This document discusses Allergology and Clinical Immunology (ACI) services in Europe. It notes that while ACI has a precise clinical identity and high socioeconomic impact, the organization of ACI services varies between countries. An ad hoc task force was appointed to develop standards for ACI services in Europe to address this issue. The task force produced a position paper that should be used as a reference for national health services to improve the organization and delivery of ACI care.
This document discusses Allergology and Clinical Immunology (ACI) services in Europe. It notes that while ACI has a precise clinical identity and high socioeconomic impact, the organization of ACI services varies between countries. An ad hoc task force was appointed to develop standards for ACI services in Europe to address this issue. The task force produced a position paper that should be used as a reference for national health services to improve the organization and delivery of ACI care.
This document discusses Allergology and Clinical Immunology (ACI) services in Europe. It notes that while ACI has a precise clinical identity and high socioeconomic impact, the organization of ACI services varies between countries. An ad hoc task force was appointed to develop standards for ACI services in Europe to address this issue. The task force produced a position paper that should be used as a reference for national health services to improve the organization and delivery of ACI care.
This document discusses Allergology and Clinical Immunology (ACI) services in Europe. It notes that while ACI has a precise clinical identity and high socioeconomic impact, the organization of ACI services varies between countries. An ad hoc task force was appointed to develop standards for ACI services in Europe to address this issue. The task force produced a position paper that should be used as a reference for national health services to improve the organization and delivery of ACI care.
Allergy and Clinical Immunology Services in Europe*
Allergology and Clinical Immunology (ACI) is an area of clinical medicine with a precise identity, relevant recent scientic achievements and well-dened edu- cational and professional needs. In spite of the high individual and socio-economic impact of allergic diseases in Europe, the organization of ACI services is imperfect and varies among countries according to their health policies and priorities. In the rm belief of the role of ACI specialists in addressing clinical issues related to the involvement of the immune system in health and diseasessuch as vaccination, immunodeciencies, susceptibility and response to microbial agents, autoimmune and allergic diseases, immune aspects of transplantation and malignancies, in vivo and in vitro immunological tests, vaccinations, immuno-modiersthe European Academy of Allergology and Clinical Immunology appointed an ad hoc Task Force to produce standards for ACI Services in Europe. The resulting position paper should be used as a consulting reference for National Health Services as a necessary pre-requisite for the free circulation to patients and health care professionals. S. Bonini 1 , I.J. Ansotegui 2 , S. Durham 3 , A.J. Frew 4 , J. Ltvall 5 , K. Nekam 6 , T. Popov 7 , R. Dahl 8 , J. Gayraud 9 , R. Gerth van Wijk 10 , K. Kontou-Fili 11 , M. Kowalski 12 , A. Todo-Bon 13 , U. Wahn 14 1 Second University of Naples amd INMM-CNR, Rome, Italy; 2 Department of Allergy and Immunology, Santiago Apstol Hospital, Santiago, Spain; 3 Department of Allergy and Clinical Immunology, Imperial College, National Heart and Lung Institute, London, UK; 4 Inflammation and Repair Division, School of Medicine, University of Southampton, Southampton General Hospital Infection, Southampton, UK; 5 Department of Respiratory Medicine and Allergology, Gteborg University, Gothenberg, Sweden; 6 Department of Allergy and Clinical Immunology, Polyclinic of the Hospitaller Brothers of St. John of God, Budapest, Hungray; 7 Clinical Center of Allergology, Medical University of Sofia, Sofia, Bulgaria; 8 Department of Respiratory Diseases and Allergology, Aarhus University Hospital, Aarhus, Denmark; 9 UEMS Allergology and Clinial Immunology Section, Tarbes, France; 10 Department of Allergology, University Hospital Rotterdam, Rotterdam, the Netherlands; 11 Dept of Allergology and Clinical Immunology, Division of Internal Medicine, LGD Hospital of Athens, Athens, Greece; 12 Department of Clinical Immunology and Allergy, Medical university of Lodz, Lodz, Polond; 13 Servicio Immunoalergia, Centro de Pneumologia, University de Coimbra, Coimbra, Portugal; 14 Department of Dermatology and Allergy, Allergy Centre Charit, Universittsmedizin Berlin, Berlin, Germany. *This article represents the position paper of the ad hoc Task Force of the European Academy of Allergology and Clinical Immunology (EAACI), produced in collaboration with GA 2 LEN; a network of excellence founded by the European Union. Drafting group: S. Bonini (Chairman), I.J. Ansotegui; S. Durham; A.J. Frew; J. Ltvall; K. Nekam; T. Popov Task Force members: R. Dahl; J. Gayraud; R. Gerth van Wijk; K. Kontou-Fili; M. Kowalski; A. Todo-Bon; U. Wahn. Prof. Sergio Bonini Internal Medicine Second University of Naples INMM-CNR 100 Via Fosso del Cavaliere 00133 Rome Italy Accepted for publication 18 January 2006 Allergy 2006: 61: 11911196 2006 The Authors Journal compilation 2006 Blackwell Munksgaard DOI: 10.1111/j.1398-9995.2006.01081.x 1191 History and background Allergology and Clinical Immunology (ACI) is an area of clinical medicine with a precise identity which deals with maintenance of the healthy state as well as with diagnosis, prevention and treatment of several diseases caused by over or under activity of the immune system that have high individual and socio-economic impact. Allergology and Clinical Immunology which found its origins in the rst half of the twentieth century was revolutionized in the 1960s by the fundamental discover- ies on the structure and functions of the immune system, immunodeciencies and allergic hypersensitivity reactions responsible for clinical diseases (1). At present, ACI represents one of the areas of medicine which underwent most signicant scientic development, as documented by the number of discoveries, scientic publications and Nobel Prizes awarded. Allergology and Clinical Immunology is not an organ specialty (such as Respiratory Medicine, Gastroenterol- ogy, etc.) and does not refer to specic diseases but to individuals (2). Certainly, several diseases that may involve the immune system such as diabetes, asthma or glomenulonephritis, are treated competently by organ- based specialists. However, only ACI specialists have the professional education required for facing the clinical issues related to the involvement of the immune system in health and disease, such as vaccination, immunode- ciencies, susceptibility and response to microbial agents, autoimmune and allergic diseases, immune aspects of transplantation and malignancies. Moreover, a large number of diagnostic in vivo and in vitro techniques are based on the interaction between antigens and antibodies (such as skin tests with tuberculin, microbial agents, professional and environmental aller- gens; immunoassays for hormones and infectious agents; ow-cytometry, etc.). This requires specic methodolo- gical competences for their performance and interpret- ation. Finally, several treatments (vaccines, immune- modiers, cancer therapies, etc.) require a good under- standing of the function and manipulation of the immune system. Accordingly, ACI is a broad clinical specialty which relates to 100% of European citizens, from birth to elderly, as well as to relevant environmental and socio- economic issues of our Society (3). The present situation in Europe Allergology and Clinical Immunology is part of the core curriculum of undergraduate students in Medicine in all European Countries. At postgraduate level, there is a consensus on having specic professional education in ACI. However, in some countries ACI represents a full specialty, in others a subspecialty and in others a professional competence (Table 1). In each European Country there is a scientic society dealing with ACI. All National European Societies refer to the European Academy of Allergology and Clinical Immunology (EAACI, http://www.eaaci.net) which is part of the International Association of Allergology and Clinical Immunology World Allergy Organization (IAACI-WAO, www.worldallergy.org). ACI Societies have been working in a very close collaboration with national and international regulatory bodies to produce standards for health care such as disease guidelines, measures of environmental control, socio-economic issues, etc. Moreover, patients suering from allergic and immunologic diseases have gathered in well-estab- lished societies harmonized and coordinated by supra- national grouping such as EFA. For all the above reasons, ACI is currently considered to be a health and scientic priority and a large number of projects and networks of excellence have been recently funded with massive investments by the European Union within the fth and sixth Framework Programmes (4). On the other hand, at the level of health care, the organiza- tion of ACI is imperfect and there is an ongoing debate about which areas should be covered by the specialty (5 7). Although ACI Services exist in all European countries, their area of competence, structuring, autonomy and recognition by the National Health System is heteroge- neous among countries and sometimes even within the same country (Table 1). The current situation has some inconveniences: 1 The large amount of new scientic information and progress in ACI produced by the scientic environment has not so far translated into better clinical care. ACI represents one of the best clinical examples of what has been referred to as Lost in Translation (8). 2 The lack of a well-dened professional specialty training and career structure has reduced the attractive- ness of the specialization and, therefore, the number of specialists in ACI. 3 As a consequence, important issues relating to the maintenance of the healthy state (vaccination, environ- mental control, etc.) as well as the management of the extremely large and increasing number of patients with allergic and immunologic diseases are referred to dierent area specialists. For example whereas it is highly appropriate that pneumologists are responsible for the pharmacotherapy and acute hospital manage- ment of acute life-threatening asthma, the global input from a consultant allergist is valuable for the identi- cation and treatment of underlying causes of asthma. Similarly ENT doctors may evaluate rhinitis whereas the allergist should be responsible for instigating allergy diagnosis environmental control measures and where appropriate, allergen immunotherapy. The same princi- ples apply to the dual role of allergists and dermatol- ogists in the management of atopic eczema. Bonini et al. 1192 Furthermore these diseases frequently co-exist and the absence of the global expertise oered by an allergist, which complements the individual specialty approach, is detrimental for individuals and increases the costs for the community, not least because multiple consultations are otherwise required. The objective of the EAACI Task Force on Allergy Services On the basis of the above considerations, the EAACI felt the need to appoint a Task Force aimed at producing standards for ACI Services to be used as a unique consulting reference for National Health Ser- vices (NHS) in their autonomous planning of health organization. This should result in a more homogen- eous structure of ACI Services in Europe, a necessary prerequisite for the free circulation of patients and healthcare professionals. General principles for structuring of ACI Services The organization of health services in each European Country varies according to the health policy and priorities of individual States as well as on resources, epidemiological and socio-economic issues, and the existing organization of other areas of medicine. Accordingly, no rigid criteria should be dened but a exible framework, to be adapted by individual NHSs. This document will address the Areas to be covered by ACI Services, the dierent levels at which ACI issues should be addressed, indicate the minimal requirements for each organizational level. Individual Health Services will adapt the number and type of ACI Services for each level and depending on regional dierences. An example of national documents which should stem from the general guidelines provided by EAACI are represented by the actions taken in UK (9). Table 1. Clinical immunology, rheumatology, oncology, pneumology, ENT, dermatology, ophthalmology, infectious diseases, paediatrics, internal medicine, laboratory medicine, pathology (depending on the country) Country Do services exist? Are they Autonomous? Linked to?1 Area covered (or suggested as to be covered) Cl L A AD ID T C I EH Albania X X X X Austria X X X X X X Belgium X X X X X X X X Bulgaria X X X X X X Croatia X X X X X X X X X Czechia X X X X X X Denmark X X X X X X X Finland X X X X X X X X X X X France X X X X X X X X X Greece X X X X X X X X Germany X X X X X X Holland X X X X X X X X X X Hungary X X X X X X X X X Iceland X X X X X X X X X X Italy X X X X X X X X X X X X Macedonia X X X X X X X Norway X X X X X X X X Poland X X X Portugal X X X X X X Romania X X X X X X X X X Russia X X X X X X X X Serbia & MN X X X X X X X Slovenia X X X X X X X Spain X X X X X X Sweden X X X X X Switzerland X X X X X X Turkey X X X X UK X X X X X Ukraine X X X X X X X X X Cl, clinical activities; L, laboratory; A, allergy; AD, autoimmune diseases; ID, immunodeficiencies; T, transplantation immunology; C, cancer immunology; ID, infectious diseases; EH, environmental health ACI Services in Europe 1193 Areas to be covered by ACI Services The following areas are considered within the competence of ACI specialist although there is no consensus among Countries and other specialists will also be involved in some of these areas, depending on the organization of NHSs: Diseases Allergic diseases Allergic asthma; allergic rhinitis; allergic eye diseases; urticaria, eczema, allergic skin diseases and anaphylaxis represent the most frequent conditions which aect c. 25% of the general population. These conditions are often present together or subsequently in the same individual, thus requiring a comprehensive approach for diagnosis and treatment. Within allergic diseases, food, drug, insect venom and occupational allergy represent areas requiring the specic competences of an ACI specialist. Autoimmune diseases Nonorgan specic autoimmunity (Rheumatoid arthritis, Systemic Lupus erythematosus, Scleroderma, etc.). Or- gan-specic autoimmunity (Type I diabetes, autoimmune thyroiditis, other autoimmune endocrine diseases, etc.). Immunodeficiencies Whilst primary immunodeciencies mainly refer to the paediatric eld, secondary immunodeciencies such as AIDS or drug-induced IDFs also occur in adults. Malignancies Apart from immunoproliferative diseases (some leu- kaemias, myeloma, mastocytosis, etc.) some malignan- cies as well as cytostatic treatment signicantly aect the immune system and increase susceptibility to infections. Transplantation Selection of patients for organ transplantation as well as monitoring of transplanted patients involve issues of primary competence for ACI specialists. Diagnostic techniques Both in vivo and in vitro diagnostic techniques are based on the antigenantibody reaction and/or phenotypic and functional studies of cells of the immune system. The most commonly used in vivo tests include: Skin tests (allergy prick tests, patch test for contact and professional dermatitis, tuberculin tests, tests for immunodeciencies). Provocation tests with allergen (bronchial, nasal, conjunctival). Imaging techniques with labelled antigen or antibody. Clinical examination as well as functional and ima- ging studies of targets of the allergic reaction (spir- ometry, non-specic provocation, etc.) Laboratory techniques that request expertise in their interpretation by ACI specialists include: Immunoassays for detection of antigens and anti- bodies; ow cytometry; cytology (immunohisto- chemistry, immunouorescence, etc.); functional studies of immune cells. Treatments The following treatments have primary or profound eects (1) on the immune system: Vaccines-Allergen immunotherapy (desensitisation) in patients with IgE-mediated disease-Microbial products (such as CpG, M. Vaccae, etc.)-Anti-allergic drugs-Immune-response modiers-Immunoglobulin treatment -Cytokines and Growth Factors-Anti- neoplastic drugs. Adverse reactions to drugs often have an immunological basis. Additional tasks Additional tasks for ACI Services should include: 1 Educational activities ACI should be taught to all undergraduate and post-graduate medical students as well as biologists, pharmacists, nurses and laboratory technicians and this should be guaranteed by ade- quate structures in all academic and teaching hospi- tals. Since ACI is part of the health care of the entire population, General Practitioners need to have Continuing Medical Education in ACI. The task of the ACI specialist is to ensure that this happens and, where appropriate, to inform and/or deliver such educational activities. The provision of accurate information to the public is best addressed by the patient-oriented charitable organization with strong professional input and advice from ACI Services. 2 Monitoring of environment Allergic and immunologic diseases are not only inuenced by occupational environment, but also by diet, exercise, life style and outdoor and indoor pollution. ACI Services should Bonini et al. 1194 ensure that relevant factors inuencing health and disease are monitored and should contribute to the promotion of healthy lifestyles and environments. 3 Consulting and Advisory Role ACI specialists should provide consulting and advisory services for decisions related to environmental measures and socio-econo- mic choices aecting allergic and immunologic dis- eases. Levels of organization and minimal requirements Many patients with mild allergic disease will self medicate or seek advice from the internet, from pharmacies or GPs and other community-based medical information services. We recognize that the boundaries between community and specialist services vary in dierent countries and we are not going to discuss community based provision further within this document. Level I Level I refers to services oered at peripheral level and includes both Specialist Units for outpatients referred to them by GPs and peripheral hospitals with divisions of Internal Medicine and/or Paediatrics. Allergology and Clinical Immunology Specialist Units should handle patients with allergic and immunologic diseases having a high prevalence in the population providing all tests needed for basic diagnosis or clear indications on referral places for further diagnostic evaluation. They should be able to anticipate all ACI disease, request and interpret the results of all diagnostic tests needed and guide the treatment and follow-up of patients by the general practitioner. The number and location on the territory of ACI Specialists Units should be based on the local prevalence of ACI diseases as well as on other organizing and regional considerations. All Divisions of Medicine and Paediatrics of Peripheral Hospitals (1) should have a specialist in ACI acting as a consultant for both inpatient and outpatient care. All diagnostic and therapeutic services not provided by the peripheral hospital should be referred to a well- dened Level II centre. Level II Level II refers to ACI Services of Central Hospitals with multiple divisions and centralized laboratory facilities. All Central Hospitals should have an ACI Service, provided in collaboration with other hospital services, oering all diagnostic and therapeutic options for patients with allergic and immunologic diseases. The centralized laboratory should provide all diagnostic tests required for each area of ACI diseases. Level III In addition to services provided at Level II ACI Services of Regional Hospitals assigned to Level III should: Have a data bank of all Level I and Level II ACI Services with documentation of the personnel and services available; Provide quality control of ACI Services of Level I and II; Represent a source of epidemiological data of ACI diseases; Oer referral service for special techniques or treat- ment not possible at Central Hospitals; Provide or coordinate environmental monitoring of the territory; Give advice to local authorities about environmental measures to be taken, drug and diagnostic test reimbursement policies, etc.; Provide CME to health professionals in ACI; Coordinate epidemiological surveys, clinical trials, drug surveillance. Level IV Centres of excellence for ACI should be established at National Level in academic centres or research hospitals. They should have research facilities and coordinate national networking of regional centres. Undergraduate and Postgraduate teaching as well as CME is assured by Level IV ACI Centres of Excellence that should also oer an advisory support for national health policy in ordinary matters (research and medical practice priorities, reimbursement policy, etc.) as well as in occasional emergencies (AIDS, SARS, bioterrorism, etc.). All European Level IV ACI Excellence Centres should be part of a permanent Network aimed at achieving harmonized guidelines and standard parameters of ser- vice throughout Europe. Acknowledgments The EAACI Task Force is grateful to the following colleagues who provided information for the countries not represented in the Task Force: A. Priftanji, Albania; D. Plavec, Croatia; R. Dubakiene, Lithu- ania; D. Dokic, Macedonia; D.Dumitrascu, Romania; G. Goud- ima, Russia; V. Djuric, Serbia & Montenegro; M. Kostnic, Slovenia; O. Kalayci, Turkey; G. Drannik, Ukraine. The contri- bution of the EAACI Specialty Committee (G.S. Del Giacco), Sections (M. Larche` ), and of the UEMS-UEA (J. Gayraud) is grateful acknowledged. We thank Elisabetta Rea for her kind assistance in editing the manuscript. ACI Services in Europe 1195 References 1. Gell PGH, Coombs RRA, Lachmann PJ. Clinical aspects of immunology, 3rd Edn. Oxford: Blackwell Scient Publ. 1975. 2. Adkinson NF Jr, Rich RR, Lichteinstein LM. Justifying a mechanisms-based spe- cialty. J Allergy Clin Immunol 1996;97:868871. 3. European Allergy White Paper. UCB, Brussels, Belgium 1997. 3 4. Bousquet J, Ansotegui IJ, van Ree R, Burney PG, Zuberbier T, van Cauwenberge P. European Union meets the challenge of the growing importance of allergy and asthma in Europe. Allergy 2004;59:14. 4 5. Platts-Mills TAE. The future of allergy and clinical immunology lies in evalua- tion, treatment, and research on allergic disease. J Allergy Clin Immunol 2002;110:565566. 6. Shaerer WT, Fathman CG. Dening the spectrum of clinical immunology. J Al- lergy Clin Immunol 2003;111:S766S773 7. Shaerer WT. Recognition of clinical immunology as a distinct medical sub- specialty: importance for the practice of allergy. J Allergy Clin Immunol 2002;110:567570. 8. Lefant C. Clinical research to clinical practice. Lost in translation? N Engl J Med 2003;149:868874. 9. Gill B. Specialised clinical immunology services. Denition No 16 & 17.CPD Bull Immunol Allergy 2002;2:3368 2003;3:69 100. Bonini et al. 1196
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