LTBP-2 Antibody (E-10): sc-166199
- LTBP-2 Antibody (E-10) is a mouse monoclonal IgG2b κ LTBP-2 antibody, cited in 7 publications, provided at 200 µg/ml
- raised against amino acids 211-480 mapping within an internal region of LTBP-2 of human origin
- LTBP-2 Antibody (E-10) is recommended for detection of LTBP-2 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-LTBP-2 Antibody (E-10) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- Contact our Technical Service Department (or your local Distributor) for more information on how to receive a FREE 10 µg sample of LTBP-2 (E-10): sc-166199.
- m-IgG Fc BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for LTBP-2 Antibody (E-10) for WB applications. These reagents are now offered in bundles with LTBP-2 Antibody (E-10) (see ordering information below).
LTBP-2 Antibody (E-10) is an IgG2b κ mouse monoclonal LTBP-2 antibody (also designated LTBP-2 antibody) that detects the LTBP-2 protein of mouse, rat and human origin by WB, IP, IF and ELISA. LTBP-2 Antibody (E-10) is available as both the non-conjugated anti-LTBP-2 antibody form, as well as multiple conjugated forms of anti-LTBP-2 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Transforming growth factor (TGF) b is secreted as a part of an inactive complex that frequently contains latent TGFβ-binding protein (LTBP). The LTBP family of proteins exhibit a multidomain structure containing cysteine-rich motifs. LTBP-2 is an integral component of elastin-containing microfibrils (1-3) and contains 20 EGF-like repeats and four copies of an 8-cysteine repeat. LTBP-2 is synthesized as a protein by human foreskin fibroblasts. LTBP-2 co-localizes with tropoelastin in several tissues, including lung, dermis, epicardium, pericardium and heart valves, throughout rodent development, and in the spleen in the young adult mouse. Pseudoexfoliation (PEX) syndrome is a systemic condition characterized by the pathologic production and accumulation of an abnormal fibrillar extracellular material in many intra- and extraocular tissues. The co-localization of LTBP-1 and LTBP-2 with latent TGFβ1 and with fibrillin-1 on PEX fibrils suggests a possible mechanism for the regulation of TGFβ1 activity in PEX eyes. The LTBP-2 gene maps to human chromosome 14q24.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
LTBP-2 Antibody (E-10) References:
- Developmental expression of latent transforming growth factor beta binding protein 2 and its requirement early in mouse development. | Shipley, JM., et al. 2000. Mol Cell Biol. 20: 4879-87. PMID: 10848613
- Role of transforming growth factor-beta1 and its latent form binding protein in pseudoexfoliation syndrome. | Schlötzer-Schrehardt, U., et al. 2001. Exp Eye Res. 73: 765-80. PMID: 11846508
- Expression of latent TGF-beta binding proteins and association with TGF-beta 1 and fibrillin-1 following arterial injury. | Sinha, S., et al. 2002. Cardiovasc Res. 53: 971-83. PMID: 11922907
- Identification and characterization of LTBP-2, a novel latent transforming growth factor-beta-binding protein. | Morén, A., et al. 1994. J Biol Chem. 269: 32469-78. PMID: 7798248
- Analysis of the human gene encoding latent transforming growth factor-beta-binding protein-2. | Bashir, MM., et al. 1996. Int J Biochem Cell Biol. 28: 531-42. PMID: 8697098
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
LTBP-2 Antibody (E-10) | sc-166199 | 200 µg/ml | $310.00 | |||
LTBP-2 Antibody (E-10): m-IgG Fc BP-HRP Bundle | sc-528919 | 200 µg Ab; 10 µg BP | $348.00 | |||
LTBP-2 Antibody (E-10): m-IgGκ BP-HRP Bundle | sc-521531 | 200 µg Ab, 40 µg BP | $348.00 | |||
LTBP-2 Antibody (E-10) AC | sc-166199 AC | 500 µg/ml, 25% agarose | $408.00 | |||
LTBP-2 Antibody (E-10) HRP | sc-166199 HRP | 200 µg/ml | $310.00 | |||
LTBP-2 Antibody (E-10) FITC | sc-166199 FITC | 200 µg/ml | $324.00 | |||
LTBP-2 Antibody (E-10) PE | sc-166199 PE | 200 µg/ml | $337.00 | |||
LTBP-2 Antibody (E-10) Alexa Fluor® 488 | sc-166199 AF488 | 200 µg/ml | $350.00 | |||
LTBP-2 Antibody (E-10) Alexa Fluor® 546 | sc-166199 AF546 | 200 µg/ml | $350.00 | |||
LTBP-2 Antibody (E-10) Alexa Fluor® 594 | sc-166199 AF594 | 200 µg/ml | $350.00 | |||
LTBP-2 Antibody (E-10) Alexa Fluor® 647 | sc-166199 AF647 | 200 µg/ml | $350.00 | |||
LTBP-2 Antibody (E-10) Alexa Fluor® 680 | sc-166199 AF680 | 200 µg/ml | $350.00 | |||
LTBP-2 Antibody (E-10) Alexa Fluor® 790 | sc-166199 AF790 | 200 µg/ml | $350.00 |