Drug Administration Route Needle Size Etc

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Administering Vaccines: Dose, Route, Site, and Needle Size

Dose

Route

Diphtheria, Tetanus, Pertussis


(DTaP, DT, Tdap, Td)

0.5 mL

IM

Haemophilus influenzae type b (Hib)

0.5 mL

IM

Use a 2325 gauge needle. Choose the injection site that is


appropriate to the persons age and body mass.

IM

Age

Vaccine

<18 yrs; 0.5 mL

Hepatitis A (HepA)

>19 yrs; 1.0 mL


<19yrs: 0.5 mL
>20 yrs: 1.0 mL

Hepatitis B (HepB)

*Persons 1115 yrs may be given Recombivax HB


(Merck) 1.0 mL adult formulation on a 2-dose schedule.

IM

Human papillomavirus (HPV)

0.5 mL

IM

Influenza, live attenuated (LAIV)

0.2 mL

Intranasal spray

6-35 mos: 0.25 mL

Influenza, inactivated (IIV)

>3 yrs: 0.5 mL

IM

Injection Site and Needle Size


Subcutaneous (SC) injection

Needle
Length


Infants (112 mos)

Injection Site
Fatty tissue over anterolat-
eral thigh muscle

8"

Children 12 mos or older, 5


8"
adolescents, and adults

Fatty tissue over anterolateral thigh muscle or fatty


tissue over triceps

Intramuscular (IM) injection


Use a 2225 gauge needle. Choose the injection site and needle
length appropriate to the persons age and body mass.
Needle
Length

Age

Injection Site

0.1 mL

ID

Measles, Mumps, Rubella (MMR)

0.5 mL

SC

5 "*
Newborns (1st 28 days)
8

Anterolateral thigh muscle

Meningococcal conjugate (MCV)

0.5 mL

IM

1"
Infants (112 mos)

Anterolateral thigh muscle

Meningococcal polysaccharide (MPSV)

0.5 mL

SC

Pneumococcal conjugate (PCV)

0.5 mL

IM


11"
Toddlers (12 yrs)
5 8 1"*

Anterolateral thigh muscle


or deltoid muscle of arm

Pneumococcal polysaccharide (PPSV)

0.5 mL

IM or SC

Polio, inactivated (IPV)

0.5 mL

IM or SC

5 8 1"*
Children & teens
1"1"
(318 years)

Deltoid muscle of arm or


anterolateral thigh muscle

IIV: Fluzone intradermal (1864 yrs)

Rotarix: 1.0 mL

Rotavirus (RV)

Rotateq: 2.0 mL

Oral

Adults 19 yrs or older



Male or female
less than 130 lbs

8 1"*

Deltoid muscle of arm

Female 130200 lbs


Male 130260 lbs

11"

Deltoid muscle of arm

Female 200+ lbs


Male 260+ lbs

1"

Deltoid muscle of arm

Varicella (Var)

0.5 mL

SC

Zoster (Zos)

0.65 mL

SC

Combination Vaccines
DTaP-HepB-IPV (Pediarix)
DTaP-IPV/Hib (Pentacel)
DTaP-IPV (Kinrix)
Hib-HepB (Comvax)

0.5 mL

IM

MMRV (ProQuad)

<12 yrs: 0.5 mL

SC

HepA-HepB (Twinrix)

>18 yrs: 1.0 mL

IM

Intramuscular (IM) injection

Subcutaneous (SC) injection

*A 5/8" needle may be used for patients weighing less than 130 lbs (<60 kg) for IM
injection in the deltoid muscle only if the skin is stretched tight, the subcutaneous
tissue is not bunched, and the injection is made at a 90-degree angle.

Intradermal (ID) administration


of Fluzone ID vaccine

Intranasal (IN) administration


of FluMist (LAIV) vaccine

90 angle
90 angle
skin

45 angle
skin

subcutaneous tissue
muscle

Administer
in area of
deltoid

subcutaneous tissue
muscle

Please note: Always refer to the package insert included with each biologic for complete vaccine administration information. CDCs Advisory Committee
on Immunization Practices (ACIP) recommendations for the particular vaccine should be reviewed as well (see www.immunize.org/acip).
Technical content reviewed by the Centers for Disease Control and Prevention

Immunization Action Coalition Saint Paul, Minnesota 651- 647- 9009 www.immunize.org www.vaccineinformation.org
www.immunize.org/catg.d/p3085.pdf Item #P3085 (9/14)

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