Critical Values List

Arterial Blood Gases

Test Value Comments
pH 7.25 or 7.6
PCO2 20 or 60 mmHg
PO2 40 mmHg
Hemoglobin 7.0g dL

Chemistry
Test Value Comments
Bicarbonate (Total CO2) < 10 or > 40 mmol/L
Bilirubin, Total 15 mg/dL
Calcium, Ionized 0.78 or 1.58 mmol/L
Calcium, Total < 6.0 or > 13.0 mg/dL
Glucose < 40 or > 450 mg/dL
Iron > 500 ug/dL
Glucose, WB POC < 60 or > 450 mg/dL
Glucose, WB, neonatal POC < 40 or > 200 mg/dL
Magnesium < 1.0 or > 9.0 mg/dL
Phosphorus < 1.0 or > 9.0 mg/dL
Potassium < 3.0 or > 6.1 mmol/L
Sodium < 120 or > 160 mmol/L
Troponin I 0.30 ng/mL

Coagulation
Test Value Comments
When ordered as part of a panel,
Prothrombin Time 46.3 seconds
other criteria apply.
INR 5.0
When ordered as part of a panel,
PTT 85 seconds
other criteria apply.
Fibrinogen < 100 mg/dL
When ordered as part of a panel,
Factors 2, 5, 8, 9, 11 5%
other criteria apply.
Factor 7 6%
Factor 10 7%
Factor 13, Activity 5%

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Infectious Disease
Test Value Comments
Detection of any infectious By
agent
Blood Positive culture, smear, or rapid AFB, bacterial, fungal, parasitic
antigen
Bone marrow Positive culture or smear AFB, bacterial, fungal, viral,
parasitic
Body fluid Positive culture or smear AFB, bacterial, fungal, viral,
(except gastrointestinal fluid or parasitic
urine sources)
CSF or other central nervous Positive culture, smear, or rapid AFB, bacterial, fungal, viral (except
system specimen antigen Enterovirus), parasitic
CSF or other central nervous Nucleic acid testing (NAT) All pathogens except enterovirus,
system specimen EBV, HIV, JC virus, CMV, HHV6,
and parvovirus
Eye (ocular) Positive culture, smear, or NAT AFB, bacterial, fungal, viral,
parasitic
Tissue Positive culture or smear AFB, bacterial, fungal, viral,
parasitic
Detection of specific By In
infectious agent
Mycobacterium sp, acid fast First positive stain 90 days
bacillus (AFB) (M. tuberculosis) Culture, nucleic acid test, and/or
resistance to primary anti-
tuberculosis agents
Zygomycete Positive culture Nasal, sinus
Select agents and other highly Positive culture and/or positive
pathogenic organisms: Bacillus probe for C. immitis
anthracis, Brucella spp.,
Burkholderia mallei,
Burkholderia pseudomallei,
Coccidiodes immitis, Francisella
tularensis, Yersinia pestis, and
C. diphtheriae, Salmonella
typhi, Vibrio cholera
5- fluorocytosine 100 g/mL

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Toxicology
Test Value Comments
Acetone > 100 mg/dL
> 150 g/mL 4 hours post ingestion; 12 hours
Acetaminophen
> 40 g/mL post ingestion
Amiodarone > 3 g/mL
Peakdraw 30 minutes post
> 30 g/mL
infusion
Amikacin
Troughdraw 30 minutes before
> 8 g/mL
infusion
Amitriptyline + Nortriptyline > 500 ng/mL
Bupropion > 400 ng/mL
Caffeine (Neonate) > 20 g/mL
Carbamazepine Epoxide > 15 g/mL
Carbamazepine, Total > 15 g/mL Trough
Carbamazepine, Free > 3.8 g/mL
Choramphenicol > 25 g/mL
Chlorpromazine (12 and older) > 750 ng/mL
Chlorpromazine (012 years) > 200 ng/mL
Clomipramine + Norclomipramine > 900 ng/mL
Clozapine > 2000 ng/mL
Cyanide > 100 g/mL
Desipramine > 500 ng/mL
Cyclosporine A > 700 ng/mL
Digitoxin > 45 ng/mL
Troughdraw 812 hours post
Digoxin > 2.4 ng/mL
dose; minimum post dose 6 hours
Disopyramide > 6 g/mL
Doxepin+Nordoxepin > 500 ng/mL
Ethanol > 250 mg/dL
Ethosuximide > 150 g/mL
Ethylene Glycol > 20 mg/dL
Everolimus > 15 ng/mL
Felbamate > 200 g/mL
Peakdraw 30 minutes post
> 12 g/mL
infusion
Gentamicin
Troughdraw 30 minutes before
> 2 g/mL
infusion
Flecainide > 1.5 g/mL
Imipramine + Desipramine > 500 ng/mL
Isopropanol > 50 mg/dL
Methanol > 20 mg/dL
> 30 minutes post IV dose after
Lidocaine > 9 g/mL
steady state (510 hours)
Lithium 1.6 mmol/L Trough

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Toxicology
Test Value Comments
Mexiletine > 2 g/mL
Mycophenolic Acid (MPA) > 25 g/mL
Nortriptyline > 500 ng/mL
Pentobarbital > 10 g/mL
> 30 g/mL Trough, 3 monthsadult
Phenytoin, Total
> 14 g/mL Trough, 03 months
> 50 g/mL Trough, 3 monthsadult
Phenobarbital
> 40 g/mL Trough, 03 months
Phenytoin, Free > 3.0 g/mL
Primidone > 15 g/mL
Propafenone > 2 g/mL
Protriptyline > 400 ng/mL
Procainamide > 12 g/mL
NAPA > 35 g/mL Trough
Quinidine > 10 g/mL Trough
Salicylate > 300 g/mL or > 30 mg/dL
Sirolimus > 25 ng/mL
> 25 g/mL Trough, 6 monthsadult
Theophylline
> 20 g/mL Trough, 06 months
TCATricyclics > 400 ng/mL
Peakdraw 30 minutes post
> 12 g/mL
infusion
Tobramycin
Troughdraw 30 minutes before
> 2 ug/mL
infusion
Valproic Acid (VPA), Free > 30 g/mL
Valproic Acid (VPA), Total > 150 g/mL Trough
Voriconazole > 6.0 g/mL
> 80 g/mL Trough
Vancomycin
> 80 g/mL Peak (not recommended)
Zonisamide > 80 g/mL

Trace and Toxic Elements

Test Value Comments
45 g/dL (birth18 years) Blood
Lead
70 g/dL ( 19 years) Blood

Transfusion Services
Test Value Comments
Antibody Screen Positive
DAT (Direct Coombs) Positive

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Hematology
Test Value Comments
Hematocrit 21% or 65%
Hemoglobin 7 or > 21.0 g/dL
Platelet Count 20 or 1000 x 103/L
White Blood Cell Count 2.0 or 40 x 103/L

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