Jurnal Resmi
Jurnal Resmi
Jurnal Resmi
628
Research Article
Kaushik et al. EUROPEAN JOURNAL European
OF PHARMACEUTICAL
Journal of Pharmaceutical and Medical Research
ISSN 2394-3211
AND MEDICAL RESEARCH
www.ejpmr.com EJPMR
ABSTRACT
In recent years there is a spurt in the interest regarding survival of Ayurvedic forms of medication. In the global
perspective, there is a shift towards the use of medicine of herbal origin, as the dangers and the shortcoming of
modern medicine have started getting more apparent, majority of Ayurvedic formulation are prepared from herbs.
Syrup is very popular dosage form of cough and cold medications, ease of patient compliance. The objective of this
study is to develop a polyherbal cough syrup and evaluate the physicochemical parameter along with turbidity/
homogeneity were compared with the changes in accelerated stability testing. Quality of final herbal syrup was
evaluated with the parameters: pH, density, total solid content. Three batches were formulated with simple syrup
40%, 50%, 60% w/v .as sugar base. All the batches were evaluated for physicochemical parameters, colour, odour,
taste, spec. gravity, pH, total solid content. i.e. Specific gravity (1.24 – 1.36), pH (4.8- 5.0), solid content(37-
56.75%). The formulated batches under gone stability studies and microbial test, no turbidity were observed for
three months studies and no microbial growth were seen. All the batches assure the reproducibility and each
parameter were complying with specifications.
KEY WORDS: Quality of final herbal syrup was evaluated with the parameters: pH, density, total solid content.
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syrups predisposes them to bacterial contamination, so expectoration, or nonproductive (dry). Therefore, the use
they often contain a preservative. of an effective antitussive agent such as
Advantages of liquid dosage form: Dextromethorphan or Codeine to suppress the
Homogeneous liquid. debilitating cough suffered by such patients seems
Drug is in solution, immediately available for Appropriate. Non-Narcotic antitussive agents anesthetize
absorption. the stretch receptor located in respiratory passages, lungs
Ease of administration. and pleura by dampening their activity and thereby
Oral liquid dosage forms usually are faster acting reducing the cough reflex at its source. [5]
than solid dosage forms. Medications are absorbed
into the bloodstream in a dissolved state. The Cough as symptom is often nagging and entails a faster
medication in a liquid dosage form is already relief from problems that make the life miserable, be it
dissolved or is present in small particles so it can just the sound effect or, a feeling of „something stuck in
readily be absorbed. In contrast, tablets must throat caused by the thickened mucus. Cough is
dissolve before they can be absorbed so it takes sometimes due to:
more time for the medications to be absorbed. environmental pollution, sometimes as a
For patients who have difficulty swallowing, oral result of self-inflicted injuries as is seen in smokers.
liquid medications may be easier to take then an oral
solid dosage form. Cough could be of different types:
Liquid medications may be used where solid dosage productive,
forms are not practical to administer. For example, dry,
medications that need to be placed directly into the spasmodic etc
ear or eye may be more practically administered as a Most families prepare home remedies such as tea
liquid rather than a solid. with honey or a mixture of one part lemon juice and
one part honey. Several other ingredients are also
Advantages of syrup common: tamarind, ginger and eucalyptus. Recipes
vary widely. Traditional medicines derived from
Ability to disguise the bad taste of medications.
plants have been and will continue to be used for
Syrups are thicker than aqueous solutions, therefore
respiratory infections in many parts of the world.
only a portion of the medication dissolved in the
There have been few efficacy studies of traditional
syrup comes in contact with the taste buds. The
medicines as therapy for the common cold.[6]
remainder of the medication is held above the
tongue by the thick syrup so it is not tasted as it is
MATERIALS AND METHOD
swallowed.
Various materials used in the preparation of polyherbal
The high sugar content of syrups gives them a sweet
cough syrup were procured from Bacfo pharmaceutical
taste that helps conceal the bad taste of the medicine.
India Ltd.
This is why syrups are commonly used for pediatric
medications.
The thick character of syrups also has a soothing
effect on irritated tissues.
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Kaushik et al. European Journal of Pharmaceutical and Medical Research
PREFORMULATION OF RAW HERBS with reference to the air dried drug using following
Determination of foreign matter formula.
Method: Weighed 500 g or the quantity specified of the
original sample and spread it out in a thinner layer. CALCULATION
Inspect the sample with the naked eye or with the 6X (Weight after drying - Weight of petridish) x 100 x 100 /
lenses and separate the foreign organic matter manually weight of sample x volume of filtrate
as completely as possible. Weighed and determine the %
of foreign organic matter from the weight taken. Determination Of Water Extractive Value
Macerated 5gm of air dried drug coarsely powdered with
Moisture content 100 ml of chloroform water (2.5 ml chloroform in
Weighed 2 g of sample & glass petri dish separately, 1000ml water) in a closed flask for 24h, shaken
then heated in hot air oven at 105˚C for 1 hour. Then put frequently for first 6h and allowed to stand for 18 h,
off the petri dish from oven and allowed to cool. thereafter filtered. Evaporated 25 ml of filtrate to dryness
Percentage moisture content was calculated using in a flat bottomed shallow dish, dry at 105ºC and weigh.
following formula: Calculated the percentage of chloroform soluble
extractive with reference to the air dried drug, using
CALCULATION following formula:
(Weight of petri dish + Weight of Sample – Dried
weight) X 100 / Weight of Sample CALCULATION
(Weight after drying - Weight of petridish) x 100 x 100 /
pH analysis weight of sample x vol. of filtrate
Prepared 1% w/v solution/suspension of sample in
distilled water, mixed it properly. Checked the pH with Determination Of Total Ash
pH meter at 27 ± 2 ºC. Incinerated about 2 g accurately weighed, of the ground
drug in a tared platinum or silica dish at a temperature
Read the pH value when temperature and pH reading not exceeding 450 ºC for 5 hours, until free from carbon,
remains constant on display. cooled and weighed.
Determination of Ethanol Extractive Value Calculated the percentage of total ash with reference to
Macerated 5gm of air dried, shaken coarsely powdered the air dried drug, using following formula:
drug with 100 ml of ethanol of 95% in a closed flask for
24 hrs. Shaken frequently for first 6h and allowed to CALCULATION
stand for 18 hours, thereafter filtered rapidly taking care (Weight after drying - Weight of crucible) x 100 / weight
of loss of ethanol. Evaporated 25 ml of filtrate to dryness of sample.
in a flat bottomed petridish, dry at 105 ºC and weighed.
Calculated the percentage of ethanol soluble extractive
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Kaushik et al. European Journal of Pharmaceutical and Medical Research
than than than than than than than 100 than than than 100
100 100 100 100 100 100 100 100 100 100
CONCLUSION
The present study “develop and evaluate polyherbal
cough syrup” revealed certain conclusion.
ACKNOWLEDGEMENT
I give my immense thanks to express my sincere thanks
to Teerthanker Mahaveer University, Moradabad.
Conflict Of Interest
We declare that there is no conflict of interests regarding
the publication of this paper.
REFERENCE
1. Moore Michael, “Herbal Formulas For Clinic and
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70.
3. Tanuja Nesari, B. K. Bhagwat, Jasmin Johnson,
Narenda S. Bhatt, and Deepa Chitre, “Clinical
Validation of Efficacy and Safety of Herbal Cough
Formula: Study of Herbal Cough Syrup”, Journal of
Herbal Pharmacotherapy, 1-12.
4. S Satam, R Jain, J Dagaonkar, C Chotalia, A Suthar,
and R Joshi, “Evaluation of Clinical Efficacy and
Tolerance of Khasceeze –SF Cough Syrup”,
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T.Satapathy, and B. Meher, “International Journal of
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6. Department of Child and Adolescent Health and
Development World Health Organization “Cough
and Cold Remedies For The Treatment Of Acute
Respiratory Infections In Young Children”,
Switzerland, 2001; 1-33.
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