Pharmaa Topnotch Review
Pharmaa Topnotch Review
Pharmaa Topnotch Review
Which of the following is combined with amoxicillin to prevent inactivation by the beta-
A. Cilastatin
B. Clavulanicacid
C. Tazobactam
D. Sulbactam
5. A 25-year-old nulligravid complained of lower abdominal pain for I week. On ultrasound, the
impression was tuba-ovarian abscess. What is the drug-of-choice
A. Cefotetan
C. Clindamycin
B. Cefmetazole
D. None of the above
8. A 23-year-old female with multiple sexual partners was diagnosed to have gonorrhea
infection. Which of the following is most preferred for this problem?
A. Ceftriaxone
B. Doxycycline
C. Levofloxacin
D. Spectinomycin
12. A patient with diarrhea was noted to have E. histolytica in his stool exam. Which of the following is the
drug of choice ?
A. Mebendazone
B. Metronidazole
C. Pyrimethamine
D. Pentamidine
14. Which of the following drug/s is/are used in the treatment roundworm infection
A. Albendazole
B. Mebendazole
C. Pyrantelpamoae
D. All of the above
15. A 35-year-old female complaining of vaginal discharge was diagnosed to have Trichomonas
vaginalis infection. Which agent is the drug of choice?
A. Doxycycline
B. Mebendazole
C. Metronidazole
D. Sulfadoxine
16. A 25 y/o woman consulted due to genital burning pain for the past 2 days which
becomes worse n urination. Physical examination revealed multiple blisters and ulcerative
lesions in the vaginal area. What agent will be the drug of choice for this case?
A. Acyclovir
B. Foscarnet
C. Oseltamivir
D. Rib virin
18. An adult on anti-TB treatment for 2 months complained of visual disturbance. You are
considering retrobulbar neuritis. Which of the following agents could have caused this?
A. Rifampicin
B. Pyrazinamide
C. Isoniazid
D. Ethambutol
19. Which of the following steps of the is most likely inhibited by enfuvirtide?
A. Entry
B. Translation
C. Transcription
D. Proteolytic cleavage
20. Which regimen is recommended to a DM Il patient who is newly diagnosed to have pulmonary TB?
A. 2HRZE/4HR
B. 2HR/4HRE
C. 2HRZE/IHRZE/5HRE
D. None of the above
23. Which of the following agents is administered with Adriamycin which provides rescue
against its adverse effects?
A. Dexrazoxane
B. Folinicacid
C. Mesna
D. Sodium bicarbonate
24. Which of the following is TRUE regarding meperidine?
A. Has atropine-like activity
B. Decrease activity of pupillary constrictor muscles
C. Chemically related to fentanyl
D. All
25. Which drug can be used in treatment program for opioid addicts? This drug can block the
Effect of heroin for 48 hours ?
A. Amphetamine
B. Buprenorphine
C. Naloxone
D. Naltrexone
26. Which of the following is the BEST drug to control severe anxiety attack?
A Paroxetene
B. Diazepam
C. ?
D. ?
28. Why is citaloprarn first line agent Of Choice in the management of PTSD?
A. anxiolytic effects occur immediately
B. it has the best safety profile
C. has a strong sedative effect
D. does not diminish sex drive
29. Which of the following effects may be expected with the use of clozapine in the treatment of
schizophrenia?
A. relieve hallucinations and delusions
B. worsen and increase occurrence of avolition
C. increased occurrence of dystonia
D. all of the above
31. Which of the following agents can be used in the treatment of mania?
A. aripiprazole
B. olanzapine
C. lithium
D. All of the above
32. Which statement is CORRECT regarding buspirone?
A. has anticonvulsant and muscle relaxant activity
B. withdrawal symptoms can be expected upon withdrawal after chronic use
C. partial agonist at 5-HTIA receptors
D. useful in the treatment of acute anxiety attack
33. Which of the following is the least choice in the management insomnia
A. Diazepam
B. Hydroxyzine
C. Phenobarbital
D. Zolpidem
34. Which of the following is the drug of choice for absence seizure?
A. carbamazepine
B. ethosuximide
C. phenytoin
D. topiramate
36. Classic symptoms of parkinsonism like bradykinesia, rigidity, and tremors result from:
A. Inhibition of the thalamus from globus pallidus interna
B. Inhibition of the globus pallidus externa
C. Decrease Ach secretion
D. Increase dopamine secretion in the substancia nigra
39. Mr. TG, 67 years Old. has been having difficulty in walking and Was observed to have shaking of his
hands even if he is not doing anything. He Was diagnosed to have Parkinson's disease. This disease is said
to be primarily due to the deficiency Of
A. GABAnergic neurons
B. Cholinergic neurons
C. Dopaminergic neurons
D. Adrenergic neurons
40. Mr. TG should be started with this drug:
A. Levodopa
B. Carbidopa
C. Pramipexole
D. Amantadine
41 an 80-year-old woman was noted to have manic symptoms accompanied with memory loss. She can
be started in this medication to minimize her manic episodes: Diagnosis: Alzheimers
A. Haloperidol
B. Trihexyphenidyl
C. Donezepil
D. Pegrolide
43. WT, an 80-year-old female, is with Alzheimer's disease. This glutamate inhibitor can be given:
A. Memantine
B. Donezepil
C. Gallantamine
D. Tacrine
45. This drug potentiates the synthesis, release, & prevents reuptake of dopamine:
A. Levodopa
B. Selegiline
C. Amantadine
D. Entecapone
49. A retired industrial worker has persistent bouts of joint pains not responsive to pain relievers.
Findings showed markedly elevated levels of uric acid and peculiar black horizontal lines in the
gum margins. The most likely toxin is
A. Cesium
B. Lead
C. Mercury
D. Thallium
50. Which chelator is most associated with hypocalcemia prior to new formulations?
A. Dimercaprol
B. Unithiol
C. Succimer
D. EDTA
51. A patient with peanut allergy should NOT be given this chelator:
C. Prussian blue
A. Dimercaprol
D. Deferoxamine
B. Succimer
53. A factory worker Subsequently displayed dermatologic lesions such as chloracne. folliculitis.
Skin dryness and hyperprgmentation. Liver enzymes are also markedly elevated.
The MOST likely cause Of toxicity is
A. aliphatic hydrocarbon
B. polychlorinated biphenyl
C. mercury
D. iron
54, A Person being chelated manifests with red orange urine. The MOST likely heavy metal
toxicity this patient is suffering from is
A. Lead
B. Copper
C. Mercury
D. Iron
55. Possible human effect of exposure to chemicals with endocrine disruptor action —
C. infertility
A. erethism
D. gingival lines
B. acrodynia
56. A gardener was brought to the ER with these signs and symptoms: BP = 80/40 mmHg, HR = 49/min, RR
= 9/min, pinpoint pupils, saliva and froth in the mouth, wheezing, underpants soaked with feces and urine.
A. Main treatment is chelation with dimercaprol
B. Mechanism of hazard is irreversible inhibition of an enzyme
C. The antidote is oxygen administration
D. Source of toxin is MOST likely lighting equipment
57. A 50-year-old male was seen at the OPD due to excruciating pain on his left big toe. The
pain started 2 days ago which gradually increased in intensity. He noticed that his toe is also
swollen. On PE, the left big toe was edematous, red and tender to touch. Synovial fluid analysis
showed crystals engulfed by phagocytes. Which of the following is most appropriate for thepatient?
A. Allopurinol
B. Aspirin
C. Colchicine
D. Methotrexate
58. A 3 year old boy was brought-at the OPD due to high grade fever and rashes. He was
diagnosed to have non-specific viral exanthema and was given Ibuprofen for fever. Which of the
following best explains the antipyretic effect of Ibuprofen?
A. It inhibits the phospholipases
B. It reduces prostaglandin level in the hypothalamus
C. It blocks prostaglandin receptors in the brain
D. It reduces leukotrienes in the skin
59. Which of the following inhibits the formation of vitamin K dependent clotting factors?
A. Waffarin
B. Coumarin
C. Heparin
D. All of the above
E. A and B only
63. A 24 year old male diagnosed with blooding disorder was complaining of throbbing
headache in his parietal area. He was later diagnosed to have tension headache. Which of the
following would be the safest drug for this patient?
A. Acetaminophen
B. Naproxen
C. Acetylsalicylic acid
D. Kotorolac
64. A 70-year-Old female was brought to the emergency room due to tinnitus. headache,
dizziness, difficulty in hearing and sweating. The patient was suffering from bone pan since She
underwent mastectomy due to breast cancer. The patient was over treating herself with oral
aspirin and topical acetylsalicylic acid. Which of the following Can be done to this patient?
A. Give Bicarbonate
B. Give Anti-diuretic hormone
C. Give Furosemide
D. A and C only
66. A 24 to a year old GIPI gave birth to a 32 week old male infant diagnosed to have PDA.
Which of the following can be used to manage this patient?
A. Low dose aspirin
B. Prostaglandin
C. Indomethacin
D. Misoprostol
67. A 16 year old boy took 39 tablets of 500mg paracetamol after his break up with his girlfriend
Of 2 months. Which of the following is/are expected to happen to this patient?
A. The patient is likely to develop myocardial infarction due to thrombosis
B. The patient may suffer from cranial bleed
C. The patient is likely to develop acute renal failure
D. The patient is most likely to develop hepatic failure
68. A 68 year old female who has undergone hysterectomy. Because of severe post-op pain
noted 5 hours after, she asked for pain reliever. Which of the following maybe given to her?
A. Oral Naproxen
B. Topical salicylate
C. Ibuprofen suppository
D. IV Ketorolac
69. A 58 year old made diagnosed recently with osteoarthritis. Three months prior to
consultation, he was diagnosed to have a peptic ulcer disease and was treated. Which of the
following can be safely given to this patient?
A. Aspirin
B. Celecoxib
C. Paracetamol
D. Naproxen
70. A 16 year old male diagnosed with haemophilia was brought to the OPD due to pain on his
hip. Which of the following is CONTRAINDICATED in this patient?
A. Paracetamol
B. Celecoxib
C. Ibuprofen
D. Aspirin
71. A 49 year old male Caucasian who was on long vacation here in the Philippines was
brought by his fiancee to the clinic due to acute pain on his ankle. He was in severe pain. He
was later diagnosed to have acute gouty arthritis. He was given a drug that inhibits tubulin
polymerization. This drug is
A. Ketoprofen
B. Uricase
C. Sulindac C. Sulindac
D. Colchicine
72. The patient came back after 3 weeks. He was in good mood and no longer complains of
pain on his ankle but his uric acid was still elevated hence he was prescribed a medication that
can lower his uric acid level. After a week of taking the medication, he came back with rashes
on his neck, elbow and upper chest. Which of the following could have caused this problem?
A. Aspirin
B. Febuxostat
C. Losartan
D. Allopurinol
73. A 42 year old male executive underwent a routine checkup. His serum uric acid level was
23mg/dL and urinate urate of 780mg/24hr. He was given e medication and 3 weeks later his
serum urate was 8.3mg/dL and urinary urate of 530mg/24hr. Which of the following could have?
been given?
A. Furosemide
B. Indomethacin
C. Probenedic
D. Febuxostat
74. An 8 year old boy was brought to the clinic due to coryza, fever and popular lesions at the palate and
anterior pharyngeal wall. He has a history of G6PD. Which of the following antipyretic would be safe to
use in this patient?
A. Aspirin
C. Ibuprofen
B. Celecoxib
D. Acetaminophen
75. A 17-year-Old girl was suffering from dysmenorrhea. Which of the following would be the most
effective for this condition?
A. Acetaminophen
B. Ibuprofen
C. Misoprostol
D. A ane B only
77. A 37-year-old female celebrity who has recently undergone drug rehabilitation was found
dead by her daughter at home. According to reports, the celebrity hosted a party where she was
seen drinking once again and has secretly tried drugs brought by her friends. On autopsy, she
was found to have low blood level of morphine not enough to cause death. Which of the
following could have been taken together with morphine which caused her death'?
A. Amphetamine
B. Marijuana
C. LSD
D. Ethanol
78. LD, a 21-year-old drop out of a medical school has been injecting smack daily for about a
month now. His "run" started at a rave party which he attended. Recently, he admitted to
smoking Black Tar. To which of the following drugs is the patient hooked?
A. Morphine
B. Cocaine
C. Heroin
D. Marijuana
79. Which of the following is the drug of choice for status asthmaticus?
A. Epinephrine
B. Theophyline
C. Chlorpheramine
D. Triamcinole
80. Which of the following is a beta 2 selective agonist with prompt and efficacious
bronchodilation effect?
A. Terbutaline
B. Albuterol
C. Thophylline
D. Isoproterenol
87. What drug decreases catabolism of ApoAI + reduces VLDL secretion from the liver?
A. Niacin
B. Gemfibrozil
C. Colestipol
D. Rosuvastatin
89. Which of the following about HMC COA reductase is not correct?
A. it mediates the first committed step in sterol biosynthesis
B. it is anatagonized by atorvastatin
C. its drug antagonists has marked hepatic first pass effect
D. One of the above
90. This drug inhibits intestinal absorption of phytosterol and cholesterol?
A. Colesevelam
B. Ezetimibe
C. Lovastatin
D. Niacin
98. All of the following are cytotoxic drugs that are classified as agents, EXCEPT.
A. Cyclophosphamide
B. Thiotepe
C. Busulfan
D. Carmustine