Endocrine Disorders Worksheetanskey2012-1
Endocrine Disorders Worksheetanskey2012-1
Endocrine Disorders Worksheetanskey2012-1
Disease
Disease Symptoms
Organ Affected
Acromegaly
- usual cause is
pituitary tumor
Increased growth of
bones of feet, jaw and
hands
Pituitary gland
Pheochromocytoma
- tumor of adrenal
medulla;
neurochromaffin
cells
Neuroblastoma
Malignant tumor
seen in infants and
children
Increased BP
Tachycardia
Headache
Symptoms may be
episodic
Proposis
(exopthalmos)
Periorbital
Ecchymosis
Symptoms of
metastasis- bone pain,
paralysis, abdominal
distension
Diarrhea, flushing of
the skin; edema; right
sided heart failure;
bronchoconstriction;
Adrenal medulla,
sympathetic
nervous system
Carcinoid Syndrome
tumor of
enterochromaffin
cells
Hormone(s) Involved
(Increase or Decrease?)
Growth Hormone -I
Epinephrine, norepinephrine
Catechloamines, all increased
Cells of GI tract,
Serotonin levels increased
lungs, heart, bilairy
tract, gall bladder,
pancreatic ducts
sudden drop in BP
Disease
Disease Symptoms
Organ Affected
Hormone(s) Involved
(Increase or Decrease?)
PTH elevated
Parathyroid gland ,
bones
SIADH - syndrome
of inappropriate
ADH secretion
Edema, confusion,
apathy, weakness,
symptoms of
hyponatremia
Kidneys, pituitary
ADH (Vasopressin)- I
Exopthalmos,
nervousness,
increased appetite,
heat intolerance,
weight loss, loose
stools
Weight gain, cold
intolerance, fatigue,
dry skin; deepening
of voice, hypotension
Thyroid
Thyroid
Hirsutism, truncal
obesity, hypertension,
Adrenal cortex,
pituitary
Cortisol- I
ACTH possible I
Hashimoto's
Thyroiditis hypothyroidism
Cushing's Syndrome
purple striae on
abdomen, buffalo
hump, moon face,
amenorrhea, glucose
intolerance
3. Dexamethasone suppression
High dose see suppression in
Cushing's disease
Low dose- no suppression
4. ACTH levels - I or D
5. FBS levels I
Disease
Disease Symptoms
Organ Affected
Hormone(s) Involved
(Increase or Decrease?)
Addison's Disease
(Adrenal
Insufficiency)
Hyperpigmentation,
salt craving, weight
loss, hypotension,
muscle weakness
Adrenal cortex,
pituitary
Cortisol levels D
ACTH I
Conn's syndromehyperaldosteronism
Increased BP,
increased urine
volume, weakness,
tetany
Adrenal cortex
Aldosterone- I
Uterus
HCG I
Choriocarcinoma
Klinefelters
Syndrome- XXY
FSH- I
LH- I
Testosterone- D
FSH- I
LH- I
Testosterone- D
(Primary
hypogonadism)
Failure to develop
Gonads
secondary sex
characteristics;
enlarged breasts,
sparse facial and body
hair, small testes,
cannot make sperm,
language difficulties
Disease
Disease Symptoms
Organ Affected
Precocious Puberty
in Males
Early development of
secondary sex
characteristics
Testicles or
Adrenal glands
Congenital Adrenal
Hyperplasia (CAH)due to absence or
deficiency of 21- or
11-B-hydroxylase
Gonads, adrenal
cortex
Hormone(s) Involved
(Increase or Decrease?)
Testosterone I
FSH- D
LH- D
Change in FSH/LH ratio
17 KS- I
DHEA- I
Androstenedione- I
Cortisol D
Aldosterone- D
Androgens I
Testosterone I
hypertension