Penicilling PDF
Penicilling PDF
Penicilling PDF
Some commonly used brand names are: treatment of acute leptospirosis in cattle, dogs, horses, and pigs.
For veterinary-labeled products—Agri-cillin; Aquacillin; Combi- The chronic shedding stage of leptospirosis is often treated with
Pen 48; Depocillin; Derapen SQ/LA; Dual-Cillin; Duplocillin tetracycline; penicillin G administered alone will not clear the
LA; Durapen; Hi-Pencin 300; Longisil; PenAqua Sol-G; Pen- carrier state.{R-73; 85}
ELUS
Aqueous; Pen BP-48; Pen-G; Pen G Injection; Penmed; Malignant edema (treatment)EL—Cattle: Penicillin G is indicated
Penpro; Pen Vet 300; Pot-Pen; Procillin; Pro-Pen-G; Propen in the treatment of malignant edema caused by susceptible
LA; R-Pen; Twin-pen; UltraPen; and UltraPen B. Clostridium septicum in cattle.{R-6}
ELUS
For human-labeled products—Pfizerpen. Metritis (treatment)EL—Cattle, horses, pigs, and sheep: Penicillin
G is indicated in the treatment of metritis caused by susceptible
Category: Antibacterial (systemic). organisms in cattle, horses, pigs, and sheep;{R-6; 20; 21} however,
therapeutic regimens often emphasize evacuation of uterine
contents as the primary treatment.{R-85}
Indications ELUS
Pyelonephritis (treatment)EL—Cattle: Penicillin G is indicated in
US
Note: The text between EL and EL describes uses that are not included the treatment of pyelonephritis caused by susceptible organisms
CAN
in U.S. product labeling. Text between EL and EL describes uses such as Corynebacterium renale in cattle.{R-6; 22; 23}
that are not included in Canadian product labeling. ELUS
Skin and soft tissue infections (treatment)EL—
US CAN
The EL or EL designation can signify a lack of product Cattle: Penicillin G is indicated in the treatment of skin and soft
availability in the country indicated. See the Dosage Forms tissue infections caused by susceptible organisms, including
section of this monograph to confirm availability. those associated with calf diphtheria, foot rot, umbilical
infections, and wounds.{R-10}
General considerations Horses: Penicillin G is indicated in the treatment of skin and soft
The spectrum of activity of penicillin G includes many aerobic and tissue infections caused by susceptible organisms, including
anaerobic gram-positive organisms. Aerobes susceptible to those associated with umbilical infections and wounds.{R-6}
penicillin G include most beta-hemolytic streptococci, beta- Pigs: Penicillin G is indicated in the treatment of skin and soft
lactamase-negative staphylococci, Actinomyces species, some tissue infections caused by susceptible organisms, including
Bacillus anthracis, Corynebacterium species, and Erysipelothrix those associated with umbilical infections.{R-6}
rhusiopathiae. Most species of anaerobes, including Clostridium Sheep: Penicillin G is indicated in the treatment of skin and soft
species, but excluding beta-lactamase-producing Bacteroides tissue infections caused by susceptible organisms, including
species, are also susceptible to penicillin G. Penicillin G is easily those associated with post-surgical tail docking or castration
inactivated by beta-lactamases and has little efficacy against site infections, and umbilical infections.{R-6; 10}
ELUS
organisms that can produce these enzymes. In addition, penicillin Streptococcus suis infection (treatment)EL—Pigs: Penicillin G
G is ineffective against those bacteria that are resistant by other potassium is indicated in Canadian product labeling for the
mechanisms, such as having a relatively impermeable cell wall. treatment of infections caused by susceptible Streptococcus
Therefore, penicillin G has little activity against many suis.{R-9}
ELUS CAN
staphylococci and most gram-negative bacteria.{R-3; 4} Tetanus (treatment)EL—Cats, cattle, dogs, horses, and EL pigsEL:
Penicillin G is indicated in the treatment of Clostridium tetani in
Accepted conjunction with tetanus antitoxin and supportive therapy.{R-6}
US
Blackleg (treatment)—Cattle and EL sheepEL: Penicillin G is indicated
in the treatment of blackleg caused by susceptible organisms such Regulatory Considerations
as Clostridium chauvoei in cattle and sheep.{R-5; 6} U.S.—
Erysipelas (treatment)—Pigs and turkeys: Penicillin G is indicated in Administration of penicillin G procaine to animals may produce
the treatment of infections caused by Erysipelothrix rhusiopathiae procaine concentrations in the blood and urine that violate
(insidiosa) in pigs and turkeys.{R-6-9} equine and greyhound racing commission prohibitions.{R-91; 92}
Pharyngitis (treatment); or Penicillin G is not for use in turkeys producing eggs for human
Rhinitis (treatment)—Cattle: Penicillin G is indicated in the treatment consumption or for use in horses intended for food.{R-7; 8}
of bacterial rhinitis or pharyngitis caused by susceptible Penicillin G Benzathine and Penicillin G Procaine Injectable
organisms such as Actinomyces pyogenes.{R-5} Suspension USP combination is not labeled for use in
Pneumonia, bacterial (treatment)—Cattle,{R-6; 7} sheep,{R-6; 7} lactating cattle or preruminating calves.{R-5}
ELUS US
horsesEL,{R-6} and EL pigsEL:{R-10} Penicillin G is indicated in the Some brands of Penicillin G Procaine Injectable Suspension USP
treatment of bacterial pneumonia caused by susceptible organisms are not labeled for use in preruminating calves.{R-53}
US US
in cattle, sheep, EL horsesEL, and EL pigsEL; however, for bacterial Withdrawal times have been established for Penicillin G
pneumonia in cattle, sheep, and pigs, penicillin G is not Potassium For Oral Solution USP, Penicillin G Benzathine
considered the drug of first choice pending culture and sensitivity and Penicillin G Procaine Injectable Suspension USP, and
results.{R-85; 87} Penicillin G Procaine Injectable Suspension USP (see the
Strangles (treatment)—Horses: Penicillin G is indicated in the Dosage Forms section).{R-5; 7; 8; 26}
treatment of strangles caused by Streptococcus equi;{R-7} however, Canada—
it may be effective only during the acute phase of the infection.{R- Administration of penicillin G procaine to animals may produce
13}
ELUS
procaine concentrations in the blood and urine that violate
Actinomycosis (treatment)EL—Cattle: Penicillin G is indicated in equine and greyhound racing commission prohibitions.{R-84}
the treatment of actinomycosis, and may be most effective in Penicillin G is not labeled for use in turkeys producing eggs for
infections in which pathogens other than Actinomyces species are human consumption.{R-9}
not yet involved.{R-6; 14} Penicillin G Benzathine and Penicillin G Procaine Injectable
ELUS
Arthritis, septic (treatment)EL—Cattle, horses, pigs, and sheep: Suspension USP combination is not labeled for use in
Penicillin G is indicated in the treatment of septic arthritis caused lactating cattle.{R-27; 28}
by susceptible bacteria in cattle, horses, pigs, and sheep.{R-6; 15; 16} Withdrawal times have been established for Penicillin G
US
EL
Leptospirosis (treatment)EL—Cattle,{R-6} dogs,{R-6; 17} Potassium For Oral Solution USP, Penicillin G Benzathine
ELCAN
horsesEL,{R-18} and pigs:{R-6} Penicillin G is indicated in the and Penicillin G Procaine Injectable Suspension USP, and
PENICILLIN G SODIUM FOR INJECTION USP USP requirements: Preserve in Containers for Sterile Solids. It is
Usual dose: ELUS,CANAntibacterialEL—See Penicillin G Potassium for sterile Penicillin G Sodium or a sterile mixture of penicillin G
Injection USP. sodium and not less than 4.0% and not more than 5.0% of Sodium
Citrate, of which not more than 0.15% may be replaced by Citric
Strength(s) usually available: Acid. Contains the labeled amount of Penicillin G, within –10%
U.S.— to +20%, and where it contains Sodium Citrate it has a potency of
Veterinary-labeled product(s): not less than 1420 and not more than 1667 Penicillin G Units per
Not commercially available. mg. Meets the requirements for Constituted solution,
Human-labeled product(s): Identification, Crystallinity, Bacterial endotoxins, Sterility, pH
5,000,000 Units (Rx) [GENERIC]. (6.0–7.5, in a solution containing 60 mg per mL), Loss on drying
Canada— (not more than 1.5%), and Particulate matter, and for Uniformity
Veterinary-labeled product(s): of dosage units and Labeling under Injections.{R-51}
Not commercially available.
Human-labeled product(s): Developed: 04/27/95
1,000,000 Units (Rx) [GENERIC]. Interim revision: 07/19/95; 07/11/96; 7/15/98; 11/5/99;
5,000,000 Units (Rx) [GENERIC]. 09/30/02; 04/05/03; 06/30/07
10,000,000 Units (Rx) [GENERIC].
References
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277-83. food animals. In: Howard JL. Current veterinary therapy 3 food
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Febiger, 1994: 224-6, 701-10. 24. Ettinger SJ. Textbook of veterinary internal medicine. 2nd ed.
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recent developments. Compend Contin Educ Pract Vet 1987; 9(1): 25. Hardman JG, Limbird LE, Gilman AG, editors. Goodman &
68-74. Gilman's The Pharmacological Basis of Therapeutics, 10th ed.
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suspension package insert (G.C. Hanford Manufacturing 26. Code of federal regulations. Washington, D.C.: Office of the
Company—US), Rev 12/93, Rec 9/7/94. Federal Register. April 1, 1993; 21(parts 500 to 599).
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www.vetoquinol.ca. Accessed on October 16, 2006. Inc., 2006.
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Canada), Rec 8/2/94. and their effect on yogurt production. J Dairy Sci 1982; 65: 426-9.
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