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    ACTIVITY 7 Milk of Magnesia

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    daven
    1) The document describes a procedure to assay the magnesium hydroxide content of milk of magnesia through acidimetric residual titration. 2) Milk of magnesia is titrated with sulfuric acid to ensure complete neutralization of magnesium hydroxide, forming magnesium sulfate. Excess acid is then determined by titrating with sodium hydroxide. 3) The percentage of magnesium hydroxide in milk of magnesia is calculated using the titration results and must be between 7-8.5% according to USP requirements.

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    ACTIVITY 7 Milk of Magnesia

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    daven
    4K views4 pages
    1) The document describes a procedure to assay the magnesium hydroxide content of milk of magnesia through acidimetric residual titration. 2) Milk of magnesia is titrated with sulfuric acid to ensure complete neutralization of magnesium hydroxide, forming magnesium sulfate. Excess acid is then determined by titrating with sodium hydroxide. 3) The percentage of magnesium hydroxide in milk of magnesia is calculated using the titration results and must be between 7-8.5% according to USP requirements.

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    1) The document describes a procedure to assay the magnesium hydroxide content of milk of magnesia through acidimetric residual titration. 2) Milk of magnesia is titrated with sulfuric acid to ensure complete neutralization of magnesium hydroxide, forming magnesium sulfate. Excess acid is then determined by titrating with sodium hydroxide. 3) The percentage of magnesium hydroxide in milk of magnesia is calculated using the titration results and must be between 7-8.5% according to USP requirements.

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    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
    Download as docx, pdf, or txt
    4K views4 pages

    ACTIVITY 7 Milk of Magnesia

    Uploaded by

    daven
    1) The document describes a procedure to assay the magnesium hydroxide content of milk of magnesia through acidimetric residual titration. 2) Milk of magnesia is titrated with sulfuric acid to ensure complete neutralization of magnesium hydroxide, forming magnesium sulfate. Excess acid is then determined by titrating with sodium hydroxide. 3) The percentage of magnesium hydroxide in milk of magnesia is calculated using the titration results and must be between 7-8.5% according to USP requirements.

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    LPBAZAN, MSPh, PhD

    Name: ____________________________________________ Date Performed:_______

    Section: _____________ Group No.: _____________________Date submitted: _______

    Exercise No. 7

    Assay of Milk of Magnesia

    OBJECTIVES:

    1. To assay the magnesium hydroxide content of milk of magnesia by acidimetric residual


    titration.
    2. To appreciate the importance of performing the assay of magnesium hydroxide content
    of milk ok magnesia.
    3. To interpret the results obtain from the analysis.

    DISCUSSION:

    Milk of Magnesia (MOM) is an antacid suspension that neutralizes acids in the stomach.
    The side effect of which is diarrhea.

    The magnesium hydroxide content of the milk of magnesia is assayed under the
    residualacidimetric neutralization analysis since solutions of sulfuric acid and sodium hydroxide
    are used.

    It is assayed with sulfuric acid solution to ensure complete neutralization of all the
    magnesium hydroxide with the formation of the soluble magnesium sulfate.

    The Milk of Magnesia is titrimetrically assayed under the acidimetric residual titration of
    neutralization method of analysis.

    The MOM is dissolved in an accurately measured excess of 1N sulfuric acid solution to


    ensure complete neutralization of all the magnesium hydroxide with the formation of the
    soluble magnesium sulfate. The excess acid is then determined by residual titration with 1N
    sodium hydroxide using methyl red as indicator.

    MATERIALS:

    Milk of Magnesia Pipet, 5 mL


    Sodium hydroxide, 1N (from Ex. #5) Erlenmeyer flask, 250 mL
    Sulfuric acid, 1N (from Ex. #6) Acid buret
    Methyl Red T.S. Fisher stand
    Aspirator pump

    1
    LPBAZAN, MSPh, PhD

    ASSAY PROCEDURE:

    1. Weigh 5 grams of milk of magnesia in an erlenmeyer flask.


    2. Add 25 mL of 1N H2SO4 using a buret. Then, add 3 drops of methyl red T.S.
    3. Titrate the excess acid with 1N sodium hydroxide until a yellow color is produced.

    Titer value: Each mL of 1N sulfuric acid is equivalent to 29.16 mg of magnesium hydroxide


    Mg(OH)2.

    Calculate the % Mg(OH)2 content of milk of magnesia using the formula:

    % Mg(OH)2 = [(VH2SO4 x N H2SO4) – (VNaOH x N NaOH)] x mEq wt. Mg(OH)2x 100


    Weight of sample (g)

    Using the Titer value:

    % Mg(OH)2 = [(V H2SO4 x N.F.) – (VNaOH x N.F.)] x titer x 100


    Weight of sample (mg)

    USP Requirement: The percentage limit for milk of magnesia is not less than 7% and not more
    than 8.5%.

    2
    LPBAZAN, MSPh, PhD

    WORK SHEET

    Name :_________________________________________ Date : __________


    Group No. : ________________________________________ Score : __________

    Exercise No. 7

    Assay Milk of Magnesia

    DATA:

    Weight of sample (g)


    Normality of H2SO4
    Normality Factor of H2SO4
    Volume of 1N H2SO4 (mL)
    Normality of NaOH
    Normality Factor of NaOH
    Volume of 1 N NaOH (mL)
    % Magnesium hydroxide

    Calculation of % Mg(OH)2 content:

    3
    LPBAZAN, MSPh, PhD

    Conclusion:

    Answer the following questions:

    1. What type of titration is involved in the assay of milk of magnesia?

    2. What are the standard solutions used in the assay? Explain why they are used?

    3. What is the purpose of adding an excess of 1 N sulfuric acid to the sample of milk of
    magnesia?

    4. Write the chemical reactions involved when the milk of magnesia is dissolved and upon
    residual titration.

    5. Calculate the Mg(OH)2 content of milk of magnesia, 12.32 g of which was dissolved in
    50 mL of 1.0340 N sulfuric acid producing a mixture that required 24.6 mL if 1.1255 N
    sodium hydroxide.

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