Nutrisi Pada Infeksi Dewasa

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Nutrisi pada Infeksi Dewasa

dr. Monica Paotiana, M.Gizi


Tujuan Pembelajaran
• Vicious cycle of undernutrition and infection
• HIV/AIDS and nutrition
• Nutrition on Critical Ill
Black, R.E. 2012. The Vicious Cycle of Diarrhea and Malnutrition: Nutritional Risk Factors. Departemen of International Health, John
Hopkins Bloomberg School of Public Health
ALUR DUKUNGAN
Alur DukunganNUTRISI
Nutrisi

Pemeriksaan klinis /Antropometri /Laboratorium / Pendukung lain



Diagnosis / status Gizi

Kebutuhan energi & Zat Gizi

Komposisi Zat Gizi

Cara pemberian – Oral / Enteral/ Parenteral

Bentuk/ jenis makanan/ formula & suplemen

Pemantauan & evaluasi
Nutritional Assesment
• Anthropometric measurments:
– Height, Weight, BMI
– % goal weight
– Ideal Body Weight and Usual Body Weight
– Fat, muscle, and body cell mass
– Waist, hip, neck, thigh circumference
• Biochemical
– Protein status (albumin, prealbumin)
– Blood lipid profile
– Glucose/insulin status
– Blood pressure
– Hb, Ht, MCV
– Liver fuction test
– Electrolytes
Nutritional Assesment
• Clinical Condition:
– Oral / intestinal condition
– Nausea, vomiting
– Diarrhea
– Anorexia, appetite
– Functional capability
– Neuropathy
• Dietary intake:
– Estimated intake and estimated need
– Food and nutrition security
– Dietary pattern
– Food intolerance / allergies
MUST
Nutrition Therapy
• General Nutrition
– Energy Requirement and Composition (Cho, Protein, Fat)
– Vitamins
– Minerals
• Specific Nutrients  Immunonutrients
– Antioxidants: A, C, E, Carotenoids, Selenium, Zinc, Copper
– Glutamine, arginine, nucleotide
– Probiotics
• Delivery: small frequent, nutrient-dense meals
• Appetite stimulants
General Nutrition
• Estimated Energy Requirement (EER)
• Makronutrien (KH, Protein, Lemak)
• Vitamin
• Mineral
Estimated Energy Requirement (EER)
• EER = BMR x PA x stress factors

• ♂: BMR = 66 + (13,7 x BB) + (5 x TB) – (6,8 x usia)


• ♀: BMR = 665 + (9,6 x BB) + (1,8 x TB) – (4,7 x usia)

• *PA= Physical Activity


Physical Activity

Rolfes, S. R., Pinna, K., & Whitney, E. (2009). Understanding Normal and Clinical Nutrition, Eighth Edition. November 3, 2001 . Canada:
Wadsworth, Cengage Learning. Appendix F
RECOMMENDED NUTRIENT COMPOSITION

Protein
SFA <7% total calorie
15%
Fat PUFA <10% total calorie
Carbohydrate <30%
>55% MUFA < 15% total calorie

Cholesterol: <300 mg/d


Fiber: 20-30 g/d

Gallagher ML. The nutrients and their metabolism. in Krause’s Food and Nutrition Terapy (Mahan, LK and Escott-Stump
S eds), 2008: p 42 – 143.
Karbohidrat
• 50-60% dari kalori total
• Minimal intake KH 130 g/hari

• SERAT: 11g/1000 kkal


20-30 g/hari
Serat

Viscous Non viscous Non viscous


• Pektin • Inulin • Selulosa
• β-glukan • Fruktooligosakarida • Hemiselulosa
• Gum • Dekstrin gandum • Lignin
• Psyllium • Polidekstrose

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INDEKS GLIKEMIK

• Definisi : perbandingan respon glikemik (naiknya kadar gula


darah) antara bahan makanan / campuran dengan bahan
makanan pembanding
• Sebagai pembanding : glukosa
FAKTOR YANG MEMPENGARUHI EFEK GLIKEMIK

• JUMLAH SERAT, LEMAK, & KH DALAM MAKANAN


1. SERAT > : MEMPERLAMBAT KECEPATAN MENCERNA & PENYERAPAN
2. LEMAK > : MEMPERLAMBAT PENGOSONGAN LAMBUNG
3. GULA > : CEPAT & MUDAH DICERNA, INDEKS 
4. POLISAKARIDA > : LEBIH LAMA KARENA HARUS DIPECAH MENJADI MONO BARU
BISA DISERAP, INDEKS 

• INTERAKSI PROTEIN & KH


DICERNA LEBIH LAMBAT  PENGOSONGAN LAMBUNG LAMBAT
GLYCEMIC LOAD (GL)
• A MATHEMATICAL EXPRESSION TO MEASURE THE INFLUENCE OF FOOD ON BLOOD
SUGAR
• LOWER GL OF DIET  THE LESS GLUCOSE BUILD UP IN THE BLOOD
• GL= (GI x CHO) : 100
© 2008 Thomson - Wadsworth
Protein
• 15-20% dari kalori total
• DRI : 0,8 g / Kg
• AKG Indonesia (usia 19-26 th)
– Pria: 62 gr
– Wanita: 56 gr
Protein Function
• Acid-basa balance : buffer
• Antibodies
• Blood clotting : netting
• Energy
• Enzymes
• Fluid and electrolyte balance
• Gene expression : DNA
• Hormones
• Structure : Muscle, Bone, Skin
• Transportation : lipid, mineral, O2
Source of Protein
Fat
SFA <7% total calorie

PUFA <10% total calorie

MUFA < 15% total calorie

Cholesterol: <300 mg/d


Source of Fat
Sepsis
Goals of Nutrition Support
• Minimize catabolism
• Meet energy requirements
• Meet protein, vitamin, and mineral needs
• Fluid and electrolyte management
• Plan nutrition therapy (oral, enteral, and/pr
parenteral nutrition)
Targeted nutrition delivery in sepsis
SEPSIS
Resistensi Ginjal (kortex)
Insulin
↑Glukoneogenesis
Hepatic
↑Glukoneogenesis
↑Glikogenolisis

HIPERGLIKEMIA

Resistensi
Insulin Perifer
Non Insulin
Insulin dependent dependent
Otot Adiposa Ginjal Eritrosit Otak
Glikogenolisis (medula )
Glikolisis Glikolisis
Lipolisis Glikolisis
anaerob
anaerob Glikolisis

Laktat Gliserol Laktat Laktat


Sintesis & Pemecahan Protein

Hill, A., G., Wilmore, D., W. 1996. The History of the Metabolic Response to Injury.
Peningkatan ekskresi N urin pada beberapa penyakit sejalan dgn waktu
44
Meet the Requirment
• Energy: 15  25 to 30 kcal/kg
• Protein: 1 g/kg/day  1.2-2 g/kg/day
• Thiamin : 2x200 mg / day IV (7 days)
• Vitamin D: 100.000 U / day (5 days)
• Vitamin C (antioxidant) : 1,5 g IV (4 days)
• Trace element / micronutrient
NUTRITION TERAPY
Plan Nutrition Therapy
• Preferred: oral  enteral
• Wait until the patient is hemodynamically
stable intestines are in a state of
hypoperfusion

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