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    Matrixyl 3000 Promotional Sheet Usa

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    api-291771056
    MatrixylTM3000 contains two matrikines(tm), Pal-GHK and PalGQPR. They act in synergy to restore and maintain skin's youthful appearance. They activate the neosynthesis of extracellular matrix macromecules. With age these mechanisms become progressively weaker.

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    Matrixyl 3000 Promotional Sheet Usa

    Uploaded by

    api-291771056
    423 views2 pages
    MatrixylTM3000 contains two matrikines(tm), Pal-GHK and PalGQPR. They act in synergy to restore and maintain skin's youthful appearance. They activate the neosynthesis of extracellular matrix macromecules. With age these mechanisms become progressively weaker.

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    matrixyl 3000 promotional sheet usa

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    MatrixylTM3000 contains two matrikines(tm), Pal-GHK and PalGQPR. They act in synergy to restore and maintain skin's youthful appearance. They activate the neosynthesis of extracellular matrix macromecules. With age these mechanisms become progressively weaker.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    423 views2 pages

    Matrixyl 3000 Promotional Sheet Usa

    Uploaded by

    api-291771056
    MatrixylTM3000 contains two matrikines(tm), Pal-GHK and PalGQPR. They act in synergy to restore and maintain skin's youthful appearance. They activate the neosynthesis of extracellular matrix macromecules. With age these mechanisms become progressively weaker.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    of 2

    Face

    MATRIXYL 3000
    TM

    Make-uup

    Patented

    Pal-G
    GHK and Pal-G
    GQPR

    Function:

    Anti-wrinkling and lifting effect

    Definition:

    MatrixylTM3000 contains two


    matrikines, Pal-GHK and PalGQPR which act in synergy to
    restore and maintain skin's
    youthful appearance.

    Properties:

    MatrixylTM3000 contains
    matrikines which are
    messengers of cutaneous
    restructuration and repair. They
    activate the neosynthesis of
    extracellular matrix
    macromecules providing
    MatrixylTM3000 with a visible
    anti-wrinkle efficacy.

    Characteristics:

    As messenger molecules,
    matrikines are capable of
    regulating cell activities. They
    interact with specific receptors
    to activate certain genes
    involved in the process of
    extracellular matrix renewal
    and cell proliferation. With age
    these mechanisms become
    progressively weaker.

    INCI Name:

    Glycerin - Butylene Glycol Aqua (Water) - Carbomer Polysorbate-20 Palmitoyl Oligopeptide Palmitoyl Tetrapeptide-3

    Applications:

    Anti-aging , face lifting and


    wrinkle treatment products.
    Suitable for gels, serums
    lotion, creams.

    Formulation:
    Water soluble

    Recommended use level:

    3 to 8%

    Sederma - member of Croda International Group

    Copyright 2004 by Sederma, Inc. All rights reserved.

    CLAIM SUBSTANTIATION

    January 2004

    in vitro tests
    Synthesis of matrix macromolecules
    Study to determine ability of fibroblasts
    incubated for 72 hours with MatrixylTM3000 (1,
    3,and 5%) to stimulate synthesis of
    extracellular matrix components.
    Stimulation of gene expression
    Study to evaluate regulation of dermal and
    epidermal genes by matrikines present in
    MatrixylTM3000, using DNA-Array techniques
    on a reconstructed epidermis and a fibroblast
    culture.

    Stimulation of synthesis (%)

    In vitro
    Collagen 1

    70

    Fibronectin

    Hyaluronic Acid

    60
    50
    40
    30
    20
    10
    0

    Concentration of MatrixylTM3000 (%)

    The profile of gene activation by the


    matrikines in Matrixyl3000 complement
    the skin's natural mechanisms for cutaneous
    restructuring.

    in vivo tests
    Visible and measurable proof of anti-wrinkle efficacy
    Clinical study in which 2 panels of 23 volunteers aged 39 to 74 applied a cream containing 3%
    Matrixyl3000 to one-half of their face against a placebo or 3% Matrixyl on the other half twice a day
    for 56 days. Anti-wrinkling and lifting efficacy was assessed by profilometry and photography, as
    compared to T0.
    Variation of parameters compared to T0 (%)
    MatrixylTM3000

    Surface occupied by deep wrinkles (>200m)


    Main wrinkle density
    Main wrinkle average depth
    Main wrinkle average volume
    Roughness
    Complexity (Lifting effect)
    ns : non significant

    *significant / T0 (p<0.05)

    44.9
    37.0**
    15.1**
    18.5**
    14.4**
    16.6**
    **

    MatrixylTM

    Placebo

    -27.7**
    -27.3*
    -9.8**
    -14.7**
    -10.8**
    -12.7**

    4.3
    -9.6
    -3.2
    -8.7*
    1.4
    4.2

    ns
    ns
    ns

    ns
    ns

    **significant /T0 (p<0.01)

    In vivo

    Effect on skin elasticity and tone

    T0 MATRIXYLTM

    T56 MATRIXYLTM

    Assessement of elasticity and tone by


    cutometry using the same panel as above.
    + 19.5%

    Variation / T0 (%)

    20
    15
    10
    5
    0

    MatrixylTM 3000
    MatrixylTM

    *
    *

    Placebo

    significant / T0

    **
    Elasticity

    T0 MATRIXYLTM3000

    T56 MATRIXYLTM3000

    Tone

    MatrixylTM3000 displays major and


    significant improvements in elasticity
    and tone.

    Sederma Inc

    E-mail: [email protected]

    www.crodausa.com

    Tel 732-692-1652

    Fax 732-417-0804

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