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Triethyl citrate (CAS 77-93-0)

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Alternate Names:
Citric acid triethyl ester
CAS Number:
77-93-0
Purity:
99%
Molecular Weight:
276.28
Molecular Formula:
C12H20O7
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Triethyl citrate is an ester derived from citric acid, a naturally occurring compound. Reacts with potassium dichromate to produce potassium citrate, or with malonic acid to form triethyl malonate. Triethyl citrate is used as a reagent in analytical techniques for determining water permeability and biological properties. Additionally, it serves as a precursor in the synthesis of dimethyl fumarate (DMF).


Triethyl citrate (CAS 77-93-0) References:

  1. Final report on the safety assessment of acetyl triethyl citrate, acetyl tributyl citrate, acetyl trihexyl citrate, and acetyl trioctyl citrate.  |  Johnson, W. 2002. Int J Toxicol. 21 Suppl 2: 1-17. PMID: 12396673
  2. Formulation study for lansoprazole fast-disintegrating tablet. II. Effect of triethyl citrate on the quality of the products.  |  Shimizu, T., et al. 2003. Chem Pharm Bull (Tokyo). 51: 1029-35. PMID: 12951443
  3. Toxicology of the citric acid esters: tributyl citrate, acetyl tributyl citrate, triethyl citrate, and acetyl triethyl citrate.  |  FINKELSTEIN, M. and GOLD, H. 1959. Toxicol Appl Pharmacol. 1: 283-98. PMID: 13659536
  4. Study of triethyl citrate migration from coating polymers to tablet cores.  |  Budavári, Z., et al. 2004. Pharmazie. 59: 893-4. PMID: 15587596
  5. Polyvinyl acetate-based film coatings.  |  Kolter, K., et al. 2013. Int J Pharm. 457: 470-9. PMID: 24076229
  6. Peculiar effect of polyethylene glycol in comparison with triethyl citrate or diethyl phthalate on properties of ethyl cellulose microcapsules containing propranolol hydrochloride in process of emulsion-solvent evaporation.  |  Afrasiabi Garekani, H., et al. 2018. Drug Dev Ind Pharm. 44: 421-431. PMID: 29098888
  7. Efficacy and tolerability of a lotion containing triethyl citrate, ethyl linoleate, and GT peptide-10 in the adjuvant treatment of hidradenitis suppurativa: Real-life data.  |  Skroza, N., et al. 2018. Dermatol Ther. 31: e12599. PMID: 29642279
  8. Triethyl Citrate (TEC) as a Dispersing Aid in Polylactic Acid/Chitin Nanocomposites Prepared via Liquid-Assisted Extrusion.  |  Herrera, N., et al. 2017. Polymers (Basel). 9: PMID: 30965710
  9. Pharmacokinetics and Metabolism of Acetyl Triethyl Citrate, a Water-Soluble Plasticizer for Pharmaceutical Polymers in Rats.  |  Kim, H., et al. 2019. Pharmaceutics. 11: PMID: 30987254
  10. Citrate ester substitutes for di-2-ethylhexyl phthalate: In vivo reproductive and in vitro cytotoxicity assessments.  |  Sung, CR., et al. 2020. J Toxicol Environ Health A. 83: 589-595. PMID: 32727286
  11. Intravitreal Administration of Acetyl Triethyl Citrate and Benzyl Benzoate Is Retinotoxic in Rabbits but Not in Cynomolgus Monkeys.  |  Andaya, R., et al. 2021. Toxicol Pathol. 49: 621-633. PMID: 33252011
  12. Viscoelastic Properties of Fully Biomass-Based Transparent Plastic Comprising Cellulose Acetate and Citrate Ester.  |  Kimura, T., et al. 2022. Materials (Basel). 15: PMID: 35591372
  13. Mechanistic toxicology of triethyl citrate in cultured mammalian cells by cinematography.  |  Jones, AB., et al. 1968. J Pharm Sci. 57: 293-9. PMID: 4868037

Triethyl citrate (77-93-0) Modulation Targets

Activator of:
DBP.

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Triethyl citrate, 25 g

sc-251320B
25 g
$45.00

Triethyl citrate, 250 g

sc-251320
250 g
$65.00

Triethyl citrate, 1 kg

sc-251320A
1 kg
$110.00