TABEL SINTESA PENELITIAN

NAMA
NIM

: ELY EKO AGUSTINA

: 0613514022
KARAKTERISTIK

NO

PENELITI DAN JUDUL

(TAHUN)

MASALAH
UTAMA
SUBJEK

1.

JUDUL
INFLUENCE
OF ACORN
INTAKE ON
BLOOD
LIPID
PROFILE
AND
LONGISIMU
SMUSCLE
CHARACTE
RISTICS OF
BLACK
SLAVONIAN
PIG(2008)
PENELITI

10 pigs of
the
localBlack
Slavonian
(BS) breed

VARIABEL

The examined pigs

were reared on
pasture utilizing
nature resources
with the
addition about of 0.5
kg of concentrate
daily per pig. In
addition, last two
mounts pigs were
fattened in piggery
with corn based
mixture (Table 1.).
Three weeks before
slaughter pigs are
randomly divided

METODE
DESAIN/
ANALISA
STATISTIK
The Student ttest for
independent
variables
(PROC TTEST;
SAS, 1999) was
used to compare
the blood lipid
data and histochemical
characteristics
of MLD from
two finishing
diet groups.

TEMUAN

Present study shown

that Ad
libitumconsumption of
acorn of Slavonian oak
(Quercus robur
L.) in the short preslaughter fattening
period cancause
positive changes in
blood lipid profile
such as decreasing of
triglycerides and total
cholesterol
concentrations without
adversely effect
on liver function in

Kreimir
SALAJPAL,
Danijel
KAROLYI,
Marija
IKI, Vesna
KANTURA,
GoranKI,
eljko
SINJERI

2.

JUDUL
Effects of Nigerian
Piliostigma thonningii
Species Leaf Extract on
Lipid Profile in Wistar
Rats(2014)
PENELITI
O. M. Ighodaro and J. O.
Omol

into two groups, the

experimental (E)
group were fed acorn
from Slavonian
oak (Quercus
roburL.) Ad
libitumand second
one (Control group,
C)were continued to
be fed
mixture diets, about
2 kg daily per pig. At
the slaughter pigs
were on average 154
22 kg and 18
Salajpal, K. et
al.Influence of acorn
intake mounts of age
Cardiovascular
The rats
The animals were
diseases and related attained a
randomly assigned
disorders are a
body weight into
major
range of
three (3) groups, A,
cause of mortality
200220 g
B, and C with each
both in men and
group containing
women all over the
ten animals (n=10).
world [1]. They are
Group A (control)
commonly
were given normal
characterized by
saline daily for 14
high levels
days. Group B were
of total cholesterol,
treated orally with
triglycerides, and
0.2 g/kg bwt ofP.
low-density
thonningiiextract

Slavonian pigs. In
addition, the
considerable amounts
of alpha linolenic acid
in acorn could have
beneficial effect on the
n-6/n-3 ratio in the
meat. On the other
hand, three
weeks of fattening
period with acorn did
not influence on
differences in IMF or
in diameter and
proportion of each
muscle fiber types.
Results are
presented as
mean
S.D (standard
deviation of
the mean)
andnrepresents
the
number of rats
used for each
experiment.
Comparisons
were done
between

he overall data obtained in

this study suggest
thatpiliostigma
thonningiileaves may
protect against
accumulation
of cholesterol and
triglycerides in the blood.
This may be
useful in the treatment or
management of
atherosclerosis
and coronary heart
disorders. However, it is

3.

JUDUL
The Effects of
Rosemary (Rosmarinus
officinalis) Leaves
Powder on Glucose
Level, Lipid Profile
and
LipidPerodoxation(201
4)

lipoprotein
cholesterol in the
serum. Increased
total cholesterol
and
more significantly
LDL cholesterol in
the serum have
been
implicated in the
etiology of
cardiovascular
diseases and are
seen as primary
risk factors [2].
Also, high level of
lipids in
the blood has been
associated with
hypertension and
lipid
peroxidation
Various herbs have
been used as
treatment and
prevention for
several chronic
diseases such as
diabetes,
hypercholesterolem
ia and
triglyceridemia;

A group of
48
individuals
divided into
23 men and
25 women
aged
between 20
to 57 years
(32 13)

daily for 14 days.

Group
C were treated orally
with 0.4 g/kg bwt of
the extract daily for
14 days. All animals
were given access to
normal laboratory
chow and waterad
libitumduring the
study

groups and
between the
basal and final
concentrations
in each by use
of one-way
analysis of
variance
(ANOVA)
followed by
post hoc tests
(leastsquare
deviation).
Pvalue of less
than 0.05 was
declared as
significant
statistically

strongly recommended that

the use of the plant extract
should be within the limits
that are nontoxic to body
cells and tissues, preferably
between 200250 mg/kg of
body weight

Lipid parameters
such
as
total
cholesterol,
triglyceride, LDL
and
HDL and some
antioxidants
markers such as
Glutathione
reductase (GR),

In this study, ttest was

conducted to
see if there
were any
statistical
differences
between
control and
intervention

In conclusion, the results

suggest that phenolic
compounds from
Rosmarinus officinalis
protect against
hyperglycemia and
hypercholesterolemiainduced oxidative stress,
increasing the activities of

PENELITI
Louay Labban
, Usama El-Sayed Mustafa
, Yasser Mahmoud Ibrahim

one of those herbs

is Rosemary,
which has
biological
antioxidant
mechanisms.
Rosemary is a
thorny
Rhamnaceous plant
which is
widely distributed
in Europe and
South-Eastern Asia.
Its used in
traditional
medicine for its
therapeutic
properties.

participated
in this
study. They
were
divided into
three groups
according to
the intake
dosage of
Rosemary
leaves
powder.

total vitamin C, Bcarotene and

malnodialdehyde
(MDA).

groups. The
data collected
were entered
into SPSS (10)
program and
significance
difference was
set at P <
0.01 and P <
0.05

antioxidant enzymes.
Moreover, rosemary leaves
powder has antioxidant
properties and has a positive
effect on Glutathione
reductase,
malnodialdehyde, vitamin C
content and B-carotene.
Supplementation with these
natural extracts may prove
valuable in limiting the
pathophysiology of
numerous disorders
associated with oxidative
damage and inflammation.
The rosemary leaves powder
was also able to improve the
serum lipid profile,
contributing to
cardiovascular disease
reduction. Both doses (2 and
5 g/day) of R. officnalis
leaves powder were found
to have therapeutic
potential. They possess
hypolipidemic,

hypoglycemic and
antioxidant properties but
the higher dose of
4.

JUDUL
Effect of Salacca Vinegar
Var. Suwaru on Lipid
Profile Diabetic Rats(2014)

Diabetes mellitus is
a group of
metabolic diseases
with hyperglycemia
characteristic that
PENELITI
occurs
because of
Elok Zubaidah, Desta Yossy
abnormalities of
Ichromasari, Oty Kiki
insulin secretion.
Mandasari
And it becomes
one of the major
degenerative
diseases in the
world. The number
of studies is
conducted to
produce
hypoglycemic
compound and
hipolipidemia as an
alternative to
chemical drugs.
One of natural
product is salacca
vinegar.

White rats
Rattus
novergicus
Wistar
strain, 3 - 4
months old,
130 - 180 g
body
weight.

The animals
were randomly
divided into four
groups and each
group consists
of 5 rats,
classified as:
normal, diabetic
control, diabetic
rats treated with
salacca vinegar
0.4 cc doses,
diabetic rats
treated with
salacca vinegar
0.7 cc doses. Each
group is separated in
different cages.
Before treatment rats
adapted to the
laboratory conditions
for 1 week in order
to adapt to the
environment and

The data were

analyzed by
ANOVA
(Analysis of
Variance). The
means were
assessed for
differences
through Least
Significant
Difference
(LSD)

10 g/day was more efficient.

Salacca
vinegar
var.
Suwaru with a dose of 0.4
cc/rat/day
and
0.7
cc/rat/day influence on
lipid profile levels of
diabetic rats which affect
on
decreasing
LDL,Trygliceride,
total
cholesterol and increasing
HDL
serum
plasmadiabetic rats

given a normal diet

(standard).

5.

JUDUL
In vitrostudies of
polyphenol compounds,
total antioxidant capacity
and other dietary indices in
a mixture of plants
(Prolipid) (2007)
PENELITI
ZENON JASTRZEBSKI
, OSCAR J. MEDINA
, L. MARLEN
MORENO2 & SHELA
GORINSTEIN

The best health and

nutrition results can
be achieved not
only from the
consumption of
fruits
and vegetables with
high antioxidant
capacities, but also
from medicinal
plants and herbs.
Therefore, in the
present
investigation, the
bioactive
compounds
(polyphenols and
flavonoids)
and the radical
scavenging
capacities of
Prolipid, a mixture
of herbs, were
studied

raw
material
used in
Prolipid
was a
mixture of
the
following
plants:
Sonchus
arvensisL.
from
theComposi
tae(Asterace
ae) family,
Guazuma
ulmifoliaL.
from the
Sterculiacea
efamily and
Murraya
paniculataL.
from
theRutaceae
family

bioactive compounds
in Prolipid, but also
the antioxidant
capacities of its
methanol
and water extracts

The values are

the
mean9standard
deviation of
three
measurements.
Where
appropriate,
data were
tested by twoway analysis
of variance
using
GraphPad
Prism,
version 2.0
(GraphPad
Software, San
Diego, CA,
USA),
following by
Duncans new
multiple range
test to assess
differences
between-group
means.

Prolipid has high amounts

of bioactive substances,
mostly such as
polyphenolsand
flavonoids, and a
corresponding high
antioxidant capacity.
Prolipid can be
Polyphenols and
antioxidant capacity in
Prolipid compared with
other medicinal plants,
herbs and fruits that are
widely used for medicinal
and nutritional purposes.

6.

7.

JUDUL
Effect of diabetan on blood
glucose, glycosylated
hemoglobin, lipid profile,
liver and kidney function
tests of diabetic patients: A
clinical, double blind,
randomized trial (2013)

Diabetes mellitus
is considered as
the most common
endocrine disease;
its prevalence
which is being
increased in
human population
(American
PENELITI
Diabetes
Association,
Behradmanesh Mohammad1997). Herbs are
Saeed, Ahmadi
rich sources of
Mohammad-Ali, Rafieiannatural
kopaei Mahmoud
antioxidants, and
are used in
Traditional
medicine for the
control and
treatment of many
diseases.
JUDUL
Cardiovascular
disease (CVD) is a
Blood cholesterol
degenerative
levels
disease
ofhypercholesterolemi
that most often
c rat (Rattus
occur and becomes

participate
in
the study,
were
selected and
divided into
2 groups of
40 patients

age, sex, weight,

blood pressure,
family history of
diabetes and
duration of the
disease was
completed

In this
study,
animals
used were
25 of male
white rats

five treatment
groups,
namely: control,
simvastatin (1.3
mL/270 g BW),
cholesterol (9:1

Differences
ofPB0.05
were
considered
significant.
The 2hpp
blood
sugar and
cholesterol
levels
decreased
significantly
in Diabetan
treated patients
as compared
to the
control group
(P<0.05).

Quantitative
data (total
cholesterol
content, LDL
cholesterol and
HDL

Results
showed
that
Diabetan tablets might be
beneficial in diabetic
patients to reduce 2hpp
and
cholesterol.
However, higher doses
might be needed to
decrease fasting blood
glucose and glycosylated
hemoglobin.

Giving VCO (Virgin

Coconut Oil) on
hypercholesterolemic white
rats (Rattus norvegicusL.)
leads to lower
cholesterol levels (total

norvegicus) after VCO

treatment (2009)
PENELITI
MARTI HARINI1,
, OKID PARAMA
ASTIRIN

8.

JUDUL
Efektivitas Ekstrak
Tanin Seledri Terhadap
Profil Lipid Tikus
Putih
Hiperkolesterolemi

a major killer in
industrialized
countries. In
Indonesia, the
National
Household Health
Survey 1992 states,
CVD became the
first rank as the
cause of death to
people over 40
years of
age. A major
cardiovascular
disease of the
productive age
is coronary heart
disease (CHD),
which is closely
related to
atherosclerosis
(Kalim et al. 1996).

(Rattus
norvegicusL
.), Wistar
strain, at
age of 2
months
with body
weight of
250-290 g

lard), VCO 1 (1
mL/270 g BW), and
VCO 2 (1.3 mL/270
g BW).
Treatment was given
orally.( bloodtotal
cholesterol, blood
LDL levels,
increasing blood
HDL in
hipercholesterolemic
white rat.)

Penyakit Jantung
Koroner ( PJK )
sebagai salah satu
penyakit yang kini
banyak
mengancam
kesehatan

tikus putih
(Rattus
norvegicus
L) galur
sprauge
dawley ,
jantan

Pemberian ekstrak
tanin pada tikus
putih dilakukan pada
kelompok I sebagai
kontrol dengan dosis
o mg/kg BB/hari
(diberi

cholesterol)
were analyzed
by T
dependent test
to determine
the effect of
10% of lard.
While, data for
treatment
effect was
analyzed by
Ancova
(Analysis co
Variance), and
when there
were real
differences, it
continued by a
contrast test at
significance
level of 5% to
find out the
differences
among the
treatments.
Analisis
dilakukan
dengan
fasilitas
pengolah
dan penyaji

cholesterol, LDL) and HDL

levels
at a significance level of
5%, not so significantly
different
from the provision of
patented drug Simvastatin
as
cholesterol-lowering drugs.

Berdasarkan
hasil
penelitian dapat diambil
kesimpulan
pemberian
ekstrak tannin seledri
(Apium graviolens L)
pada
tikus
putih

PENELITI
Umarudin , R. Susanti, Ari
Yuniastuti

masyarakat dan
menjadi
penyebab kematian
utama dan paling
ditakuti
(Baraas 1993).
Upaya pengobatan
secara modern
memerlukan biaya
relatif mahal,
sehingga
hanya dapat
dinikmati oleh
golongan ekonomi
menengah atas.
Selain itu
konsumsi obat
dalam
jangka waktu lama
dan terus menerus
dapat
menyebakan
terjadinya stres
oksidatif yang
bersifat toksik dan
meningkatkan
keparahan
penyakit
degeneratif. Oleh
karena itu perlu
mencari alternatif
baru untuk

berumur 2
bulan
dengan
berat badan
139-169,
sebanyak 20
ekor .

pelarut air),
kelompok II diberi
ekstrak tanin
seledri dosis 25mg/
200gBB/hari,
kelompok III
diberi ekstrak tanin
seledri dosis
50mg/200gBB/hari,
kelompok III diberi
ekstrak
tanin seledri dosis
75mg/200gBB/hari
(Febrina
et al 2009).
Pemberian ekstrak
tanin dilakukan
selama 14 hari.
Pengukuran kadar
kolesterol
total, LDL,
trigliserida dan HDL
dilakukan
pada hari ke-15

data
Statistical
Product and
Service
Solution
(SPSS)
12
for Windows
(Santoso,
2012).

hiperkolestrolemi secara
oral selama 14 hari
menunjukkan adanya efek
signifikan
menurunkan
kadar kolesterol total dan
LDL.Akan tetapi ekstrak
tanin
seledri
tidak
berpengaruh
siginifikan
terhadap kadar trigliserida
dan HDL. Dosis yang
paling
efektifuntuk
menurunkan
kadar
kolesterol total dan LDL
adalah
dosis
75
mg/kgBB/hari

9.

JUDUL
Pengaruh Pemberian
Ekstrak Air Daun Jati
Belanda (Guazuma
UlmifoliaLamk.)
terhadap Kadar Lipid
Darah pada Tikus
Jantan
PENELITI
Elin Yulinah Sukandar
, Elfahmi, Nurdewi

pengobatan
penyakit pembuluh
darah vaskuler
tersebut
yaitu melalui
penggunaan obat
tradisional
Lipid, walaupun
merupakan
suatu senyawa
yang esensial, jika
terdapat dalam
jumlah yang
berlebihan
dapat
membahayakan.
Kondisi yang
menunjukkan
peningkatan kadar
kolesterol total,
LDL dan
trigliserida
dalam darah
dinamakan dengan
istilah
hiperlipidemia.
Hiperlipidemia bila
berkelanjutan dapat
memicu
terbentuknya
aterosklerosis dan
aterosklerosis

tikus jantan
galur Wistar
dengan
bobot badan
ratarata 200
g,

Sediaan diberikan
dalam dosis
25 dan 50 mg/kg bb,
dibuat dalam
bentuk larutan
dengan pengental
tragakan 1%, dengan
volume pemberian
1mL/200 g bb tikus.
Sediaan Pembanding
Simvastatin dengan
dosis 0,72
mg/kg bb
disuspensikan dalam
tragakan 1%, dengan
volume pemberian
1mL/200 g bb tikus.

analyzed
statistically
using SPSS
program

Ekstrak air daun jati

belanda
dengan dosis 50mg/kg bb
mampu
menghambat peningkatan
kadar
kolesterol total dan LDL
secara berbeda
bermakna terhadap kontrol
(p<0,05).

10.

JUDUL
PENGARUH TEH
HERBAL BERBASIS
DAUN CINCAU
HIJAU (Premna
oblongifolia
Merr.)TERHADAP
GLUKOSA DARAH
DAN PROFIL LIPID
TIKUS
HIPERGLIKEMIA
PENELITI
Prajwalita Rukmakharisma
Rizki, Rizca Dwi Jayanti
, Tri Dewanti Widyaningsih

menjadi penyebab
utama
terjadinya penyakit
kardiovaskular
yang
merupakan
penyebab kematian
tertinggi
di Indonesia
Diabetes mellitus
merupakan
penyakit
metabolik yang
terjadi akibat
kelainan sekresi
insulin, kerja
insulin ataupun
keduanya. Penyakit
ini ditandai dengan
adanya
peningkatan kadar
glukosa darah
(hiperglikemia)
dan abormalitas
metabolisme
lemak
(dislipidemia).
Daun cincau
hijau dan kulit
buah naga merah
memiliki senyawa
bioaktif yang

Tikus wistar
jantan
dewasa
umur 2-3
bulan
dengan
berat 150200 gram

Tahap 1
adalah
pembuatan
teh herbal
dengan
Rancangan
Acak
Kelompok
(RAK) yang
terdiri dari 2
faktor,
masingmasing
faktor terdiri
dari 3 level
dan diulang
sebanyak 3
kali. Faktor
1 adalah
formulasi
filtrate daun
cincau hijau
dan kulit

Rancangan
Acak
Kelompok
(RAK)

Formulasi terbaik dari

pembuatan teh herbal
adalah pada formulasi
filtrate daun daun cincau
hijau : kulit buah naga
sebesar 90:10 dengan
penambahan kayu manis
sebesar 1.5%. Didapatkan
hasil antioksidan sebesar
68.63% nilai IC50 sebesar
182
ppm,
flavonoid
392.67 g CEQ/ml, serat
kasar sebesar 0.15% dan
pH 7.63. Pada penelitian
in vivo menunjukkan
bahwa
perlakuan
pemberian teh herbal
berbasis
daun
cincau
hijau formulasi terbaik
memberikan
pengaruh

dapat
memperbaiki
abnormalitas
tersebut sehingga
dipilihlah teh
herbal sebagai
minuman
fungsional yang
memiliki
manfaat bagi
kesehatan tubuh.

buah naga
merah
(70:30 (v/v),
80:20 (v/v),
90:10 (v/v)).
Faktor 2
adalah
formulasi
penambahan
filtrate kayu
manis
(0.5% (b/v),
1% (b/v),
1.5% (b/v)).
Data yang
didapatkan
dianalisis
menggunaka
n ANOVA
dan
dilakukan
uji lanjut
BNT
dengan
selang
kepercayaan
5%.
Penentuan
perlakuan
terbaik
menggunaka
n metode

nyata terhadap penurunan

glukosa darah dan profil
lipid.
Hasil
uji
menunjukkan
bahwa
pemberian teh herbal
dosis 2 (5.4 ml/150 gr
BB)
memberikan
pengaruh
penurunan
paling besar dibandingkan
pemberian teh herbal dosis
1.
Penurunan
kadar
glukosa sebanyak 43.21%,
total kolestero lsebesar
47.67%,
trigliserida
sebesar 40.84%, kadar
LDL sebesar 64.81% dan
kenaikan HDL sebesar
36.08%.The C-index was
the body adiposity marker
best associated with high
risk of fatal CHD in these
patients with type 2
diabetes.

Zeleny.
Penelitian
tahap 2
yaitu in
vivo
menggunaka
n metode
tersarang
(nested)
dengan 5
kelompok
perlakuan
yaitu
kelompok
normal,
hiperglikemi
a, obat
gibenklamid
, teh herbal
dosis 1
(2.7ml/150g BB)
dan kelompok teh
herbal dosis 2
(5.4ml/150g BB).