44th Annual Meeting of the Deutsche
Gesellschaft für Medizinische Physik (DGMP) 2013, Cologne, Germany.
33. A Müller-Lutz, N Khalil, B Schmitt, V Jellus, G Pentang, G Oeltzschner, G Antoch, RS
Lanzman, HJ Wittsack. pH-Bildgebung mittels des CEST-Kontrastmittels Iopamidol an einem
3T MRT. 44th Annual Meeting of the Deutsche Gesellschaft für Medizinische Physik (DGMP)
2013, Cologne, Germany.
FUNDING
1K99AG062230-01 (PI Oeltzschner) 04/01/2019 – 03/31/2021
NIH/NIA $170,968 (total cost)
Towards a comprehensive neurometabolic profile in patients with mild cognitive impairment
This project is dedicated to developing advanced spectral edited MRS/MRSI techniques with large
spatial coverage to investigate brain metabolite levels in patients with mild cognitive impairment.
ORGANIZATIONAL ACTIVITIES
Professional societies
2015-present Member, International Society for Magnetic Resonance in Medicine (ISMRM)
2015-present Member, Organization for Human Brain Mapping (OHBM)
2012 Member, German Society for Medical Physics (DGMP)
Committee memberships
2020-present Founding member, Committee on MRS Code and Data Sharing, MRS Study Group
of the International Society for Magnetic Resonance in Medicine (ISMRM)
Editorial activities
Georg Oeltzschner, PhD
[email protected]September 30th, 2020
Journal reviewer
2020-present Scientific Reports
2018-present Magnetic Resonance Materials in Physics, Biology, and Medicine
2018-present Journal of Magnetic Resonance
2017-present Magnetic Resonance in Medicine
2017-present NeuroImage: Clinical
2016-present Biological Psychiatry
2016-present Journal of Magnetic Resonance Imaging
2016-present NeuroImage
Institutional administrative appointments
2017-2018 Treasurer, Johns Hopkins Postdoc Association (JHPDA)
Member, 2017-2018 JHPDA Executive Board
2016-2017 Treasurer, Johns Hopkins Postdoc Association (JHPDA)
Member, 2016-2017 JHPDA Executive Board
Conference and workshop organization
2020 Organizing committee, Virtual EDITINGSCHOOL (Online workshop on theory
and practice of spectral editing)
2019 Organizing committee, 5th International Symposium on GABA and Advanced MRS,
Park City, Utah, USA
2018 Organizing committee, EDITINGSCHOOL (Workshop on theory and practice of
spectral editing), Playa del Carmen, Mexico
2018 Organizing committee, 5th Annual Johns Hopkins Postdoctoral Retreat, Baltimore,
USA
09/23/2017 Session chair, 4th International Symposium on MRS of GABA, Leuven, Belgium
2017 Organizing committee, 4th International Symposium on MRS of GABA, Leuven,
Belgium
2017 Organizing committee, 4th Annual Johns Hopkins Postdoctoral Retreat, Baltimore,
USA
RECOGNITION
Honors, Awards
2020 1st Prize of the MR Spectroscopy Study Group, 28th Annual Meeting of the
International Society for Magnetic Resonance in Medicine (ISMRM) 2020 (virtual
meeting)
2019 Educational Stipend, 27th Annual Meeting of the International Society for Magnetic
Resonance in Medicine (ISMRM), Montréal, Canada
2018 Educational Stipend, 26th Annual Meeting of the International Society for Magnetic
Resonance in Medicine (ISMRM), Paris, France
2017 Best Presentation, 20th Annual Division of Johns Hopkins MR Research Retreat,
Liberty Mountain, USA
2017 Educational Stipend, 25th Annual Meeting of the International Society for Magnetic
Resonance in Medicine (ISMRM), Honolulu, USA
2013 Student Presentation Award, 2nd International Symposium on MRS of GABA,
Cardiff, UK
Georg Oeltzschner, PhD
[email protected]September 30th, 2020
Panels
01/29/2020 “In-vivo magnetic resonance spectroscopy of GABA to study anxiety”
Panel “The Highs and Lows of Gabaergic Transmission in Anxiety: Reconciling
Contradictory Findings from Rodents and Humans Studies”, Winter Conference on
Brain Research (WCBR) 2020, Big Sky, United States
Invited talks
09/25/2020 “New techniques in edited magnetic resonance spectroscopy”, Vanderbilt University
Institute of Imaging Science, Vanderbilt University, Nashville, United States
06/25/2020 “MRSHub – An Online MRS Code & Data Repository”, ISMRM MR Spectroscopy
Study Group Virtual Meeting (joint talk with Brian J. Soher and William Clarke)
04/28/2020 “Progress in edited magnetic resonance spectroscopy”, joint virtual talk with Richard
Edden, Wellcome Center for Integrative Neuroscience, University of Oxford,
Oxford, UK
12/05/2019 “New Frontiers in edited magnetic resonance spectroscopy”, Athinoula A. Martinos
Center for Biomedical Imaging, Massachusetts General Hospital / Harvard Medical
School, Boston, United States
11/06/2019 “New Frontiers in edited magnetic resonance spectroscopy”, Department of
Kinesiology, University of Georgia, Athens, United States
05/09/2019 “New Frontiers in edited magnetic resonance spectroscopy”, CERVO Brain
Research Centre, Université Laval, Québec City, Canada
11/20/2018 “New Frontiers in edited magnetic resonance spectroscopy”, Neuroscience Institute,
New York University Medical Center, New York City, United States
10/31/2017 “An Introduction to Edited MRS of GABA”, Department of Physiology, University
of Ljubljana, Ljubljana, Slovenia
9/26/2017 “New Frontiers in edited MRS – Measuring multiple metabolites in multiple
regions”, Central Institute for Mental Health, Mannheim, Germany
6/23/2017 “Edited Magnetic Resonance Spectroscopy of GABA – Applications and New
Frontiers”, Department of Psychiatry, University of British Columbia, Vancouver,
Canada
PROFESSIONAL SKILLS
Strong proficiency
Clinical MRI scanner operator on various platforms (Siemens 3T, Philips 3T/7T)
Data acquisition from healthy and clinical populations of all ages (pediatric, adult, elderly)
Protocol design, sequence optimization, acquisition and analysis of conventional and edited MRS
All major MRS analysis software packages (LCModel, jMRUI, Tarquin, Vespa)
Full density-matrix simulations of MRS experiments in MATLAB
Full software development in MATLAB (Osprey, Gannet)
Good proficiency
Analysis of functional and structural MRI data with various major software packages (SPM, FSL)
Statistical analysis (R, SPSS)
Basic proficiency
Georg Oeltzschner, PhD
[email protected]September 30th, 2020
Philips and Siemens MR sequence development
DWI/DTI/DKI acquisition and analysis
Software development in C/C++ and Python
TEACHING ACTIVITIES
Mentees
2020 – present Helge Jörn Zöllner, postdoctoral research fellow
Supervised students
2016 Marc Jonuscheit, BSc
2015 Helge Jörn Zöllner, MSc
2014 Frithjof Wickrath, MSc; Viktor Pfaffenrot, BSc; Dennis Pantke, BSc
2013 Lukas Gottwald, BSc; Helge Jörn Zöllner, BSc
2012 Elif Cankaya, BSc
REFERENCES
Prof. Richard A.E. Edden, Johns Hopkins University, Baltimore, United States
Prof. Peter B. Barker, Johns Hopkins University, Baltimore, United States
Prof. Alfons Schnitzler, Heinrich Heine University, Düsseldorf, Germany
Prof. Hans-Jörg Wittsack, Heinrich Heine University, Düsseldorf, Germany
Georg Oeltzschner, PhD
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