Molecular structure of Beryllium fluoride, CAS Number: 7787-49-7
Beryllium fluoride (CAS 7787-49-7)
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Application:
Beryllium fluoride is a chemical used in protein crystallography as a mimic of phosphate. ADP and beryllium fluoride together tend to bind to ATP sites and inhibit protein action, making it possible to crystallise proteins in the bound state. Principal precursor for the manufacture of beryllium metal.
CAS Number:
7787-49-7
Purity:
≥99%
Molecular Weight:
47.01
Molecular Formula:
BeF2
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Beryllium fluoride (BeF2) has a variety of applications across different fields. In the study of thermodynamic analysis of batteries, it is used to determine the energy density. In protein crystallography, it is used as a substitute for phosphate and in conjunction with ADP to inhibit protein action and crystallize proteins in the bound state. Beryllium fluoride is also used as a precursor in the production of beryllium metal, a catalyst in organic synthesis, and in the manufacturing of beryllium oxide. Due to its high refractive index, it is used in the production of optical devices like lenses, mirrors, and prisms. Beryllium fluoride has also been found to be an effective inhibitor of acetylcholinesterase, a nerve impulse regulator, and can affect the activity of other proteins like phosphodiesterase, which is involved in nucleotide breakdown.
Beryllium fluoride (CAS 7787-49-7) References:
- Transition state complexes of the Klebsiella pneumoniae nitrogenase proteins. Spectroscopic properties of aluminium fluoride-stabilized and beryllium fluoride-stabilized MgADP complexes reveal conformational differences of the Fe protein. | Miller, RW., et al. 2001. Eur J Biochem. 268: 809-18. PMID: 11168422
- Beryllium fluoride-induced cell proliferation: a process requiring P21(ras)-dependent activated signal transduction and NF-kappaB-dependent gene regulation. | Misra, UK., et al. 2002. J Leukoc Biol. 71: 487-94. PMID: 11867686
- Characterization of stable beryllium fluoride, aluminum fluoride, and vanadate containing myosin subfragment 1-nucleotide complexes. | Werber, MM., et al. 1992. Biochemistry. 31: 7190-7. PMID: 1386527
- The structure of bovine F1-ATPase inhibited by ADP and beryllium fluoride. | Kagawa, R., et al. 2004. EMBO J. 23: 2734-44. PMID: 15229653
- Inhibition of myosin ATPase by beryllium fluoride. | Phan, B. and Reisler, E. 1992. Biochemistry. 31: 4787-93. PMID: 1534258
- Highly variable effects of beryllium and beryllium fluoride on tubulin polymerization under different reaction conditions: comparison of assembly reactions dependent on microtubule-associated proteins, glycerol, dimethyl sulfoxide, and glutamate. | Hamel, E., et al. 1991. Arch Biochem Biophys. 286: 57-69. PMID: 1680309
- Formation of the stable structural analog of ADP-sensitive phosphoenzyme of Ca2+-ATPase with occluded Ca2+ by beryllium fluoride: structural changes during phosphorylation and isomerization. | Danko, S., et al. 2009. J Biol Chem. 284: 22722-35. PMID: 19561071
- Beryllium fluoride exchange rate accelerated by Mg²⁺ as discovered by ¹⁹F NMR. | Liu, Y., et al. 2015. J Phys Chem A. 119: 24-8. PMID: 25531030
- Metal Fluoride Inhibition of a P-type H+ Pump: STABILIZATION OF THE PHOSPHOENZYME INTERMEDIATE CONTRIBUTES TO POST-TRANSLATIONAL PUMP ACTIVATION. | Pedersen, JT., et al. 2015. J Biol Chem. 290: 20396-406. PMID: 26134563
- Sodium fluoride as a nucleating factor for Mg-actin polymerization. | Tsaplina, OA. and Khaitlina, SY. 2016. Biochem Biophys Res Commun. 479: 741-746. PMID: 27693791
- Characterization of the aluminum and beryllium fluoride species bound to F-actin and microtubules at the site of the gamma-phosphate of the nucleotide. | Combeau, C. and Carlier, MF. 1989. J Biol Chem. 264: 19017-21. PMID: 2808407
- Identification of beryllium fluoride complexes in mechanically distorted gels using quadrupolar split 9Be NMR spectra resolved with solution-state selective cross-polarization. | Romanenko, K., et al. 2021. Phys Chem Chem Phys. 23: 16932-16941. PMID: 34337629
- The Na+,K+-ATPase in complex with beryllium fluoride mimics an ATPase phosphorylated state. | Fruergaard, MU., et al. 2022. J Biol Chem. 298: 102317. PMID: 35926706
- Formation of the stable myosin-ADP-aluminum fluoride and myosin-ADP-beryllium fluoride complexes and their analysis using 19F NMR. | Maruta, S., et al. 1993. J Biol Chem. 268: 7093-100. PMID: 8463244
- Binding of phosphate, aluminum fluoride, or beryllium fluoride to F-actin inhibits severing by gelsolin. | Allen, PG., et al. 1996. J Biol Chem. 271: 4665-70. PMID: 8617730
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Beryllium fluoride, 5 g | sc-263025 | 5 g | $258.00 | |||
| US: (Out of Stock: Availability May 12, 2025) | ||||||