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    Parameters of The Model: Name Deterministialpha Beta Description

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    Angga Prawira Kautsar
    The document describes the parameters used in a Markov model to analyze the costs and benefits of monotherapy versus combination therapy. It lists the transition probabilities (e.g. tpA2B) between health states, direct medical costs and community care costs for each state, drug costs, treatment effect and discount rates. It then shows sample Markov models for monotherapy and combination therapy with health states A through D over 20 years, calculating total life years and costs with and without discounting for each. The analysis section compares the deterministic results of life years, costs, life years gained and incremental cost-effectiveness ratio between the two therapies.

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    Parameters of The Model: Name Deterministialpha Beta Description

    Uploaded by

    Angga Prawira Kautsar
    30 views5 pages
    The document describes the parameters used in a Markov model to analyze the costs and benefits of monotherapy versus combination therapy. It lists the transition probabilities (e.g. tpA2B) between health states, direct medical costs and community care costs for each state, drug costs, treatment effect and discount rates. It then shows sample Markov models for monotherapy and combination therapy with health states A through D over 20 years, calculating total life years and costs with and without discounting for each. The analysis section compares the deterministic results of life years, costs, life years gained and incremental cost-effectiveness ratio between the two therapies.

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    The document describes the parameters used in a Markov model to analyze the costs and benefits of monotherapy versus combination therapy. It lists the transition probabilities (e.g. tpA2B) between health states, direct medical costs and community care costs for each state, drug costs, treatment effect and discount rates. It then shows sample Markov models for monotherapy and combination therapy with health states A through D over 20 years, calculating total life years and costs with and without discounting for each. The analysis section compares the deterministic results of life years, costs, life years gained and incremental cost-effectiveness ratio between the two therapies.

    Copyright:

    © All Rights Reserved
    Download as XLS, PDF, TXT or read online from Scribd
    Download as xls, pdf, or txt
    30 views5 pages

    Parameters of The Model: Name Deterministialpha Beta Description

    Uploaded by

    Angga Prawira Kautsar
    The document describes the parameters used in a Markov model to analyze the costs and benefits of monotherapy versus combination therapy. It lists the transition probabilities (e.g. tpA2B) between health states, direct medical costs and community care costs for each state, drug costs, treatment effect and discount rates. It then shows sample Markov models for monotherapy and combination therapy with health states A through D over 20 years, calculating total life years and costs with and without discounting for each. The analysis section compares the deterministic results of life years, costs, life years gained and incremental cost-effectiveness ratio between the two therapies.

    Copyright:

    © All Rights Reserved
    Download as XLS, PDF, TXT or read online from Scribd
    Download as xls, pdf, or txt
    of 5

    Parameters of the model

    Name deterministialpha beta description

    Transition probabilities
    events complement
    tpA2A Transition probability from A to A
    tpA2B Transition probability from A to B
    tpA2C Transition probability from A to C
    tpA2D Transition probability from A to D
    tpB2B Transition probability from B to B
    tpB2C Transition probability from B to C
    tpB2D Transition probability from B to D
    tpC2C Transition probability from C to C
    tpC2D Transition probability from C to D

    Costs

    dmca Direct medical costs associated with state A


    dmcb Direct medical costs associated with state B
    dmcc Direct medical costs associated with state C
    ccca Community care costs associated with state A
    cccb Community care costs associated with state B
    cccc Community care costs associated with state C

    Drug costs

    cAZT Zidovudine drug cost


    cLam Lamivudine drug cost

    Other parameters

    RR Treatment effect (RR)


    cDR Annual discount rate - costs (%)
    oDR Annual discount rate - benefits (%)
    Markov model

    MONOTHERAPY Life Years


    Year A B C D no disc disc
    0 1 check
    1
    2
    3
    4
    5
    6
    7
    8
    9
    10
    11
    12
    13
    14
    15
    16
    17
    18
    19
    20

    sum
    Costs COMBINATION THERAPY Life
    no disc disc A B C D no disc
    1 check

    sum
    Years Costs
    disc no disc disc
    Analysis

    Mono Comb Difference Estimated


    LYs Cost LYs Cost LYG incCost ICER
    Deterministic

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