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Drug Study Haldol

A 46-year-old male diagnosed with undifferentiated schizophrenia was prescribed haloperidol (Haldol), an antipsychotic, at a dose of 5.10 mg twice daily. Haloperidol is a phenylbutyl-piperadine derivative that blocks dopamine receptors in the brain to exert its antipsychotic effects. Some key considerations for use include monitoring for potential adverse effects like extrapyramidal reactions and neuroleptic malignant syndrome, avoiding abrupt withdrawal, and advising patients on activities requiring alertness until effects are known.

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Gracia Evangelista
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421 views

Drug Study Haldol

A 46-year-old male diagnosed with undifferentiated schizophrenia was prescribed haloperidol (Haldol), an antipsychotic, at a dose of 5.10 mg twice daily. Haloperidol is a phenylbutyl-piperadine derivative that blocks dopamine receptors in the brain to exert its antipsychotic effects. Some key considerations for use include monitoring for potential adverse effects like extrapyramidal reactions and neuroleptic malignant syndrome, avoiding abrupt withdrawal, and advising patients on activities requiring alertness until effects are known.

Uploaded by

Gracia Evangelista
Copyright
© © All Rights Reserved
Available Formats
Download as DOCX, PDF, TXT or read online on Scribd
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Submitted By: Evangelista, Grayzalyn T.

DRUG STUDY

Name: A.G
Age: 46 y/o
Diagnosis: Undifferentiated Schizophrenia
Generic Name: haloperidol
Brand Name: Haldol
Functional Class: Antipsychotic
Chemical Class: Phenylbutyl-piperadine derivative
Action: A butyrophenone that probably exerts antipsychotic effects by blocking postsynaptic
dopamine receptors in the brain.
Pregnancy Risk Category: C
- Animal studies have shown an adverse effect on the fetus, but adequate studies
havent been conducted in humans. The benefits from use in pregnant women may
be acceptable despite potential risks.
Indication:
- Psychotic Disorders
- Chronic Psychosis requiring prolonged therapy.
- Nonpsychotic behaviour disorders
Contraindication: Contraindicated in patients hypersensitive to drug and in those with
Parkinsonism, coma, or CNS depression.
Usual Dose: Tablet: 0.5 mg, 1 mg, 2 mg, 5 mg, 10 mg, 20 mg.
Actual Dose: 5.10 mg BID
Drug Interactions:
Anticholinergics: May increase anticholinergic effects and glaucoma. Use together
cautiously.
Azole antifungal, buspirone, macrolides: May increase haloperidol level. Monitor
patient for increased adverse reactions; haloperidol dose may need to be adjusted.
Carbamazepine: May decrease haloperidol level. Monitor patient.
CNS depressants: May increase CNS depression. Use together cautiously.
Lithium: May cause lethargy and confusion after high doses. Monitor patient.
Methyldopa: May cause dementia. Monitor patient closely.
Rifampin: May decrease haloperidol level. Monitor patient for clinical effect.
Side Effects: Headache, Dry mouth, Diarrhea, Constipation, Nausea and Vomiting,
Abdominal Pain.
Adverse Effects:
CNS: Severe extrapyramidal reactions, tardive dyskenisia, neuroleptic malignant
syndrome, seizure, sedation, drowsiness, lethargy, insomnia, confusion, vertigo.
CV: tachycardia, hypotension, hypertension, ECG changes, torsades de pointes, with
IV use.
EENT: Blurred vision
GI: anorexia, dyspepsia.
GU: Urine retention, menstrual irregularity, priapism.
Hematologic: Leukocytosis, leukopenia
Hepatic: jaundice
Skin: Rash, other skin reactions, diaphoresis
Other: Gynecomastia
Nursing Consideration:
- Monitor patient for tardive dyskinesia, which may occur after prolonged use. It
may not appear until months or years later and may disappear spontaneously or
persist for life, despite ending drug.
- Watch for signs and symptoms of neuroleptic malignant syndrome
(extrapyramidal effect, hyperthermia, autonomic disturbances), which is rare but
commonly fatal.
- Dont withdraw drug abruptly unless required by severe adverse reactions.
Patient Teaching:
- Although drug is the least sedating of the antipsychotics, warm patient to avoid
activities that require alertness and good coordination until effects of drugs are
known.
- Warm patients to avoid alcohol during therapy.
- Tell patient to relieve dry mouth with sugarless gum or hard candy.

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