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Review3 03

This document provides an overview of different classes of viruses: 1) Retroviruses like HIV and HTLV contain the enzyme reverse transcriptase and integrate their genetic material into the host cell genome. They have complex life cycles and can cause diseases like AIDS. 2) Parvoviruses and polyomaviruses are small DNA viruses with few genes. Parvoviruses cause diseases like fifth disease while polyomaviruses can cause cancers. 3) Herpesviruses are enveloped DNA viruses like herpes simplex that can cause latent and recurrent infections as well as several cancers in humans.

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AyioKun
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25 views1 page

Review3 03

This document provides an overview of different classes of viruses: 1) Retroviruses like HIV and HTLV contain the enzyme reverse transcriptase and integrate their genetic material into the host cell genome. They have complex life cycles and can cause diseases like AIDS. 2) Parvoviruses and polyomaviruses are small DNA viruses with few genes. Parvoviruses cause diseases like fifth disease while polyomaviruses can cause cancers. 3) Herpesviruses are enveloped DNA viruses like herpes simplex that can cause latent and recurrent infections as well as several cancers in humans.

Uploaded by

AyioKun
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© Attribution Non-Commercial (BY-NC)
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CLASS REVIEW SESSION III

I. VIRUSES WITH REVERSE TRANSCRIPTASES


RETROVIRIDAE
EIGHT GENERA: ONCORNAVIRUS, LENTIVIRUS HIV-1, SIVs
FOUR ENZYMES: RT, RNAseH, INT & PRO RSV, MMTV
LTR-gag-pol-env-LTR HTLV-1
UNUSUAL LIFE CYCLE WITH INTEGRATION many others
POLYPROTEINS & PROGRAMMED FRAMESHIFTING
DISCOVERY OF V-ONCs, AIDS
HEPADNAVIRIDAE HBV
PARTIALLY DS DNA CIRCLE
RT MAKES >FULL-LENGTH mRNA
FOUR PROMOTERS - FOUR PROTEINS
II. THE NON-ENVELOPED, DNA VIRUSES
PARVOVIRIDAE
ONLY SS DNA VIRUS FAMILY
TWO GENES - REPLICASE & CAPSID AAV1-6,
SELF-PRIMED DNA SYNTHESIS, NICKASE B19, CPV
FIFTH'S DISEASE
POLYOMAVIRIDAE SV-40, JC,BK
EARLY & LATE TRANSCRIPTION: T & VP MOUSE POLYOMA
CCC DNA, CIRC BIDIRECT REPLICATION
VIRAL ONCOGENES (BINDING p53 & Rb)
PML AND JC VIRUS
PAPILLOMAVIRIDAE WART VIRUSES
E AND L GENES 82 HPVs
TWO OR THREE PROMOTERS, SPLICING HPV-16 & -18
E5, E6 & E7 ARE ONCOGENES
HUMAN CANCERS
ADENOVIRIDAE HAdV1-HAdV51
EARLY (E1-E4) & LATE (VIRION) GENES
LATE GENE SPLICING, PROTEIN PRIMER
ARD AND OTHER RESPIRATORY DISEASES
III. THE ENVELOPED, DNA VIRUSES
HERPESVIRIDAE
ICOSAHEDRAL (T=16) CAPSID, COMPLEX DNA 8 HUMAN VIRUSES:
THREE CLASSES OF mRNA, PROTEINS HERPES SIMPLEX
LATENT-RECURRENT INFECTIONS VZV, EBV, CMV
SEVERAL HUMAN CANCERS
POXVIRIDAE
COMPLEX VIRUS, CLOSED DNA VARIOLA, MCV
MININUCLEUS, MANY ENZYMES
SMALLPOX & ITS ERADICATION
IV. SATELLITE RNAs AND SATELLITE VIRUSES
PLANT VIRUSES WITH HELPER TMVS, PMVS
OTHERS: P2-P4, AAVs, HDV
RNAs PACKAGED WITH PLANT VIRUSES CARNA5,VIRUSOIDS
V. VIROIDS AND PRIONS
VIROIDS ARE PLANT PATHOGENS PSTVd, CCCVd
SMALL RNAs, REP BY RNAPII
c
PRIONS - INFECTIOUS PROTEIN PRNP & PrP
MAMMALIAN GENE & ITS PROTEIN
FATAL NEUROLOGICAL DISEASES: CJD, KURU

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