Scribd Logo
Upload

Welcome to Scribd!

  • 98 views

    RBC Pathology

    Uploaded by

    Kent Cruz
    The document provides an outline and descriptions of various red blood cell pathologies including Auer rods, normocytic normochromic anemia, microcytic hypochromic anemia, and microangiopathic hemolytic anemia. Key details are given on how to evaluate red blood cell size and color on a peripheral blood smear and the associated laboratory parameters for different conditions. Potential causes of microcytic hypochromic anemia are highlighted.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd

    RBC Pathology

    Uploaded by

    Kent Cruz
    98 views7 pages
    The document provides an outline and descriptions of various red blood cell pathologies including Auer rods, normocytic normochromic anemia, microcytic hypochromic anemia, and microangiopathic hemolytic anemia. Key details are given on how to evaluate red blood cell size and color on a peripheral blood smear and the associated laboratory parameters for different conditions. Potential causes of microcytic hypochromic anemia are highlighted.

    Original Description:

    Demo slide

    Copyright

    © © All Rights Reserved

    Available Formats

    PDF, TXT or read online from Scribd

    Did you find this document useful?

    Is this content inappropriate?

    The document provides an outline and descriptions of various red blood cell pathologies including Auer rods, normocytic normochromic anemia, microcytic hypochromic anemia, and microangiopathic hemolytic anemia. Key details are given on how to evaluate red blood cell size and color on a peripheral blood smear and the associated laboratory parameters for different conditions. Potential causes of microcytic hypochromic anemia are highlighted.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    98 views7 pages

    RBC Pathology

    Uploaded by

    Kent Cruz
    The document provides an outline and descriptions of various red blood cell pathologies including Auer rods, normocytic normochromic anemia, microcytic hypochromic anemia, and microangiopathic hemolytic anemia. Key details are given on how to evaluate red blood cell size and color on a peripheral blood smear and the associated laboratory parameters for different conditions. Potential causes of microcytic hypochromic anemia are highlighted.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    of 7

    PATHOLOGY

    RBC Pathology
    Lab Validation
    Transcribers: Aquino, P., Arellano, Armamento,
    Arquines
    Editor: Avanceña

    OUTLINE:
    Demo Slide: Auer Rods
    Demo Slide: Normocytic, Normochromic Anemia
    PBS 3: Microcytic, Hypochromic Anemia
    Demo Slide: Microangiopathic Hemolytic Anemia
    Demo Slide: Auer Rods

    Clumps of azurophilic granular material


    that combine and become rod-like.
    There is pigmentation which means
    there is maturation.
    Demo Slide: Normocytic, Normochromic Anemia
    NORMOCYTIC, NORMOCHROMIC ANEMIA
    (“Normo, normo”)
    • To evaluate size of RBC in a peripheral blood smear
    (PBS): Use Small Lymphocyte as a reference cell
    o Normocytic: if size of RBC is same as nucleus of
    a small lymphocyte, or RBC slightly smaller than a
    lymphocyte size (RBC size is within 6 – 7.5 um)
    o Microcytic: if size of RBC is smaller than nucleus of
    small lymphocyte
    o Macrocytic: if size of RBC is larger than nucleus of
    small lymphocyte
    • To evaluate color of RBC in a PBS: look for the central
    pallor of RBC
    o Normochromic: central pallor is 1/3 of diameter of
    RBC
    o Hypochromic: central pallor is > 1/3 of diameter of
    RBC
    • Laboratory parameters:
    o Mean Cell Volume (MCV): within 80-94 fL
    o Mean Cell Hemoglobin Concentration (MCHC):
    within 32-36 g/dL
    o Mean Cell Hemoglobin (MCH): within 25-34 pg
    • Majority of anemias are classified under this; No
    abnormality in Hemoglobin
    • Acute Blood Loss
    PBS 3: Microcytic, Hypochromic Anemia

    MICROCYTIC, HYPOCHROMIC ANEMIA (“Micro,


    hypo”)
    • Microcytic: if size of RBC is smaller than nucleus
    of lymphocyte (RBC size is < 6 um)
    • Hypochromic: central pallor is > 1/3 of diameter
    of RBC
    • Laboratory parameters:
    o MCV: < 80 fL
    o MCHC: < 32 g/dL
    o MCH: < 25 pg
    • Abnormality in Hemoglobin
    • REMEMBER! (esp. in blue)
    o T – Thalassemia
    o A – Anemia of Chronic
    Inflammation/Disorder
    o I – Iron Deficiency Anemia
    o L – Lead Poisoning
    o S – Sideroblastic Anemia
    MICROCYTIC, HYPOCHROMIC
    ANEMIA Microcytic, hypochromic Anemia.
    Microcytic/hypochromic erythrocytes
    • REMEMBER! (esp. in blue)
    indicate some inadequacy of
    o T - Thalassemia
    structural matter, usually, not
    o A - Anemia of Chronic
    enough hemoglobin.
    Inflammation/Disorder
    o I - Iron Deficiency Anemia
    o L - Lead Poisoning
    o S – Sideroblastic Anemia
    Demo Slide: Microangiopathic Hemolytic Anemia
    Fragmented
    RBC at the
    pointer. The
    rest of the
    smear shows
    poikilocytosis
    (↑ variation in
    shapes) and
    anisocytosis
    (↑ variation is
    sizes)
    MICROCYTIC, HYPOCHROMIC ANEMIA
    • Hemolytic anemia resulting from trauma to RBC due to
    obstructions or narrowing in vessels.
    • Pathogenesis &
    o Microvascular lesion that results in luminal
    narrowing, often due to deposition of fibrin and
    platelets
    o These vascular changes produce shear stresses that
    mechanically injure passing RBCs leading to
    appearance of red cell fragments
    (SCHISTOCYTES), BURR CELLS, HELMET
    CELLS, TRIANGLE CELLS in the smear
    • Most commonly seen w/ DIC, but also occur in TTP,
    HUS, Malignant HTN, SLE, Disseminated Cancer
    REFERENCES:
    • Kumar, V., Abbas, A., and Aster, J. Robbins and
    th
    Cotran Pathologic Basis of Disease. 9 Edition. 2015.
    Saunders, Elsevier Inc.
    • Klatt, Edward C. Robbins and Cotran Atlas of
    rd
    Pathology. 3 Edition. 2015. Saunders, Elsevier Inc.
    • UERM Pathology Laboratory CD. 2017.
    th
    • Manual of Pathology for Second Year Students. 16
    Edition. 2016. UERMMMCI.

    You might also like