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    Bone Tumour Staging - Pathology

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    o7113
    The document discusses two main bone tumor staging systems: the Musculoskeletal Tumor Society (MSTS) or Enneking System and the American Joint Committee on Cancer (AJCC) Staging System. The MSTS system stages malignant bone tumors using Roman numerals (I-III) based on tumor grade, size, and presence of metastasis. A 13-year-old girl presented with a high grade distal femur osteosarcoma extending into soft tissue without metastasis, which corresponds to Stage IIB in the MSTS system. The AJCC system also considers tumor grade, size, and metastasis in assigning a stage (I-IV) to bone tumors. Prognosis depends on grade, size, presence of nodes and

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    Bone Tumour Staging - Pathology

    Uploaded by

    o7113
    219 views2 pages
    The document discusses two main bone tumor staging systems: the Musculoskeletal Tumor Society (MSTS) or Enneking System and the American Joint Committee on Cancer (AJCC) Staging System. The MSTS system stages malignant bone tumors using Roman numerals (I-III) based on tumor grade, size, and presence of metastasis. A 13-year-old girl presented with a high grade distal femur osteosarcoma extending into soft tissue without metastasis, which corresponds to Stage IIB in the MSTS system. The AJCC system also considers tumor grade, size, and metastasis in assigning a stage (I-IV) to bone tumors. Prognosis depends on grade, size, presence of nodes and

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    Bone tumour staging

    Original Title

    Bone tumour staging - Pathology - Orthobullets.com

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    The document discusses two main bone tumor staging systems: the Musculoskeletal Tumor Society (MSTS) or Enneking System and the American Joint Committee on Cancer (AJCC) Staging System. The MSTS system stages malignant bone tumors using Roman numerals (I-III) based on tumor grade, size, and presence of metastasis. A 13-year-old girl presented with a high grade distal femur osteosarcoma extending into soft tissue without metastasis, which corresponds to Stage IIB in the MSTS system. The AJCC system also considers tumor grade, size, and metastasis in assigning a stage (I-IV) to bone tumors. Prognosis depends on grade, size, presence of nodes and

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    219 views2 pages

    Bone Tumour Staging - Pathology

    Uploaded by

    o7113
    The document discusses two main bone tumor staging systems: the Musculoskeletal Tumor Society (MSTS) or Enneking System and the American Joint Committee on Cancer (AJCC) Staging System. The MSTS system stages malignant bone tumors using Roman numerals (I-III) based on tumor grade, size, and presence of metastasis. A 13-year-old girl presented with a high grade distal femur osteosarcoma extending into soft tissue without metastasis, which corresponds to Stage IIB in the MSTS system. The AJCC system also considers tumor grade, size, and metastasis in assigning a stage (I-IV) to bone tumors. Prognosis depends on grade, size, presence of nodes and

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    of 2

    Bone Tumor Staging Systems

    Author: Patrick O'Donnell

    Topic updated on 03/12/13 10:14am

    Introduction
    Prognosis of bone cancer depends on the following variables
    1. overall stage of disease (incorperates all of the below)
    2. presence of metastasis
    3. skip (discontinous) lesions within the same bone
    4. histologic grade
    5. tumor size
    The are two staging systems that are commonly used:
    MSTS or Enneking System
    AJCC Staging System
    MSTS (Enneking) Staging System
    Introduction
    most popular and useful for orthopaedic surgeons
    two systems - one for malignant lesions and one for benign lesions
    malignant lesions are defined using Roman numerals (e.g. I, II, III)
    see table below
    e.g. osteosarcoma most commonly presents as stage IIB
    benign lesions are defined using Arabic numbers (1,2,3)
    1 = latent lesion
    e.g. non-ossifying fibroma
    enchondroma
    2 = active lesion
    e.g. ABC, UBC
    chondromyxoid fibroma
    chondroblastoma
    3 = aggressive lesion
    e.g. giant cell tumor of bone
    Stage

    Grade

    Site (1)

    Metastasis

    IA

    Low Grade

    T1 - intracompartmental

    M0 (none)

    IB

    Low Grade

    T2 - extracompartmental

    M0 (none)

    IIA

    High Grade

    T1 - intracompartmental

    M0 (none)

    IIB

    High Grade

    T2 - extracompartmental

    M0 (none)

    III

    Metastatic

    T1 - intracompartmental

    M1 (regional or distant)

    III

    Metastatic

    T2 - extracompartmental

    M1 (regional or distant)

    Tumor Compartments
    intracompartmental
    bone tumors are confined within the cortex of the bone
    extracompartmental
    bone tumors extend beyond the bone cortex
    Tumor Grade
    histologically, tumors are graded based on the percentage of cellular atypia
    low grade tumors
    low metastatic potential
    e.g. parosteal osteosarcoma
    high grade tumors
    greater metastastatic potential
    e.g. intramedullary osteosarcoma, Ewing's sarcoma, dedifferentiated
    chondrosarcoma
    AJCC Staging System
    Stage

    Grade

    Size

    Depth
    any

    Node
    none

    Metastasis
    none

    5 yr. survival

    IA

    Low Grade

    < 8cm

    98%

    IB

    Low Grade

    > 8cm

    IIA

    High Grade

    < 8cm

    any

    none

    none

    82%

    IIB

    High Grade

    > 8cm

    superficial

    none

    none

    82%

    none

    III

    any

    discontinuous (skip) lesion deep

    none

    none

    IVA

    any

    any

    none

    lung

    IVB

    any

    any

    present

    other than
    lung

    any

    52%

    30%

    Prognosis for soft tissue tumors depends on


    grade
    low grade: G1 and G2
    high grade: G3 and G4
    size
    T1: < 8 cm
    T2 > 8 cm
    nodes
    N0: no regional nodes
    N1: regional nodes
    metastasis
    presence of distant metastasis automatically elevates patient to stage IV disease

    Please Rate Educational Value!

    Average 4.0 of 9 Ratings

    Qbank (1 Questions)
    Question:

    of 1Question:

    of 1
    TAG

    (OBQ05.7) A 13-year-old girl presents with an isolated distal femur osteosarcoma that extends into the soft tissue. Work-up is
    negative for metastasis, but biopsy reveals a high grade lesion. What is the stage of this tumor by the Musculoskeletal Tumor
    Society system?
    Review Topic
    1.
    2.
    3.
    4.
    5.

    IA
    II A
    IB
    II B
    III

    PREFERRED RESPONSE

    Groups
    Oral Boards: Bone Tumor Staging Systems
    General - Oral Boards Review

    Evidence & References Show References

    Topic Comments

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    7/29/2011
    0 responses

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