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    Final F & Ar

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    ORIGINAL ARTICLE Comparison of low-density lipoprotein cholesterol calculated by Friedewald formula and Anandaraja’s formula in Bangladeshi population MR Rahman, M Saiedullah, S Shermin, M Ferdoush 1Department of Biochemistry, Delta Medical College, Dhaka. 2Bangladesh Institute of Health Sciences, Dhaka. 3BIRDEM OPD, Dhaka. Abstract: The reference method for determination of low density lipoprotein cholesterol (LDLC) is ß-quantification which is time consuming, labor intensive and is

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    Final F & Ar

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    ORIGINAL ARTICLE Comparison of low-density lipoprotein cholesterol calculated by Friedewald formula and Anandaraja’s formula in Bangladeshi population MR Rahman, M Saiedullah, S Shermin, M Ferdoush 1Department of Biochemistry, Delta Medical College, Dhaka. 2Bangladesh Institute of Health Sciences, Dhaka. 3BIRDEM OPD, Dhaka. Abstract: The reference method for determination of low density lipoprotein cholesterol (LDLC) is ß-quantification which is time consuming, labor intensive and is

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    FINAL F & AR

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    ORIGINAL ARTICLE Comparison of low-density lipoprotein cholesterol calculated by Friedewald formula and Anandaraja’s formula in Bangladeshi population MR Rahman, M Saiedullah, S Shermin, M Ferdoush 1Department of Biochemistry, Delta Medical College, Dhaka. 2Bangladesh Institute of Health Sciences, Dhaka. 3BIRDEM OPD, Dhaka. Abstract: The reference method for determination of low density lipoprotein cholesterol (LDLC) is ß-quantification which is time consuming, labor intensive and is

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as DOC, PDF, TXT or read online from Scribd
    Download as doc, pdf, or txt
    125 views1 page

    Final F & Ar

    Uploaded by

    saied2010
    ORIGINAL ARTICLE Comparison of low-density lipoprotein cholesterol calculated by Friedewald formula and Anandaraja’s formula in Bangladeshi population MR Rahman, M Saiedullah, S Shermin, M Ferdoush 1Department of Biochemistry, Delta Medical College, Dhaka. 2Bangladesh Institute of Health Sciences, Dhaka. 3BIRDEM OPD, Dhaka. Abstract: The reference method for determination of low density lipoprotein cholesterol (LDLC) is ß-quantification which is time consuming, labor intensive and is

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    of 1

    ORIGINAL ARTICLE

    Comparison of low-density lipoprotein cholesterol calculated by Friedewald formula

    and Anandaraja’s formula in Bangladeshi population

    MR Rahman1, M Saiedullah2, S Shermin3, M Ferdoush2


    1
    Department of Biochemistry, Delta Medical College, Dhaka.
    2
    Bangladesh Institute of Health Sciences, Dhaka.
    3
    BIRDEM OPD, Dhaka.
    Abstract:
    The reference method for determination of low density lipoprotein cholesterol (LDL-
    C) is ß-quantification which is time consuming, labor intensive and is not suitable for
    general laboratories. Direct method is also a costly one. There are several formulae
    for estimation of LDL-C and Friedewald’s formula (fLDL-C) is the most widely used
    one which requires serum total cholesterol, serum triacyl glycerol and serum high-
    density lipoprotein cholesterol for calculation. An alternative to Friedewald’s formula
    that does not require the measurement of serum high density lipoprotein cholesterol
    was published by Anandaraja et. al. In this work we aimed to examine the
    applicability of Anandaraja’s formula (aLDL-C) as a replacement of Friedewald’s
    formula in Bangladeshi subjects. 273 fasting samples were randomly chosen
    irrespective of age, sex & health status during the period of January 2009 to June
    2009. Calculated fLDL-C and aLDL-C was compared with LDL-C measured by direct
    method (dLDL-C). The mean LDL-C values of direct, Friedewald’s and Anandaraja’s
    were 130.66±47.61, 126.8±52.59 and 121.1±50.09 respectively. Both the calculated
    values significantly differ from the value obtained by direct method. Both the
    calculated values correlate significantly (r = 0.9838 for fLDL-C & 0.9737 for aLDL-C)
    with the directly measured value. Though the value obtained from Friedewald’s and
    Anandaraja’s formulas independently differ significantly from the directly measured
    value the mean difference is negligible from clinical point of view. It can be
    concluded that Anandaraja’s formula can be used with effective caution & limitation
    in context of our country. [Originally published in Bang J Med Biochem
    2009;2(1):18-20]
    Key words:
    LDL-C = Low density lipoprotein cholesterol, fLDL-C - LDL-C calculated by Friedewald’s
    formula, aLDL-C - LDL-C calculated by Anandaraja’s formula, dLDL-C - LDL-C measured by
    direct method.

    Introduction: Low density lipoprotein general laboratories. Direct methods


    cholesterol (LDL-C) is one of the which do not require any pretreatment
    important components of lipid and are also available but all are costly. As a
    considered as an important risk factor of result most laboratories use
    ischemic heart disease. The reference Friedewald’s equation for the
    method for determination of LDL-C is ß- determination of serum LDL-C from
    quantification which is time consuming, serum total cholesterol (TC), serum
    labor intensive and is not suitable for triacyl glycerol (TG) and serum high-

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