```

Curriculum Vitae

of

Mr. David R Lawrence

BSc (Hons)., MBBS (Lond)., FRCS (Eng)., FRCS (CTh)., MS (Lond).

Current Appointment
Consultant in Cardiothoracic Surgery
The Heart Hospital, UCL Hospitals NHS Trust

Curriculum Vitae of David Lawrence Page 1

Personal Details

Name: Mr David Romesh Lawrence

Address: 95 Halford Road

Ickenham,
Uxbridge, Middlesex
UB10 8QA

Telephone: 01895 232468 (Home) 07956 547017 (Mobile)

Fax: 0207 504 8943

E mail: [email protected]

Date of Birth: 07 September 1965

Age: 45 years

Nationality: British

Marital Status: Married

GMC Reg Status: Full

GMC Reg No: 3486495

MPS No: 180117

UK CCST: In Cardiothoracic Surgery, awarded 24th May 2002

UK Specialist Register: Admitted on 24th June 2002

Curriculum Vitae of David Lawrence Page 2

2. Education

a) Secondary Education

September 1981 Wallington High School for Boys,

to Croydon Road,
June 1983. Wallington, Surrey.

Exams passed
June 1983 GCE A Level Physics A
Mathematics A
Chemistry B
GCE S Level Mathematics Credit

b) University Education

Medical School (Pre-clinical):

October 1984 Kings' College London,
to The Strand Campus,
July 1986 London WC2.

Intercalated BSc (Pre Clinical):

October 1986 Kings' College London,
to The Kensington Campus,
July 1987 London W2.

Medical School (Clinical):

September 1987 Kings' College Hospital Medical School,
to Denmark Hill,
July 1990 London SE5 8RX.

Curriculum Vitae of David Lawrence Page 3

3. Academic Qualifications

June 1986 BSc (Hons) University of London. Basic Medical

Sciences and Biochemistry
(First Class Honours).

June 1990 MBBS University of London (Distinction in

Clinical Pharmacology and Therapeutics).

January 1992 Primary FRCS Royal College of Surgeons of England.

May 1994 Part II FRCS Royal College of Surgeons of England.

October 2001 Part III FRCS (CTh) Intercollegiate Specialty Boards

Specialty Examination in
Cardiothoracic Surgery

December 2004 MS (Lond) University of London

4. Scholarships, Prizes and other Awards

August 1987 MRC Scholarship for funding of BSc (awarded to the top ten
students at the second MB examination). This year was spent
studying molecular genetics.

October 1989 Jocelyn Almond Prize in Diseases of Children (awarded for a

medical student dissertation on the use of gene probes in the
prenatal diagnosis of genetically inherited diseases).

November 1998 Grant from the trustees of St George's Hospital, London for one
years' salary and £5000 towards laboratory expenses to study the
effect of combining gene therapy and chemotherapy on malignant
mesothelioma.

Curriculum Vitae of David Lawrence Page 4

5. Previous Appointments

A. Pre Registration House Officer (1 year)

1. August 1990 to January 1991 - House Physician

Firm C and Haematology

Kings' College Hospital, London SE5.
Consultants: Dr J Costello, Professor John Moxham
Professor A Bellingham, Dr G Mufti

I spent three months as PRHO to the Department of Thoracic Medicine and the remaining
three months in the Department of Haematological Medicine. This was a busy job with an
average medical take of 20 patients per day.

2. February 1991 to July 1991 - House Surgeon

Firm I and Cardiothoracic Surgery,

Kings' College Hospital, London SE5.
Cardiothoracic Consultants: Mr J Desai and Mr A T Forsyth.
General Surgical Consultants: Mr H Berry and Mr J Dawson.

I spent the first three months of this appointment in General Surgery and the second three
months in Cardiothoracic Surgery. It was during this job that I developed a special
interest in Cardiothoracic Surgery.

Curriculum Vitae of David Lawrence Page 5

B. Basic Surgical Training (SHO) Posts (3 years)

1. August 1991 to July 1992 - SHO Accident and Emergency & Anatomy Demonstrator
Kings' College Hospital, London SE5.
Head of Anatomy: Professor K Webster. Consultant A&E: Dr E Glucksman.
This year was spent working part time in the busiest A & E Department in London and
part time as an Anatomy demonstrator at the attached University. This had the advantage
over two separate six month jobs in that I spent a full academic year teaching anatomy,
enabling me to demonstrate the entire human body. During this appointment I gained
valuable experience in the management of trauma.
2. August 1992 to January 1993 - SHO Cardiothoracic Surgery
Hammersmith Hospital, London W12.
Consultants: Professor K Taylor, Mr Bruce Keogh and Mr Peter Smith.
During this appointment I was responsible for covering the patients on the ward and the
ITU. There was no shortage of operative exposure and at the end of my six months I was
able to harvest a long saphenous vein and was regularly the first assistant at coronary
artery bypass grafting. I also gained experience in assisting at valve surgery and a weekly
thoracic list. I was allowed to perform median sternotomy and close chests under
supervision.
3. February 1993 to July 1993 - SHO Orthopaedic Surgery
Whipps Cross Hospital, London E11 1NR.
Consultant: Mr Tom Mc Auliffe.
I enjoyed working in this busy Orthopaedic center as the teaching was excellent. I had, by
the end of the job gained valuable experience with an arthroscope and had good exposure
to current methods of external and internal fixation.
4. August 1993 to July 1994 - SHO General Surgery
St Helier Hospital, Carshalton, Surrey, SM5 1AA.
Consultants: Mr N J Bett, Mr A Nash, Mr J Edwards and Mr A Chilvers.
In undertaking this appointment, I completed the requirements for the clinical part of the
FRCS (Eng) exam. This job exposed me to busy elective major and day case lists and also
given me good emergency surgical experience as the hospital has a busy A & E
Department. By the end of this job I was performing my own day case lists and being
supervised in major surgery. I was able to gain experience in laparoscopic procedures,
having assisted at laparoscopic cholecystectomies, laparoscopic Nissen fundoplications,
laparoscopic hernia repairs and laparoscopically assisted hemicolectomies. I have
performed 3 laparoscopic cholecystectomies. It was during this post that I passed the
clinical section of the FRCS (Eng) examination.

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C. Post Fellowship, Pre Rotation Cardiothoracic Experience (17 months)

1. August 1994 to December 1994 - SHO Cardiothoracic Surgery

St Mary's Hospital, London W2.
Consultants: Mr R Sapsford, Mr B Glenville, and Mr R Stanbridge.

This six month position enabled me to build on the experience I had previously gained as
Cardiothoracic SHO at the Hammersmith Hospital. My ward duties included taking ward
rounds, admitting patients and being responsible for their post-operative care.
Operatively, in addition to harvesting the long saphenous and arm vein, I began routinely
opening and closing chests. I gained some experience in aortic cannulation and
preparation of the internal mammary artery for grafting.

2. January 1995 to December 1995 - Locum Registrar Cardiothoracic Surgery

King's College Hospital, London SE5 9RS.
Consultants: Mr J B Desai, Mr M Marrinan and Mr A T Forsyth

This post gave me good exposure to adult cardiac and thoracic surgery. I performed
thirty eight cases of coronary artery bypass grafting, seven of which were with SHO
assistance only. I also performed three aortic valve replacements. I routinely prepared
and cannulated patients undergoing mitral valve surgery. I performed three right lower
lobectomies and also a left upper lobectomy. I was also exposed to video assisted
thoracoscopic surgery and able to build on this experience at the Ethicon VATS course I
attended in Hamburg in September 1995.

My other duties included covering intensive care, taking ward rounds and being able to
admit patients. I attended a weekly outpatient clinic, where I saw patients with follow up
appointments. I sometimes saw new patients as well. I presented a monthly audit and a
paper review at the weekly journal club.

Curriculum Vitae of David Lawrence Page 7

D. Higher Surgical Training (Cardiothoracic Trainee, West London Rotation)
(6.5 years including 1 year of full time research)
1. January 1996 to February 1997 - SpR in Cardiothoracic Surgery

Harefield Hospital, Harefield, Middlesex, UB9 6JH

01 January 1996 to 30 June 1996
Consultants: Mr E R Townsend, Mr S W Fountain

The first 6 months of this rotation focussed on Thoracic Surgery. I attended daily
operating lists and was responsible for the pre and post op management of the patients on
the wards. On-call duties were centered around the busy intensive care unit.

01 July 1996 to 28th February 1997

Consultants: Professor Sir Magdi Yacoub, Mr A Khagani, Mr M Haw

I then moved into the department of Cardiac Surgery where I gained further experience in
Coronary artery bypass grafting and began operating independently. I also had exposure
to the use of homografts and stentless valves in cardiac surgery. I learned to perform
organ retrieval for transplantation during this time.

2. March 1997 to February 1998 - SpR in Cardiothoracic Surgery

St George's Hospital, Tooting, London SW17 0QT
Consultants: Professor T Treasure, Mr John Smith, Mr A Murday, Mr J Gaer and
Mr RE Sayer (Thoracic)

During this job I was able to consolidate the basic cardiac surgical work, the thoracic
surgical experience and the transplant experience I had gained at Harefield Hospital.

3. March 1998 to October 1998 - SpR in Cardiothoracic Surgery

The Hammersmith Hospital, Du Cane Road, London W12 0HS
Consultants: Professor K Taylor, Mr P Smith and Mr C Ratnatunga.
This year was interrupted to undertake my year of research at the Rayne Institute, Kings
College London. (see below).

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 4. November 1998 to October 1999 - Research Registrar
St George's Hospital, Tooting, London SW17 0QT
Supervisor: Professor T Treasure

My research was carried out with a grant from the trustees of St George's Hospital,
London. The work was actually performed at the Rayne Institute, King's College London
in the Department of Molecular Medicine. Professor Farzin Farzaneh is head of
Department and Dr Bernard Souberbielle is my lab supervisor. My project involved the
investigation of gene therapy in the treatment of mesothelioma and lung cancer.

5. November 1999- February 2000 - SpR in Cardiothoracic Surgery

The Hammersmith Hospital, Du Cane Road, London W12 0HS
Consultants: Prof K Taylor, Mr P Smith, Mr J Anderson and Mr P Punjabi.

Having interrupted this year to undertake a year of research, I returned to clinical

cardiothoracic surgery where I was able to continue where I left off. I was allowed to
perform more difficult but routine cardiac surgery and my valve experience increased.
There was only modest thoracic experience available during this attachment.

6. March 2000 to December 2000 - SpR in Cardiothoracic Surgery

The Hammersmith Hospital, Du Cane Road, London W12 0HS
Consultants: Prof K Taylor, Mr P Smith, Mr J Anderson and Mr P Punjabi.
I was allowed a second clinical year at the Hammersmith, but this time as the senior
specialist registrar. My additional duties involved organising waiting lists, prioritising
patients on the waiting lists and those referred for inpatient opinion.

7. January 2001 to December 2001 - SpR in Cardiothoracic Surgery

Harefield Hospital , Harefield, Middlesex, UB9 6JH

Consultants: Mr E R Townsend, Mr S W Fountain (Thoracic)

Consultants: Professor Sir Magdi Yacoub, Mr A Khagani, Mr J Gaer,
Mr M Amrani and Professor Gilles Dreyfus.
My second clinical year at Harefield allowed me to consolidate my experience in thoracic
surgery under the guidance of Mr S W Fountain and Mr E R Townsend. This unit is well
respected on the rotation as, being a dedicated thorac unit, the standard of thoracic
training is second to none.

Curriculum Vitae of David Lawrence Page 9

 During the second six months in cardiac surgery I had the privilege of working with Mr
Mohammed Amrani and Mr Asghar Khagani. The highlight of this period was that during
it I learned to perform both off pump cardiac surgery and also became competent at
minimally invasive direct coronary artery bypass surgery. I also worked with Professor
Gilles Dreyfus whose experience in mitral valve repair is well recognised.

8. January 2002 to 30th June 2002. Final year SpR in Cardiothoracic Surgery
The Heart Hospital, UCL Hospitals Trust, Westmoreland Street, London W1.

Consultants: Mr R K Walesby, Mr C W Pattison, Mr P Kallis, Mr M J Hayward and Mr S

K Kolvekar

I enjoyed the last six months of my rotation being allowed to tackle difficult clinical cases
including aortic root surgery, redo coronary and valvular surgery and resection of stage
IIIa lung cancer. The trust then offered me the position of Locum Consultant in
Cardiothoracic Surgery with effect from 01 July 2002.

9. 01 July 2002 to 31st May 2003. Locum Consultant Cardiothoracic Surgeon

The Heart Hospital, UCL Hospitals Trust, Westmoreland Street, London W1G 8PH

I now enjoy the experience of working as a consultant, yet having the benefit of working
with senior colleagues with whom I am familiar. They will be to hand for discussion and
supporting me with challenging clinical scenarios. I believe that the current clinical
climate that we work in requires that we recognize our limitations and are not shy to seek
help from more experienced colleagues when appropriate. I continue to be involved in
teaching medical students and other junior doctors at our twice weekly meeting. I have
also continued to be involved in the administration of the SHO and SpR rotas and
ensuring compliance of the unit with the national junior doctors hours requirements.

I have undertaken three audits projects this year. Analysis of the above average death
rates for patients undergoing cardiac surgery in the UCLH Trust during 1999-2001
revealed that small coronary vessels were associated with an increased mortality in low
risk patients undergoing coronary artery surgery. This was supported in the second audit
for the year 2001-2002. An audit of the deaths for 2002-2003 (part year) showed that
poor left ventricular function, diabetes, peripheral vascular disease and renal
insufficiency were associated with increased mortality in high risk patients. Our practice
has consequently been adjusted and has helped result in a reduction in our units operative
mortality from 4.8% (2001-2002) to 2.9% (2002-2003) (8 months) for patients
undergoing 1st time coronary artery bypass surgery.

Curriculum Vitae of David Lawrence Page 10

F. Research Experience

1. November 1998 to October 1999 - Research Registrar

St George's Hospital, Tooting, London SW17 0QT.
Laboratory Supervisor: Dr Bernard Souberbielle,
Educational Supervisor:Professor T Treasure.

My research was carried out with a grant from the trustees of St George's Hospital,
London. The work was performed at the Rayne Institute, King's College London in the
Department of Molecular Medicine. Professor Ferzin Farzaneh is head of Department
and Dr Bernard Souberbielle is my lab supervisor.

The project involved the investigation of the effect of combining Herpes Simplex Virus
Thymidine Kinase (HSV-tk) suicide gene therapy with established chemotherapy regimens
in the treatment of malignant mesothelioma and lung cancer.

This thesis was completed, bound and submitted to the University of London for
consideration for the award of the MS degree on the 11th October 2002. The degree of
MS (London) was conferred on 31st January 2005.

Curriculum Vitae of David Lawrence Page 11

 A copy of the abstract summarising my research is shown below

THE EFFECT OF COMBINING GENE THERAPY AND CHEMOTHERAPY ON

MALIGNANT MESOTHELIOMA.

Objective. To investigate the effect of combining allogeneic suicide gene therapy with
traditional chemotherapy in the treatment of malignant mesothelioma.

Methods. a) in vitro: Three human mesothelioma cell lines were treated with
allogeneic Herpes Simplex Virus Thymidine Kinase (HSV-tk) gene therapy and
Gancyclovir. The same cell lines were treated with Mitomycin, Vinblastine and
Cisplatin. Expression of p53, p21 (WAF-1), cyclin D1 and retinoblastoma proteins
were assessed by western blotting. Apoptosis and cell death were assessed by trypan
blue exclusion, Annexin V expression and propidium iodide exclusion. Survival was
assessed by MTT assay. b) in vivo: Mesothelioma was induced in the peritoneal cavity
of 55 mice. These were treated with gene therapy, chemotherapy and a combination of
the two modalities. The effects were assessed by post mortem study at 9 days.

Results. Gene therapy of mesothelioma cells resulted in a rapid non sustained induction
of cell cycle proteins compared to a more gradual but sustained (72 hour) response to
chemotherapy. Gene therapy was more effective at killing human mesothelioma cells
than chemotherapy (p less than 0.02). Combining the two therapies resulted in
synergistic killing of cells in vitro. Gene therapy was more effective reducing
mesothelioma tumour load than chemotherapy (p less than 0.05). Combining
chemotherapy with gene therapy however resulted in a reduction of the efficacy of gene
therapy.

Conclusions. Whilst gene therapy is potentially a promising modality of anti-tumour

therapy, its dependence on a vigorous host immunological anti-tumour response may
prohibit its concurrent use with established chemotherapeutic regimens. This does not
preclude sequential treatment by the two modalities, the effect of which is likely to be
potent because the treatments induces cell death by different mechanisms.

Curriculum Vitae of David Lawrence Page 12

6. Trainee Operative Experience

a. Non Cardiothoracic

Orthopaedic Surgery Assisted Performed

Arthroscopy of knee 74 12
Dynamic Hip screw 18 17
Austin Moore hemi arthroplasty 13 13
Thompson hemi arthroplasty 02 01
Exeter total hip replacement 57 01
Total knee replacement 48 01
Femoral intermedullary nailing 06
Tibial intermedullary nailing 05
Humeral intermedullary nailing 02

General Surgery Assisted Performed

HSV ligations 12 74
Lichtenstein hernia repair 10 38
Right hemicolectomy 03 02
Hemi thyroidectomy 14 01

Mastectomy and level 1

axillary dissection 09 02
Laparoscopic cholecystectomy 27 03
Femoral embolectomy 06 02

Curriculum Vitae of David Lawrence Page 13

6. Operative Experience (cont)

b. Cardiothoracic Surgery (as a trainee)

Assisted Performed
Cardiac surgery

Coronary artery bypass graft

Using cardio pulmonary bypass -- 730
Off - pump CABG 25 28
Redo CABG -- 14
MIDCAB 6 5

Aortic valve replacement

Mechanical/ Stented 59 81
Homograft 12 2
Stentless porcine 14 1

Mitral valve repair 18 9

Mitral valve replacement 58 23
Median sternotomy for redo operation 53

Transplantation
Retrievals for transplant
Heart 38
Heart Lung 14
Transplantation
Heart 16 1
Lungs (single) 09 -
Heart Lung 08 -

Perfusion: Cardiopulmonary Bypass

Assisted Performed
02 02

I spent a week in the Department of Clinical Perfusion at Kings' College Hospital where I was
instructed in running a Cardiopulmonary Bypass Machine. I learnt about the construction and
disassembly of the pump and concluded with performing two supervised cases.

Curriculum Vitae of David Lawrence Page 14

Thoracic surgery (as a trainee)
Assisted Performed
Mediastinoscopy 125
Tracheostomy 55
Rigid bronchoscopy 130
Lobectomy 90
Pneumonectomy 20

Oesophagectomy 51 3
Trans Thoracic Hiatus Hernia 12 -

Video assisted thoracoscopy (as a trainee)

Performed
261

This involves thoracoscopy for lung biopsy, pleurodesis, pleurectomy and excision of
pericardial cyst. I have also performed VATS for assessing resectability of lung carcinoma
and in the treatment of empyema.

Curriculum Vitae of David Lawrence Page 15

8. Publications and Presentations
i) Publications

1. A 45 degree two stage venous cannula: advantages over standard two stage
venous cannulation. Lawrence DR, Desai JB. Ann Thorac Surg 1997; 63: 253-4

2. Thoracoscopic Debridement of Empyema Thoracis. Lawrence DR, Ohri SK,

Moxon RE, Townsend ER, Fountain SW. Ann Thorac Surg 1997;64:1448-50

3. Homograft as a conduit for Superior Vena Cava Syndrome. Ohri SK, Lawrence
DR, Townsend ER. Ann Thorac Surg 1997;64:531-533.

4. The effects of Cardiopulmonary Bypass Perfusion Protocols upon Gut Tissue

Oxygenation and Blood Flow. Ohri SK, Bowles CW, Mathie R, Lawrence DR,
Keogh BE, Taylor KM. Ann Thorac Surg 1997;64:163-70.

5. Iatrogenic Oesophageal Perforations: A Clinical Review. Lawrence DR, Ohri S,

Moxon R, Townsend E, Fountain SW. Ann R Coll Surg Engl 1998;80:115-118

6. Primary Oesophageal Repair for Boerhaave's syndrome. Lawrence DR, Ohri S,

Moxon R, Townsend E, Fountain SW. Ann Thorac Surg 1999;67:818-820

7. Forearm fasciotomy post cardiac surgery. Poullis M, Lawrence DR, Ratnatunga

C. European Journal of Cardiothoracic Surgery 1999;16:580-581

8. The effect of combining Gene Therapy and Chemotherapy on mesothelioma cell

lines. Lawrence DR, Zweri J, Farzeneh F and Souberbielle B.British Journal of
Cancer 1999;80 (2):23-24

9. The Parsonnet Score is a good predictor of post-operative complications and

duration of intensive care unit stay. Lawrence DR, Valencia O, Smith EEJ,
Murday A, Treasure T. Heart 2000;83:429-432

10. Indications for cardiopulmonary bypass for non cardiac operations. Nair KS,
Lawrence DR, Punjabi PP, Taylor KM. Perfusion 2002;17(3):161-166.

11. An unusual cause of mixed mitral valve disease. Nair KS, Lawrence DR, Smith
P. Heart 2002;88(6):560-561

Curriculum Vitae of David Lawrence Page 16

 12. Thesis on the use of suicide gene therapy and chemotherapy on malignant
mesothelioma. Lawrence DR. MS (Lond) with the University of London, 2005

13. Unique type of isolated cardiac valvular amyloidosis. Iqbal S, Reehana S,

Lawrence D. Journal of Cardiothoracic Surgery 2006, 1:38

14. Are Coronary Angiograms of value in predicting mortality following coronary

artery bypass surgery. Lawrence D, Somaskanthan R, Barnard M, Keogh B.
Ann R Coll Surg Eng 2009;91:330-335.

15. Remote Ischaemic preconditioning reduces myocardial injury in patients

undergoing cardiac surgery with cold blood cardioplegia:a randomised
controlled trial. Venugopal V, Hausenloy DJ, Ludman A, Di Salvo C Mr,
Kolvekar S, Yap J, Lawrence D, Bognolo G, Yellon DM. Heart
2009Oct;95(19):1553-5.

16. Thoracic empyema: current opinions in medical and surgical management.Lee

SF, Lawrence D, Booth H, Morris-Jones S, Macrae B, Zumla A.Curr Opin Pulm
Med. 2010 May;16(3):194-200.

17. Failure to Recapture Cardioprotection with High dose atorvastatin in Coronary

Artery Bypass Surgery: A randomized controlled trail. LudmannAJ, Hausenloy
D, Babu G, Haselton J, Venugopal V, Boston-Griffiths E, Yap J, Lawrence D,
Hayward M, kolvekar S, Bognolo G, Rees P, Yellon D.Basic Research Cardiolol
2011:DOI10.1007/s00395-011-0209-5.

18. Beyond late gadolinium enhancement: the role of diffuse myocardial fibrosis in
severe aortic stenosis – an Equilibrium Contrast CMR study Andrew S. Flett,
Dan Sado, Giovanni Quarta, Sanjay Banypersad, DerekHausenloy, Denis
Pellerin, David Lawrence, Christopher McGregor, Perry M. Elliott, Andrew M
Taylor, James C. JournCardiovasMagRes 2012:13(1)O39

19. Outcomes from Surgical Management of pleural infections: 12-year experience

from a tertiary Cardiothoracic Centre: DJB Marks1,2*, M Fisk, CY Koo, D
Lawrence, RF Miller, A Zumla; BTS 2010 dci:101136/thx2010,15097918.
PLOSOne 2012;7:30074-8

20. Pulmonary mass in a 19 year old male. Laura-Jane E Smith1, Sam Janes2, Irfan
Kayani3 Mary Falzon4, David Lawrence5, Neal Navani2. Thorax
2011:doi:10.1136/thoraxjnl-2011-200732

Curriculum Vitae of David Lawrence Page 17

 21. Left atrial and right ventricular myxoma: An uncommon presentation of a rare tumour.
Diaz, A., di Salvo, C., Lawrence, D., Hayward, M. Interactive Cardiovascular and
Thoracic Surgery. volume 12, issue 4, year 2011, pp. 622 - 623

22. Endobronchial Ultrasound–guided Transbronchial Needle Aspiration Prevents

Mediastinoscopies in theDiagnosis of Isolated Mediastinal Lymphadenopathy. A
Prospective Trial.Neal Navani1,2, David R. Lawrence3, Shyam Kolvekar3,
Martin Hayward3, Dorcas McAsey3,Gabrijela Kocjan4, Mary Falzon4, Arrigo
Capitanio4, Penny Shaw5, Stephen Morris6,Rumana Z. Omar7, and Sam M.
Janes1,2; on behalf of the REMEDY Trial Investigators. Am J Respir Crit Care
Med Vol 186, Iss. 3, pp 255–260, Aug 1, 2012

23. Measurement of Myocardial Extracellular Volume Fraction by Using

Equilibrium Contrast-enhanced CT: Validation against Histologic Findings.
Steve Bandula, MA, MB BChir, Steven K. White, BSc, MBChB, Andrew S.
Flett, MD, David Lawrence,, Francesca Pugliese, PhD, Michael T. Ashworth,
MD, Shonit Punwani, PhD, Stuart A. Taylor, MD and James C. Moon, MD.
http://radiology.rsna.org/content/early/2013/07/17/radiol.13130130.abstract

24. Massive pulmonary carcinoid tumor deemed inoperable until 68Gallium Dotatate
Positron Emission Tomography/Magnetic Resonance Imaging. Katherine
Ordidge James Brown, Laura Succony, Georgia Hardavella, David Lawrence,
Francesco Fraioli, Ashley Groves.

25. Primary mucoepidermoid carcinoma of the thymus presenting with myasthenia gravis.
Woo WL,Panagiotopoulos N, Gvinianidze L, Proctor I, Lawrence D. J Thorac Dis.
2014 Oct;6(10):E223-5.doi: 10.3978/j.issn.2072-1439.2014.09.19.

26. The challenging management of lung choriocarcinoma. Gvinianidze L, Panagiotopoulos

N, Woo.WL, Borg E, Lawrence D. J Thorac Dis. 2014 Oct;6(10):E220-2. doi:
10.3978/j.issn 2072-1439.2014.09.18.

27. The challenging management of hepatopulmonary fistulas. Panagiotopoulos N,

Kontoravdis N, Lawrence D. J Thorac Dis. 2014 Sep;6(9):1336-9. doi:
10.3978/j.issn.2072-1439.2014.07.19. Review.

28. Aetiology and Management of Spontaneous Haemothorax. Davide Patrini, Nikolaos

Panagiotopoulos, Jonathan Pararajasingham, Lasha Gvinianidze MD, David Lawrence.
Accepted for publication Journal of Thoracic Disease.

29. Woo WL, Panagiotopoulos N, Gvinianidze L, Fhadil S, Borg E, Falzon M, Lawrence

D. Primary synovial sarcoma of the lung: can haemothorax be the first manifestation? J
Thorac Dis 2014;6(12):E249-E251. doi: 10.3978/j.issn.2072-1439.2014.11.01.

Curriculum Vitae of David Lawrence Page 18

 30. A novel technique for the management of recurrent pericardial effusions.
Panagiotopoulos N, Lawrence D. Accepted for publication Journal of Cardiothoracic
Surgery. Under review

31. Inflammatory Myofibroblastic Tumor of the lung: a reactive lesion or a true neoplasm?
Panagiotopoulos N, Gvinianidze L, Borg E, Lawrence D. Journal of Thoracic
Oncology.

32. Diagnosis and management of pulmonary blastoma. Jonathan Pararajasingham,

Nikolaos Panagiotopoulos, Davide Patrini1, Elaine Borg, David Lawrence. Journal of
Thoracic Disease.

33. Spatial and temporal diversity in genomic instability processes define early stage lung
cancer evolution Elza de Bruin1,*, Nicholas McGranahan2,*, Richard Mitter2,*, Max
Salm2,*, David Wedge3,*, Lucy Yates3,§, Mariam Jamal-Hanjani1,§, Nirupa Murugaesu1,
Seema Shafi1, Marco Gerlinger2,#, Andrew Rowan2, Stuart Horswell2, Ignacio Varela4,
David Lawrence5, Mary Falzon5, Arrigo Capitanio5, Timothy Harkins?, Clarence Lee6,
Warren Tom6, Chaitali Parikh6, Sharmin Begum2, Benjamin Phillimore2, Zoltan
Szallasi7, Nik Matthews2, Aengus Stewart2, Peter Campbell3, Charles Swanton1,2.
1
University College London Cancer Institute, UK, 2 Cancer Research UK London
Research Institute, UK, 3Wellcome Trust Sanger Institute, UK, 4Instituto de
Biomedicina Y Biotecnologia de Cantabria, Spain, 5University College London
Hospitals, UK, 6 ThermoFisher Scientific, CA, USA, 7 Technical University of
Denmark, Denmark. Accepted by Science

34. Dacron Patch Bronchoplasty For Mucoepidermoid Carcinoma. J Nandi, N

Panagiotopoulos, J Felderhoff,, J George, M Hayward, D Lawrence. In
progress.

35. Inflammatory Myofibroblastic Tumor of the lung: a reactive lesion or a true

neoplasm? Panagiotopoulos N, Gvinianidze L, Borg E, Lawrence D. Journal of
Thoracic Oncology.

36. Diagnosis and management of pulmonary blastoma. Jonathan Pararajasingham,

Nikolaos.Panagiotopoulos, Davide Patrini1, Elaine Borg, David Lawrence.
Journal of Thoracic Disease

37. Hepatopulmonary Fistula - A complication Of Hydatid Disease, Davide Patrini,

Mohamed A Gulamhussein; Jonathan Pararajasingham, MBBS; Benjamin Adams, MD;
David R Lawrence, FRCS; Nikolaos Panagiotopoulos, MD International Journal of
Infectous Diseases Submitte Manuscript Number: IJID-D-15-00092

Curriculum Vitae of David Lawrence Page 19

 38. A novel technique for the management of reccurent malignant pericardial effusions
Updated scheduling information, final category and publication numbers will be
available shortly on the ELCC 2015 website via
http://www.esmo.org/Conferences/ELCC-2015-Lung-Cancer/Programme

39. EJCTS/2015/440891 Is brachytherapy effective for local recurrence control

in sublobar resections for non small cell lung cancer?, TOC Category:
Thoracic oncologic, Best Evidence Topic (ICVTS) (received: July 21, 2015)

40. Is brachytherapy effective for local recurrence control in sublobar resections for non-
small-cell lung cancer? Patrini D, Lawrence D, Adams B, Panagiotopoulos N. Interact
Cardiovasc Thorac Surg. 2015 Nov; 21(5):677-81.

41. 2. The application of Plasmajet Surgical System for the Thoracic Empyema
decortication- A novel technique. Panagiotopoulos N, Patrini D, Shukla R, Hayward M,
Lawrence D. Published on CTSnet (http://ctsnet.org).

42. 3. Inflammatory Myofibroblastic Tumour of the lung – A reactive lesion or a true

neoplasm? Panagiotopoulos N, Patrini D, Gvinianidze L, Woo Wl, Borg E, Lawrence D.
J Thorac Dis 2015.

43. 4. Etiology and management of spontaneous haemothorax. Patrini D, Panagiotopoulos

N, Pararajasingham J, Iqbal Y, Gvinianidze L, Lawrence D. J Thorac Dis 2015
Mar;7(3):520-6

44. 5. Iatrogenic tracheal rupture- the role of a thoracic surgeon. Panagiotopoulos N,

Gulamhussein M, Patrini D, Shukla R, Lees M, Hayward M, Kolvekar S, Lawrence D.
Int J Respir Pulm Med 2015, 2:4.ISSN: 2378-3531.

45. 6. Hepatopulmonary Fistula: a life threatening complication of hydatid disease.

Gulamhussein MA, Patrini D, Pararajasingham J, Adams B, Shukla R, Velissaris D,
Lawrence D, Panagiotopoulos N. J Cardiothorac Surg. 2015 Jul 29;10(1):103.

46. 7. A novel sutureless technique for the repair of coronary sinus injuries.
Panagiotopoulos N, Patrini D, Adams B, Lawrence D, Roberts N. J Thorac Dis. 2015
Dec;7(12):2359-61. doi: 10.3978/j.issn.2072-1439.2015.12.43.

47. 8. 3rd Generation EGFR TKIs- A Major Breakthrough for NSCLC Treatment.
Panagiotopoulos N, Lawrence D. J. of Respiratory Res.2015 November 1(1):49-60.
ISSN 2409-0579.

48. 9. Key Features in the Management of Pulmonary Carcinosarcoma. Panagiotopoulos N,

Patrini D, Adams B, Pararajasingham J, Shukla R, Borg E, Hayward M, Lawrence D.
Case Rep Pulmonol. 2016;2016:2020146.

49. 10. Sclerosing hemangioma of the lung showing strong FDG avidity on PET scan: Case
report and review of the current literature. Patrini D, Shukla R, Lawrence D, Borg E,
Hayward M, Panagiotopoulos N. Respiratory Medicine Case Reports, Vol. 17, p20–23.

50. 11. The Potential Malignancy of a Solitary Fibrous Tumour of the Lung. Shukla R,
Patrini D, Borg E, Lawrence D, Hayward M, Panagiotopoulos N. Case Rep Pathol.

Curriculum Vitae of David Lawrence Page 20

 2015;2015:209490.

51. IgG4 related lung disease extending to the thoracic vertebrae, get info

ii) Presentations

1. A not so Septic Shock. A presentation to the General Grand Round of the Hammersmith
Hospital on a case of a dissecting aortic aneurysm. This audiovisual presentation
included a discussion on the current methods of imaging the thoracic aorta and the
options available in the management of such a case. December 1992.

2. The use of Bilateral ITA for CABG gives good early results in patients aged 70 years
and over. Lawrence DR, Desai JB, Marrinan M, Forsyth A.Presented at the Annual
Meeting of the Society of Cardiothoracic Surgeons of Great Britain and Ireland at
Llandudno, 20-22 March 1996.

3. Thoracoscopic Debridement of Empyema Thoracis.Lawrence DR, Ohri SK, Moxon

RE, Townsend ER, Fountain SW.Presented at the 10th Annual Meeting of the European
Association for Cardiothoracic Surgery in Prauge in September 1996.

4. Primary oesophageal repair for Boerhaave's syndrome.Lawrence DR, Ohri S, Moxon R,

Townsend E, Fountain S. W. Presented at the 11th Annual Meeting of the European
Association for Cardiothoracic Surgery in Copenhagen, 27th September 1997 to 1st
October 1997.

5. The Parsonnet Score is a good predictor of post-operative complications and duration of

intensive care unit stay. Lawrence DR, Valencia O, Poloniecki J, Smith EEJ.Presented
at the Annual Meeting of the Society of Cardiothoracic Surgeons of Great Britain and
Ireland at Edinburgh, March 1998.

6. The effect of combining Gene Therapy and Chemotherapy on mesothelioma cell lines
Lawrence DR, Zweri J, Farzeneh F and Souberbielle B. Presented at the British Cancer
Research Meeting, Edinburgh, 13th July 1999.

7. The effect of combining Gene Therapy and Chemotherapy on human mesothelioma, in

vivo and ex vivo experience Lawrence DR, Zweri J, Farzeneh F and Souberbielle

Curriculum Vitae of David Lawrence Page 21

 B.Presented at the 8th European Conference on General Thoracic Surgery. European
Association of Thoracic Surgeons Meeting, London, United Kingdom, 1-3 November
2000.

8. A review of the low Parsonnet deaths following coronary artery surgery in our unit. A
review of 1300 cases (1999-2001). An audit presentation following the release of the
Doctor Foster report. Lawrence DR. Presented to the Audit meeting of the Heart
Hospital, April 2002.

9. Why do patients with low Parsonnet Scores sometimes die following Coronary artery
bypass surgery Lawrence DR. An audit presentation to the Board of University
College Hospitals NHS Trust including members from the Department of Health. UCH
Audit Day, 11th July 2002.

10. A review of the mortality following cardiac surgery in our unit (2002 2003).
Identification of risk factors for surgery and preparation of protocols for the optimisation
of patients prior to undergoing cardiac surgery.Lawrence DR, Smith A. 11th December
2002.

11. Are coronary angiograms of value in the risk stratification of patients undergoing
coronary artery bypass surgery? Lawrence DR, Somaskanthan R, Barnard MJ, Curtis
M, Keogh BE. Presented at the 56th meeting of the European Society for Cardio-
Vascular Surgery, Venice Italy 19th May 2007. C11-5.

12. Outcomes from Surgical Management of pleural infections: 12-year experience from a
tertiary Cardiothoracic Centre: DJB Marks1,2*, M Fisk, CY Koo, D Lawrence, RF
Miller, A Zumla; BTS 2010 dci:101136/thx2010,15097918.

13. Inflammatory Myofibroblastic Tumour Of The Lung - A Reactive Lesion Or A True

Neoplasm? . Lasha Gvinianidze, Nikolaos Panagiotopoulos, Wen Ling Woo, David
Lawrence.

14. A novel technique for the management of reccurent malignant pericardial

effusionsUpdated scheduling information, final category and publication numbers will
be available shortly on the ELCC 2015 website via
http://www.esmo.org/Conferences/ELCC-2015-Lung-Cancer/Programme

15. The application of Argon Plasma Energy for thoracic empyema decortication: a novel
technique. Patrini D, Hayward M, Shukla R, Lawrence D, Panagiotopoulos N. 24th
European Conference on General Thoracic Surgery, Naples, 29 May- 1 June 2016.

Curriculum Vitae of David Lawrence Page 22

 16. The potential malignancy of a solitary fibrous of the pleura. Patrini D, Hayward M,
Ekeowa U, Russell P, Lawrence D, Panagiotopoulos N. American Thoracic Society
International Conference, San Francisco, 13-18 May 2016.

17. Pulmonary alveolar microlithiasis. Garg S, Panagiotopoulos N, Lawrence D, Hayward

M, Kolvekar S. American Thoracic Society International Conference, San Francisco,
13-18 May 2016.

18. Lobectomy for non-small cell lung cancer in octogenarians. A 7-year single centre
experience. Panagiotopoulos N, Patrini D, De Cabanyes S, Hayward M. European Lung
Cancer Conference (ELCC). Geneva, 13-16 April 2016.

19. A novel technique for thoracic empyema decortication. Panagiotopoulos N, Shukla R,

Patrini D, Hayward M, Lawrence D. 3rd International Joint Meeting on Thoracic
Surgery, Barcelona, 18-20 November 2015.

20. Sclerosing pneumocytoma - An unexpected benign lesion. De Cabanyes S, Shukla R,

Patrini D, Hayward M, Lawrence D, Panagiotopoulos N. 3rd International Joint Meeting
on Thoracic Surgery, Barcelona, 18-20 November 2015.

21. Pulmonary lymphangioleiomyomatosis – The role of a thoracic surgeon. Petko M,

Hayward M, Lawrence D, Panagiotopoulos N. 3rd International Joint Meeting on
Thoracic Surgery, Barcelona, 18-20 November 2015.

22. The Application Of The Plasmajet Surgical System (PSS) For Thoracic Empyema
Decortication – A Novel Technique. Shukla R, Patrini D, Hayward M, Lawrence M,
Panagiotopoulos N. ANZSCTS Annual Scientific Meeting 2015, Adelaide, 15- 18
November 2015.

23. Key features in the management of pulmonary carcinosarcoma. Adams B, Patrini D,

Pararajasingham J, Lawrence D, Panagiotopoulos N. 23rd Annual Meeting of the Asian
Society for Cardiovascular and Thoracic Surgery, Hong Kong, 11-14 May 2015.

24. A sutureless technique for the repair of coronary sinus injuries. Panagiotopoulos N,
Patrini D, Adams B, Roberts N. 23rd Annual Meeting of the Asian Society for
Cardiovascular and Thoracic Surgery, Hong Kong, 11-14 May 2015.

25. Iatrogenic tracheal rupture: An intricate diagnosis. Panagiotopoulos N , Patrini D ,

Witzke ., Ashley E, Lees M , Kolvekar S. 23rd Annual Meeting of the Asian Society for
Cardiovascular and Thoracic Surgery, Hong Kong, 11-14 May 2015.

26. Pulmonary Blastoma, A rare primary lung malignancy. Pararajasingham J, Patrini D,

Adams B, Gulamhussein M, Lawrence D, Panagiotopoulos N. 23rd Annual Meeting of
the Asian Society for Cardiovascular and Thoracic Surgery, Hong Kong, 11-14 May
2015.

27. A novel technique for the management of recurrent malignant pericardial effusions.
Panagiotopoulos N, Patrini D, Adams B, Lawrence D. European Lung Cancer
Conference ELCC, Geneva, 15-18 April 2015.

Curriculum Vitae of David Lawrence Page 23

 28. Hepatopulmonary Fistula – A life threatening complication of hydatic disease.
Gulamhussein M, Patrini D, Adams B, Pararagasigham J, Lawrence D, Panagiotopoulos
N. European Society of Thoracic Imaging Meeting, Barcelona, Spain 4-6 June 2015.

9. Courses attended

November 1991 Sloame Course for primary FRCS. This two month evening
course was an essential part of success at the primary FRCS
examination.

May 1994 St Thomas' Hospital Course for part B FRCS. The three week
full time course consolidated the knowledge I had acquired over
the past three years and helped me to be successful at the
examination in June 1994.

May 1994 Rowley Bristow Orthopaedic Course. This two weekend course
was run by Professor Appley and his colleagues at St Peters'
Hospital, Chertsey. It consisted of lectures, practical
demonstrations and assessments.

November 1994 Advanced trauma and life support course at Kings' College
Hospital. After completing this course I was invited return to
undertake the ATLS instructor course.

May 1995 Cardiac Surgery '95. This course was run by Professor Sir
Magdi Yacoub and provided a current update of the basic
sciences (including molecular biology) and clinical aspects of
cardiothoracic surgery.

September 1995 Ethicon Video Assisted Thoracoscopy Course at the European

Surgical Institute, Hamburg. This covered pleurodesis,
pleurectomy, lung biopsy, lobectomy, pneumonectomy, PDA
ligation and division of vascular rings.

September 1996 International Paediatric Conference at GOS Hospital

October 1998 Applied Basic Science for Cardiothoracic Surgeons

Curriculum Vitae of David Lawrence Page 24

 Royal College of Surgeons of England. Course covenors
Professor Tom Treasure and Mr Jules Dussek.

March 1999 Aortic Valve, Homograft and Aortic Root replacement

workshop at St George's Hospital, as part of the SpR training day.

May 1999 Mitral valve workshop at the Hammersmith Hospital, as part of

the SpR training day.

July 1999 International Cancer Gene Therapy Conference 1999 at the

Hammersmith Hospital, 8-9 July 1999

July 1999 British Cancer Research Meeting 1999. Edinburgh Conference

Centre, Herriott Watt University, Edinburgh, 12-14 July 1999

November 2000 Course in techniques of mitral valve repair.

Hospital Cardiologie, Lyon, France. Professor J Obadia.

April 2001 Revision Course in Paediatric Cardiac Surgery

Gt Ormond Street Hospital
Professor R Anderson and Mt V Tsang.

September 2001 Birmingham Heartlands Course in Cardiothoracic Surgery.

Heartlands Hospital, Birmingham. Mr R Rajesh and Tim Graham.

December 2001 Clinical Management Course for Specialist Registrars. Royal

College of Surgeons. 17th to 19th November 2001.

November 2002 TOE Course, University College Hospitals NHS Trust.

Dr Sue Wright and Dr Bruce Martin 4th to 7th November 2002.

April 2003 Cardiothoracic Training the Trainers. The Royal College of

Surgeons of England. 24-25th April 2003.

August 2003 Recruitment and Selection Procedure for UCLH NHS Trust
A 2 day course on the backgroung and Trust Procedures. UCLH
Trust Headquarters.

May 2004 Perimount Magna Meeting. Sponsored by Edwards

Lifesceinces, this study was a forum for cardiothoracic surgeons
with an interest in this valve. Gleneagles, Scotland.

October 2004 Curative Approaches to Lung Cancer. The Belfrey, Wishaw,

Birmingham. RCP 4 Credits. 7th October 2004

Curriculum Vitae of David Lawrence Page 25

December 2004 Heart Valve Club Meeting. This is the new revamped “Club
Mitrale”. A forum for Consultants with an interest in Mitral
repair. Chaired by Alain Carpentier, 6th – 8th Dec 2004.

May 2005 Perimount Magna – A UK Review. I spoke on this course as I

am experienced with this valve, explaining the techniques of
implantation to UK Cardiothoracic Surgeons. Gleneagles
Scotland.
March 2006 Heart to Heart Series, first forum on aortic stenosis. Sevilla,
Spain. A forum for consultants with an interest in Aortic Valve
disease. 30th March to 1st April 2006

May 2007 87th Meeting of the American Association for Thoracic

Surgeons. Washington DC, USA. May 5th to May 9th 2007

May 2007 Contemporary Approaches and controversial Directions in the

Surgical treatment of Atrial Fibrillation. Washington DC, USA.
6th May 2007.

May 2007 56th meeting of the European Society for Cardio-Vascular

Surgery, Venice, Italy 20th May 2007.

June 2007 Master of Mitral Valve introductory course. Hospital

Universitari Clinic, Barcelona, Spain. June 4th to 6th 2007

September 2007 ‘An update on Techniques and Outcomes of Surgical

treatment of Atrial fibrillation’. Barcelona, Spain. 2nd to 4th
September 2007.

January 2008 London trainers and Educational Supervisors Day

The Royal College of Surgeons. Chairman Nigel Stansfield. 24th
January 2008

September 2008 Towards Safer Repeat Cardiac and Thoracic Surgery

Friday September 19th 2008 @ University College london

December 2008 Perioperative echocardiography and Mitral Valve Repair

Workshop. Glenfield Hospital 3rd and 4th December 2008.

June 2009 8th Emergencies in Cardiology Course for Consultants

25th and 26th June 2009. Chair Dr J Mc Ewan.

September 2009 Voyage into Innovation. Course by Sorin for education into the
manufacture of Biological prostheses. 23rd to 24th September 2009
Saluggia, Italy.

November 2009 TAIP Course

University College Londons Hospitals NHS Trust. 4th November
2009.
November 2009 Training the Trainers Completion

Curriculum Vitae of David Lawrence Page 26

 University College Londons Hospitals NHS Trust. 4th November
2009.

November 2009 Educational Supervisors Course.

University College Londons Hospitals NHS Trust. 26th November
2009.

January 2010 WHO Surgical Safety Checklist Programme. Simulation

Training Day. University College Londons Hospitals NHS Trust.
26th January 2010

July 21st 2010 Innovation: Ethicon Biosurgery Innovation Lab, European

Surgery institute, Hamburg- Norderstedt, Germany. 1st Juy 2010

Aug/Sep 2010 Emergency Cardiology Course for Consultants x 2

September 2010 National Advanced Communication Skills Training (ACST)

Ashford Hospital, 27th to 29th September 2010.

October 6th 2010 Innovation (Speaker): Ethicon Biosurgery Innovation Lab,

European Surgery institute, Hamburg- Norderstedt, Germany.
Faculty.

October 20th 2010 Innovation (Speaker): Ethicon Biosurgery Innovation Lab,

European Surgery institute, Hamburg- Norderstedt, Germany.
Faculty

Nov 2010 East Anglian Society of Thoracic Physicians: EASTP Meeting

Harlow (Faculty)

Nov 2010 Colorectal Mets Meeting (Faculty)

Nov 2010 Recent Advances in Lung Cancer Management (Faculty):

Royal Society of Medicine

Feb 2011 Equality, Diversity and Interview Techniques Training

Course. Royal College of Surgeons, London UK 25th February
2011

May 2011 Peer to Peer Haemostasis Baxter Biosurgery Conference.

Vienna. 13th May 2011

July 2011 GP Meeting Lecture, Royal Society of Medicine

September 2011 Medicolegal Expert Witness Training, Healthcare Knowledge

Ltd. London.

January 2012 El Khaboury 8th International Advanced Valve Repair

Symposium. Advanced Techniques in Mitral Valve Repair.
16th -17 January 2012 Brussels.

Curriculum Vitae of David Lawrence Page 27

February 2013 Recent Advances in Medicine and Surgery,The RSM, Delegate
and Speaker, RSM, 1 Wimpole Street, London W1.

October 2013 Tracer –X Study Day. 04th Otober 2013. Tracking Non Small
Cell Cancer through Evolution. UCLH.

November 2013 UCLH Basic Life Support Refresher Course, 12th November
2013. UCLH

February 2014 SCTS Thoracic Forum, 7-8th February 2014. Oxford.

September 2014 Mitral Valve Repair (Neochordae Course), 23rd and 24th
September Prof. Gerosa, Padua, Italy.

Aug 2014 : 6th Latin American Conference on Lung Cancer 21-23 Aug 2014
Lima,Peru. MUCOEPIDERMOID CARCINOMA OF THE
THYMUS AND MYASTHENIA GRAVIS. IS THERE AN
ASSOCIATION? Wen Ling Woo, Nikolaos Panagiotopoulos,
Lasha Gvinianidze, David Lawrence.

October 2014 VATS Lobectomy Course, Bristol Royal Infirmary, 6th and 7th
October 2014.

November 2014 Peri operative Care of Thoracic Surgical Patient ( organising

committee) , 8 November 2014,London. VATS versus open
lobectomyand the future of thoracic surgery

December 2014 Cardiac Surgery 2014 : Oxford Deanery Regional Cardiology Teaching
-Oxford Deanery Regional Cardiology Teaching -. Trust Education
Centre, Royal Berkshire Hospital, RG1 5AN.

Feb 2015 SCTS Thoracic Forum, 6-7th February 2015. Hull

April 2015 British Nuclear Medicine Conference 2015; Brighton

May 2015 Merck Study day (Lecturer)

October 2015 Training in France Marseilles re Robot with Cristof Donnely

December 2015 Intuitive traininig Strasburgh. 7th to 8th December 2015

February 2016 Thoracic Forum, Southampton

October 2016 International VATS Conference, Royal College of Physicians

Curriculum Vitae of David Lawrence Page 28

Curriculum Vitae of David Lawrence Page 29
10. Examiner for University of London

June 2004 University of London, Final MBBS, Examiner, Surgical Short

Station.

August 2005 University of London: 3rd year OSCE Examiner

June 2006 University of London, Final MBBS, Examiner, Surgical Short

Station.

June 2007 University of London, Final MBBS, Examiner, Surgical Short

Station.

August 2007 University of London: 3rd year OSCE Examiner

11. Professional Aims and Interests.

I have made a career in adult cardiothoracic surgery. I have been privileged to be a member of
the West London Cardiothoracic Rotation and received excellent training with good exposure to
both adult cardiac and thoracic surgery (Jan 1996 - December 2002).

I enjoy the all aspects of adult cardiothoracic surgery and am particularly comfortable with
performing coronary artery bypass surgery (both on and off pump) routine aortic and mitral
valvular surgery and all aspects of thoracic surgery. I have made a special effort to gain
experience in off pump coronary artery surgery and mitral valve repair. My operative mortality
for coronary artery surgery, is described on the peer reviewed Healthcare Commission website
as “better than expected” when compared to equivalent surgeons across Europe.

My commitment to thoracic surgery is demonstrated by choice of the field of my research. I

intend to commence a clinical trial in gene therapy of malignant mesothelioma using previously
transfected allogeneic cells. Allogeneic suicide gene therapy does not include exposure of the
patients to viral vector, which would bypass the justifiable concerns of the consequences of
exposure of medical personnel to genetically modified vectors. Molecular biology is a relatively
new tool with which progress into the understanding and treatment of disease is being steadily
made. I feel that I am now in a position to undertake clinically relevant research that is likely to
have an impact on the management of our patients.

I enjoy teaching both medical students and junior members of staff and believe that this is an
important obligation doctors have. I am aware that it is due to the efforts of my senior
colleagues that I am able to operate independently today and this is only repayable by doing the
same for junior members of the team. I am familiar with current information technology

Curriculum Vitae of David Lawrence Page 30

systems and am able to help the department make full use of the wide range of resources to
hand. This has been of value in analysing the units cardiac surgical outcomes data

Curriculum Vitae of David Lawrence Page 31

12. Outside Interests

Tennis I have played tennis at inter school and inter club level. I am
currently captain of the David Lloyd Ealing Mens First Team and
play Middlesex League and National League Tennis. I have a UK
LTA rating of 5.1

Cricket I was a 1st XI player at School and University. I represented

Wallington High School for Boys, King's College London, Kings
College Hospital and finally my local club as an opening batsman
and fast bowler. As a Registrar at Kings College Hospital, I led
the team on a fortnights tour of Barbados, West Indies in August
1995.

Rugby Football Played to under 17 level. Vice captain at under 13 and under 15
year age group. Position: Scrum half.

Scuba Diving I am a Professional Association of Diving Instructors (PADI)

certified Open Water recreational SCUBA diver.

12. Referees
Professor W McKenna,
Medical Director,
The Heart Hospital,
London W1G 8PH.
Tel: 0207 573 8888.

Professor Sir Bruce Keogh,

Director of Cardiothoracic Surgery,
The Heart Hospital,
London W1G 8PH.
Tel: 0207 573 8888

Curriculum Vitae of David Lawrence Page 32