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    Herpes Simplex Virus Handout PDF

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    deme
    Herpes simplex virus (HSV) is a recurrent, lifelong infection with no cure. HSV occurs in two biologically, serologically, and epidemiologically distinguishable types.

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    Herpes Simplex Virus Handout PDF

    Uploaded by

    deme
    92 views3 pages
    Herpes simplex virus (HSV) is a recurrent, lifelong infection with no cure. HSV occurs in two biologically, serologically, and epidemiologically distinguishable types.

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    Herpes simplex virus (HSV) is a recurrent, lifelong infection with no cure. HSV occurs in two biologically, serologically, and epidemiologically distinguishable types.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    92 views3 pages

    Herpes Simplex Virus Handout PDF

    Uploaded by

    deme
    Herpes simplex virus (HSV) is a recurrent, lifelong infection with no cure. HSV occurs in two biologically, serologically, and epidemiologically distinguishable types.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    of 3

    Herpes Simplex Virus

    By: Demetra Mensah- Bonsu


    OVERVIEW & BACKGROUND
    Herpes Simplex Virus (HSV) is a recurrent, lifelong infection with no cure. HSV belongs to a family of DNA viruses
    known as Herpesviridae. Herpes Simplex Viruses are enclosed in enveloped particles and are surrounded by a group
    of glycoproteins known as tegument. HSV occurs in two biologically, serologically, and epidemiologically
    distinguishable types. Type 1 (HSV-1) primarily involves infections of the face and eyes while type 2 (HSV-2) primarily
    causes genital infections.

    CLINICAL MANIFESTATIONS
    Orolabial Herpes

    Genital Herpes

    Primary Infection

    Cause: Mainly HSV-1


    Incubation period: 2 to 12
    days
    Symptoms: fever,pain,
    burning, tingling at site of
    eruption
    Children:ulcers, inflamed
    gums
    Adults: inflammation of
    pharynx and tonsils

    Cause: either type of HSV


    Incubation period: 2 to 12
    days
    Symptoms: fever, headache,
    pain, itching
    Duration: severe and
    prolonged

    Recurrent Infection

    Symptoms: cold sores,


    blisters, occurs infrequently,
    triggered by external factors
    Duration: milder and shorter

    Symptoms: tenderness, pain,


    burning at site of eruption
    Duration: milder and shorter

    EPIDEMIOLOGY
    1.

    Factors affecting the spread of disease


    a.

    2.

    increased age, female gender, black race, marital status, socioeconomic status

    Prevalence and Incidence


    a.

    global prevalence among 0-49 year olds 67%

    b.

    highest in Africa 87%

    c.

    lowest in the Americas 40-50%

    d.

    20 million incident cases each year in the United States

    e.

    increase in genital HSV-1 prevalence among college ages students

    INTERVENTION STRATEGIES
    Primary Prevention

    Reducing sexual risk behaviors

    use of condoms during anal, vaginal and oral sex

    avoid sexual activity with seropositive individual during viral shedding

    Vaccine Development

    there is no effective vaccine for HSV infection

    development is focused on

    prophylactic vaccines- induces sterilizing immunity that prevents primary infection from
    occurring

    therapeutic vaccines- reduces symptomatic and asymptomatic shedding

    live-virus vaccines-enables host to mount successful immune response

    Secondary Prevention

    Screening is not recommended for general population due to lack of complications with HSV infection

    Screening is recommended for high risk individuals

    at risk for STD/HIV infection

    infected with HIV

    pregnant women

    Diagnosis involves physician evaluation and laboratory testing for confirmation

    HerpSelect ELISA is most widely used test because it is a type specific serology

    Sensitivity 91% (HSV-1), Specificity 92% (HSV-1)

    Sensitivity 96% (HSV-2), Specificity 97% (HSV-2)

    Tertiary Prevention

    Antiviral medication for genital herpes and orolabial herpes

    acyclovir, famciclovir

    Over the counter medication for cold sores

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