Care of The Patient Receiving Total Parenteral Nutrition (TPN)
Care of The Patient Receiving Total Parenteral Nutrition (TPN)
Care of The Patient Receiving Total Parenteral Nutrition (TPN)
TABLE OF CONTENTS
Introduction
Learning Objectives
Competency Process
What is TPN?
TPN Administration
10
14
18
References
26
TPN Post-Test
27
INTRODUCTION
Total parenteral nutrition (TPN) is the provision of intravenous nutrients to patients whose
gastrointestinal (GI) tract is not functioning or cannot be accessed and to patients whose nutritional needs
cannot be met with oral diets or enteral feeding. The patient receives a combination of nutrients- crystalline
amino acids, dextrose, electrolytes, vitamins, minerals, trace elements and lipid/fat emulsion administered
intravenously.
Once limited to critical care areas, TPN is now present on post surgical floors and medical units, when
feeding by mouth is not possible, when a person's digestive system cannot absorb nutrients due to chronic
disease, or, alternatively, if a person's nutritional requirements cannot be met by enteral feeding (tube
feeding) and/or through oral diet.
Caring for patients receiving TPN requires additional knowledge and skill. This learning package has
been developed to provide information to nursing staff caring for patients receiving TPN for nutritional
support.
LEARNING OBJECTIVES
The Registered Nurse/Registered Practical Nurse will be able to:
1.
2.
Describe the composition of the TPN solution and the rationales for each solution.
3.
4.
5.
6.
7.
8.
COMPETENCY PROCESS
1) Review of self-directed learning package.
2) Complete and obtain a minimum of 80% on the TPN post-test.
3) Attend a lecture/review session with CNE and perform TPN administration competency in simulated
environment.
4) Perform one return demonstration of TPN administration on actual patient.
WHAT IS TPN?
Total parental nutrition (TPN) is the practice of nourishing a patient intravenously, bypassing the usual
process of eating and digestion. It is a form of specialized nutrition, including amino acids, dextrose, fat
emulsion, vitamins, minerals and trace elements given intravenously.
The TPN solution is osmotically active and must be administered carefully to prevent trauma to the
vascular portal of entry. It is administered intravenously and can be administered through a peripherally
inserted central catheter (PICC), a central venous line (CVC) or a large peripheral line. In order to administer it
carefully, TPN is ALWAYS administered through an infusion pump. The sterile bags of nutrients are infused
continuously through the pump over a 12 hour or 24 hour period to prevent vascular trauma and metabolic
instability.
CLINICAL MANIFESTATION
CONDITION
Non functional
GI tract
Paralytic ileus
Intestinal obstruction
Severe malabsorption
5
Extended bowel rest
Enterocutaneous fistula
Severe diarrhea
functioning GI tracts
6
The ingredients are individually listed on the bag and must be verified with the physicians order on
the eMAR by the nurse hanging the bag, following the 8 rights of medication administration. In addition the
bag will be scanned with Caremobile (see pages 21 & 22).
Lipid emulsions are prepared in 100 ml or 250 ml bags and contains essential fatty acids [appears milky]. Lipid
emulsions are ordered to prevent fatty acid deficiency that causes scaly dermatitis, alopecia,
thrombocytopenia, and growth retardation in children.
At NYGH, lipids are dispensed in 20% solutions and are commonly run over a 12 hour period only.
Remove the bag from the sealed package, verify the physicians order on the eMAR, including the rate of
administration, fill in the label provided including the rate, date/time and your initials. The bag will also be
scanned with the Caremobile (see pages 21 & 22).
7
Below is a chart which summarizes the access routes and TPN administration plan of care.
Chart 2: Access routes and TPN administration plan of care
ACCESS TYPE
PLAN OF CARE
PICC (PERIPHERALLY
INSERTED CENTRAL
cephalic vein [in the arm], advanced into basilica or cephalic vein, then
VENOUS CATHETER)
Inserted when TPN is expected to run > 1 week in patients who are
VENOUS CATHETER)
PERIPHERAL
INTRAVENOUS
CATHETER
8
Below is a chart which summarizes the recommended entry sites and concentrations of TPN solutions for
administration.
Chart 3: Recommended entry sites and concentrations of TPN solutions.
SHOULD be:
MUST be:
Fat = 20%
Fat = 20 %
ELECTROLYTES: standard electrolytes in TPN: Na, K, Ca, PO4, Mg, Cl, Acetate
VITAMINS: -MVI-12, vitamin K
MINERALS: Zinc, copper, manganese, selenium, chromium
NOTE: It is critical that a peripheral site not be used for the administration of TPN suitable for a CVC or
PICC site. Administrating a concentrated TPN solution into a peripheral vein will cause vascular trauma.
However a CVC or PICC site can safely be used for the administration of all concentrations of TPN solutions.
TPN ADMINISTRATION
Below is a diagram of a patient with a TPN administration setup:
Amino acid/travasol- large bag (A)
Lipid small bag (B)
Infusion pump (C)
Travasol tubing with 0.2 micron filter (D)
E
D
9
TPN is NOT compatible with any other solutions and must be administered by itself. A dedicated
intravenous line should be labeled for TPN use only.
There are two different IV tubings used for TPN administration:
Amino acids/Travasol - has a 0.2 micron filter to counteract the acidity of the amino acid
solution and filter out any impurities.
Lipid emulsion - has a 1.2 micron filter to reduce the risk of particles entering the patient.
Typically in a clean area with clean hands, prime TPN lines with 0.9% NaCl.
TPN solutions must be connected to new sterile tubing q 24hrs.
Swab connection ports with 2% Chlorhexidine gluconate and 70% isopropyl alcohol swabs prior
to connecting.
When administering the lipid emulsion, piggyback the lipid tubing to the Travasol line below all
infusion filters and at the port closest to the patient.
An infusion pump must be used to regulate the administration of all TPN solutions. Our infusion pumps
have two regulators so one pump can regulate two different solutions running at different rates. This
pump should be plugged into the wall at all times but has a battery back up mechanism to temporarily
allow the pump to run should it need to be disconnected from the wall outlet. When the battery is low
the pump will alarm to notify you that it needs to be plugged into the wall outlet.
NOTE: Do not abruptly discontinue TPN (this is especially the case in patients who are on insulin), because
this may lead to hypoglycemia. If for whatever reason you run out of solution while awaiting another bag,
you can hang D5W at the same rate of the infusion in the mean time.
Do not obtain blood samples or CVP readings from same port as TPN infusions.
10
Consider this scenario: A patient on bowel rest is NPO, the physicians order reads:
If all three solutions were running at the ordered rates (80 + 20 + 42 = 142mL/hr) the total fluid infused
would be 142 mls which is 20 mls over the ordered TFI of 122 mls/hr. To correct this, the peripheral IV
(0.9% NS) must be decreased to 60 mls/hr during the 12 hour period when the lipid infusion is running (60
+ 20 + 42 = 122 mL/hr). Then when the lipid emulsion is completed (from 0200 to 1400 hours), the IV 0.9%
NS must be increased back to 80 mL/hr along with the Travasol at 42mls/hr (80 + 42 = 122 mL/hr).
RATIONALE
limits.
tissue.
- Do not apply antibiotic ointment to catheter insertion site- will
cause fungal and AROs colonization.
- Dextrose content of CVC/ PICC solutions is higher than
peripheral solutions, increasing the risk of infection at site. For at
risk patients [i.e. diabetics], be vigilant in your aseptic practices.
**This is not always the case as 10% dextrose solution can be
provided centrally**
11
Explain purpose of TPN support
RATIONALE
abnormalities.
and weekly.
and rate.
12
VERIFY the Total Fluid Intake (TFI) ordered - To prevent fluid overload from intravenous fluids.
by the physician.
RATIONALE
- Reduces transmission of microorganisms
administration.
yellow in color.
to run solution from 1400 hrs to 1400 hours the next day.
13
end of tubing to central/peripheral
catheter line.
hand hygiene.
D. Evaluation
ACTION
RATIONALE
& weekly).
- Documentation in Cerner.
The following should be noted on the
patients chart:
infusion.
- Site of IV catheter and verification of patency.
- Status of dressing and site condition, if visible.
- Vital signs and weight.
- Client tolerance to TPN.
- Client response to therapy and understanding of instructions.
14
- Address patients response and
understanding of TPN.
Administration-related Complications
Sepsis
Actions:
of tubing.
Pneumothorax
Actions:
immediately.
cyanosis.
Embolism
Actions:
hypotension.
Actions:
15
Symptoms: Unable to flush line.
Actions:
hypoxemia.
Actions:
Hypoglycemia or hyperglycemia.
Actions:
Electrolyte imbalance.
Actions:
16
- Malaise
- Palpitations
- Muscle weakness
Symptoms can be specific:
- Cardiac arrhythmia or sudden death.
Hypokalemia
Mild symptoms:
- Elevation of blood pressure
- Cardiac arrhythmias
- Muscular weakness
- Myalgia
- Muscle cramps
- Constipation
Severe symptoms:
- Flaccid paralysis
- Hyporeflexia
- Tetany
- Respiratory depression
- ECG changes
Hypocalcemia
Early signs:
- Personal tingling and paresthesia
- 'Pins and needles' sensation over the extremities of hands and feet.
- Tetany, carpopedal spasm are seen.
- Latent tetany
- Trousseau sign of latent tetany (eliciting carpal spasm by inflating the
blood pressure cuff and maintaining the cuff pressure above systolic)
- Chvostek's sign (tapping of the inferior portion of the zygomatic will
produce facial spasms)
- Tendon reflexes are hyperactive
- Life threatening complications
- Laryngospasm
- Cardiac arrhythmias
- ECG changes
17
Hypercalcemia
Hypoglycemia
- Shaky
- Headache
- Hunger
- Anxious
- Mood swings
Hyperglycemia
- Excessive thirst
- Hunger
- Excessive urination
- Disorientation and confusion
Consult religious leaders about continuous infusion of TPN solutions during fasting periods i.e.
18
fluid intake by the patient from ALL sources. The TFI amount identified in the physicians orders must be
mirrored on the total intake section of the Intake and Output record.
Information
19
details.
Performed date/time:
Volume: Volume of
20
correct. Now sign by clicking on
the green checkmark at the top
left hand side.
21
22
23
24
25
26
References
Dudek, S.G. [2006]. Nutrition Essentials for Nursing Practice (5th Edition). eBook available via the
University of Toronto Library at
http://ovidsp.tx.ovid.com.myaccess.library.utoronto.ca/spb/ovidweb.cgi
Ferreira, P (2007). Total parenteral nutrition. Powerpoint presentation available at North York General
Hospital at www.nygh.on.ca
Ohio State University: University Medical Center (1999). Health for life: Total parenteral nutrition.
Available at http://medicalcenter.osu.edu/pdfs/PatientEd/Materials/PDFDocs/nut-diet/tpn/tpn.pdf
Perry, A.G. & Potter, P.A. (2006). Clinical Nursing Skills and techniques: 6th edition. Philadelphia: Elsevier
Mosby
Smith-Temple, J. & Young Johnson, J. [2002]. Nurses' Guide to Clinical Procedures eBook available via the
University of Toronto Library at http://ovidsp.tx.ovid.com.myaccess.library.utoronto.ca/spb/ovidweb.cg
27
Unit :
Date :
TPN therapy can be prescribed if there is intolerance to oral feeds and the patient is
NPO for 3 or more days.
2. True False
TPN is not compatible with any other solution and must be administered by itself, with a
dedicated labeled IV line for TPN use only.
3. True False
Travasol can be administered over 24 hours, while lipids are commonly over 12 hours.
4. True False
Only TPN solutions of >10% dextrose can be administered into a peripheral IV site, to
prevent vascular trauma.
5. True False
6. True False
It is important to have a baseline electrolyte, renal and hepatic blood work prior
to initiating TPN.
b)
verify the MDs orders against the composition label on the bags
c)
d)
e)
f)
b only
b)
c)
d)
28
9. Patients receiving TPN will have their Laboratory values specifically monitored for:
a) electrolyte imbalances
b) increased WBC and thyroid levels
c) readjustment in TPN composition
d) assess renal and hepatic function
e) a, b, c
f) a, c, d
10. Fluid monitoring/management with patients receiving TPN is crucial in order to prevent fluid
overload. A patients TPN orders are as follows:
Travasol @ 45mls/hr
Lipid emulsion @ 20mls/hr
IV 0.09 % NaCl @ 75mls/hr
TFI order is 115mls/hr
a) If all 3 infusions are running at the same time as ordered, what is the TFI____________mls/hr
b) This makes the TFI over by _____________mls from the MDs order for 115mls/hr.
c) You realize that in order to keep the TFI at 115mls/hr you have to:
i) increase the lipid emulsion infusion to 22mls/hr
ii) decrease the travasol solution to 25mls/hr
iii) decrease the NaCl infusion to 50 mls/hr for 12hrs while the Lipids are infusing then
increase it back to 75mls/hr when the lipids have infused
11. When hanging TPN tubing and connection port considerations include:
a)
b)
c)
d)
e)
f)
g)
a, b, d only
29
12. During TPN administration the following is monitored:
a) PICC or peripheral IV insertion sites
b) Blood glucose and electrolytes
c) Intake and output
d) Potential fluid overload
e) Weight and nutritional status
f) All of the above
g) b, c, d only
13. Signs and symptoms of a patient experiencing fluid overload while receiving TPN are:
a) Crackles to lung fields, SOB, difficulty breathing
b) Vomiting, constipation, shaky, mood swings
c) Possible Pulmonary Edema
d) Hypertension, Distended jugular veins
e) All of the above
f) a, c, d only
14. An electrolyte imbalance of hypocalcemia can cause:
a) Tetany, facial spasms
b) Pins and needles over extremities
c) Hyperactive wrist reflexes and severe lethargy
d) Cardiac arrhythmias
e) All of the above
f) a, b, d only
15. Place the correct solution (either Travasol or Lipids) in column 1.
Column 1
Prepared in 1000 or 2000 ml bag, contains varied concentrations of dextrose and
solution can be yellow from multivitamins.
Requires IV tubing with a 1.2 micron filter and is dispensed in 20% solutions.
Prepared in 100 or 250 ml bag, appears milky and usually administered over 12 hours.
Requires IV tubing with a 0.2 micron filter and is ordered, based on the patients
clinical presentation and blood work, to support their metabolic needs.
/20