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Amoclav

Amoclav is a combination of amoxicillin and clavulanic acid used to treat infections caused by beta-lactamase-producing bacteria. It works by inhibiting the beta-lactamase enzyme produced by these bacteria, allowing amoxicillin to kill the bacteria. It comes in tablet, chewable tablet, and oral suspension forms. Nurses should monitor patients for signs of allergic reaction like rash and report them promptly to the physician.

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4K views

Amoclav

Amoclav is a combination of amoxicillin and clavulanic acid used to treat infections caused by beta-lactamase-producing bacteria. It works by inhibiting the beta-lactamase enzyme produced by these bacteria, allowing amoxicillin to kill the bacteria. It comes in tablet, chewable tablet, and oral suspension forms. Nurses should monitor patients for signs of allergic reaction like rash and report them promptly to the physician.

Uploaded by

ianecunar
Copyright
© Attribution Non-Commercial (BY-NC)
Available Formats
Download as DOC, PDF, TXT or read online on Scribd
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Brand name: Amoclav

Generic name: Amoxicillin and Clavulanic acid


Indications: infections caused by susceptible beta-lactamase-producing organisms: lower
respiratory tract infections, otitis media, sinusitis, skin and soft tissue infections,
UTI, pre and post surgical procedures.
Drug classification: antiinfective; beta-lactam antibiotic; amino penicillin
Mechanism of action: used alone, clavulanic acid antibacterial activity is weak. In
combination, it inhibits enzyme (beta-lactamase) degradation of amoxicillin and by
synergism extends both spectrum of activity and bactericidal effect of amoxicillin
against many strains of beta-lactamase-producing bacteria resistant to amoxicillin
alone.
Dosage: tab: Adult & children> 12 yr mild to moderate dental infection 375mg tid. Severe
infection 625mg tid or 1g bid. 312mg/5ml suspension. Children >6yr 5ml tid,
156mg/5ml suspension. 1-6yr 5ml tid. <1yr 25mg/kg/d in divided doses every 8h in
more serious infections the dosage may be increase up to 50mg/kg/d in divided
dosage every 8h. vial: Adult&children >12yr 1.2g 8h. severe infection 6h daily.
3months-12yr 5/25mg/kg 8h, 0-3months 5/25mg/kg 12h. may increase to 8h.
Special precaution: super infections involving pseudomonas or candida. Pregnancy and
lactation.
Pregnancy risk category: B
Adverse reaction: GI: diarrhea, nausea, vomiting. Skin: skin rashes and urticaria. Other:
candidal vaginitis, abdominal discomfort, flatulence and headache, increases in
serum ALT, AST; glomerulonephritis; agranulocytosis.
Contraindication: history of penicillin associated jaundice or hepatic dysfunction. Possible
cross sensitivity with other β-lactam antibiotics; infectious mononucleosis.
Form: 250mg, 500mg, 875mg tablets; 125mg, 200mg, 400mg chewable tablets; 125mg/5ml,
200mg/5ml, 250mg/5ml, 400mg/5ml, 600mg/5ml oral suspension.
Nursing responsibility:
 Determine previous hypersensitivity reactions to penicillins, cephalosporins, and
other allergens prior to therapy.
 Monitor for signs and symptoms of urticarial rash (usually occurring within a few
days after start of drug) suggestive of a hypersensitivity reaction. If it occurs, look
for other signs of hypersensitivity (fever, wheezing, generalized itching, dyspnea),
and report to physician immediately.
 Lab tests: baseline C&S test prior to initiation of therapy; start drug pending results.
Note: generalized, erythematous, maculopapular rash (ampicillin rash) is not due to
hypersensitivity. It is usually mild, but can be severe. Report onset of rash to physician, since
hypersensitivity should be ruled out.

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