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HEADACHES

Ma. Carmencita B. Gonzalez, M.D.

Headaches
At the end of the unit, the student will be able to:
COGNITIVE
Describe headache
Classify the different types of headache and give its
signs and symptoms
Enumerate the different pain sensitive and insensitive
structures of the brain
Explain the different mechanisms that cause headache

AFFECTIVE
Realize that headaches could be a part of the signs and
symptoms of an underlying brain pathology
Realize that HA could be caused by other organ systems
aside from the nervous system
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Headaches
Types of headache
Primary headache
Migraine headache
Tension headache
Cluster headache

Secondary headache

Different structures of head that may and


may not cause pain
Pain sensitive structures
Pain insensitive structures

Mechanisms causing headache


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Pain Sensitive Structures


Scalp and Aponeurosis
Middle Meningeal Artery

Dural Sinuses
Falx Cerebri
Proximal segments of the large pial
arteries
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Mechanisms of Pain Production


Distention, traction or dilatation of
intracranial and extracranial arteries
Traction or displacement of large
intracranial veins or their dural envelope
Compression, traction, or inflammation of
cranial and spinal nerves

Mechanisms of Pain Production


Spasm, inflammation and trauma to
cranial and cervical muscles
Meningeal irritation and raised
intracranial pressure
Perturbation of intracerebral
serotonergic projections
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Pain Insensitive Structures


Ventricular ependyma
Choroid plexus
Pial veins
Much of the brain parenchyma

Nerves Subserving Pain


Trigeminal nerve - supratentorial
structures of the anterior and middle
fossa
First three cervical nerves - posterior fossa
and infradural structures
Glossopharyngeal and Vagus nerves posterior fossa, refers pain to the ear and
throat
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Evaluation of Headaches
Headache attacks
How it begins
Precipitating event, illness, injury

Headache attack descriptions


Frequency and patterns
Any significant changes

Location
Time to peak intensity
Duration
Quality and intensity
Warning symptoms and aura
Associated symptoms and level of disability
Triggers and aggravating or relieving factors

International Headache Society


Classification of Primary Headaches
2004
1. Migraine
a. Migraine without aura
b. Migraine with aura
2. Tension-type Headache
3. Cluster Headache and Other Trigeminal
Autonomic Cephalgias
4. Other Primary Headaches
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International Headache Society


Classification of Primary Headaches
2004
5. Headache Attributed to Head and/or
Neck Trauma
6. Headache Attributed to Cranial or
Cervical Vascular Disorder
7. Headache Attributed to Non-vascular
Intracranial Disorder
8. Headache Attributed to a Substance or
its Withdrawal
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International Headache Society


Classification of Primary Headaches
2004
9. Headache Attributed to Infection
10. Headache Attributed to Disorder of
Homoeostasis
11. Headache or Facial Pain Attributed to
Disorder of Cranium, Neck, Eyes, Ears,
Nose, Sinuses, Teeth, Mouth, or Other
Facial or Cranial Structures
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International Headache Society


Classification of Primary Headaches
2004
12.Headache Attributed to Psychiatric
Disorder
13.Cranial Neuralgias and Central Causes
of Facial Pain
14. Other Headache, Cranial Neuralgia,
Central or Primary Facial Pain
a. Trigeminal Neuralgia
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MIGRAINE
1.1 Migraine without Aura
1.2 Migraine with aura

1.3 Childhood Periodic Syndromes that are


commonly Precursors of Migraine
1.4 Retinal Migraine
1.5 Complications of Migraine

1.6 Probable Migraine


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MIGRAINE
Benign recurring headache with or without
recurring neurologic dysfunction

Pain free interludes


Provoked by stereotyped stimuli

More common among females


With hereditary predisposition
Onset usually in childhood, adolescent years
or early adulthood
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Symptoms of Migraine
Unilateral headache = 62%
Pulsating quality = 78%
Moderate or severe intensity = 99%
With nausea = 82%
With photophobia & phonophobia = 83%/86%
Aggravated by physical activity = 96%
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Risk Factors for Migraine


Family history
Menstruation, Oral contraceptives,
Menopause
Stress, Fatigue
Bright lights
Meteorologic changes, high altitude
Medicines - vasodilators
Head trauma
Hunger
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Predisposing Factors & Triggers


Family history
h/o travel sickness
h/o cyclical vomiting in
childhood
Stress
Menstrual cycle
Menopausal
Head & neck trauma
Strenuous exercise
Meteorologic changes,
high altitude

Relaxation after stressweekend migraine


Change of habit-missed
meals /sleep
Bright lights
Loud noise
Smells-perfume /petrol
Dietary/Food
Medications

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Migraine without Aura


Common Migraine; Hemicrania Simplex
Recurrent headache disorder manifesting
in attacks lasting 4-72 hours.
Typical characteristics - unilateral,
pulsating, moderate or severe,
aggravation by routine physical activity
and association with nausea and/or
photophobia and phonophobia
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Diagnostic Criteria
Migraine without Aura
DIAGNOSTIC CRITERIA:
A. At least five attacks fulfilling criteria B-D
B. Headache attack lasts 4-72 hours (untreated or
unsuccessfully treated)
C. Headaches with at least 2 of the following:
1.
2.
3.
4.

Unilateral location
Pulsating quality
Moderate or severe intensity
Aggravation by or causing avoidance of routine physical
activity (eg. walking or climbing stairs )

D. During headache, at least one of the following


A. Nausea and/or vomiting
B. Photophobia and phonophobia

E. Not attributed to another disorder

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Migraine with Aura


Classic or classical migraine, Ophthalmic,
Hemiparaesthetic, Hemiplegic or aphasic
migraine, Migraine accompagnee, Complicated
migraine
Recurrent disorder of reversible focal
neurological symptoms that develop gradually
over 5-20 minutes and last for less than 60
minutes
Headache with the features of migraine without
aura usually follows the aura symptoms
Less commonly, headache lacks migrainous
features or is completely absent
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Diagnostic Criteria
Migraine with Aura
A. At least two attacks fulfilling criterion B
B. Migraine aura fulfilling criteria B and C for one
of the subforms 1.2.1-1.2.6
C. Not attributed to another disorder
1.2.1
1.2.2
1.2.3
1.2.4
1.2.5
1.2.6

Typical aura with migraine headache


Typical aura with non-migraine headache
Typical aura without headache
Familial hemiplegic migraine
Sporadic hemiplegic migraine
Basilar-type migraine
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B. Aura consisting of at least one of the following, but


no motor weakness:
1. Fully reversible visual symptoms including positive features
(eg. Flickering lights, spots or lines) and/or negative
symptoms (ie. Loss of vision)
2. Fully reversible sensory symptoms including positive
features (ie, pins and needles) and/or negative features (ie,
numbness)
3. Fully reversible dysphasic speech disturbance

C. At least two of the following:


1. Homonymous visual symptoms and/or unilateral sensory
symptoms
2. At least one aura symptom develops gradually over 5
minutes and/or different aura symptoms occur in
succession over 5 minutes
3. Each symptom lasts 5 and 60 minutes

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Basilar Migraine
B. Aura consisting of at least one of the following, but no motor
weakness:
1.
2.
3.
4.
5.
6.

Dysarthria
Vertigo
Tinnitus
Hypacusia
Diplopia
Visual symptoms simultaneously in both temporal and nasal fields
of both eyes
7. Ataxia
8. Decreased level of consciousness
9. Simultaneously bilateral paraesthesias

C. At least two of the following:


1. At least one aura symptom develops gradually over 5 minutes
and/or different aura symptoms occur in succession over 5
minutes
2. Each aura symptom lasts 5 and 60 minutes
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Pathogenesis of Migraine
Vascular theory
Spreading Depression Theory
Present Concept:
1. Brain stem generation
2. Vasomotor activation
3. Activation of the cells of the trigeminal
nucleus caudalis and release of
vasoactive neuropeptides at the
terminations of the trigeminal nerve on
blood vessels
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Management of Migraine

Medications
Lifestyle modifications
Regular sleep
Regular meals
Moderate amount of exercise
Drink plenty of water
Limit caffeine, alcohol and other drugs
Reduce stress

Tension-Type Headache
Tension, Muscle contraction, Psychomyogenic,
Stress, Ordinary, Essential, Idiopathic, Psychogenic
Headache
Most common type of Primary headache; 3078%

2.1
2.2
2.3
2.4

Infrequent episodic tension-type headache


Frequent episodic tension-type headache
Chronic tension-type headache
Probable tension-type headache
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Tension-Type Headache
At least two of the following pain
characteristics

- Bilateral location
Pressing/tightening (non-pulsating) quality
Mild to moderate intensity
No aggravation by walking stairs or similar
routine physical activity

Both of the following

No nausea or vomiting (anorexia may occur)


No more than one of photophobia or
phonophobia

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Cluster Headache and Other


Trigeminal Autonomic Cephalalgias
3.1 Cluster headache
3.2 Paroxysmal hemicrania

3.3 Short-lasting Unilateral Neuralgiform


Headache Attacks with Conjunctival
Injection and Tearing (SUNCT)
3.4 Probable Trigeminal Autonomic
Cephalalgia
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Cluster Headache
Ciliary neuralgia, Erythro-melalgia of
the head, Erythroprosopalgia of Bing,
Hemicrania angioparalytica, Hemicrania
Neuralgiformis Chronica, Histaminic
Cephalalgia, Hortons headache, HarrisHortons disease, Migrainous Neuralgia
(of Harris), Petrosal Neuralgia (of
Gardner)
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Diagnostic Criteria
Cluster Headache
A. At least 5 attacks fulfilling criteria B-D
B. Severe or very severe unilateral orbital, supraorbital and/or
temporal pain lasting 15-180 minutes if untreated
C. Headache is accompanied by at least one of the following:

Ipsilateral conjuctival injection and/or lacrimation


Ipsilateral nasal congestion and/or rhinorrhea
Ipsilateral eyelid edema
Ipsilateral forehead and facial sweating
Ipsilateral miosis and/or ptosis
A sense of restlessness or agitation

D. Attack have a frequency from one every other day to eight


per day
E. Not attributed to another disorder

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Other Types of Headache

Cough Headache
Coital Headache
Post concussion Headache
Giant Cell Arteritis
Lumbar Puncture Headache
Brain Tumor Headache
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Diseases Which Present


with Headaches

Head and/or Neck Trauma


Cranial or Cervical Vascular Disorder
Non-vascular Intracranial Disorder
Substance Use or its Withdrawal
Infections
Disorder of Homoeostasis
Disorders of Cranium, Neck, Eyes, Ears, Nose,
Sinuses, Teeth, Mouth or other Facial or Cranial
Structures
Psychiatric disorders
Cranial Neuralgias and Central Causes of Facial Pain
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Red Flags of Headaches


Headaches only felt in one particular area of
the head
Headache which peaks in an instant
thunder-clap
Sleep deprivation
Headaches accentuated by eye movement
Headache accentuated by bending, lifting,
coughing
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Diagnosis of Secondary Headaches


Red flag symptoms which should prompt referral for further investigation

New onset or change in headache in patients over 50..remember ESR


Thunderclap headache
Focal neurological symptoms e.g. limb weakness/ aura lasting >1 hr
Non-focal neurological symptoms e.g. impaired cognitive function
Change in headache frequency/characteristics
Abnormal neurological examination
Headache that change with posture
Headache wakening patient up
Headache precipitated by physical exertion eg cough,/straining valaslva/
Neck stiffness/fever
New onset headache in patient with cancer
Sleep deprivation
Headaches felt persistently on the same area

Trigeminal Neuralgia
Tic doloureux
Management: Carbamazepine, surgery

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Diagnostic Criteria
Trigeminal Neuralgia
A. Paroxysmal attacks of pain lasting from a fraction
of a second to 2 minutes, affecting one or more
divisions of the trigeminal nerve and fulfilling
criteria B and C
B. Pain has at least one of the following
characteristics
1. intense, sharp, superficial or stabbing
2. Precipitated from trigger areas or by trigger factors

C. Attacks are stereotyped in the individual patient


D. There is no clinically evident neurological deficit
E. Not attributed to another disorder

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