Safety Data Sheet Refrigerant R404A
Safety Data Sheet Refrigerant R404A
Safety Data Sheet Refrigerant R404A
Refrigerant R404A
Version 2
Revision Date: 23.07.2013
1.2. Relevant identified uses of the substance or mixture and uses advised against
Use: Refrigerant.
Advised Against: No identified use advised against.
Directives 67/458/EEC or The product does not need to be labelled in accordance with Directive 1999/45/EC or Annex Vi
1999/45/EC: to 67/548/EEC.
Special labelling of certain Contains 1,1,1-Trifluoroethane, Pentafluoroethanr. 1,1,1,2-Tetrafluoroethane.
substances and mixtures: Contains fluorinated greenhouse gases covered by the Kyoto Protocol.
2.3. Other hazards
Rapid evaporation of the liquid may cause frostbite.
Vapours are heavier than air and can cause suffocation by reducing oxygen available for
breathing.
Misuse or intentional inhalation abuse may cause death without warning symptoms, due to
cardiac effects.
May cause cardiac arrhythmia.
3.1. Substances
Page 1 of 12
SAFETY DATA SHEET
Refrigerant R404A
Version 2
Revision Date: 23.07.2013
Hazardous Ingredients:
3.2 Mixtures
1,1,1-TRIFLUOROETHANE (HFC143a)(REGISTRATION No. 01-2119492869-13)
EINECS CAS 67/548/EEC Classification CLP Classification Percent
206-996-5 420-46-2 F+, R12 H220: Flammable gas 52%
H280: Gas under pressure
PENTAFLUOROETHANE (HFC125)(REGISTRATION No. 01-2119485636-25)
EINECS CAS 67/548/EEC Classification CLP Classification Percent
206-557-8 354-33-6 - H280 Gas under pressure 44%
1,1,1,2-TETRAFLUOROETHANE (HFC134a)(REGISTRATION No. 01-21194559374-33)
EINECS CAS 67/548/EEC Classification CLP Classification Percent
212-377-0 811-97-2 - H280 Gas under pressure
For the full text of the H-Statements and R-Phrases mentioned in this Section, see Section 16.
Skin contact: Take off all contaminated clothing immediately. Flush area with lukewarm water. Do not use
hot water. If frostbite has occurred get medical attention.
Eye contact: Hold eyelids apart and flush eyes with plenty of water for at least 15 minutes. Get medical
attention.
Inhalation: Remove from exposure, lie down. Move to fresh air. Keep patient warm and rest. Artificial
respiration and/or oxygen may be necessary. Get medical attention.
General advice: Never give anything by mouth to an unconscious person. When symptoms persist or in all
cause of doubt seek medical advice.
Skin contact: Skin contact may cause the following symptoms: Redness, frostbite.
Eye contact: Eye contact will cause the following symptoms: redness, frostbite, cornea damage.
Inhalation: Misuse or intentional inhalation abuse may cause death without warning symptoms, due to
cardiac effects. Other symptoms potentially related to misuse or inhalation abuse are:
Anaesthetic effects, Light-headedness, dizziness, confusion, incoordination, drowsiness,
unconsciousness, irregular heartbeat, with a strange sensation in the chest, heart thumping,
apprehension, feeling of fainting or weakness, Narcosis.
Delayed/immediate effects: Skin contact may not give immediate symptoms of frostbite.
4.3. Indication of any immediate medical attention and special treatment needed
Page 2 of 12
SAFETY DATA SHEET
Refrigerant R404A
Version 2
Revision Date: 23.07.2013
Special hazards arising from Pressure build-up. Fire or intense heat may cause violent rupture of cylinders.
the mixture: Hazardous thermal decomposition products may form. They are: Carbon oxides, Hydrogen
Fluoride, Fluorinated compounds. Exposure to decomposition products may be hazardous to
health.
Advice for fire-fighters: In event of a fire wear self-contained breathing apparatus. Use personal protective equipment.
Wear neoprene gloves during cleaning up work after a fire.
Personal precautions: Evacuate personnel to safe areas. Ventilate area, especially low or enclosed places where
heavy vapours might collect. Refer to protective measures listed in Sections 7 and 8.
Environmental precautions: Do not release into the environment. Treat according to local and national regulations.
Handling requirements: Avoid breathing vapours or mist. Avoid contact with the skin, eyes and clothing. Provide
sufficient air exchange and/or exhaust in work rooms. For personal protection see Section 8.
Vapours are heavier than air and may spread along the floor.
Page 3 of 12
SAFETY DATA SHEET
Refrigerant R404A
Version 2
Revision Date: 23.07.2013
Hazardous ingredients:
1,1,1,2-TETRAFLUOROETHANE (HFC134a)(CAS No. 811-97-2)
Workplace exposure limits
Type/form of Exposure Control Parameter Basis
3
TWA 4 240 mg/m EH40 WEL
1 000 ppm
Predicted No Effect
Concentrations (PNEC):
Value: 1 mg/l
Compartment: Water
Remarks: Intermittent use/release
Page 4 of 12
SAFETY DATA SHEET
Refrigerant R404A
Version 2
Revision Date: 23.07.2013
Value: 1 mg/l
Compartment: Water
Remarks: Intermittent use/release.
Value: 73 mg/l
Compartment: Water
Remarks: Sewage treatment plants.
Exposure Controls
Engineering measures: Ensure adequate ventilation, especially in confined areas. Local exhaust shouldbe used when
large amounts are released.
Respiratory protection: For rescue and maintenance work in storage tanks use self-contained breathing apparatus.
Vapours are heavier than air and can cause suffocation by reducing the oxygen available for
breathing. Respiratory protection to comply with EN 137.
Eye protection: Wear safety glasses or coverall chemical splash goggles. Eye protection should comply with
EN 166 or ANSI Z87.1.
Wear a face shield where the possibility exists for face contact due to splashing, spraying or
airborne contact with this material.
Skin protection: Wear suitable protective equipment. Wear as appropriate: impervious clothing.
Protective Measures: Self-contained breathing apparatus (SCBA) is required if a large release occurs. The type of
protective equipment must be selected according to the concentration and amount of the
substance at the specific workplace.
Hygiene Measures: Handle in accordance with good industrial hygiene and safety practice.
10.1. Reactivity
Page 5 of 12
SAFETY DATA SHEET
Refrigerant R404A
Version 2
Revision Date: 23.07.2013
Conditions to avoid: Avoid open flames and high temperatures. The product is not flammable in air under ambient
conditions of temperature and pressure. When pressurised with air or oxygen, the mixture may
become flammable. Certain mixtures of HFCs with chlorine may become flammable or
reactive under certain conditions. Pressurized container: Do not pierce or burn even after use.
o
Keep at temperature not exceeding 52 C
Materials to avoid: Alkali metals, Alkaline earth metals, Powdered metals, Powdered metal salts.
Hazardous decomposition Hazardous thermal decomposition products may include: Carbon oxides, Hydrogen fluoride,
products Carbonyl fluorides, and Fluoeocarbons.
Pentafluoroethane
Not applicable
1,1,1,2-Tetrafluoroethane
Not applicable
Inhalation toxicity
1,1,1-Trifluoroethane
LC50/rat: 591 000 ppm
/dog
Cardiac sensitization
Pentafluoroethane
LC50/rat: > 800 000 ppm
/dog
Cardiac Sensitization
1,1,1,2-Tetrafluoroethane
LC50/rat: 567 000 ppm
/dog
Cardiac sensitization
Dermal toxicity
1,1,1-Trifluoroethane
Not applicable.
Page 6 of 12
SAFETY DATA SHEET
Refrigerant R404A
Version 2
Revision Date: 23.07.2013
Pentafluoroethane
Not applicable
1,1,1,2-Tetrafluoroethane
Not applicable
Pentafluoroethane
Not tested on animals
Classification: Not classed as an irritant
Result: No skin irritation
Not expected to cause skin irritation based on expert review of the properties of the
substance.
1,1,1,2-Tetrafluoroethane
Rabbit
Classification: Not classed as an irritant
Result: Slight irritation
Not expected to cause skin irritation based on expert review of the properties of the
substance.
Human
Classification: Not classified as an irritant
Result: No skin irritation.
Eye irritation
1,1,1-Trifluoroethane
Not tested on animals
Classification: Not classed as an irritant
Result: No eye irritation
Not expected to cause eye irritation based on expert review of the properties of the
substance.
Pentafluoroethane
Not tested on animals
Classification: Not classed as an irritant
Result: No eye irritation
Not expected to cause eye irritation based on expert review of the properties of the
substance.
1,1,1,2 Tetrafluoroethane
Rabbit
Classification: Not classed as an irritant
Result: slight eye irritation
Not expected to cause eye irritation based on expert review of the properties of the
substance.
Human
Classification: Not classified as an irritant.
Result: No eye irritation.
Page 7 of 12
SAFETY DATA SHEET
Refrigerant R404A
Version 2
Revision Date: 23.07.2013
Sensitisation: 1,1,1-Trifluoroethane
Not tested on animals
Classification: Not a skin sensitizer
Not expected to cause sensitization based on expert review of the properties of the
substance.
Pentafluoroethane
Not tested on animals
Classification: Not a skin sensitizer
Not expected to cause sensitization based on expert review of the properties of the
substance.
1,1,1,2-Tetrafluoroethane
Guinea pig
Classification: Not a skin sensitizer
Result: Did not cause sensitization on laboratory animals
Not expected to cause sensitization based on expert review of the properties of the
substance.
Pentafluoroethane
Inhalation rat
No toxicologically significant effects were found
1,1,1,2-Tetrafluoroethane
Inhalation rat
No toxicologically significant effects were found
Pentafluoroethane
Not classified as a human carcinogen.
1,1,1,2-Tetrafluoroethane
Not classified as a human carcinogen.
Pentafluoroethane
Animal testing did not show any mutagenic effects.
Tests on bacterial or mammalian cell cultures did not show mutagenic effects.
1,1,1,2-Tetrafluoroethane
Animal testing did not show any mutagenic effects.
Tests on bacterial or mammalian cell cultures did not show mutagenic effects.
Page 8 of 12
SAFETY DATA SHEET
Refrigerant R404A
Version 2
Revision Date: 23.07.2013
Pentafluoroethane
No toxicity to reproduction.
1,1,1,2-Tetrafluoroethane
No toxicity to reproduction.
Inhalation
Sever shortness of breath, narcosis, irregular cardiac activity.
Futher information: Rapid evaporation of the liquid may cause frostbite. May cause cardiac arthymia.
12.1. Toxicity
Pentafluoroethane
LC50/ 96 h /Oncorhynchus mykiss (rainbow trout): > 81.8 mg/l
Information given based on data obtained from similar substances.
1,1,1,2-Tetrafluoroethane
LC50 / 96 h / Oncorhynchus mykiss (rainbow trout): 450 mg/l
Pentafluoroethane
EC50 / 75 h /Pseudokirchneriella subcapitata (green algae): >118 mg/l
Information given based on data obtained from similar substances.
1,1,1,2-Tetrafluoroethane
EC50 / 72 h / Algae: > 118 mg/l
Information given based on data obtained from similar substances.
Pentafluoroethane
EC50 / 48 h / Daphnia magna (Water flea): > 200 mg/l
Information given based on data obtained from similar substances.
Page 9 of 12
SAFETY DATA SHEET
Refrigerant R404A
Version 2
Revision Date: 23.07.2013
1,1,1,2-Tetrafluoroethane
EC50 / 48 h / Daphnia magna (Water flea): 980 mg/l
Ecotoxic values:
Global Warming Potential 3922 (CO2 = 1)
(GWP):
Recovery Operations: Consult the manufacturer or supplier for information regarding recovery and recycling of the
product. If recovery is not possible, incinerate at a licensed installation.
N.B. The users attention is drawn to the possible existence of regional or national regulations
regarding disposal.
14.1. ADR
UN Number: 3337
Proper Shipping Name: REFRIGERANT GAS R 404A
Class: 2A
Packing Group: n/a
Tunnel Code: (C/E)
Transport Group: 2.2
14.2. IMDG
UN Number: 3337
Proper Shipping Name: REFRIGERANT GAS R 404A
Class: 2.2
Packing Group: n/a
EmS codes: F-C, S-V
Page 10 of 12
SAFETY DATA SHEET
Refrigerant R404A
Version 2
Revision Date: 23.07.2013
Marine Pollutant: No
15.1. Safety, health and environment regulations/legislation specific for the substance or mixture
Contains fluorinated greenhouse gases covered by the Kyoto Protocol.
15.2. Chemical Safety Assessment
Chemical safety assessment: A chemical safety assessment has not been carried out by the supplier of this mixture.
Page 11 of 12
SAFETY DATA SHEET
Refrigerant R404A
Version 2
Revision Date: 23.07.2013
Page 12 of 12