2018년 한국생체재료학회

추계학술대회 및 총회
2018 FALL MEETING OF
THE KOREAN SOCIETY FOR BIOMATERIALS

발표논문집
제22권 3호

● 일 시 : 2018년 10월 18일(목)~19일(금)

● 장 소 : 판교 차바이오컴플렉스(CHA Bio Complex)
●후 원: 한국여성과학기술인지원센터

http://www.ksbm.or.kr
 ᇥ‫ݚ‬₉ᄲᬱ ᖵ✡ქᜅ ᬕ⧪ ᄡĞᦩԕ

ᇥ‫ݚ‬₉ᄲᬱ ᖵ✡ქᜅ ᬕ⧪ŝ šಉ⦹ᩍ ݅ᮭŝ zᯕ ᬕ⧪᜽eᯕ ᄡĞ

ࡹᨩᮝ‫ܩ‬ ₙŁ⦹ᩍ ᵝ᜽ʑ ၵ௮‫݅ܩ‬.

- ݅ ᮭ -

1.ᄡĞᯝ᜽: 2015֥ 11ᬵ 11ᯝ ~ ḡᗮ

2.ᬕ⧪Ǎe: ᇥ‫⟝⌁ݚ‬ᜅ⳩ᇥ‫ݚ‬₉ᄲᬱ⳩₉ၵᯕ᪅⍕⥭౪ᜅ⳩❱Ʊᩎ
3.ᬕ⧪᜽e: 07:30ᇥ~18:50ᇥʭḡ(Ǎᩎᄥ 40ᇥ eĊᬕ⧪)
ⲻ
☁᫵ᯝⰑᯝ᫵ᯝⰑŖ⮕ᯝ ၙᬕ⧪
4.ʑ┡ : - ᖵ✡ქᜅ ┲᜚ 5ᇥ ᱶࠥ ᯝ ӹ᪅᜽ʑ ၵ௮‫݅ܩ‬.
- ᱱᝍ᜽e ၙᬕ⧪(12:00 ~ 12:50)

؎५ ̘ࢷ ঋ५ : 07‫ ݡ‬30ٔ
ࡈପˮɻ / ϝ۱߄έѣ ɻʵ
40ٔ
̘࣮ տ५ : 18‫ ݡ‬00ٔ

`
ٔз১ે‫ݘ‬ ٔз५‫ࡒظ‬ CHA Bio Complex ળ˩ࠄ(1‫؞‬঴ˮ)

ٔз১ે‫ݘ‬ ٔз५‫ࡒظ‬ CHA Bio Complex ળ˩ࠄ CHA Bio Complex ٔз५‫ࡒظ‬ ٔз১ે‫ݘ‬
07:30 07:40 07:50 07:55 08:00 08:10 08:20
08:00 08:10 08:20 08:25 08:30 08:40 08:50
08:30 08:40 08:50 08:55 09:00 09:10
09:30 09:40 09:45 09:50 10:00
10:10 10:20 10:25 10:30 10:40
10:50 11:00 11:05 11:10 11:20
11:30 11:40 11:45 11:50 12:00
ࢺ‫ݤݪ‬ɾ ‫ࡋ׵‬ଭ(12:00 ~ 12:50)
‫ࡋ׵‬ଭ
12:50 13:00 13:05 13:10 13:20
‫ࡋ׵‬ଭ
13:30 13:40 13:45 13:50 14:00
14:10 14:20 14:25 14:30 14:40
14:50 15:00 15:05 15:10 15:20
15:30 15:40 15:45 15:50 16:00
16:10 16:20 16:25 16:30 16:40
16:50 17:00 17:05 17:10 17:20 17:30
17:40 17:50 18:00 18:05 18:10 18:20 18:30
18:00 18:10 18:20 18:25 18:30 18:40 18:50

ⲻƱ☖ᔢ⫊ᨱ ঑௝ 40ᇥ eĊ ᱶ᜽ᬕ⧪ᯕ ᨕಅᬙ ᙹ ᯩᮝ‫ܩ‬ ᧲᮹ၵ௮‫݅ܩ‬.

B1 도면

B1
Ÿ 국제회의실 International conference room : Lecture Room
Ÿ 대강당 Auditorium : Lecture Room
Ÿ 식당 : 점심, 18일 Reception

B2
Ÿ 강의실 Lecture room B230 : Lecture Room
Ÿ 강의실 Lecture room B217 : Lecture Room
Ÿ 홀 : Poster Presentation Session
 ϔ ଛ˯۟঎࢟Ջଚୠ ঱ˀ ଚܺлୠ ‫ ׽‬ণୠ
1EV  
6JW
ળ˩ ५‫ࠚࢄ׿‬৴଍Ԥ‫ݘ‬

6KOG +PVGTPCVKQPCN EQPHGTGPEG TQQO #WFKVQTKWO .GEVWTG TQQO .GEVWTG TQQO

 5HJLVWUDWLRQ3RVWHU ,QVWDOODWLRQ

 2SHQLQJ &HUHPRQ\

 2NGPCT[ .GEVWTG  #PFTGU , )CTEKC *HRUJLD ,QVWLWXWH RI 7HFKQRORJ\ 86$

 2NGPCT[ .GEVWTG  0QDWJKMQ ;WK 7RN\R 0HGLFDO DQG 'HQWDO 8QLY -$3$1

 %QORCP[ 5GUUKQP Ǫ 3RVWHU 3UHVHQWDWLRQ 6HVVLRQ Ǥ

 .6%0 *HQHUDO 0HHWLQJa DQG /XQFK

5GUUKQP  5GUUKQP  5GUUKQP 

 4GEGPV CFXCPEGOGPVU -QTGCPś%JKPGUGś,CRCPGUG 9+5'6-5$/ 5RGEKCN 5GUUKQP
KP &TWI &GNKXGT[ 5[UVGO ;QWPI 5EKGPVKUV 5GUUKQP

 &RIIHH %UHDN

5GUUKQP 
5GUUKQP 
5GUUKQP  5GUUKQP  2GTHQTOCPEG 4GRQTV QH -QTGC
 5VWFGPV 1TCN %QORGVKVKQP Ǫ
+PPQXCVKXG 5VGO %GNN 4GUGCTEJ -5$/ ;QWPI 5EKGPVKUV 5GUUKQP 'XCNWCVKQP +PUVKVWVG QH
+PFWUVTKCN 6GEJPQNQI[
-'+6

 $ZDUGLQJ &HUHPRQ\ <RXQJ 6FLHQWLVW $ZDUG DQG 5HFHSWLRQ

 ϔ ଛ˯۟঎࢟Ջଚୠ ঱ˀ ଚܺлୠ ‫ ׽‬ণୠ
1EV  
(TK
ળ˩ ५‫ࠚࢄ׿‬৴଍Ԥ‫ݘ‬

6KOG +PVGTPCVKQPCN EQPHGTGPEG TQQO #WFKVQTKWO .GEVWTG TQQO

 5HJLVWUDWLRQ3RVWHU ,QVWDOODWLRQ

 (TQO 4GUGCTEJ VQ %QOOGTEKCNK\CVKQP

 %QORCP[ 5GUUKQP ǫ 3RVWHU 3UHVHQWDWLRQ 6HVVLRQ ǥ

 /XQFK

5GUUKQP 
5GUUKQP  5GUUKQP 
 2TQITGUU KP & RTKPVKPI  & 2NCVHQTOU
/GFKECN %QUOGVKE 4GUGCTEJ + 5VWFGPV 1TCN %QORGVKVKQP ǫ
HQT 6KUUWG 'PIKPGGTKPI

 &RIIHH %UHDN

5GUUKQP 
5GUUKQP  5GUUKQP 
 #RRNKECVKQP QH $KQOCVGTKCNU HQT /GFKECN
$KQOCVGTKCNUDCUGF (WUKQP 6GEJPQNQI[ /GFKECN %QUOGVKE 4GUGCTEJ ++
&GXKEG CPF *CTF 6KUUWG

 $ZDUGLQJ &HUHPRQ\ 6WXGHQW 2UDO &RPSHWLWLRQ $ZDUG  3RVWHU 3UHVHQWDWLRQ 6HVVLRQ $ZDUG DQG &ORVLQJ 5HPDUN
&$%, :U`` AYYh]b[ cZ H\Y ?cfYUb GcW]Yhm Zcf 6]caUhYf]U`g               

1EV  

6JW
6KOG +PVGTPCVKQPCN EQPHGTGPEG TQQO
 #WFKVQTKWO
 .GEVWTG TQQO $ .GEVWTG TQQO $

 5HJLVWUDWLRQ3RVWHU ,QVWDOODWLRQ

 2SHQLQJ &HUHPRQ\

2NGPCT[ .GEVWTG     &KDLU  <RQJ+HH .LP +DQ\DQJ 8QLY .L 'RQJ 3DUN $MRX 8QLY
 =2.? %LRHQJLQHHUHG K\GURJHOV IRU UHJHQHUDWLYH PHGLFLQH
#PFTGU , )CTEKC *HRUJLD ,QVWLWXWH RI 7HFKQRORJ\ 86$

=2.? (PHUJHQFH RI VXSUDPROHFXODU ELRPDWHULDOV XVLQJ SRO\URWD[DQH IUDPHV


0QDWJKMQ ;WK 7RN\R 0HGLFDO DQG 'HQWDO 8QLY -$3$1

%QORCP[ 5GUUKQP Ǫ
&KDLU  Οʢɼо ̀ࠝ୉̖ࠝ˓о
=%5? 
$UWLILFLDO JUDIWV IRU VRIW WLVVXH DXJPHQWDWLRQ LQ LPSODQW GHQWLVWU\
؎ऎࡆࢿϠ‫ݛ‬
 =%5?  3RVWHU 3UHVHQWDWLRQ 6HVVLRQ Ǥ
5HFHQW UHVHDUFK WUHQG RI QHZ PDWHULDO IRU FRVPHWLFV        
ࢄߣங߾ࢇ৔ࠀ߾ࢇળց਀
=%5? 
5HFRQVWUXFWLRQ RI KXPDQ WLVVXH PRGHO DQG LWV DSSOLFDWLRQ WR WR[LFLW\
WHVW
ࢄܶୀ‫ܙࠝࢇ؂‬Ք‫܊‬
 .6%0 *HQHUDO 0HHWLQJa DQG /XQFK

5GUUKQP   4GEGPV CFXCPEGOGPVU KP &TWI &GNKXGT[ 5[UVGO 5GUUKQP   -QTGCPś%JKPGUGś,CRCPGUG ;QWPI 5EKGPVKUV 5GUUKQP
5GUUKQP   9+5'6-5$/ 5RGEKCN 5GUUKQP
&KDLU  +DQVRR 3DUN &KXQJDQJ 8QLY &KDLU  ,QVXS 1RK 6HRXO 1DW
O 8QLY RI 6FL  7HFK
&KDLU  ּ୊ࢽʢ˲о ‫ࡕ˱ࠉ˃̛߅ܹ؃‬
0LQVHRN .ZDN 3XN\RQJ 1DW
O 8QLY <RQJ .\X /HH .RUHD 1DW
O 8QLY RI 7UDQVSRUWDWLRQ
=5-.?  =;5? 3RO\SKHQ\OERURQLF DFLG D EXLOGLQJ EORFN RI VHOIDVVHPEOHG =9+5'6ś-5$/12? 
7HPSRUDO WDUJHWLQJ RI WXPRU PLFURHQYLURQPHQW XVLQJ VHOIDVVHPEOHG QDQRFRQVWUXFW IRU ELRPHGLFDO DSSOLFDWLRQ            ([RVRPHELRDGKHVLYHV QDQRDJJUHJDWHV IRU PLFUR51$EDVHG FDQFHU
ORFDOL]HG K\GURJHOV ,WPUGQM .GG 3267(&+ .25($ GLDJQRVLV
#XKPCUJ $CLCL ,QGLDQ ,QVWLWXWH RI 6FLHQFH ,1',$ =;5? 'HVLJQ V\QWKHVLV DQG ELRPHGLFDO DSSOLFDWLRQ RI QHZ PROHFXODU ࢝‫ࢺ״‬.$,67
LPDJLQJ SUREHV =9+5'6ś-5$/12? 
=5-.?  &CP &KPI 1DQNDL 8QLY &+,1$ 5DSLG IRUPDWLRQ RI YDVFXODUL]HG PLFURWLVVXH XVLQJ FRFXOWXUH
,QWHUYHQWLRQDO LPDJH JXLGHG WKHUDSHXWLF GHOLYHU\ DQG PXOWLIXQFWLRQDO =;5? )DEULFDWLRQ RI LQWUDFHOOXODU $73UHVSRQVLYH SRO\LRQ FRPSOH[ VSKHURLGV
FDUULHUV PLFHOOHV IRU VPDUW QXFOHRWLGH WKHUDSHXWLFV GHOLYHU\ ̞ࡲ‫ײ‬ଞߦо
&QPI*[WP -KO 1RUWKZHVWHUQ 8QLY 86$ /KVUWTW 0CKVQ 7KH 8QLYHUVLW\ RI 7RN\R -$3$1 =9+5'6ś-5$/12? 
=;5? 0XOWLIDFHWHG ELRPHGLFDO DSSOLFDWLRQV RI IXQFWLRQDO JUDSKHQH $JH GHSHQGHQW DWWHQXDWLRQ RI FHOOXODU PHFKDQRVHQVDWLRQ
=5+.?  QDQRPDWHULDOV IRU VNHOHWDO PXVFOH WLVVXH UHJHQHUDWLRQ ଙࢺࡒˈԮо
 7XPRU PLFURHQYLURQPHQWUHVSRQVLYH QDQRPHGLFLQH IRU FDQFHU ;QPI %JGQN 5JKP 3XVDQ 1DW
O 8QLY .25($
LPDJLQJ DQG WKHUDS\ =;5? 'HYHORSPHQW RI EDFWHULDUHVSRQVLYH ELRGHJUDGDEOH SRO\PHUV =9+5'6ś-5$/+.? 
5CPI[QPI ,QP .$,67 IRU WKH WUHDWPHQW RI EDFWHULDO LQIHFWLRXV GLVHDVH -RXUQH\ WR GLVFRYHU\ DQG GHYHORSPHQW +LVWRU\ RI SHSWLGH
/GPIJWC :KQPI 6RXWK &KLQD 8QLY RI 7HFKQRORJ\ &+,1$ DSSOLFDWLRQ
=5+.?  =;5? 'HYHORSPHQWRI IXQFWLRQDOQDQRSDUWLFOHV IRUWKH GHWHFWLRQRIEDFWHULD ‫ࢺࡩ؀‬۰ࡌо
6LWHVSHFLILF FRQMXJDWLRQ RI DOEXPLQ WR SURWHLQ GUXJV IRU ORQJ DFWLQJ ;WLK 6UWEJKFQ 5,.(1 -$3$1
GHOLYHU\ 6&$/$'( =;5? ' FHOO SDWWHUQLQJ RI K\GURJHO IRU WLVVXH HQJLQHHULQJ       =9+5'6ś-5$/+.? 
+PEJCP -YQP *,67 ,KUQQ 5JKP <RQVHL 8QLY .25($ *HQGHUHG LQQRYDWLRQV LQ ELRPHGLFDO PDWHULDOV UHVHDUFK
=;5? 7LVVXH LQGXFLQJ ELRLQNV IRU ' ELRSULQWLQJ ߣ‫঻ࡩۺ‬Χо
=5+.?  %JCPIUJWP 4WCP &KLQHVH $FDGHP\ RI 6FLHQFHV &+,1$
/'1$ WHWUDKHGURQ $ WXPRUWDUJHWHG GUXJ GHOLYHU\ V\VWHP =;5? /DUJHVFDOH SUHSDUDWLRQ RI KDLU IROOLFOH JHUPV IRU KDLU =9+5'6ś-5$/? 
&CG4Q #JP .,67 UHJHQHUDWLYH PHGLFLQH :,6(7.6%0 ۢ঑ࢢՎ ࠆ‫˕۽‬ଝ࢕ όઝࡓ਺
6CVUWVQ -CIG[COC .,67(& -$3$1 ‫ ࢶ˓۽‬ऑԻ ੎ۛࡶ ࡢଞ ‫ݦ‬ऑࣸʺ %ULGJLQJ 0HQWRULQJ
=;5? 'UXJ FRQMXJDWHG R[\JHQ QDQREXEEOH IRU WKHUDSHXWLF DSSOLFDWLRQ ଛ˯۟঎࢟Ջଚୠ ࠃ‫ࡒ࡟ۺ‬ୠ
,CPIUWP *YCPI &KXQJ$QJ 8QLY .25($
 &RIIHH %UHDN
&$%, :U`` AYYh]b[ cZ H\Y ?cfYUb GcW]Yhm Zcf 6]caUhYf]U`g                                  

1EV  

6JW
6KOG +PVGTPCVKQPCN EQPHGTGPEG TQQO
 #WFKVQTKWO
 .GEVWTG TQQO $ .GEVWTG TQQO $

5GUUKQP   2GTHQTOCPEG 4GRQTV QH -QTGC 'XCNWCVKQP +PUVKVWVG QH

5GUUKQP   +PPQXCVKXG 5VGO %GNN 4GUGCTEJ 5GUUKQP   -5$/ ;QWPI 5EKGPVKUV 5GUUKQP 5GUUKQP   5VWFGPV 1TCN %QORGVKVKQP Ǫ
+PFWUVTKCN 6GEJPQNQI[
-'+6
&KDLU  ̀੓̎ˁٖࢂо ̡੓୉ࣸߒо &KDLU  ‫ݦ‬சܹଞߦо ̡ˬ‫ࢉإ‬ঊо &KDLU  ̡̛ܹٕ‫ۏ‬о Ϡ୊Ԅ۰ࡌ˕̛о
&KDLU  ߦоୂɼо ˈࠒ࣯‫ࠝࢇ؂ߦ۔‬હ

=5+.?  =5+.?  =51%? 1DQRILOP FRDWLQJ RQ PHVHQFK\PDO VWHP FHOO WR =5+.? 
0HVHQFK\PDO VWHP FHOOV IRU LQWHUYHUWHEUDO GLVF UHSDLU *ORZLQJ VHQVRUV IRU FRQWLQXRXV JOXFRVH PRQLWRULQJ PDLQWDLQ VXVWDLQHG HIIHFW RI SURPRWLQJ FKRQGURJHQHVLV  'HYHORSPHQW RI SDWLHQW VSHFLILF FURZQ DQG URRW DQDORJXH
ଛࢆ‫ؼ‬८ࢂ˕ଝо ଭࡩࢺˁஜо ଛࡿࠏࠉ‫ۿ‬о GHQWDO LPSODQW PRGXOH
=51%? (IIHFW RI IXQFWLRQDO DGGLWLYHV RQ PHFKDQLFDO SURSHUWLHV ࣌ࡩୋјફࡏ
=5+.?  =5+.?  DQG LQIODPPDWLRQ VXSSUHVVLRQ LQ 3RO\/ODFWLF DFLG FRPSRVLWHV
6PDOO PROHFXOHEDVHG OLQHDJH VZLWFK RI KXPDQ DGLSRVHGHULYHG ,PDJHJXLGHG ORFDO GUXJ GHOLYHU\ ZLWK QDQRSDUWLFOHV WR IRU ELRPHGLFDO DSSOLFDWLRQV    =5+.? 
VWHP FHOOV LQWR QHXUDO VWHP FHOOV DQG IXQFWLRQDO *$%$HUJLF PRGXODWH WXPRU PLFURHQYLURQPHQW 70( IRU WXPRU WUHDWPHQW ʅࡲࠏ८ࢂ˕ଝо 'HYHORSLQJ HFRQRLPFDO PDQXIDFWXULQJ WHFKQLTXHV IRU DURPDWLF
QHXURQV ‫ࡆ؀‬ԃ८ࢂ˕ଝо =51%? 6WXGLHV RQ F\WRWR[LFLW\ DQG LQ YLYR ELRVDIHW\ RI 3((. SRO\NHWRQHV DQG WKHLU UHLQIRUFHG FRPSRVLWHV FRPSUHVVLYH
࢝‫ܷײ‬۰ࡌо ৔о FRPSRVLWH IRU VSLQH FDJH           VWUHQJWK !  03D IRU PHGLFDO DSSOLFDWLRQV
=5+.?  ࢴ࣮ࡆ‫˗̎۽‬о ̞ࠏ࣮‫˗̎۽‬о
=5+.?  +XPDQ %%%RQDFKLS IRU GUXJ GLVFRYHU\ =51%? :DWHU VROXEOH FHULD QDQRSDUWLFOHHPEHGGHG FRQWDFW
6HOHFWLYH HOLPLQDWLRQ RI FXOWXUHDGDSWHG KXPDQ HPEU\RQLF VWHP ‫؀‬੐ࡲ81,67 OHQV IRU WKH WUHDWPHQW RI GU\ H\H V\QGURPH =5+.? 
FHOOV ZLWK %+ PLPHWLFV ন‫˗̎۽ࡆݠ‬о 'HYHORSPHQW RI KLJKVWUHQJWKELRUHVRUEDEOH SRO\JO\FROLF
५ିऎ۰ࡌо ߟо =5+.?  =51%? 7XPRU WDUJHWLQJ 3/*$ QDQRSDUWLFOHV IRU FKHPRWKHUDS\ DFLGEDVHG EORFN FRSRO\PHUV DQG WKHLU UHLQIRUFHG FRPSRVLWH ZLWK
$SSOLFDWLRQ RI QDWXUDO UHVRXUFHGHULYHG ELRPDWHULDOV ZLWK      DWHQVLOH VWUHQJWK RI  03DRU KLJKHU IRU VSLQDO IL[DWLRQ
=5+.?  QDQRWHFKQRORJ\ DQG ' SULQWLQJ WHTXHQLFV ࣌୾‫ה‬ଞ˲ࡕ࢕ԯࢂଝࡕ ࢝ࠏࡇଞߦо
5HDOWLPH PRQLWRULQJ RI JOXWDWKLRQH LQ OLYLQJ FHOOV UHYHDOV D ۱ࡆ୮ܻঊо =51%? 5\OHQH G\HV HQFDSVXODWHG SRO\PHULF QDQRSDUWLFOHV IRU

UHTXLUHPHQW RI LWV KLJK OHYHOV IRU PDLQWDLQLQJ VWHP FHOO FHOOXODU GHWHFWLRQ DQG LPDJLQJ           =5+.? 
IXQFWLRQ =5+.?  ʅ‫״‬ʾٕˁо 'HYHORSPHQW RI ELRORJLFDO ZRXQG GUHVVLQJ PDWHULDOV XVLQJ
‫ݣ‬ѭֵࡌ‫ࢂۏ‬о ۰ࡌ߅‫ࡕػۏ‬ '1$ QDQRWHFKQRORJ\ PHUJHG ZLWK VHPLFRQGXFWRU WHFKQRORJ\ =51%? ' +XPDQ %ORRG%UDLQ %DUULHU LQ YLWUR PRGHO IRU ELRDFWLYH SURWHLQV GHULYHG IURP KXPDQ DGLSRVH WLVVXH
‫ࢉ࣮ࠏܛ‬ঊо WHVWLQJ %%%RSHQLQJ DJHQWV                   ࣌ࡅࡆଞߦо
=5+.?  ۭܶࠏ.,67
7KH DSSOLFDWLRQV RI NLGQH\ RUJDQRLGV GHULYHG IURP KXPDQ =51%? ,Q VLWX K\GURJHODWLRQ LQ D GHHS WLVVXH XVLQJ DOWHUQDWLQJ =5+.? 
L36&V PDJQHWLF ILHOG DQG PDJQHWLF QDQRSDUWLFOHV 'HYHORSPHQW RI IXQFWLRQDOL]HG PHGLFDO JUDGH ELRGHJUDGDEOH
̞ࡅ̋ɼ੸պࢂо ࢄ୚࢟˝࣯˕̛ࡕ SRO\HVWHU
=51%? 6LOLFRQH LPSODQWV FDSDEOH RI WKH ORFDO FRQWUROOHG ˅ࠏ࣬‫ࠝࢇ؂ߦ۔‬હ
GHOLYHU\ RI WULDPFLQRORQH IRU WKH SUHYHQWLRQ RI ILEURVLV ZLWK
PLQLPL]HG GUXJ VLGH HIIHFWV      =521 ` 21? 2GTHQTOCPEG 4GRQTV QH 2TQLGEV HQT 6GEJPKECN
‫ظݣ‬ୋ۰ࡌо &GXGNQROGPV QH /CVGTKCN 2CTVU
=51%? &KDUDFWHULVWLFV RI KXPDQ QDVDO VHSWDO FDUWLODJHGHULYHG
SURJHQLWRUV HQFDSVXODWHG LQ FROODJHQ DV LQMHFWDEOH WKHUDSHXWLF
DJHQW IRU FDUWLODJH GHIHFW UHSDLU
ࢋ‫ײ‬ୀɼ੸պо
=51%? $QWLWXPRU HIIHFWV RI LQWUDDUWHULDO GHOLYHU\ RI
XOWUDVRXQG DFWLYDWHG PLFUREXEEOHGR[RUXELFLQ ORDGHG DOEXPLQ
QDQRSDUWLFOH IRU WUDQVDUWHULDO FKHPRHPEROL]DWLRQ RQ 9; UDEELW
OLYHU WXPRUV
̞ѣࠆ۰ʈо
 $ZDUGLQJ &HUHPRQ\ <RXQJ 6FLHQWLVW $ZDUG DQG 5HFHSWLRQ
&$%, :U`` AYYh]b[ cZ H\Y ?cfYUb GcW]Yhm Zcf 6]caUhYf]U`g                                  

1EV  

(TK
6KOG +PVGTPCVKQPCN EQPHGTGPEG TQQO
 #WFKVQTKWO
 .GEVWTG TQQO $


 5HJLVWUDWLRQ3RVWHU ,QVWDOODWLRQ

(TQO 4GUGCTEJ VQ %QOOGTEKCNK\CVKQP  &KDLU  ର॰ࠒٗк۰ࡌо‫ࣱۘ؃ ࡕػ‬ଞ˲ࡕ࢕ԯࢂଝࡕ

=+.? &OLQLFDO DSSOLFDWLRQ RI WKUHHGLPHQVLRQDOO\ SULQWHG ELRPDWHULDO SRO\FDSURODFWRQH3&/ LQ DXJPHQWDWLRQ UKLQRSODVW\
 ‫ࠏ؀‬ऎʈΧ‫۽۽۔‬୉࠹˕ࢂࡕ

=+.? &KLQHVH FRVPHWLFV PDUNHW SUHVHQW FRQGLWLRQ DQG SURVSHFW

ࢄऎ୆ࢿࢇࣱ਍‫֩ݛ‬બ

%QORCP[ 5GUUKQP ǫ
&KDLU  ࢽ࡬̛.,67 ʈଞॷɼо

=%5? 
 +RZ IDU KDYH UHJHQHUDWLYH PHGLFLQH DQG ' ELRSULQWLQJ WHFKQRORJ\ FRPH LQ FOLQLFDO 3RVWHU 3UHVHQWDWLRQ 6HVVLRQ ǥ
XVH"
ࢄଯ࣬Իੇ
=%5? 
,QWURGXFWLRQ RQ &ROODJHQ 6ROXWLRQV 3/&
‫ࡅॴ؀‬ਐԂʰ‫ܙ‬Ք‫܊‬इ

 /XQFK

5GUUKQP   2TQITGUU KP & RTKPVKPI  & 2NCVHQTOU HQT 6KUUWG 'PIKPGGTKPI 5GUUKQP   /GFKECN %QUOGVKE 4GUGCTEJ + 5GUUKQP   5VWFGPV 1TCN %QORGVKVKQP ǫ
&KDLU  ࡬ஜܺࢢՎࠉ˱‫ࡕ۽̡ ܕ‬ɼ੸պࢂо &KDLU  ̡ऑࡒଞߦо ‫؃‬एࡒ۰ࡌо‫ؿ‬Ԃ֐‫ࡕػ‬ &KDLU  ‫؃‬॰ஜࢷٖо ‫ࢢୃୖ؃‬Վࠉ˱‫ܕ‬

=5+.?  =5+.?  =51%? 526LQGXFHG FHOO VKHHW GHWDFKPHQW DQG WUDQVIHU EDVHG RQ SKRWRVHQVLWLYH
' SULQWLQJ ZLWK PHGLFDO LPDJLQJ IRU FOLQLFDO DSSOLFDWLRQ 5HFHQW WUHQGV LQ FRVPHWLF GHUPDWRORJ\ SRO\PHU ILOP                         
̞Τ˯۰ࡌ߅‫ࡕػۏ‬ ࣌‫ࠆܒ‬۰ࡌࢂо ˮ‫ۿࠉ߂״‬о
=51%? ,QNMHWVSUD\ ODPLQDWLRQ SULQWLQJ IRU IUHHIRUP IDEULFDWLRQ RI JHODWLQH
=5+.?  =5+.?  PHWKDFU\OR\OEDVHG K\GURJHO VWUXFWXUH
'HYHORSPHQW RI ELRPLPHWLF ([YLYR V\VWHP DQG VFDIIROGV RI DOYHRODU ERQH DQG 'LJLWDO WUDQVIRUPDWLRQ LQ GHUPRFRVPHWLFV ࡩ‫ࢺۼ‬3267(&+
PHQLVFXV FDUWLODJH ̞ୀࢺ۰ࡌࢂՎࡕ =51%? 0LFURIOXLGLFVDVVLVWHG IDEULFDWLRQ RI PDFURSKDJH PLFURWLVVXHV ZLWK WXQDEOH
ࢄ‫˝ࡕ࢟ݠ‬о SK\VLFDO SURSHUWLHV IRU GHYHORSLQJ LQ YLWUR PXOWLSOH[ WLVVXH PRGHO       
=5+.?  ࢄѭऎ81,67
=5+.?  3RVWVXUJLFDO UHFRYHU\  UHMXYHQDWLRQ LQ SODVWLF VXUJHU\ =51%? $GKHVLYH KHPRVWDWLF SDWFK XVLQJ PDULQH ELRPDWHULDOV
(PHUJLQJ SODWIRUP WHFKQRORJLHV ' SULQWLQJ  FRWWRQ FDQG\ PDFKLQH ‫ࡆ࢟؀‬%,2 ‫۽‬୉࠹˕ࢂࡕ ࢄ࢟ࡩ3267(&+
‫ۺ‬ଚ࣮ࠉ‫ۿ‬о =51%? 'XDO GHOLYHU\ RI LQVXOLQOLNH JURZWK IDFWRU DQG DGLSRVHGHULYHG VWHP FHOOV

=5+.?  XVLQJ FRDFHUYDWHHPEHGGHG LQWHUSHQHWUDWLQJ FRPSRVLWH K\GURJHOV IRU FDUWLODJH UHSDLU
=5+.?  &OLQLFDO LPSRUWDQFH DQG LPSURYHPHQW GLUHFWLRQ RI ILOOHU LQGXFHG FKURQLF FRPSOLFDWLRQV ࣌େԁࢉঊо
,QNMHWEDVHG ELRSULQWLQJ DQG ELRPDWHULDOV ˅ࢅܶˈ࢈ܹ‫۽‬୉࠹˕ =51%? ' SULQWHG PLFURILEURXV 3&/ELRFHUDPLFV EXQGOHV ZLWK DOLJQHG WRSRORJLFDO
ࢺ‫࣮ۺ‬3267(&+ FXH IRU ERQH WLVVXH UHJHQHUDWLRQ
̞࣬ࠆ‫˗̎۽‬о
=5+.?  =51%? $QWLERG\WDUJHWHG OHXNHPLD VL51$ GHOLYHU\ IRU HQKDQFHG FKHPRWKHUDS\ 
%LRSULQWLQJ IRU UHJHQHUDWLYH PHGLFLQH ࡅ‫آۮ‬ଞߦо
̞‫ࡒۺ‬ɼ੸պࢂо =51%? +LJKWKURXJKSXW VLQJOHFHOO DQDO\VLV RQ WKH PHFKDQRVHQVDWLRQ RI
PDFURSKDJH
̞ࢺ̘ˈԮо
=51%? 7KHUDSHXWLF HIILFDF\SRWHQWLDWHG DQG GLVHDVHG RUJDQWDUJHWLQJ QDQRYHVLFOHV
GHULYHG IURP PHVHQFK\PDO VWHP FHOOV IRU VSLQDO FRUG LQMXU\ WUHDWPHQW       
̞ଛࠏ۰ࡌо
=51%? 6WLPXODWLQJ DQJLRJHQHVLV LQ LVFKHPLF WLVVXH YLD VRODU FHOO
ࢺ̏࢟۰ࡌ‫ࡕػ۽۔‬
 &RIIHH %UHDN
&$%, :U`` AYYh]b[ cZ H\Y ?cfYUb GcW]Yhm Zcf 6]caUhYf]U`g                                  

1EV  

(TK

6KOG +PVGTPCVKQPCN EQPHGTGPEG TQQO

 #WFKVQTKWO
 .GEVWTG TQQO $


5GUUKQP   $KQOCVGTKCNUDCUGF (WUKQP 6GEJPQNQI[ 5GUUKQP   /GFKECN %QUOGVKE 4GUGCTEJ ++ 5GUUKQP   #RRNKECVKQP QH $KQOCVGTKCNU HQT /GFKECN &GXKEG CPF *CTF 6KUUWG
&KDLU  ‫ࢊۿܘ‬८ࢂ˕ଝо ࢽ‫̒ه‬۰ʈо &KDLU  Οࢢࡋܻঊо ଞ‫˝ۿ‬3267(&+ &KDLU  ࢇܹୖѰ˲о ࢇࢢୱࠉ‫ۿ‬о

=5+.?  =5+.?  =5+.? 

&RQGXFWLYH HODVWRPHULF QDQRFRPSRVLWH IRU HOHFWURPHFKDQLFDO FDUGLRSODVW\ )RUPXODWLRQ WHFKQRORJLHV LQ FRVPHWLFV IRU LPSURYHG WRSLFDO DSSOLFDWLRQ RI DFWLYH %LRDFWLYH QDQRSDUWLFOHV IRU GHQWDO DSSOLFDWLRQ
̞л୆۰ࡌо LQJUHGLHQWV ࢄࢺୗЯ˲о
̞ࡅऎ߅ֻԦ૊‫ݤ‬କ
=5+.?  =5+.? 
1DQRHOHFWURQLFHV PHGLDWHG LQ YLYR UHSURJUDPPLQJ IRU QHXURGHJHQHUDWLYH GLVHDVHV =5+.?  5HJHQHUDWLRQ RI SHULLPSODQW WLVVXH E\ XVLQJ RVWHRLQGXFWLYH PDWHULDOV
̞ࣔଔѰ˲о &HUDPLGHEDVHG ELRFRPSDWLEOH VNLQ YHVLFOHV ५࢟˯ࠉ‫ۿ‬о
ࢄ࣮؎਍‫ݛ֑ݛ‬
=5+.?  =5+.? 

(QKDQFLQJ FDQFHU LPPXQRWKHUDS\ XVLQJ ELRPDWHULDOV =5+.?  $GGLWLYH SRO\PHU PDQXIDFWXULQJ LQ GHQWLVWU\ DSSOLFDWLRQ DGYDQWDJH DQG YDULDEOHV
‫؀‬ই˽‫˗̎۽‬о 6WXG\ RQ GHYHORSPHQW RI GHSLJPHQWDU\ FRPSRXQGV EDVHG RQ LQ YLWUR H[SHULPHQW DIIHFWLQJ SURGXFWV
ࢄॴ‫ࡶۮ‬एо գ࣮࢟ˈԮо
=5+.? 
7RXFKDEOH ELRVHQVLWLYH QDQRWRSRORJLFDO PDWHULDOV IRU PROHFXODU GLDJQRVLV =5+.?  =5+.? 
ࢄ‫࢟ۮ‬ΟϠࣗଢ̛ܽࡕ &U\VWDOOL]DWLRQ DQG FURVVOLQNLQJ RI QDWXUDO SRO\PHUV 7KHLU DSSOLFDWLRQ WR FRVPHWLFV &RPSRXQG ' D QDWXUDO FRPSRXQG IURP 6KLLWDNH PXVKURRP LQKLELWV
࣌ࡲঈଞߦо RVWHRFODVWRJHQHVLV E\ PRGXODWLQJ 1)$7F VLJQDOLQJ SDWKZD\V
=5+.?  ̞ʾୗ঻ٖо
$Q HQJLQHHUHG KXPDQ )FPDQQRVHELQGLQJOHFWLQ IRU GLDJQRVWLF DQG WKHUDSHXWLF =5+.? 
DSSOLFDWLRQV (QFDSVXODWLRQ RI IUDJUDQFH LQ SRO\PHULF PLFURFDSVXOHV YLD GURSOHWEDVHG PLFURIOXLGLFV =5+.? 
ʅ࣬ଯ81,67 ࢄ୧‫״‬3267(&+ &31( $ QHZ SURWHLQ IRU WXEXODU GHQWLQ UHJHQHUDWLRQ
‫࣬؀‬ঈ۰ࡌо

 $ZDUGLQJ &HUHPRQ\ 6WXGHQW 2UDO &RPSHWLWLRQ $ZDUG  3RVWHU 3UHVHQWDWLRQ 6HVVLRQ $ZDUG DQG &ORVLQJ 5HPDUN
 Plenary Lecture
10월 18일 (목)
(AM 10:00 ~ 11:20 Chair : Yong-Hee Kim, Ki Dong Park)

PL-1 Bioengineered hydrogels for regenerative medicine

Andrés J. García *
1,

1
Executive Director, Parker H. Petit Institute for Bioengineering and Bioscience, Petit Director's Chair in Bioengineering and
Bioscience, Regents' Professor, George W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology,
Atlanta, GA, U.S.A. [email protected]
PL-2 Emergence of supramolecular biomaterials using polyrotaxane frames
Nobuhiko Yui*
Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, [email protected]

Keynote Lecture
10월 18일 (목)
(PM 14:00 ~ 14:40 Chair : Hansoo Park, Minseok Kwak)

KL-1 Temporal targeting of tumor microenvironment using self-assembled localized hydrogels

Avinash Bajaj*
Regional Centre For Biotechnology, NCR Biotech Cluster, Faridabad-121001. [email protected]

KL-2 Interventional image guided therapeutic delivery and multifunctional carriers

Dong-Hyun Kim1,2,*
Department of Radiology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA, 2Robert H.
1

Lurie Comprehensive Cancer Center, Chicago, Illinois 60611, USA, [email protected]

 Oral Presentation I
10월 18일 (목)

Company Session I

(AM 11:20 ~ 12:40 Chair : 나건, 권오형)

CS-1 Artificial grafts for soft tissue augmentation in implant dentistry

Jin Woo Bae*
GENOSS Co., Ltd [email protected]

CS-2 Recent research trend of new material for cosmetics

YangHee Lee*
H&A PharmaChem Co., LTD [email protected]

CS-3 Reconstruction of human tissue model and its application to toxicity test
Su-Hyon Lee*
R&D Institute, Biosolution Co., Ltd. [email protected]

Session 1 : Recent Advancements in Drug Delivery System

(PM 14:00 ~ 15:40 Chair : Hansoo Park, Minseok Kwak)

S1-IL-1 Tumor microenvironment-responsive nanomedicine for cancer imaging and therapy

Sangyong Jon1,2,*
Department of Biological Sciences, KAIST 2Center for Precision Bio-Nanomedicine, KAIST [email protected]
1

S1-IL-2 Site-specific conjugation of albumin to protein drugs for long acting delivery (SCALADE)
Inchan Kwon1,*, Byeongseop Yang1, Jinhwan Cho1
School of Materials Science and Engineering, Gwanju Institute of Science and Technology (GIST), [email protected]
1

S1-IL-3 L-DNA tetrahedron: A tumor-targeted drug delivery system

Dae-Ro Ahn1,2,*
Center for Theragnosis, Korea Institute of Science and Technology, 2Division of Bio-Med Sci & Tech, UST-KIST School
1

[email protected]

Session 2 : Korean·Chinese·Japanese Young Scientist Session

(PM 14:00 ~ 15:40 Chair : Insup Noh, Yong Kyu Lee)

YS1 Poly(phenylboronic acid): a building block of self-assembled nanoconstruct for biomedical

application
Junseok Lee1, Jinhwan Kim1, Sungjin Jung2, Yeong Mi Lee1, Sooseok Im2, and Won Jong Kim1,2,*
1
Department of Chemistry, POSTECH 2School of Interdisciplinary Bioscience and Bioengineering, POSTECH
[email protected]

YS2 Design, synthesis and biomedical application of new molecular imaging probes
Dan Ding1,*
College of Life Sciences, Nankai University, [email protected]
1

YS3 Fabrication of intracellular ATP-responsive polyion complex micelles for smart nucleotide
therapeutics delivery
Mitsuru Naito1, Naoto Yoshinaga2, Takehiko Ishii2, Akira Matsumoto3, Yuji Miyahara3, Kanjiro Miyata2,
Kazunori Kataoka4,5,*
1
Graduate School of Medicine, The University of Tokyo (7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033 JAPAN) 2Graduate School
of Engineering, The University of Tokyo, 3Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University,
4
Policy Alternatives Research Institute, The University of Tokyo, 5Innovation Center of NanoMedicine, Kawasaki Institute of
Industrial Promotion, [email protected]
YS4 Multifaceted biomedical applications of functional graphene nanomaterials for skeletal muscle tissue
regeneration
Yong Cheol Shin1, Suck Won Hong2, Jin-Woo Oh3, Dong-Wook Han2,*
1
Rsearch Center for Energy Convergence Technology, Pusan National University, Korea, 2Department of Cogno-Mechatronics
Engineering, Pusan National University, Korea, 3Department of Nanoenergy Engineering, Pusan National University, Korea,
*[email protected]
YS5 Development of bacteria-responsive biodegradable polymers for the treatment of bacterial infectious
disease
Menghua Xiong1,*
1
School of Biomedical Science and Engineering, National Engineering Research Center for Tissue Restoration and
Reconstruction, South China University of Technology, [email protected]

YS6 Development of functional nanoparticles for the detection of bacteria

Yuji Tsuchido1,2,*
1
Department of Materials and Life Sciences, Faculty of Science and Technology, Sophia University, 7-1 Kioi-cho, Chiyoda-ku,
Tokyo 102-8554, Japan, [email protected] 2Current address: Bioengineering Laboratory, Cluster for Pioneering
Research, RIKEN, 2-1 Hirosawa, Wako-shi, Saitama 351-0198, Japan.

YS7 3D cell patterning of hydrogel for tissue engineering

Jisoo Shin1, Byungjun Kang2, Hyungsuk Lee2, Seung-Woo Cho1,*
1
Department of Biotechnology, Yonsei University, 2School of Mechanical Engineering,Yonsei University
[email protected]

YS8 Tissue inducing bio-inks for 3D bio-printing

Changshun Ruan1,*, Xinyun Zhai2, Haobo Pan3 and William W. Lu4
1
Research Center for Human Tissue and Organs Degeneration, Institute Biomedical and Biotechnology, Shenzhen Institutes
of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, China, E-mail: [email protected] 2Research
Center for Human Tissue and Organs Degeneration, Institute Biomedical and Biotechnology, Shenzhen Institutes of
Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, China 3Research Center for Human Tissue and
Organs Degeneration, Institute Biomedical and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese
Academy of Sciences, Shenzhen, 518055, China, 4Department of Orthopaedic and Traumatology, The University of Hong
Kong, 21 Sassoon Road, Pokfulam, Hong Kong, China

YS9 Large-scale preparation of hair follicle germs for hair regenerative medicine
Tatsuto Kageyama1,2, Junji Fukuda1,2*
Kanagawa Institute of Industrial Science and Technology, 2Faculty of Engineering, Yokohama National University,
1

[email protected]

YS10 Drug conjugated oxygen nanobubble for therapeutic application

Jangsun Hwang and Jonghoon Choi*
School of Integrative Engineering, Chung-Ang University, Seoul 06974, Republic of Korea

Session 3 : WISET-KSBM Special Session

(PM 14:00 ~ 15:40 Chair : 목혜정, 박수아)

WISET·KSBM-OP-1 Exosome-bioadhesives nanoaggregates for microRNA-based cancer diagnosis

Minjeong Jang1, Jae-Ho Cheong2 and Pilnam Kim1*
1
Department of Bio and Brain Engineering, KAIST, Republic of Korea 2Sevrance Hospital, Yonsei University,
Republic of Korea *e-mail: [email protected]

WISET·KSBM-OP-2 Rapid formation of vascularized micro-tissue using co-culture spheroids

Eun Mi Kim1,2, Hayeon Byun1,2, Heungsoo Shin1,2,*
Department of Bioengineering, Hanyang University 2BK21 Plus Future Biopharmaceutical Human Resources
1

Training and Research Team, Hanyang University [email protected]

WISET·KSBM-OP-3 Age dependent attenuation of cellular mechanosensation

Jungwon Hah1 and Dong-Hwee Kim1,*
1
KU-KIST Graduate School of Converging Science and Technology, Korea University
[email protected]
WISET·KSBM-IL-1 Journey to discovery and development: History of peptide application
Yoon Jeong Park1,2,*
1
Department of Oral Biochemistry/Dental Regenerative Biotechnology Major, Dental Research Institute,
School of Dentistry, Seoul National University, 2NIBEC, Korea [email protected]

WISET·KSBM-IL-2 Gendered innovations in biomedical materials research

Sung Yun Yang1,*
1
Department of Organic Materials Engineering, Chungnam National University, [email protected]

Session 4 : Innovative Stem Cell Research

(PM 16:00 ~ 17:40 Chair : 권태균, 김태형)

S4-IL-1 Mesenchymal stem cells for intervertebral disc repair

Inbo Han*
CHA University, School of Medicine [email protected]

S4-IL-2 Small molecule-based lineage switch of human adipose-derived stem cells into neural stem cells
and functional GABAergic neurons
Mi-Sook Chang*
Lab. of Stem Cell & Neurobiology, Department of Oral Anatomy, Dental Research Institute and School of Dentistry, Seoul
National University, Seoul, Korea, [email protected]

S4-IL-3 Selective elimination of culture-adapted human embryonic stem cells with BH3 mimetics
Seung-Ju Cho1*, Keun-Tae Kim1*, Ho-Chang Jeong1, Ju-Chan Park5, Ok-Seon Kwon5, Yun-Ho Song4,
Joong-Gon Shin1, Seungmin Kang2, Wankyu Kim2, Hyoung Doo Shin1, Mi-Ok Lee3, Sung-Hwan Moon4# and
Hyuk-Jin Cha5#
Department of Life Sciences, Sogang University, Seoul, 04107, Republic of Korea, 2Ewha Research Center for Systems
1

Biology, Division of Molecular & Life Sciences, Ewha Womans University, Seoul, Republic of Korea, 3Immunotherapy
Convergence Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon 34141, Republic
of Korea, 4Department of Medicine, School of Medicine, Konkuk University, Seoul 05029, Republic of Korea 5School of
Pharmacy, Seoul National University, Seoul 08826 [email protected]

S4-IL-4 Real-time monitoring of glutathione in living cells reveals a requirement of its high levels for
maintaining stem cell function
Jisun Lim1,2, Jinbeom Heo1, Eui Man Jeong2, Kihang Choi3, In-Gyu Kim2, Dong-Myung Shin1,*
1
Department of Biomedical Sciences, University of Ulsan College of Medicine, 2Department of Biochemistry and Molecular
Biology, Seoul National University College of Medicine, 3Department of Chemistry, Korea University [email protected]

S4-IL-5 The applications of kidney organoids derived from human iPSCs

Yong Kyun Kim1,2,*
1
Cell Death Disease Research Center, College of Medicine, The Catholic University of Korea, Seoul, Korea; 2Department
of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea [email protected]

Session 5 : KSBM Young Scientist Session

(PM 16:00 ~ 17:40 Chair : 신흥수, 김교범)

S5-IL-1 Glowing sensors for continuous glucose monitoring

Yun Jung Heo1,*
Department of Mechanical Engineering, Kyung Hee University, [email protected]
1

S5-IL-2 Image-guided local drug delivery with nanoparticles to modulate tumor microenvironment (TME) for
tumor treatment
Wooram Park1,*
Department of Biomedical Science, CHA University, Republic of Korea [email protected]
1

S5-IL-3 Human BBB-on-a-chip for drug discovery

Tae-Eun Park1,*
School of Life Sciences, Ulsan National Institute of Science and Technology [email protected]
1
S5-IL-4 Application of natural resource-derived biomaterials with nanotechnology and 3D printing tequenics
Hoon Seonwoo1,*, Taeyoung An1, Ju O Lee1, Sung Hyuk Kim1, and Kyeong Sik Choi1
1
Department of Industrial Machinery Engineering, College of Life Sciences and Natural Resources, Sunchon National
University, Republic of Korea, [email protected]

S5-IL-5 DNA nanotechnology merged with semiconductor technology

Youngjun Song1,*
1
College of Life Science and Bioengineering, Incheon National University, [email protected]

Session 6 : Student Oral Competition I

(PM 16:00 ~ 17:40 Chair : 김기수, 노혜란)

SOC-1 Nanofilm coating on mesenchymal stem cell to maintain sustained effect of promoting
chondrogenesis
Uiyoung Han and Jinkee Hong*
Department of Chemical & Biomolecular Engineering, College of Engineering, Yonsei University, 50 Yonsei-ro,
Seodaemun-gu, Seoul 03722, Republic of Korea, [email protected] (Jinkee Hong)

SOC-2 Effect of functional additives on mechanical properties and inflammation suppression in Poly(L-lactic
acid) composites for biomedical applications
Eun Young Kang1,2, Wooram Park1, Ik Hwan Kim2, and Dong Keun Han1,*
1
Department of Biomedical Science, CHA University 2Department of Biotechnology, Korea University *[email protected]

SOC-3 Studies on cytotoxicity and in vivo biosafety of PEEK composite for spine cage
Joonwoo Chon1, Ji Eun Jung2, Young Jun Kim2, In Sung Jun3, Jae Young Cho3, Da Hyun Jung4,
Jin Ho Kim4, and Dong June Chung1,*
1
Department of Polymer Science & Engineering, Sungkyunkwan University, [email protected], 2School of Chemical
Engineering, Sungkyunkwan University, 3School of Chemical and Biological Engineering, Seoul National University,
4
Department of Chemistry, Incheon National University

SOC-4 Water soluble ceria nanoparticle-embedded contact lens for the treatment of dry eye syndrome
Seung Woo Choi1, Bong Geun Cha2, Jaeyun Kim1,2,3,*
1
Department of Health Sciences and Technology, Samsung Advanced Institute for Health Sciences & Technology (SAIHST),
Sungkyunkwan University (SKKU), 2School of Chemical Engineering, Sungkyunkwan University (SKKU), 3Biomedical Institute
for Convergence at SKKU (BICS), Sungkyunkwan University (SKKU) *[email protected]

SOC-5 Tumor targeting PLGA nanoparticles for chemotherapy

Wheemoon Cho1,2, Eunsun Lee1, Sang Jun Park1, Youngsook Son2 and Chun-Ho Kim1,*
Laboratory of Tissue Engineering, Korea Institute of Radiological and Medical Science, 2Department of Genetic Engineering,
1

College of Life Science and Graduate School of Biotechnology, Kyung Hee University [email protected]

SOC-6 Rylene dyes encapsulated polymeric nanoparticles for cellular detection and imaging
Mingyeong KANG1,2, Minseok KWAK1,*
1
Department of Chemistry, Pukyong National University 2Interdisciplinary Program of Marine Convergence Design, Pukyong
National University [email protected]

SOC-7 3D Human Blood-Brain Barrier in vitro model for testing BBB-opening agents
Suyeong Seo1,2, Seung-Yeol Nah3, Hyewhon Rhim4,5, Kangwon Lee2, Nakwon Choi1,5 and Hong-Nam Kim1,5,*
1
Center for BioMicrosystems, Brain Science Institute, Korea Institute of Science and Technology (KIST) 2Program in Nano
Science and Technology, Graduate School of Convergence Science and Technology, Seoul National University 3Department
of Physiology, College of Veterinary Medicine, Konkuk University 4Center for Neuroscience, Brain Science Institute, Korea
Institute of Science and Technology (KIST) 5Division of Bio-Medical Science & Technology, KIST School, Korea University
of Science and Technology (UST) *[email protected]

SOC-8 In situ hydrogelation in a deep tissue using alternating magnetic field and magnetic nanoparticles
Hwangjae Lee1, Guru Karthikeyan Thirunavukkarasu1, Semin Kim1, and Jae Young Lee1,2,*
1
School of Materials Science and Engineering, Gwangju Institute of Science and Technology 2Department of Biomedical
Science and Engineering, Gwangju Institute of Science and Technology [email protected]
SOC-9 Silicone implants capable of the local, controlled delivery of triamcinolone for the prevention of
fibrosis with minimized drug side effects
Byung Ho Shin1, Chan Yeong Heo2,3,4,5,* and Young Bin Choy1,3,6,*
1
Department of Biomedical Engineering, College of Medicine, Seoul National University, Seoul, Republic of Korea 2Institute
of Human-Enviornment Interace Biology, Seoul National University Medical Research Center, Seoul, Republic of Korea
3
Interdisciplinary Program for Bioengineering, College of Engineering, Seoul National University,Seoul, Republic of Korea
4
Department of Plastic and Reconstructive Surgery, College of Medicine, Seoul National University, Seoul, Republic of Korea
5
Department of Plastic and Reconstructive Surgery, Seoul National University Bundang Hospital, Seongnam, Republic of
Korea 6Institute of Medical & Biological Engineering, Medical Research Center, Seoul National University, Seoul, Repulic
of Korea [email protected]

SOC-10 Characteristics of human nasal septal cartilage-derived progenitors encapsulated in collagen as

injectable therapeutic agent for cartilage defect repair
Mi hyun Lim1, Jung Ho Jeon1, Byeong Gon Yun1, Sun Hwa Park1, Jung Yeon Lim1,*, Sung Won Kim1,2,*
1
Postech-Catholic Biomedical Engineering Institute, College of Medicine, The Catholic University of Korea, Seoul, South
Korea 2Department of Otolaryngology head and Neck Surgery, the Catholic University of Korea, College of Medicine, Seoul,
South Korea *[email protected] *[email protected]

SOC-11 Antitumor effects of intra-arterial delivery of ultrasound activated microbubble-doxorubicin loaded

albumin nanoparticle for trans-arterial chemoembolization on VX2 rabbit liver tumors
Doyeon Kim1, Minkyu Seo1, Jiwon Kim1, Hyuncheol Kim1,2,*
1
Department of Chemical and Biomolecular Engineering, Sogang University 2Department of Biomedical Engineering, Sogang
University *[email protected]

Session 7 : Performance Report of Korea Evaluation Institute of Industrial Technology (KEIT)

(PM 16:00 ~ 17:40 Chair : 양대혁, 고영주)

S7-IL-1 Development of manufacturing technology of patient specific crown and root analogue dental
implants
Yoon Ho Cho1,*, Pan Gyu Kim1, Byoung Kook Kim1, and Sang-Wan Shin1
Department of research and development center, Dentium Co. Ltd, [email protected]
1

S7-IL-2 Developing econoimcal manufacturing techniques for aromatic polyketones and their reinforced
composites (compressive strength > 180 MPa) for medical applications
Sung Keun Park1,*, Hyun Kyung Lee1, Sun Kyun Hwang2, Heon Kyu Kwon3, In Sung Jeon4, Jae Young Jho4,
Seung Mook Lee5, Xin Yang5, Young Jun Kim5, Youn Chul Kim5, Joon Woo Chon5, Dong June Chung5, and
So Hyun Chung6, Jin Ho Kim6
Kolon Plastic, 2IT Chem, 3GS Medical, 4Seoul National University, 5Sungkyunkwan University, 6Incheon National University
1

[email protected] *[email protected]
5

S7-IL-3 Bioresorbable polyglycolic acid-based block copolymers for spinal fixation applications
Young-Wook Chang1,*, Jinho Yang1, Young Jun Kim2, Dong June Chung3 and Jae Young Jho4
Department of Materials and Chemical Engineering, Hanyang University, 2Schhool of Chemical Engineering, Sungkyunkwan
1

University, 3Department of Polymer Science & Engineering, Sungkyunkwan University, 4School of Chemical & Biological
Engineering, Seoul university [email protected]

S7-IL-4 Tissue engineering using human adipose tissue-derived extracellular matrix

Chang Hee Woo, Ye Eun Yun, So Young Park, and Yong Woo Cho*
Department of Material Science & Chemical Engineering, Hanyang University ERICA [email protected]

S7-IL-5 Development of functionalized medical grade biodegradable polyester

Youngjoo Koh1*, Heung Jae Chun2, Young-Hwan Park3 and Juwoong Jang4
R&D center, Samyang Biopharmaceuticals Co, [email protected], 2College of Medicine, the Catholic University
1

of Korea, 3Industrial Convergence Technology Division, Korea Institute of Industrial Technology, 4R&D Center, Cellumed Co.
 Oral Presentation II
10월 19일 (금)

From Research to Commercialization

(AM 10:00 ~ 11:20 Chair : 허찬영, 박상준)

IL-1 Clinical application of three-dimensionally printed biomaterial polycaprolactone(PCL) in augmentation

rhinoplasty
Young Jin Park, MD,PhD1,*
1
Kangnam-Samsug Aesthetic Plastic Surgery, Seoul, S. Korea. 06614 Gangnam Daero 65 Gi-1, Seocho-Gu, Seoul, Korea
E-mail; [email protected]

IL-2 Chinese cosmetics market present condition and prospect

Jin Hyung Lee*
JAYJUN COSMETIC

Company Session II

(AM 11:20 ~ 12:40 Chair : 정윤기, 강한창)

CS-4 How far have regenerative medicine and 3D bioprinting technology come in clinical use?
Heon Ju Lee1,*
ROKIT HealthCare, B-1106, Gabul Great Valley, 32 Digital-ro 9-gil, Geumcheon-gu, Seoul, Korea, [email protected]
1

CS-5 Introduction on Collagen Solutions PLC

Chang Yong Park1,*
APAC Commercial Manager at Collagen Solutions Plc, [email protected]
1

Session 8 : Progress in 3D printing & 3D Platforms for Tissue Engineering

(PM 14:00 ~ 15:40 Chair : 윤희숙, 김성원)

S8-IL-1 3D printing with medical imaging for clinical application

Namkug Kim1,*
Dept. of Convergence medicine Univ. of Ulsan College of Medicine/Asan Medical Center, [email protected]
1

S8-IL-2 Development of biomimetic Ex-vivo system and scaffolds of alveolar bone and meniscus cartilage
Hun-Jin Jeong1, Nae-Un Kang1, Myoung Wha Hong2, Young Yul Kim2, Se-Won Lee3, Jeong-Ho Youn4,
Young-Sam Cho1, Seung-Jae Lee1,*
Department of Mechanical and Design Engineering, Wonkwang University 2Department of Orthopedics, Daejeon St. Mary's
1

Hospital, Catholic University 3Department of Orthopedics, Seoul St. Mary's Hospital, Catholic University 4Department of
Periodontics, Chonbuk National University Dental Hospital [email protected]

S8-IL-3 Emerging platform technologies: 4D printing & cotton candy machine

Hak-Joon Sung1,2
Department of Medical Engineering, College of Medicine, Yonsei University, Seoul, Korea 2Department of Mechanical
1

Engineering, George W. Woodruff School of Mechanical Engineering, Georgia Tech, GA, US.
[email protected] /[email protected]

S8-IL-4 Inkjet-based bioprinting and biomaterials

Sungjune Jung*
Department of Creative IT Engineering / School of interdisciplinary bioscience and bioengineering POSTECH
[email protected]

S8-IL-5 Bioprinting for regenerative medicine

Sung Won Kim1,2,*
1
Department of Otolaryngology-Head and Neck Surgery, Seoul St. Mary's Hospital 2Department of Biomedicine and Health
Science, The Catholic University of Korea [email protected]
 Session 9 : Medical Cosmetic Research I

(PM 14:00 ~ 15:40 Chair : 김진웅, 박지웅)

S9-IL-1 Recent trends in cosmetic dermatology

Soyun Cho*
Department of Dermatology, Seoul National University and Boramae Medical Center, Seoul, Korea [email protected]

S9-IL-2 Digital transformation in dermocosmetics

Hyunjung KIM*
Dept. of Dermatology, Seoul Medical Center [email protected]

S9-IL-3 Postsurgical recovery & rejuvenation in plastic surgery

Jae Woo Park*
BIO Plastic Surgery Clinic [email protected]

S9-IL-4 Clinical importance and improvement direction of filler induced chronic complications
Koh, Iksoo*
KohIksoo Plastic Surgery [email protected]

Session 10 : Student Oral Competition II

(PM 14:00 ~ 15:40 Chair : 박찬희, 박홍현)

SOC-12 ROS-induced cell sheet detachment and transfer based on photosensitive polymer film
Min-Ah Koo1,2, Mi Hee Lee1, Gyeung Mi Seon1,2, Seung Hee Hong1,2 and Jong-Chul Park1,2,*
1
Department of Medical Engineering, 2Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of
Medicine, [email protected]

SOC-13 Inkjet-spray lamination printing for freeform fabrication of gelatine methacryloyl-based hydrogel
structure
Sejeong Yoon1, Ju An Park2, Hwa-Rim Lee2, Woong Hee Yoon3 and Sungjune Jung1,2,3,*
1
Division of Interdisciplinary Bioscience and Bioengineering, Pohang University of Science and Technology 2Department
of Creative IT Engineering, Pohang University of Science and Technology 3Division of Integrative Bioscience and
Biotechnology, Pohang University of Science and Technology [email protected] [email protected]

SOC-14 Microfluidics-assisted fabrication of macrophage microtissues with tunable physical properties for
developing in vitro multiplex tissue model
Dongjin Lee1, Kangseok Lee1, Chaenyung Cha1,*
School of Materials Science and Engineering, Ulsan National Institute of Science and Technology, [email protected]
1

SOC-15 Adhesive hemostatic patch using marine biomaterials

Jaeyun Lee1, Hyo Jeong Kim1, Eun Young Jeon1, Tae Yoon Park1, Geunho Choi1, Eun Jin Kim3, Ki Joo Kim3,
Kye Il Joo1, Bong-Hyuk Choi1,2 Jong Won Rhie3 and Hyung Joon Cha1,2,*
1
Department of Chemical Engineering, Pohang University of Science and Technology 2Nature Gluetech Co., ltd. 3Department
of Plastic Surgery, College of Medicine, The Catholic University of Korea *[email protected]

SOC-16 Dual delivery of insulin-like growth factor and adipose-derived stem cells using coacervate-
embedded interpenetrating composite hydrogels for cartilage repair
Hyeran Cho1, Junhyung Kim2, Byung-Jae Kang2, Kyobum Kim1,*
Division of Bioengineering, College of Life Sciences and Bioengineering, Incheon National University, Incheon, 22012 Korea
1

2
Department of Veterinary Surgery, College of Veterinary Medicine and Institute of Veterinary Science, Kangwon National
University, Chuncheon 24341, Korea

SOC-17 3D printed microfibrous PCL/bioceramics bundles with aligned topological cue for bone tissue
regeneration
JuYeon Kim1, WonJin Kim1, Minseong Kim1, Ji Un Lee1, and GeunHyung Kim1,*
1
Department of Biomechatronic Engineering, College of Biotechnology and Bioengineering, Sungkyunkwan University, Suwon
[email protected]
SOC-18 Antibody-targeted leukemia siRNA delivery for enhanced chemotherapy
Seok-Beom Yong1, Jee Young Chung1, Yong-Hee Kim1,*
1
Institute for Bioengineering, Hanyang University *Corresponding author, [email protected]

SOC-19 High-throughput single-cell analysis on the mechanosensation of macrophage

Jeong-Ki Kim1 and Dong-Hwee Kim1,*
1
KU-KIST Graduate School of Converging Science and Technology, Korea University [email protected]

SOC-20 Therapeutic efficacy-potentiated and diseased organ-targeting nanovesicles derived from

mesenchymal stem cells for spinal cord injury treatment
Han Young Kim1, Hemant Kumar2, In-Bo Han2,*, Byung-Soo Kim1,*
1
School of Chemical and Biological Engineering, Seoul National University, Seoul 2Department of Neurosurgery, CHA
University, CHA Bundang Medical Center [email protected]

SOC-21 Stimulating angiogenesis in ischemic tissue via solar cell

Gun-Jae Jeong1, Jin Young Oh2, Yeon-Ju Kim3, Suk Ho Bhang4, Byung-Soo Kim5, and Dong-ik Kim1,*
Division of Vascular Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, 2Department of
1

Materials Science and Engineering, Yonsei University, 3Department of Physiology, School of Medicine, Pusan National
University, 4School of Chemical Engineering, Sungkyunkwan University, 5School of Chemical and Biological Engineering,
Seoul National University, [email protected].

Session 11 : Biomaterials-based Fusion Technology

(PM 16:00 ~ 17:40 Chair : 손세일, 정봉근)

S11-IL-1 Conductive elastomeric nanocomposite for electromechanical cardioplasty

Dae-Hyeong Kim1,2,*
Center for Nanoparticle Research, Institute for Basic Science 2School of Chemical and Biological Engineering Seoul National
1

University, Seoul 08826, Korea

S11-IL-2 Nanoelectronices mediated in vivo reprogramming for neurodegenerative diseases

JongPil Kim1,*
1
Dept. of chemisty, Dongguk University, [email protected]

S11-IL-3 Enhancing cancer immunotherapy using biomaterials

Chun Gwon Park1,*
1
Department of Biomedical Engineering, SKKU Institute for Convergence, ungkyunkwan University (SKKU)
[email protected]

S11-IL-4 Touchable bio-sensitive nanotopological materials for molecular diagnosis

Seok Jae Lee*, AND Kyoung G. Lee
NanoBio Application Team, National Nanofab Center (NNFC), [email protected]

S11-IL-5 An engineered human Fc-mannose-binding-lectin for diagnostic and therapeutic applications

Joo H. Kang*
Department of Biomedical Engineering, School of Life Sciences, UNIST, [email protected]

Session 12 : Medical Cosmetic Research II

(PM 16:00 ~ 17:40 Chair : 나재운, 한세광)

S12-IL-1 Formulation technologies in cosmetics for improved topical application of active ingredients
Eun-mi Kim and Yong-Jin Kim1,*
Materials Lab, R&D unit, Amorepacific corp, [email protected]

S12-IL-2 Ceramide-based biocompatible skin vesicles

Jun Bae Lee*
Innovation Lab, Cosmax R&I Center, [email protected]
S12-IL-3 Study on development of depigmentary compounds based on in vitro experiment
Chang Seok Lee*
Department of Beauty and Cosmetic Science, Eulji University, [email protected]

S12-IL-4 Crystallization and crosslinking of natural polymers: Their application to cosmetics

Hyung Jun Lim1, Do Hoon Kim2, Ji Eun Song3, and Eun Chul Cho3,*
1
Amorepacific Corporation R&D Center, 2ANCORS, 3Department of Chemical Engineering, Hanyang University,
[email protected]

S12-IL-5 Encapsulation of fragrance in polymeric microcapsules via droplet-based microfluidics

Hyomin Lee1,*
Department of Chemical Engineering, Pohang University of Science and Technology (POSTECH), [email protected]
1

Session 13 : Application of Biomaterials for Medical Device and Hard Tissue

(PM 16:00 ~ 17:40 Chair : 이수홍, 이재훈)

S13-IL-1 Bioactive nanoparticles for dental application

Jung-Hwan Lee1,*
1
Department of Biomaterials Science in Dental College & Institute of Tissue Regeneration Engineering, Dankook University,
Cheonan, Korea, [email protected]

S13-IL-2 Regeneration of peri-implant tissue by using osteoinductive materials

Jae-Kook Cha1,*
Department of Periodontology, College of Dentistry, Yonsei University, [email protected]
1

S13-IL-3 Additive polymer manufacturing in dentistry; application, advantage, and variables affecting products
Jae Jun Ryu1,*
Anam Hospital, Korea University, [email protected]
1

S13-IL-4 Compound D, a natural compound from Shiitake mushroom, inhibits osteoclastogenesis by

modulating NFATc1 signaling pathways
Sheunghun Lee1, Jisu Lee1, Sun-Ju Yi1, Kyunghwan Kim1,*
School of Biological Sciences, Chungbuk National University, [email protected]
1

S13-IL-5 CPNE7, A new protein for tubular dentin regeneration

Joo-Cheol Park1,*
School of Dentistry, Seoul National University, [email protected]
1
 Poster Session I
10월 18일 (목)

분야 0 : Performance Report of Korea Evaluation Institute of Industrial Technology (KEIT)

PO-1 The development of rapid diagnosis kit for dengue fever and dengue hemorrhagic fever
Sang-Jin Park1,*, Tae Yong Kim1, Dong Hoon Shin2, Jeeyong Kim3 and Min Soo Kim1
Diagnosis Headquarters, ImmuneMed, Inc., 2Department of Laboratory Medicine, Hallym University, 3Department of
1

Laboratory Medicine, Korea University *[email protected]

PO-2 Development of acute myocardial infarction diagnostic technology with time-resolved fluorescence
detection
Hanshin Kim1, Jong-Myeon Park1, Heejun Kim1, Sungjoon Kim1* and Kyujeong Song1
R&D Center, Precision Biosensor Inc., [email protected], [email protected]
1

PO-3 Development of natural product for improving menopausal symptoms, such as hot flash, arthralgia,
sleep disorder, depression and fatigue
Yongwook Lee1,*, Chulyung Choi2, Jaeyong Kim2, Huwon Kang2, Doolri Oh2, Gyuok Lee2, Chansung Park1,
Junkee Hong1, Joohyun Oh1, Sukkyung Lee1, Suhyon Kim1, Jimin Kim1, Inae Kwak1, Haneul Jo1
Herbal Hormone Research Institute, Naturalendo Tech Co., Ltd 2Jeonnam Institute of Natural Resources Research
1

[email protected]
PO-4 Development of fluorescence, hematolysis, dilution, cleaning and attaching agents in hematology
analysers for the comprehensive analysis of whole blood
Jin Woo Park1,*, Seong Jong Park2, Yong Goo Kim3, Tae Gyu Nam4
BioActs, Inc., 2New Optics, Inc., 3Seoul St Mary's Hospital, College of Medicine, The Catholic University of Korea,
1

Department of Pharmacy and Institute of Pharmaceutical Science and Technology, Hanyang University *[email protected]
4

PO-5 ACCEL ELISA for highly sensitive rapid simple and convenient detection of aflatoxin B1 in maize
Yoon Jae Lee, Haeyoung Eo, Yeonsu Park and Sun Hee Lim*
Plexense, Inc., Yongin-si, Gyeonggi-do 17015, Republic of Korea *E-mail: [email protected]

PO-6 Development of an injectable tissue adhesive for surgical applications

Kyung-Hee Hwangbo1, Jin Woo Bae1,*, Ki Dong Park2 and Sung-Min Jung1
GENOSS Co., 2Dept. of Molecular Science & Tech., Ajou University *[email protected]
1

PO-7 Development of next generation implant: high strength, durability and low elastic modulus Ti alloy
applied biomedical implant and growth factor added functional implant
Jong Hwan Lee1, Pan Gyu Kim1, Yoon Ho Cho1,*
Department of research and development, Dentium. Co. Ltd. *[email protected]
1

PO-8 Development of magnetic-antibody fusion technology for multiplex real-time diagnosis of infectious
diseases
JinWoo Park1*, JaeHo Choi1, Euiyul Choi2, Jae-Seok Kim3
1
BioActs Co. Ltd., 2Boditech Med Inc., 3Department of Laboratory Medicine, Hallym University College of Medicine,
*[email protected]
PO-9 Development of innovative technology for high sensitive in vitro diagnostics based on multifunctional
magnetic beads
SungIl Kim, Young-Seon Joo, Jae-Wan Jung, Saem Mun, Myoung-Ho Kim, Soonil Kwon, Myung Ryul Lee*
AMOLIFESCIENCE Co., Ltd., Gangneung, 25451, Republic of Korea *[email protected]

PO-10 Wound healing effect of a novel extracellular matrix sheet dressing derived from human adipose
tissue in rat skin defect model
Yoonjae Lee2, Sujin Lee1, Kijoo Kim2, Suko Moon2, Jongwon Rhie2,*
Department of Biomedicine and Health Sciences, College of Medicine, The Catholic University of Korea 2Department of
1

Plastic and Reconstructive Surgery, College of Medicine, The Catholic University of Korea. *[email protected]
PO-11 Development of FGF7 with collagen pad for improvement mature protein stability
Young Sik Kim1,2, You Lim Bang1, In Keun Kim1, Jung Soo Lee1 and Ju Woong Jang1,*
1
The Institute of Biomaterial and Medical Engineering, Cellumed CO., Ltd, Korea 2Department of Molecular Science and
Technology, School of Medicine, Ajou University, Suwon, Republic of Korea
Tel(02)2104-0475/Fax(02)2104-0479; e-mail: [email protected]
PO-12 Whole process the up & down stream and analysis of recombinant human bone morphogenetic
protein-2 activity produced by CHO cell expression system
Young Sik Kim1,2, Eun-Lee1, You-Lim Bang1, In Keun Kim1 and Ju Woong Jang1,*
1
The Institute of Biomaterial and Medical Engineering, Cellumed CO., Ltd, Korea 2Department of Molecular Science and
Technology, School of Medicine, Ajou University, Suwon, Republic of Korea
Tel(02)2104-0475/Fax(02)2104-0479; e-mail: [email protected]

PO-13 Hydrophilic treated silk fiber reinforced hydrogel with non-invasive, high modulus and toughness
Sungsoo Lim1, Jinwoo MA1, Ramesh Subbiah2, Kwideok Park2,*, Jeong-Yun Sun1,*
1
Department of Materials Science and Engineering, Seoul National University 2Center for Biomaterials, Biomedical Research
Institute, Korea Institute of Science Technology *[email protected], *[email protected]

PO-14 Medium optimization of lactobionic acid production of pseudomonas taetrolens by response surface
methodology
Bo-Young Jeong, Young-Ah Jang, Jang-Ho Kim, Si-Beom Seong and Gyeong Tae Eom*
1
Bio-based Chemistry Research Center, Korea Research Institute of Chemical Technology (KRICT), 406-30, Jongga-ro,
Ulsan, Republic of Korea Email : [email protected]

분야 I : Functional biomaterials

PO-15 Fabrication of calcium deficiency hydroxyapatite microspheres for bioapplications

Kyubin Byun1,2, Honghyun Park1, Hui-suk Yun1,2,*
1
Korea Institute of Materials Science(KIMS), Changwon, South Korea 2
Korea University of Science and Technology(UST),
Daejeon, South Korea [email protected]

PO-16 Promotion of diabetic wound healing by injectable chitosan hydrogels with antioxidant activity
Dieu Linh Tran, Phuong Le Thi, Thai Thanh Hoang Thi, and Ki Dong Park*
Department of Molecular Science and Technology, Ajou University [email protected]

PO-17 Calcium peroxide-mediated surface modification of biopolymers for antifouling substrates

Jeong Ah An, Kyung Min Park*
Department of Bioengineering and Nano-Bioengineering, Incheon National University [email protected]

PO-18 Dermal fillers market analysis for skin care application

Se Lee Kang1,2, Hyeok Mi Kwon2, and Dae Hyeon Lim2,*
Department of New Material Engineering, Hong-Ik University 2Idea Commercialization Center, KISTI, Seoul 02456, Korea
1

[email protected]

PO-19 Evaluation of antimicrobial and thrombosis activity of multi-functional cardiac catheter

Gyeung Mi Seon1,2, Mi Hee Lee1, Min-Ah Koo1,2, Seung Hee Hong1,2, Ye Jin Park1,3, Ki Dong Par4
and Jong-Chul Park1,2,3*
1Cellbiocontrol Laboratory, Department of Medical Engineering, 2Brain Korea 21 PLUS Project for Medical Science,
3
Department of Medical Device Industry, Yonsei University College of Medicine, 4Department of Molecular Science and
Technology, Ajou University [email protected]

PO-20 Developing a recombinant secondary antibody mimic in immunoassays

Yoonji Bae*, Hyukjun Choi*, Seong Guk Park and Sebyung Kang
Department of Biological Sciences, School of Life Sciences, Ulsan National Institute of Science and Technology (UNIST),
Ulsan, 44919, Korea [email protected]

PO-21 PEG grafting of PMMA based ocular prostheses surface for improving hydrophilicity
Kanghee Cho1, Hye Jin Hong1, Hye Yeon Gong1, Jin Sook Yoon2, and Won-Gun Koh1,*
Department of Chemical and Biomolecular Engineering, Yonsei University, Korea 2Department of Ophthalmology, Severance
1

Hospital, Institute of Vision Research, Yonsei University College of Medicine, Korea *E-mail: [email protected]

PO-22 Study of blood compatible copolymer using MPC and stability of MPC copolymer and polyolefin
elastomer composite
Seung Kyun Yoon1, Dong June Chung1,*
Department of polymer science & engineering, Sungkyunkwan university [email protected]
1
PO-23 In vivo and in vitro study of bio-resorbable polyglycolic acid-based block copolymer composite
for spinal fixation
Seung Kyun Yoon1, Xin Yang2, Young Jun Kim2, Jin-Ho Yang3, Young-Wook Chang3, Han Seung Ko4,
Do Young Lee4, Jae Young Jho4, Dong June Chung1,*
1
Department of polymer science & engineering, Sungkyunkwan University 2Department of chemical engineering,
Sungkyunkwan University 3Department of material &chemical engineering, Hanyang University 4School of chemical and
biological engineering, Seoul National University [email protected]

PO-24 Polymer-based non-penetrated sunscreen agent

Yohan Jeong, Sukyoung Heo, hee suk hwang, and Kun Na*
Center for Photomedicine, Department of Biotechnology, The Catholic University of Korea, Bucheon-si, Gyeonggi do, 14662,
Republic of Korea. [email protected]

PO-25 Toward durable antibacterial coating based on structural change in polysaccharide multilayer film
Sohyeon Park, Jiwoong Heo and Jinkee Hong*
Department of Chemical & Biomolecular Engineering, College of Engineering, Yonsei University, Seoul, 03722 Korea
*[email protected]
PO-26 Core-shell structural bio-mimic nanoparticle with polysaccharide and photosensitizer for tumor
therapy
Changjoo Lee1, Jieun Han1, Kun Na1,*
Department of Biotechnology, The Catholic University of Korea [email protected]

PO-27 Fabrication of micro-sized injectable gene carrier for clinical application

Hye Jin Kim1, Se Won Yi1, Hyun Jyung Oh1, Jung Sun Lee1, Ji Sun Park1 and Keun-Hong Park1*
Department of Biomedical science, collage of Life science, CHA University, Korea [email protected]
1

PO-28 Toughness enhancement of polyelectrolyte hydrogel with skin adhesion

Jung Min Hwang1, Yang Ho Na1,*
Department of Advanced Materials & Chemical Engineering, Hannam University [email protected]
1

PO-29 The research for a design of shape memory polymer of biocompatible TPU can be applied as
medical devices
DONGYEOB KWON*, SUKHEE PARK, HAEJIN CHOI, DOO HO KANG and JONGCHUL PARK
Department of Medical engineering, Yonsei University, biomedical engineering, [email protected]

PO-30 Protein identification in human amnion and chorion membrane extracts

Yoonyoung Go1, Jae-Jun Song1,*
Department of Otolaryngology-Head and Neck Surgery, Korea University College of Medicine, [email protected]
1

PO-31 Combinatorial therapeutic effect of NIPEP-H33 on rheumatoid arthritis animal by the inhibition of
IL-6 and IFN-γ cytokine
Da Hyeon Choi1, Kwang-Sook Park2, Dong Woo Lee3, Jue Yeon Lee3, Yoon Jeong Park2,3,*, Yoon Shin Park1,*
1
Major in Microbiology, School of Biological Sciences, College of Natural Sciences, Chungbuk National University, Cheongju
28644, Republic of Korea 2Dental Regenerative Biotechnology, Dental Research Institute, School of Dentistry, Seoul National
University, Seoul, Republic of Korea. 3Central Research Institute, Nano Intelligent Biomedical Engineering Corporation
(NIBEC), Seoul, Republic of Korea. [email protected]

PO-32 Application of ROS releasing hydrogel sheet system for controlling mesenchymal stem cell
senescence
Young Seo Jo1, Da Hyeon Choi1, Joo Young Son2, Ju Kwang Choi1, Kyeong Eun Lee1, Hyojin Lee2,
Inho Jo3, Ki Dong Park2, Yoon Shin Park1,*
1
Major in Microbiology, School of Biological Sciences, College of Natural Sciences, Chungbuk National University, Cheongju
28644, Republic of Korea 2Department of Molecular Science and Technology, Ajou University, Suwon 16499, Republic of
Korea. 3Department of Molecular Medicine & Ewha Tonsil-derived Mesenchymal Stem cells Research Center (ETSRC),
School of Medicine, Ewha Womans University, Seoul 07985 [email protected]

PO-33 Inclusion complex system between thermogelling polymer and alpha-cyclodextrin derivatives
Heeju Kim, Piao Zhengyu and Byeongmoon Jeong*
Department of Chemistry and Nano Science, Ewha Womans University *[email protected]
PO-34 Delivery of immune stimulating peptides to lymph nodes using nature-derived vesicles
Ok Park1, Eun Seo Choi1, Gyeonghui Yu, Jun Young Kim, Yoon Young Kang, Heesun Jung and Hyejung Mok*
Department of Bioscience and Biotechnology, Konkuk University, Seoul, Republic of Korea *[email protected]
1

PO-35 Study of the chemical and physical effect of the polymer substrates on cell culture for application
to microfluidics
Da Reum Kim1, Sung Yun Yang*
1
Department of Polymer Science and Engineering, Chungnam National University, 99 Daehak-ro, Yuseong-Gu, Daejeon
305-764, Korea *[email protected]

PO-36 Alginate-α-TCP based ionically crosslinked hybrid hydrogel for tissue engineering and 3D-printing
applications
Dipankar Das1,2, Tran Nguyen Hao1,2, Janarthanan Gopinathan1,2, and Insup Noh1,2*
Department of Chemical and Biomolecular Engineering, 2Convergence Institute of Biomedical Engineering and Biomaterials,
1

Seoul National University of Science and Technology, Seoul 01811 Korea (Republic of); *[email protected]

PO-37 Enzymatic conjugation of catechol onto chitosan with highly adhesion on wet tissues
Mi Kyung Park1,2, Yoonsun Jang1, Ik Hwan Kim2, and Yoon Ki Joung1,3*
Center for Biomaterials, Korea Institute of Science and Technology, 2Department of Biotechnology, Korea University, 3Division
1

of Bio-Medical Science and Technology, Korea University of Science and Technology [email protected]

PO-38 Reducing friction coefficient of the cross-linked polyethylene by immobilizing poly(sulfobetaine

methacrylate) on the surface
Chung-Man Lim1, Jiae Seo2, Joon Hur2, Yoon Ki Joung1,3, Ji-Hun Seo2*
1
Center for Biomaterials, Biomedical Research Institute, Korea Institute of Science and Technology, 2Department of materials
science and engineering, Korea University 3University of Science and Technology [email protected]

PO-39 Fabrication and characterization of hydrogen peroxide stimuli diselenide compound

Eunsun Lee1,2, Wheemoon Cho1,3, Sang Jun Park1, Yong-Hee Kim2 and Chun-Ho Kim1,*
1
Laboratory of Tissue Engineering, Korea Institute of Radiological and Medical Science, 2Department of Bioengineering,
Institute for Bioengineering and Biopharmaceutical Research, Hanyang University, 3Department of Genetic Engineering,
College of Life Science and Graduate School of Biotechnology, Kyung Hee University *[email protected]

PO-40 Hexanoyl glycol chitosan inhibits senescence and promotes the proliferation of human mesenchymal
stem cells in vitro
Young-Hoon Jeong1, Hye Min Oh2, Seul-Gi Lee1, C-Yoon Kim1, Chanyang Joo2, Hyung-Min Chung1,
Sun-Woong Kang3*, Kang Moo Huh2* and Sung-Hwan Moon1*
1
Department of Medical Science, Konkuk University School of Medicine, Seoul 05029, Korea. 2Department of Polymer
Science and Engineering, Chungnam National University, Daejeon 34134, Korea. 3Predictive Model Research Center, Korea
Institute of Toxicology, Daejeon 34114, Korea. *Correspondence: [email protected] (S.-W.K.); [email protected] (K.M.H.);
[email protected] (S.-H.M)

PO-41 Control of degradation behavior of biodegradable magnesium alloy stent

Hyunwook Kim, Hyein Jeon, Won jong Lee, Yu bin Park, Hyun A Park, Ki Chang Song*
Department of Biomedical Materials, Konyang University *[email protected]

분야 II : Drug and gene delivery systems

PO-42 Coacervate-mediated exogenous growth factor delivery for scarless skin regeneration
Uiseon Park1,#, Min suk Lee2,#, Jin Jeon2, Hee seok Yang2,*, and Kyobum Kim1,*
1
Division of Bioengineering, Incheon National University, Incheon, Republic of Korea 2Department of Nanobiomedical Science
& BK21 PLUS NBM Global Research Center for Regenerative Medicine, Dankook University, Cheonan, Republic of Korea
[email protected]

PO-43 Combination of chemotherapy and photodynamic therapy for cancer treatment with sonoporation effects
Hohyeon Lee1, Suhyeon Park1, Daein Park1, Hyuncheol Kim1,2,*
1
Department of Chemical and Biomolecular Engineering, Sogang University 2 Department of Biomedical Engineering, Sogang
University *[email protected]

PO-44 Mitochondria-targeting nanosized drug carriers having intracellular glutathione-triggered release

Yeon Su Choi, Han Chang Kang*
Department of Pharmacy, The Catholic University of Korea, [email protected]
PO-45 Improved targeting ability of chlorin e6/p18-4 conjugated nanohybrids for photodynamic therapy of
breast cancer
Ye-Ji Kim1, Young-Jin Kim1,*
Department of Biomedical Engineering, Daegu Catholic University [email protected]
1

PO-46 Extracellular vesicles for acidic tumor targeting

Hyuk Lee1 and Eun Seong Lee1,*
Department of Biotechnology, The Catholic University of Korea, [email protected]
1

PO-47 PH/Redox dual-sensitive degradable quantum dot-based breast cancer targeting theranostic agents
Jae Seo Lee1, Na Re Ko2, Md Nafiujjaman4, Yun Hee Youn5, Yong-kyu Lee3,4, and Il Keun Kwon2,*
1
Department of Dentistry, Graduate School, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447,
South Korea 2Department of Dental Materials, School of Dentistry, Kyung Hee University, 26 Kyungheedae-ro,
Dongdaemun-gu, Seoul 02447, South Korea 3Department of Green Bioengineering, Korea National University of
Transportation, 50 Daehak-ro, Daesowon-myeon, Cheongju, Chungcheongbuk-do 27469, South Korea 4Department of
Chemical & Biological Engineering, Korea National University of Transportation, 50 Daehak-ro, Daesowon-myeon, Cheongju,
Chungcheongbuk-do 27469, Republic of Korea 5Interdisciplinary Program for Bioengineering, Seoul National University,
1 Gwanak-ro, Gwanak-gu, Seoul 08826 South Korea [email protected]

PO-48 MT1-MMP responsive doxorubicin conjugated poly(lactic-coglycolic acid)/poly(styrene-alt-maleic

anhydride) core/shell microparticles for intrahepatic arterial chemotherapy of hepatic cancer
Sumin Kang, Enkhzaya Davaa, Ratchanpol Jenjob, and Su-Geun Yang*
Department of New Drug Development, School of Medicine, Inha University, [email protected]

PO-49 Effect of PVA/PVP ratio on microneedle detachability for corneal drug delivery
YeJin Lee1, SeungHyun Park1, WonHyoung Ryu1,*
Department of Mechanical Engineering, Yonsei University [email protected]
1

PO-50 Chemically modified substance P promotes therapeutic effectiveness in diabetic peripheral arterial
disease
Hyun-Ji Park1, Sunna Kim2, Eun Je Jeon1, Soojeong Choi1, Youngsook Son2, Hyun Sook Hong2 and
Seung-Woo Cho1,3,*
1
Department of Biotechnology, Yonsei University, Korea 2College of Medicine/East-West Medical Research Institute, Kyung
Hee University 3Center for Nanomedicine, Institute for Basic Science (IBS), Korea *[email protected]

PO-51 Enteric coated MCM-48 nanoparticles for oral vaccine delivery

Chang Hee Min1+, Se Na Kim1+, and Young Bin Choy1,2,3*
1
Interdisciplinary Program in Bioengineering, College of Engineering, Seoul National University 2Department of Biomedical
Engineering, College of Medicine, Seoul National University 3Institute of Medical & Biological Engineering, Medical Research
Center, Seoul National University *[email protected]

PO-52 Wound dressing utilizing poly(acrylic acid)/poly(lactic-co-glycolic acid) electrospun nanofiber to

enhancing wound healing
Minsu Kim1, Kanghee cho1, So Young Noh1 and Won-Gun Koh1*
1
Department of Chemical and Biomolecular Engineering, Yonsei University, 134 Sinchon-dong, Seodaemoon-gu,
Seoul 120-749, Republic of Korea *[email protected]

PO-53 Development of rhamnolipid nanoparticles for drug delivery and photodynamic therapy in vivo
Gawon Yi1,2, Jihye Yoo1,2, Changhee Park1,2, Donghyun Lee1,2, and Heebeom Koo1,2,*
Department of Medical Lifescience, College of medicine, The Catholic University of Korea 2Department of Biomedicine &
1

Health Sciences, College of medicine, The Catholic University of Korea [email protected]

PO-54 ROS-sensitive thioether-bearing polymers for cancer-targeted therapy

Yoon-Seok Kim1, Sumin Kim2, and Min Suk Shim1*
Division of Bioengineering, Incheon National University, Incheon 22012, Republic of Korea. *Corresponding author:
1

[email protected] 2Department of Pharmacy, College of Pharmacy, The Catholic University of Korea, Gyeonggi-do, Republic
of Korea.

PO-55 Treatment of cholangiocarcinoma with drug-loaded liposomes for photodynamic therapy and
immunotherapy
Taebum Lee1, Dahye Kim1, Kun Na*
Department of Biotechnology, The Catholic University of Korea, [email protected]
1
PO-56 Effective doxorubicin delivery system by control physiochemical dimension of 2D graphene oxide
sheets
Jiwoong Heo1, Junjira Tanum1, Daheui Choi1, Sohyeon Park1, Hyejoong Jeong1, Uiyoung Han1 and Jinkee
Hong1,*
1
Department of Chemical & Biomolecular Engineering, College of Engineering, Yonsei University
E-mail: [email protected]
PO-57 Cancer microenvironment sensitive multi-armed polymeric photosensitizer
Young-Um Jo1, Chung-Sung Lee, Wooram Park Kun Na*
Department of Biotechnology, The Catholic University of Korea, [email protected]
1

PO-58 Preparation and characterization of SPIONs loaded poly(ethylene glycol)-poly(aspartic acid)-

doxorubicin conjugate nanoparticles for cancer theragnosis
Hongcheol Kim1, Yugyeong Kim1, Kang Moo Huh1,*
1
Department of Polymer Science and Engineering, Chungnam National University, 99 Daehak-ro, Yuseong-gu, Daejeon,
34134, Republic of Korea, [email protected]
PO-59 Biomaterial interfaces as localized and sustained AAV delivery platforms
Seung-Hyun Kim1, Slgirim Lee1,2, Heehyung Lee1, Mira Cho1, Joo Won Kim1, and Jae-Hyung Jang1*
1
Department of Chemical and Biomolecular Engineering, Yonsei University, Seoul, Korea, 120-749 2Simpson Querrey Institute
for BioNanotechnology, Northwestern University, Chicago, IL, USA, 60611 Corresponding author e-mail: [email protected]
PO-60 Heptafluorobutyric acid conjugated low molecular weight poly(ethylenimine) for gene delivery
Gyeong Jin Lee1, Jaehong Park1, Minkyoung Lee1, Hye Ji lee1 and Tea-il Kim1*
1
Department of Biosystems & Biomaterials Science and Engineering, College of Agriculture and Life Sciences, Seoul National
University [email protected]
PO-61 Inhibition of metallothionein-dependent cisplatin resistance by RNA interference mediated by non-
viral gene delivery
Yoonsung Song1, Hyunjoon Wee1, Jaehyun Kim1, Sehee Ra1, Yong-Hee Kim1,2,*
Department of Bioengineering, Hanyang University, Seoul, Korea 2Institute for Bioengineering and Biopharmaceutical
1

Research, Hanyang University, Seoul, Korea *[email protected]

PO-62 Intradermal co-delivery of plasmid DNA and hydrophobic adjuvant via dissolving microneedles for
enhanced cancer immunotherapy
Yue Yin, Da Hwun Kim, Jae Baek and Ji hoon Jeong*
School of Pharmacy, Sungkyunkwan University [email protected]

PO-63 hMSC osteogenic differentiation using CaP/ Catechol-HA gene delivery vector by inducing
osteogenic differentiation
E Seul Kim, Jung Eun Lee, Su Yeon Lim, Da Hwun Kim, Jae Baek Jung, Ji Hoon Jeong*
School of Pharmacy, Sungkyunkwan University *[email protected]

PO-64 Enzyme-responsive polymeric micelles by controlled depolymerization for anticancer drug delivery
Seokhee Jo1, Jaehyun Park2, and Won Jong Kim1,2,*
1
Department of Chemistry, POSTECH, 2School of Interdisciplinary Bioscience and Bioengineering, POSTECH
[email protected]
PO-65 Functional DNA modified gold nanomachine for triple combinational anti-tumor therapy
Hyeongmok Park1, Jinhwan Kim2, Sungjin Jung3, Won Jong Kim1,3,*
Department of Chemistry, Pohang University of Science and Technology (POSTECH), Pohang, Korea 2Center for self-
1

assembly and complexity, Institute of Basic Science (IBS), Pohang, Korea 3School of Interdisciplinary Bioscience and
Bioengineering, Pohang University of Science and Technology (POSTECH), Pohang, Korea [email protected]
PO-66 Combination treatment chemotherapy and phototherapy using drug contained HA-GNRs
Geonwoo Lim1, Chanhyun Cho1 and Myoung-Hwan Park1
Department of Chemistry, Sahmyook University, Seoul, Korea, [email protected]
1

PO-67 Improvement of osteogenic effects by controlled growth factor release using double layered cryogel
Jiwoon Jeong1, Seunghun S. Lee1, Jung Hun Kim2, Chan Yeong Heo1,4,5,* and Nathaniel S. Hwang1,2,3,*
Interdisciplinary Program in Bioengineering, Seoul National University, Seoul, Korea 2School of Chemical and Biological
1

Engineering, the Institute of Chemical Processes, Seoul National University, Seoul, Korea 3BioMAX/N-Bio Institute, Seoul
National University, Seoul, Korea 4Department of Plastic and Reconstructive Surgery, Seoul National University Bundang
Hospital, Seongnam, Korea 5Department of Plastic and Reconstructive Surgery, College of Medicine, Seoul National
University, Seoul, Korea *[email protected], *[email protected]
 분야 III : Tissue engineering

PO-68 Lactic acid assisted three-dimensional bioactive fibrous scaffold for tissue engineering : fabrication
strategy and characterization
Sunny Lee1, Mahesh Kumar Joshi2, Chan Hee Park1,3*, Cheol Sang Kim1,3*
1
Department of Bionanosystem Engineering, Graduate School, Chonbuk National University, Jeonju 561-756, Republic of
Korea 2Department of Chemistry, Tri-Chandra Mlutiple Campus, Tribhuvan University, Kathmandu, Nepal 3Divison of
Mechanical Design Engineering Chonbuk National University [email protected], [email protected],
[email protected]

PO-69 Growth factor-immobilized porous microparticles as a cell/growth factor carrier for intervertebral disc
reconstruction
Min Ji Kim1, Jae-Hoon Lee2, Jun-Soo Kim2, Jin Ho Lee3, and Se Heang Oh1,4,*
Department of Nanobiomedical Science, Dankook University, 2Institute of Animal Medicine, College of Veterinary Medicine,
1

Gyeongsang National University, 3Department of Advanced Materials, Hannam University, 4Department of Pharmaceutical
Engineering, Dankook University, *[email protected]

PO-70 Synthesis of the micro/nanopatterned conductive support based on the fiber-templated technique
for neural regeneration
Ji Hong Min1,2, Minsu Kim1, Gyeongju Kim1, and Won-Gun Koh1,*
1
Department of Chemical and Biomolecular Engineering, Yonsei University, Seoul, Republic of Korea, 2Active Polymer Center
for Pattern Integration (APCPI), Yonsei-ro 50, Seoul, Republic of Korea *[email protected]

PO-71 Tailorable nano/macro hybrid fibrous scaffolds fabricated by nanoscale resolution 3D printing for
biomedical applications
Jeong In Kim1, Chan Hee Park3*, Cheol Sang Kim4*
1
Department of Bionanosystem Engineering, Graduate School, Chonbuk National University 2Division of Mechanical Design
Engineering, College of Engineering, Chonbuk National University, E-mail: [email protected] (C.S.Kim), [email protected]
(C.H.Park)

PO-72 Enhaced osteodifferentiation on Ti surfaces with electrochemical nanopattern formation

Su-Jin Song1, Yong Cheol Shin2, Moon Sung Kang1, Yu Bin Lee1, Heejung Seo1, Bongju Kim3, Doohun Kim4,
and Dong-Wook Han1,*
1
Department of Cogno-Mechatronics Engineering, College of Nanoscience & Nanotechnology, Pusan National University,
Busan 46241, Republic of Korea 2Research Center for Energy Convergence Technology, Pusan National University, Busan
46241, Republic of Korea 3Dental Life Science Research Institute & Clinical Translational Research Center for Dental Science,
Seoul National University Dental Hospital, Seoul 03080, Republic of Korea 4Korea Electro-technology Research Institute
(KERI), Changwon 51543, Republic of Korea [email protected]

PO-73 Poly(vinylidene fluoride) composite nanofibers containing polyhedral oligomeric silsesquioxane-(−)-

epigallocatechin gallate conjugate for hard tissue regeneration
Jeong-Hun Kwon1, Jung-Hee Lee2, Young-Jin Kim1,*
Department of Biomedical Engineering, Daegu Catholic University 2Misung Tech Inc *[email protected]
1

PO-74 Metal coordinated adhesive hydrogel based on mussel adhesive protein for stem cell delivery
Seong-Woo Maeng1, Tae Yoon Park1 and Hyung Joon Cha1,*
1
Department of Chemical Engineering, Pohang University of Science and Technology, Pohang 37673, Korea
[email protected]

PO-75 Controlled delivery of stem cell spheroids using a thermally expandable and sticky hydrogels
Jaesung Park1,2, Se-jeong Kim1,2, Heungsoo Shin1,2,*
1
Department of Bioengineering, Hanyang University, Seoul, Korea 2BK21 Plus Future Biopharmaceutical Human Resources
Training and Research Team, Seoul, Republic of Korea *[email protected]

PO-76 Fabrication and characterization of electrospun tubular scaffolds for esophageal tissue engineering
Yanru Wu1, Yun Gyeong Kang2, Eun Jin Lee2, Ji Eun Kim2, Min Ju Kim2, Hyun Ah Nam2
and Jung-Woog Shin1,2,3*
Department of Health Science and Technology. Inje University, 2Department of Biomedical Engineering, Inje University,
1

CMDC/Institute of Aged Life Redesign/UHARC *[email protected]

3

PO-77 Microwell-patterned thermoresponsive hydrogel scaffold for spheroid formation and retrieval of stem
cells
Gyeongju Kim1, Jae Sang Lee, Kyungmin Lee and Won-Gun Koh1,*
Department of Chemical and biomolecular Engineering, Yonsei University, Korea *[email protected]
1
PO-78 Carbon nanofiber incorporated electrically conductive 3D polymeric scaffolds with nano-honeycomb
garland structures for human cartilage tissue engineering
Janarthanan Gopinathan1,6,7, Mamatha M Pillai2, S. Shanthakumari3, S. Gnanapoongothai3, B. K. Dinakar Rai3,
K. Santosh Sahanand4, R. Selvakumar2, Amitava Bhattacharyya1,5,*, Insup Noh6,7,*
1
Advanced Textile & Polymer Research Lab./2Tissue Eng. Lab., PSG Inst. of Advanced Studies, Peelamedu, 3PSG Institute
of Medical Sci. & Res., 4Department of Orthopaedic Surgery, Ortho One Orthopaedic Speciality Centre, 5Dept. of Electronics
& Communication Eng., PSG College of Tech., Coimbatore 641004 India 6Dept. of Chemical & Biomolecular Eng.,
7
Convergence Institute of Biomedical Eng. & Biomaterials, Seoul National Univ. of Sci. and Tech., Seoul 01811 Korea;
*[email protected]; [email protected]
PO-79 Glycation-mediated matrix remodeling induces fibroblast activation
Yunji Lee, Minjung Jang, Heounkyu Lee and Pilnam Kim*
Department of Bio and Brain Engineering, KAIST *[email protected]

PO-80 Chondrogenesis of bone marrow mesenchymal stem cells (BMSCs) in miR-30a-loaded silk/gellan
gum hydrogel
Eun Yeong Shin, Jong Ho Park, David Kim, Myeong Eun Shin, Jeong Eun Song, Muthukumar Thangavelu
and Gilson Khang*
Department of BIN Convergence Technology, Polymer Fusion Research Center, Department of Polymer·Nano Science &
Technology, Chonbuk National University

PO-81 Ultravioleted RPEs helps in differentiation of bone marrow stem cells into retinal pigment epithelial
cells in a direct co-culture environment
Eunyeong Shin, Minjoung Choi, David Kim, Hansol Kim, Jinsu Kim, Jeongeun Song, Muthukumar Thangavelu
and Gilson Khang*
Department of BIN Convergence Technology, Department of PolymerNano Science & Technology and Polymer Materials
Fusion Research Center, Chonbuk National University, 567 Baekje-daero, Deokjin-gu, Jeonju-si, Jeollabuk-do, 54896
Republic of Korea

PO-82 Osteogenesis evaluaiton of bone marrow mesenchymal stem cells (BMSCs) on gallus gallus
domesticus drived DBP sponges
Jong Ho Park1, Eun Yeong Shin1, Myeong Eun Shin1, Jeong Eun Song1, Muthukumar Thangavelu1,
Alessio Bucciarelli2, Claudio Migliaresi2, Antonella Motta2 and Gilson Khang1,*
1
Department of BIN Convergence Technology, Department of PolymerNano Science & Technology and Polymer Materials
Fusion Research Center, Chonbuk National University, 567 Baekje-daero, Deokjin-gu, Jeonju-si, Jeollabuk-do, 54896
Republic of Korea. 2Department of Industrial Engineering, University of Trento, via Sommarive 9, Trento, Italy BIOTech
Research Center, University of Trento, via delle Regole 101, Trento, Italy and European Institute of Excellence on Tissue
Engineering and Regenerative Medicine, Trento, Italy.

PO-83 Generation of traceable gellan gum modified in FITC and evaluation of cell growth rate by density
Jongho Park1, Hunhwi Cho1, David Kim1, Wonkyung Kim1, Eunyeong Shin1, Jeongeun Song1,
Muthukumar Thangavelu1, Isabel Oliveira2, Joaquim Miguel Oliveira2, Rui L. Reis2 Gilson Khang1,*
1
Department of BIN Convergence Technology, Department of PolymerNano Science & Technology and Polymer Materials
Fusion Research Center, Chonbuk National University, 567 Baekje-daero, Deokjin-gu, Jeonju-si, Jeollabuk-do, 54896
Republic of Korea 23B's Research Group - Biomaterials, Biodegradable and Biomimetics, Headquarters of the European
Institute of Excellence on Tissue Engineering and Regenerative Medicine, AvePark, 4805-17, Barco, Guimares, Portugal

PO-84 Gallus gallus var domesticus demineralized bone powder/gellan gum scaffold for osteochondral
tissue regeneration: in vitro evaluation
Han Sol Kim1, David Kim1, Hun Hwi Cho1, Eun Yeong Shin1, Min Joung Choi1, Jeong Eun Song1,
Muthukumar Thangavelu1, Isabel Oliveira2, Joaquim Miguel Oliveira2, Rui L. Reis2 and Gilson Khang1,*
1
Department of BIN Convergence Technology, Department of PolymerNano Science & Technology and Polymer Materials
Fusion Research Center, Chonbuk National University, 567 Baekje-daero, Deokjin-gu, Jeonju-si, Jeollabuk-do, 54896
Republic of Korea 23B's Research Group - Biomaterials, Biodegradable and Biomimetics, Headquarters of the European
Institute of Excellence on Tissue Engineering and Regenerative Medicine, AvePark, 4805-17, Barco, Guimares, Portugal

PO-85 Evaluation of cartilage regeneration using demineralized bone particles incorporated gellan gum
hydrogel
Joo Hee Choi1, Ok Kyun Choi1, Won Kyung Kim1, Ain Park1, Sumi Lee1, Jeong Eun Song1,
Muthukumar Thangavelu1, Joaquim Miguel Oliveira2, Rui L. Reis2 and Gilson Khang*
1
Department of BIN Convergence Technology, Department of PolymerNano Science & Technology and Polymer Materials
Fusion Research Center, Chonbuk National University, 567 Baekje-daero, Deokjin-gu, Jeonju-si, Jeollabuk-do, 54896
Republic of Korea 23B's Research Group - Biomaterials, Biodegradable and Biomimetics, Headquarters of the European
Institute of Excellence on Tissue Engineering and Regenerative Medicine, AvePark, 4805-17, Barco, Guimares, Portugal
PO-86 TGF-β3 conjugated & stiffness regulated hyaluronic acid hydrogel induced chondrogenesis of
human adipose-derived stem cell
Jinsung Ahn1, Bogyu Choi1, Yoshie Arai2, Deogil Kim1, Soo-hong Lee2*
Department of Biomodical Science, CHA university 2Department of medical biotechnology, dongguk university
1

*[email protected]

분야 IV : Nanomedicine

PO-87 M1 macrophage-derived extracellular nanovesicles potentiate the anticancer efficacy of immune

checkpoint blockade therapy
Yeon Woong Choo1,†, Mikyung Kang2,†, Han Young Kim1, Jin Han1, Seokyung Kang1, Ju-Ro Lee1,
Gun-Jae Jeong1, Sung Pil Kwon1, Seuk Young Song1, Seokhyeong Go2, Mungyo Jung1, Jihye Hong2,
Byung-Soo Kim1,2,3,*
School of Chemical and Biological Engineering, Seoul National University, Seoul 08826, Republic of Korea 2Interdisciplinary
1

Program for Bioengineering, Seoul National University, Seoul 08826, Republic of Korea 3Institute of Chemical Processes,
Seoul National University, Seoul 08826, Republic of Korea †These authors contributed equally to this work. *Byung-Soo
Kim, Ph.D., [email protected]
PO-88 Detection and isolation of pancreatic cancer cell secreted exosome by development of lectin-janus
nanoparticles
Yonghyun Choi1, Jangsun Hwang1, Muhammad Saad Khan1, Sachin Ganpat Chavan1, Kyungwoo Lee1, Chanhwi Park1,
Dasom Kim1, Jaehee Jang1, Yejin Kwon1, Joohye Hong1, Nayeong Kim1, Taemu Lee1 and Jonghoon Choi1*
School of Integrative Engineering, Chung-Ang University, Seoul 06974, Republic of Korea [email protected]
1

PO-89 Development of antimicrobial material using silver and copper nanoparticles decorated on graphene oxide
Chanhwi Park1, Jangsun Hwang1, Yonghyun Choi1, Muhammad Saad Khan1, Sachin Ganpat Chavan1,
Kyungwoo Lee1, Dasom Kim1, Jaehee Jang1, Yejin Kwon1, Joohye Hong1, Nayeong Kim1, Taemu Lee1 and
Jonghoon Choi1*
School of Integrative Engineering, Chung-Ang University, Seoul 06974, Republic of Korea [email protected]
1

PO-90 Porous platinum nanoparticles as a high-Z and oxygen generating nanozyme for enhanced
radiotherapy in vivo
Yan Li1, Kum-Hee Yun1, Hyeri Lee1, Sung-Ho Goh2, Yang-Gun Suh3, and Yongdoo choi1*
Biomarker Branch, National Cancer Center, Republic of Korea, 2Therapeutic Target Discovery Branch, National Cancer
1

Center, Republic of Korea, 3Proton Therapy Center, National Cancer Center, Republic of Korea [email protected]
PO-91 Development of bioorthogonally reactive Cas9 protein for multi-functionalization
Ju-Kang Kim1, Hyun Jung Chung1,2,*
Graduate School of Nanoscience and Technology, 2Department of Biological Sciences, Korea Advanced Institute of Science
1

and Technology, Daejeon, Republic of Korea [email protected]

PO-92 TLR-3 based nanovaccine induce anti-tumor immune response against B16F10 melanoma Tumor
Adityanarayan Mohapatra, Santhosh Kalash Rajendrakumar, In-Kyu Park*
Department of Biomedical Science and BK21 PLUS Center for Creative Biomedical Scientists at Chonnam National University,
Chonnam National University Medical School, Gwangju 501-746, Korea.
PO-93 A carboxymethyl dextran-based foreign antigen delivery for cancer immunotherapy
Seok Ho Song1, Jung Min Shin1 and Jae Hyung Park1*
School of Chemical Engineering, Sungkyunkwan University, [email protected]
1

PO-94 Immunogenic porous silicon nanoparticle as a potent cancer vaccine

Hansol Kim1, Moon-Kyoung Jeong1, Jinyoung Kang2, Dokyoung Kim2, Michael J. Sailor2, Ji-Ho Park*
1
Department of Bio and Brain Engineering, KAIST Institute for Health Science and Technology, Korea Advanced Institute
of Science and Technology (KAIST), Daejeon, Republic of Korea 2Department of Chemistry and Biochemistry, University
of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093-0358, United States *[email protected] 1these
authors contributed equally to this work

분야 V : Nano-micro-biotechnology

PO-95 Cellular age dependent attenuated mechanosensation

Jungwon Hah1, Jung-Won Park1, and Dong-Hwee Kim1,*
KU-KIST Graduate School of Converging Science and Technology, Korea University [email protected]
1
PO-96 Durotactic guidance of tumor cell migration in heterogeneous three-dimensional extracellular matrix
Jaesun Ha1, Jeong-Ki Kim1, Geonhui Lee1, and Dong-Hwee Kim1,*
KU-KIST Graduate School of Converging Science and Technology, Korea University *[email protected]
1

PO-97 Development of lectin-exosome binding assay for detection of pancreatic cancer cell
Uiseon Park1, Yonghyun Choi2, Jonghoon Choi2,*, and Kyobum Kim1,*
Division of Bioengineering, Incheon National University, Incheon, Republic of Korea 2School of Integrative Engineering,
1

Chung-Ang University, Seoul 06974, Republic of Korea *[email protected]

PO-98 Biodegradable muco-adhesive MAP- microneedle patch for treatment of aphthous stomatitis
Soo Mee Lim1, Eun Young Jeon1, and Hyung Joon Cha1*
1
Department of Chemical Engineering, Pohang University of Science and Technology, Pohang 37673, Korea
Fax: +82-54-279-5528 E-mail address: [email protected] (H.J. Cha).
PO-99 Physical passivation of herceptine to ZAIS fluorescent nanocrystals for a target-specific cell imaging
Soon-Hee Sul1, Hyunjung Seo1, Seungeon Yeon1, Joung Kyu Park2 and Jong-Jin Jung1,*
Departmmt of Chemistry in Han-Nam University. Daejeon, Korea 2Center for Membranes, Korea Research Institute of
1

Chemical Technology, Daejeon, Korea *Correspondence: [email protected]

PO-100 Synergistic effect of electrical shock and conductive reinforced nanocomposites for inducing hMSCs
into neuron-like cells
Jung Sun Lee1, Se Won Yi1, Hye Jin Kim1, Hyun Jyung Oh1, Ji Sun Park1, Keun Hong Park1,*
1
Department of Biomediacal science, collage of Life science, CHA University, 689 Sampyung-dong, Bundang-gu,
Seongnam-si, Gyenggi-do,463-400, Korea *[email protected]

분야 VI : Bio-imaging

PO-101 Biocompatible polymer coated magnetic nanoparticles for tumor therapy

Joo Young Lee1, Kun Na1,*
Department of biotechnology, The Catholic University of Korea [email protected]
1

PO-102 Formation of periodic mesoporous organosilica nanocubes for bio-imaging

Phornsawat Baipaywad1, Dong Kyung Sung2, Jung-Sub Wi3, Yun Sil Chang2, Taejong Paik1,*,
and Hansoo Park1,*
1
Department of Integrative Engineering, Chung-Ang University 2Department of Pediatrics, Samsung Medical Center,
Sungkyunkwan University School of Medicine 3Center for Nano-Bio Measurement, Korea Research Institute of Standards
and Science *E-mail: [email protected], [email protected]
PO-103 Multivalent mannose-conjugated nanocarriers for pan lymph nodes targeting
Hoon Hyun1,*
Department of Biomedical Sciences, Chonnam National University Medical School *[email protected]
1

PO-104 Supramolecular nanocarrier assembled by heterobifunctional PEG and host-guest complex for
targeted drug delivery
Dae Hyeok Yang, Young Jin Yun and Heung Jae Chun*
Institute of Cell & Tissue Engineering, Department of Biomedical Sciences, College of Medicine, The Catholic University
of Korea Email: [email protected]

분야 VII : Regenerative medicine

PO-105 Enhanced skull bone regeneration by sustained release of BMP-2 in interpenetrating composite
hydrogels
Sungjun Kim1,#, Junhyung Kim2,#, Gajendiran Mani1, Byung-Jae Kang2,*, and Kyobum Kim1,*
Division of Bioengineering, College of Life Sciences and Bioengineering, Incheon National University, Incheon, 22012 Korea
1

2
Department of Veterinary Surgery, College of Veterinary Medicine and Institute of Veterinary Science, Kangwon National
University, Chuncheon 24341, Korea [email protected]
PO-106 Development of stem cell therapeutics with enhanced angiogenic and osteogenic potential to treat
osteonecrosis of the femoral head
Eugene Lee1, Ji-yun Ko2, Songhee Lee2, Juyoung Kim2, Gun-Il Im1,2,*
Department of Orthopedics, Dongguk University Ilsan Hospital, Goyang, Republic of Korea, 2Research Institute for Integrative
1

Regenerative Biomedical Engineering, Dongguk University, Goyang, Republic of Korea *[email protected]

PO-107 Designed anti-inflammatory peptide via dual inhibition of the HDAC and NF-kB pathways for the
treatment of arthritis
Jue Yeon Lee1, Dong Woo Lee1, Beom Soo Jo1, Kwang-Sook Park2, Yoon Shin Park3, Chong Pyoung Chung1,
and Yoon Jeong Park1,2*
Central Research Institute, Nano Intelligent Biomedical Engineering Corporation (NIBEC), 2Dental Regenerative Biotechnology,
1

Dental Research Institute, School of Dentistry, Seoul National University, 3Major in Microbiology, School of Biological Science,
College of Natural Science, Chungbuk National University *[email protected]

PO-108 Amelioration of skin inflammation by anti-inflammatory and anti-microbial peptide

Beom Soo Jo1, Kwang-Sook Park2, Yoon Shin Park3, Chong Pyoung Chung1, and Jue Yeon Lee1*
Central Research Institute, Nano Intelligent Biomedical Engineering Corporation (NIBEC), 2Dental Regenerative Biotechnology,
1

Dental Research Institute, School of Dentistry, Seoul National University 3Major in Microbiology, School of Biological Science,
College of Natural Science, Chungbuk National University [email protected]

분야 VIII : Medical devices

PO-109 Bioresorbable vascular scaffolds by 3D printing system

Jun-Kyu Park1,2, Jae-Woon Nah2,*
1
CGBio Co. Ltd, 2Department of Polymer Science and Engineering, College of Engineering, Sunchon National University
[email protected]

PO-110 Preparation of in-situ pullulan hydrogels as an injectable hemostatic agent

Jiyoung Lee, Suran Kim, Hyeyoung Lee, Oh Hyeong Kwon*
Department of Polymer Science and Engineering, Kumoh National Institute of Technology, Gumi 39177, Korea
*[email protected]
PO-111 Bioresorbable materials and electronics to monitor intracranial pressure and temperature
Jae-Young Bae1, Sung-Geun Choi1, Ju-yong Lee1, Jae-Hwan Lee1, Kyung-Sub Kim1, Gun-Hee Lee1,
Seung-Kyun Kang1,*
1
Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology (KAIST),
[email protected]

PO-112 Application of biocompatible materials as anti-adhesion barrier

Jeongman An1, Young-kyu Lee1,*
1
Department of Chemical and Biological Engineering,,Korea National University of Transportation, Daehak-ro 50, Chungju
27469, Republic of Korea.

PO-113 Guideline development -chemical property evaluation on nickel included intravascular stent
Dong-Kuk Kang1,*, Hyoki Min1, Ina Kim1, Seok-Kyoung Kong1
Medical Supplies Evaluation Center, Korea Testing Laboratory [email protected]
1

PO-114 Local tumor ablation technique combined with immune adjuvant for effective cancer immunotherapy
Eun-Jin Go1, Hanna Yang2, Hong Jae Chon2, Dasom Yang3, WonHyoung Ryu3, Chan Kim2*, Wooram Park1*,
Dong Keun Han1*
Department of Biomedical Science, CHA University, Republic of Korea 2Medical Oncology, CHA Bundang Medical Center,
1

CHA University, Republic of Korea 3School of Mechanical Engineering, Yonsei University, Republic of Korea
*[email protected], *[email protected], and *[email protected]
PO-115 A thermal drawing process for improvement of mechanical properties of biodegradable PLLA stent
with reduced strut thickness
Ginam Han, Wooram Park*, and Dong Keun Han*
Department of Biomedical Science, CHA University *[email protected] and *[email protected]

분야 IX : 3D printing

PO-116 Enhanced osteogenic activities of hybrid structure consisting of fibrilliated collagen layer and PCL
struts for bone tissue regeneration
Soo Jung Chae, Minseong Kim, Ji Un Lee and GeunHyung Kim*
Department of Bio-mechatronic Engineering, College of Biotechnology and Bioengineering, Sungkyunkwan
University(SKKU), *[email protected]
PO-117 Development of new concept laser sintering deposition system for fabrication of 3D bio-ceramic
scaffold
Chang-Hee Lee1, Seung-Hyeok Choi1, Min-Woo Sa2 and Jong Young Kim1,*
Department of Mechanical Engineering, Andong National University 2Research Institute, SJ TOOLS [email protected]
1

*[email protected]
PO-118 Photocrosslinkable hyperbranched polyglycerol (HPG)-based bioink for 3D printing of soft tissue
constructs
Jisu Hong1, Chaenyung Cha1,*
School of Material Science & Engineering, Ulsan Natational Institute of Science and Technology, [email protected]
1

PO-119 Synthesis and characterization of gelatin chain extended polyurethane scaffold for potential cartilage
tissue engineering
Min Jeong Lee1, Sung Wook Choi1,*
Department of Biotechnology, The Catholic University of Korea, [email protected]
1

PO-120 3D-printed composite hydrogel for bone tissue regeneration

Jae-Woo Kim1 and Young-Jin Kim1,*
Department of Biomedical Engineering, Daegu Catholic University [email protected]
1

분야 X : Stem cells

PO-121 The restorable efficacy of human adipose derived stem cell spheroid on skeletal muscle of MDX mouse
Jin Jeon, Min Suk Lee and Hee Seok Yang*
Department of Nanobiomedical Science & BK21 PLUS NBM Global Research Center for Regenerative Medicine, Dankook
University, Cheonan, 330-714, Republic of Korea. *[email protected]
PO-122 Label-free quantitative analysis of human adipose-derived mesenchymal stem cell differentiation
into specific linage
Intan Rosalina Suhito1, Yoojoong Han1, Cheolhwi Kim1, Dayun Park, Hyungbin Son1, Tae-Hyung Kim1,2*
1
School of Integrative Engineering, Chung-Ang University, Seoul 06974, Republic of Korea 2Integrative Research Center
for Two-Dimensional Functional Materials, Institute of Interdisciplinary Convergence Research, Chung-Ang University, Seoul
06974, Republic of Korea *[email protected]
PO-123 Electrochemical detection of human embryonic stem cells using gold nanostructure composites
Intan Rosalina Suhito1, Ee-Seul Kang1, Da-Seul Kim1, Tae-Hyung Kim1,2*
1
School of Integrative Engineering, Chung-Ang University, Seoul 06974, South Korea 2Integrative Research Center for
Two-Dimensional Functional Materials, Institute of Interdisclipinary Convergence Research, Chung Ang University, Seoul
06974, South Korea *[email protected]
PO-124 Biological aging parameters can be improved in old rats after autologous adipose-derived stem
cell injection
Jai Sun Lee, PhD1, Hahn-Sol Bae, MD1, Hye-Youn Son, PhD1, Sundong Kim, PhD2 and Ji-Ung Park, MD1,*
1
Department of Plastic and Reconstructive Surgery, Seoul National University Boramae Medical Center, Seoul, Republic
of Korea 2Senior Science Life Corporation, Seoul, Republic of Korea [email protected]
PO-125 Confirmation of hematopoietic stem/progenitor cells migration to the encapsulated osteoblasts in
hydrogel under mechanical stimulation
Eunjin Lee1, Yungyeong Kang1, Yanru Wu2, Jieun Kim1, Minju Kim1, Minjeong Kim1 and Jung-Woog Shin1,2,3*
Department of Biomedical Engineering, Inje University, 2Department of Health Science and Technology, Inje University,
1

CMDC/Institute of Aged Life Redesign/UHARC, Inje University *[email protected]

3

PO-126 Potential application of human neural crest-derived nasal stem cells in models of alzheimer's
disease as a clinically applicable therapy
Jung Yeon Lim1, Soon A Park2, Sang In Park, Sun Hwa Park1, Byeong Gon Yun1, Sung Won Kim1*
Department of Otolaryngology-Head and Neck Surgery, Seoul ST. Mary's Hospital, The Catholic University of Korea
1

Department of Neurosurgery, SeoulSt.Mary'sHospital, The Catholic University of Korea *[email protected]

2

PO-127 Differention of BMSCs to chondrocyte using a transwell system

Han Sol Kim1, David Kim1, Yongwoon Jeong1, Jeong Eun Song1, Muthukumar Thangavelu1, Isabel Oliveira2,
Joaquim Miguel Oliveira2, Rui L. Reis2 and Gilnson Khang*
1
Department of BIN Convergence Technology, Department of PolymerNano Science & Technology and Polymer Materials
Fusion Research Center, Chonbuk National University, 567 Baekje-daero, Deokjin-gu, Jeonju-si, Jeollabuk-do, 54896
Republic of Korea 23B's Research Group - Biomaterials, Biodegradable and Biomimetics, Headquarters of the European
Institute of Excellence on Tissue Engineering and Regenerative Medicine, AvePark, 4805-17, Barco, Guimares, Portugal
 분야 XI: Other areas

PO-128 Development of poly(HEMA-Am) polymer hydrogel filler for soft tissue reconstruction by facile
polymerization
Sujin Kim1, Chan Yeong Heo2,3,4,5,* and Kangwon Lee1,6,*
1
Department of Transdisciplinary Studies, Graduate School of Convergence Science and Technology, Seoul National
University, Seoul, Republic of Korea 2Institute of Human-Enviornment Interace Biology, Seoul National University Medical
Research Center, Seoul, Republic of Korea 3Interdisciplinary Program for Bioengineering, College of Engineering, Seoul
National University,Seoul, Republic of Korea 4Department of Plastic and Reconstructive Surgery, College of Medicine, Seoul
National University, Seoul, Republic of Korea 5Department of Plastic and Reconstructive Surgery, Seoul National University
Bundang Hospital, Seongnam, Republic of Korea 6Advanced Institutes of Convergence Technology, Gyeonggi-do, Republic
of Korea [email protected]
PO-129 siRNA nanoparticle targeting of Etv2/Er71 inhibited tumor angiogenesis and growth
Ashraf Ul Kabir1,2,#, Tae-Jin Lee3,#, Hua Pan4, Jeffrey C. Berry5, Hee-Kyoung Kang6, Kristina Hinman7,
Lihua Yang5, Samantha Hamilton5, Qingyu Zhou8, Deborah V. Novack5, Robert P. Mecham7, Samuel A.
Wickline4, Mark J. Miller5, Suk Ho Bhang3,*, Kyunghee Choi1,2,9,*
Department of Pathology and Immunology, 2Molecualr and Cell Biology program, 5Department of Medicine, 7Department
1

of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, MO, USA, 3School of Chemical
Engineering, Sungkyunkwan University, 4Health Heart Institute, Morsani College of Medicine, 8Department of Pharmaceutical
Science, College of Pharmacy, University of South Florida, Tampa, FL, USA, 6Department of Pharmacology, School of
Medicine, Jeju National University, Jeju, South Korea, 9Graduate School of Biotechnology, Kyung Hee University, Yongin,
South Korea. #These authors contributed equally, [email protected], [email protected]
PO-130 Upconversion nanoparticles / hyaluronate-rose bengal conjugate complex for noninvasive
photochemical tissue bonding
Seulgi Han1, Byung Woo Hwang1, Eun Young Jeon2, Hyung Joon Cha2 and Sei Kwang Hahn1,*
1
Department of Materials Sciences and Engineering, Pohang University of Science and Technology (POSTECH), 77
Cheongam-ro, Nam-gu, Pohang 790-784, Korea 2Department of Chemical Engineering, Pohang University of Science and
Technology (POSTECH), 77 Cheongam-ro, Nam-gu, Pohang 790-784, Korea *[email protected]
PO-131 Coating techniques using natural-derived substances to inhibit the inflammatory of vascular stents
Ji Yeon Lee1, Ludwig Erik Aguilar2, Joshua Lee2, Joon Yeon Moon2, Chan Hee Park2,3,*, Cheol Sang Kim2,3,*
Department of Mechanical Design Engineering, Chonbuk National University 2Bionanosystem Engineering Department,
1

Chonbuk National University 3Division of Mechanical Design Engineering, Chonbuk National University
[email protected], [email protected], [email protected]
PO-132 Blue light diminishing contact lens from LED displaying devices for human eyes
Junseok Lee1,2, Hongjin Choi1,2, Wonhyung Choi1,2, Hyunsung Jang1, Kitae Park1,2, JeongKoo Kim1,2,*
Department of Biomedical Engineering, Inje University 2Inje bio med center (ICCE), Inje University [email protected]
1

PO-133 Purse string contraction mediated artificial wound healing via stromal cells on 3D microgap model
Avelino Dos Santos Da Costa1,2, In-Suk Choi3, Kwideok Park1,2,*
Center for Biomaterials, Korea Institute of Science and Technology (KIST), Seoul 02792, Republic of Korea 2Division of
1

Bio-Medical Science and Technology, KIST School, University of Science and Technology (UST), Seoul 02792, Republic
of Korea 3Department of Materials Science and Engineering, Seoul National University, Seoul 08826, Republic of Korea
[email protected]
PO-134 Chlorin e6-conjugated hybrid nanoparticles for theranostic application of tumor
Sang-Joon Lee1,*
A Gwangju Health Univ., Gwangju, 62287, Korea, [email protected]
1

PO-135 Lipid conjugated-heparin assembled shape-controllable instant cell aggregate with PGA templates
Eunsol Kim1, Jong Chul Kim1, Kiyoon Min1, Meeichyn Goh1 and Giyoong Tae1,*
1
School of Materials Science and Engineering, Gwangju Institute of Science and Technology, Gwangju 61005, Republic
of Korea [email protected]
PO-136 Hydrogel blends of alginate/pectin with calcium for optimal wound dressing application
Gun-Woo Oh1,2, Seok-Chun Ko2 and Won-Kyo Jung1,2,*
1
Department of Biomedical Engineering, and Center for Marine-Integrated Biomedical Technology (BK21 Plus) Pukyong
National University, Busan 48513, Republic of Korea, 2Marine-Integrated Bionics Research Center, Pukyong National
University, Busan, Republic of Korea *[email protected]
PO-137 In vitro stroke model for dcEF stimulation evaluation
E. M. Ko1, E. Y. Park1, U. H. Ko1 and Jennifer H. Shin1,*
Dept. of Mechanical Engineering, KAIST, Republic of Korea, *[email protected]
1
 Poster Session II
10월 19일 (금)

분야 I : Functional biomaterials

PO-1 A highly permselective electrochemical glucose sensor employing cell membrane

Insu Kim1, Gyudo Lee1 and Dae Sung Yoon1,*
Department of Bio-convergence Engineering, Korea University [email protected]
1

PO-2 Tetronic/β-cyclodextrin-based injectable hydrogels for sustained release of hydrophobic drugs

Hyo Jin Lee, Ho Jun Kwon, Thi Phuong Le, Ki Dong Park*
Department of Molecular Science and Technology, Ajou University [email protected]

PO-3 Nanofiber-infused hydrogels for enhanced mechanical properties and electrical conductivity for
biomedical applications
Suntae Kim1 and Chaenyung Cha1,*
School of Material Science and Engineering, Ulsan National Institute of Science and Technology (UNIST) [email protected]
1

PO-4 Oxygen-generating gelatin-based tissue adhesives for the wound management

Sohee Lee and Kyung Min Park*
Department of Bioengineering and Nano-Bioengineering, Incheon National University, [email protected]

PO-5 Controlled release of growth factors from multifunctional fibrous or bioactive-hydrogel ring scaffold
for functional recoveries in crushed sciatic nerve
Hye Jin Hong1, Byung Ju Yun1, Semin Kim1, and Won-Gun Koh1,*
Department of Chemical & Biomolecular Engineering, Yonsei University [email protected]
1

PO-6 Vitamin D-conjugated gold nanoparticles: osteogenic functionalized drug carrier

Haram Nah1, Donghyun Lee2, Ho-Jin Moon2, Il-Keun Kwon2*
Department of Dentistry, Graduate School, Kyung-Hee University 2Department of Dental Materials, School of Dentistry,
1

Kyung-Hee University [email protected]

PO-7 Targeted hyaluronate - hollow gold nanosphere conjugate for anti-obesity photothermal lipolysis
Jung Ho Lee1, Sei Kwang Hahn1,*
1
Department of Materials Sciences and Engineering, Pohang University of Science and Technology (POSTECH), 77
Cheongam-ro, Nam-gu, Pohang 790-784, Korea *[email protected]

PO-8 Effect of osmotic agent in microneedle on swelling behavior

Seung Hyun Park1, Yejin Lee1, WonHyoung Ryu*
Department of Mechanical Engineering, Yonsei University *corresponding author, [email protected]
1

PO-9 Nanoreactor formation through clustring functionalized protein cage nanobuilding blocks
Hyukjun Choi, Hansol Kim, Sebyung Kang*
Department of Biological Sciences, School of Life Sciences, Ulsan National Institute of Science and Technology (UNIST),
Ulsan, 44919, Korea, E-mail: [email protected]

PO-10 Development of dopamine functionalized polyurethane as anti-fouling adhesive

Joon Woo Chon1, Dong June Chung1,*
Department of Polymer Science & Engineering, Sungkyunkwan University, [email protected]
1

PO-11 Long alkyl chain based organosilicate synthesis and fabrication of multilayer film with bactericidal
effect
Sungwon Jung, Sohyeon Park and Jinkee Hong*
Department of Chemical & Biomolecular Engineering, College of Engineering, Yonsei University *[email protected]

PO-12 Enhanced cancer therapy using pH-sensitive and cancer receptor targeting polymeric nanocarrier
conjugated photosensitizer
Byoung jun Lim1, Chung sung Lee, Kun Na1,*
Department of Biotechnology, The Catholic University of Korea, [email protected]
1
PO-13 Synthesis of biocompatible P(MMA-b-MPC) amphipathic copolymers applicable to biocarriers by
controlled/"living" radical polymerization
Seo Yoon Lee1, Dong June Chung1*
Department of Polymer Science & Engineering, Sungkyunkwan University, [email protected]
1

PO-14 Mussel protein-based magnetically-guidable smart microgels for localized stem cell delivery
Hyun Sun Choi1, Yun Kee Jo1, and Hyung Joon Cha*
Department of Chemical Engineering, Pohang University of Science and Technology, Pohang 37673, Korea
*Tel.: +82 54 279 2280; fax: +82 54 279 5528; e-mail: [email protected]
PO-15 Modeling new electrical stimulation of electroactive sheets for differentiating into neuron-like cells
Hyun Jyung Oh1,* Keun Hong Park1, Ji Sun Park1, Se Won Yi1, Hye Jin Kim1, Jung Sun Lee1
1
Department of Biomediacal science, collage of Life science, CHA University, 689 Sampyung-dong, Bundang-gu,
Seongnam-si, Gyenggi-do,463-400, Korea [email protected]

PO-16 Polyelectrolyte hydrogel for tissue-adhesive

Dong Keon Lee1, Yang Ho Na1,*
Department of Advanced Materials & Chemical Engineering, Hannam University [email protected]
1

PO-17 Stable and sustained release of nitric oxide delivery from multilayers graphene oxide film
Junjira Tanuma, Hyejoong Jeonga, Jiwoong Heoa, Moonhyun Choia, Kyungtae Parka and Jinkee Honga*
Department of Chemical and Biomolecular Engineering, Yonsei University [email protected]

PO-18 Design of drug eluting core-shell nanofiber coated trachea stent for prevention of inflammation-
induced fibrotic tissue formation
Junghan, Lee1, Min-Kyoung Kim1, Enkhzaya Davaa1, Su-Min Kang1 and Su-Geun Yang1,*
Department of New Drug Development, School of Medicine, Inha University, Incheon, Korea [email protected]
1

PO-19 Atificial skin using flatways-spinned cocoon

You-Young Jo*, HaeYong Kweon
Sericultural & Apicultural Materials Division, National Institute of Agricultural Science, RDA, Wanju 565-851, Republic of
Korea [email protected]

PO-20 Genomic portrait of human tonsil-derived mesenchymal stem cell senescence

Da Hyeon Choi1, Ju Kwang Choi1, Young Seo Jo1, Kyeong Eun Lee1, Jue-Yeon Lee2,3, Yoon Jeong Park2,3,
Inho Jo4, Yoon Shin Park1,*
1
Major in Microbiology, School of Biological Sciences, College of Natural Sciences, Chungbuk National University, Cheongju
28644, Republic of Korea 2Dental Regenerative Biotechnology Major, Seoul National University, Seoul, Republic of Korea
3
Central Research Institute, Nano Intelligent Biomedical Engineering Corporation (NIBEC), Seoul, Republic of Korea
4
Department of Molecular Medicine & Ewha Tonsil-derived Mesenchymal Stem cells Research Center (ETSRC), School of
Medicine, Ewha Womans University, Seoul 07985 [email protected]

PO-21 Tonsil-derived mesenchymal stem cell-embedded in situ crosslinkable gelatin hydrogel for bone
regeneration in ovariectomized mice
Da Hyeon Choi1, Gyungah Kim2, Yunki Lee3, Ki Dong Park3, Yoon Jeong Park4,5, Yoon Shin Park1,*, Inho Jo2,*
1
Major in Microbiology, School of Biological Sciences, College of Natural Sciences, Chungbuk National University, Cheongju
28644, Republic of Korea 2Department of Molecular Medicine & Ewha Tonsil-derived Mesenchymal Stem cells Research
Center (ETSRC), School of Medicine, Ewha Womans University, Seoul 07985 3Department of Molecular Science and
Technology, Ajou University, Suwon 16499, Republic of Korea 4Dental Regenerative Biotechnology, Dental Research Institute,
School of Dentistry, Seoul National University, Seoul, Republic of Korea. 5Central Research Institute, Nano Intelligent
Biomedical Engineering Corporation (NIBEC), Seoul, Republic of Korea. [email protected]/ [email protected]

PO-22 Impact of sustained exposure to low concentrations of nitric oxide on morphological recovery of
senescent tonsil-derived mesenchymal stem cell
Ju Kwang Choi1, Da Hyeon Choi1, Hyojin Lee2, Young Seo Jo1, Kyeong Eun Lee1, Joo Young Son2,
Inho Jo3, Ki Dong Park2, Yoon Shin Park1,*
1
Major in Microbiology, School of Biological Sciences, College of Natural Sciences, Chungbuk National University, Cheongju
28644, Republic of Korea 2Department of Molecular Science and Technology, Ajou University, Suwon 16499, Republic of
Korea 3Department of Molecular Medicine & Ewha Tonsil-derived Mesenchymal Stem cells Research Center (ETSRC),
School of Medicine, Ewha Womans University, Seoul 07985, Republic of Korea [email protected]
PO-23 Versatile effects of magnesium hydroxide nanoparticles in PLGA scaffold-mediated chondrogenesis
Kwang-Sook Park1, Wooram Park2, Yoon Ki Joung1, and Dong Keun Han2*
Center for Biomaterials, Biomedical Research Institute, Korea Institute of Science and Technology, 2Department of Biomedical
1

Science, CHA University, [email protected]

PO-24 Bioactive drug release and osteoblast cells behaviors from micro-patterned Gel
Dipankar Das1,2, Tran Nguyen Hao1,2, Kang Cheol1, and Insup Noh1,2,*
Department of Chemical and Biomolecular Engineering, 2Convergence Institute of Biomedical Engineering and Biomaterials,
1

Seoul National University of Science and Technology, Seoul 01811 Korea (Republic of); *[email protected]
PO-25 Development and analysis of hluronate-based terpolymeric hydrogel for biomedical applications
Dipankar Das1,2, Eunchong Cha1, Nahye Kim1, Tran Nguyen Hao1,2, and Insup Noh1,2*
Department of Chemical and Biomolecular Engineering, 2Convergence Institute of Biomedical Engineering and Biomaterials,
1

Seoul National University of Science and Technology, Seoul 01811 Korea (Republic of); *[email protected]
PO-26 Coating neural interfacing devices with neuronal cell membrane to support neuronal growth
Ga Eul Kim1,2, Mahmoud A. Elnaggar1, Hyun Cheol Kim2, Yoon Ki Joung1,3,*
Center for Biomaterials, Korea Institute of Science and Technology, 2Interdisciplinary Program of Integrated Biotechnology,
1

Sogang University, 3Department of Biomedical Engineering, Korea University of Science and Technology e-mail: [email protected]
PO-27 Surface modification of poly(dimethyl siloxane)-based biomedical devices by hydrophilic polymers
Eun-Seo Ko1, Da Reum Kim1, Sung Yun Yang1,*
1
Department of Polymer Science and Engineering, Chungnam National University, 99. Daehak-ro, Yuseong-Gu, Daejeon
305-764, Korea *[email protected]
PO-28 Tissue-derived decellularized extracellular matrix for tissue engineering and bioprinting applications
Song Mi Lee1, Changhwan Kim1, Mi-Hee Lee1, Sorim Nam1, Eunhye Park1, Jung Seok Yun1, Mi-Jeong Kim1,
Geunseon Ahn1 and Songwan Jin2,*
Research Institute, T&R Biofab Co. Ltd., 237 Sangidaehak-Ro, Siheung, 15073, Republic of Korea 2Department of
1

Mechanical Engineering, Korea Polytechnic University, 237 Sangidaehak-Ro, Siheung, 15073, Republic of Korea
*[email protected]
PO-29 Preparation of injectable glycol chitosan hydrogel systems containing BMP-2 and TGF-1 for the
enhancement of bone formation in a rat tibial defect model
Dae Hyeok Yang, Young Jin Yun and Heung Jae Chun*
Institute of Cell & Tissue Engineering, Department of Biomedical Sciences, College of Medicine, The Catholic University
of Korea Email: [email protected]
PO-30 Visible light-cured glycol chitosan hydrogel dressing containing endothelial growth factor and basic
fibroblast growth factor accelerates wound healing in vivo
Dae Hyeok Yang, Young Jin Yun and Heung Jae Chun*
Institute of Cell & Tissue Engineering, Department of Biomedical Sciences, College of Medicine, The Catholic University
of Korea Email: [email protected]

분야 II : Drug and gene delivery systems

PO-31 Development and evaluation of a CEACAM6-targeting theranostic nanomedicine for photoacoustic-

based diagnosis and chemotherapy of metastatic cancer
Hohyeon Lee1, Yongho Jang1, Hyuncheol Kim1,2,*
1
Department of Chemical and Biomolecular Engineering, Sogang University 2 Department of Biomedical Engineering, Sogang
University *[email protected]
PO-32 Development of coacervates using mPEGylated poly(ethylene arginylaspartate diglyceride) cationic
polymers for protein delivery
Heejung Jo1, Gajendiran Mani1, Kyobum Kim1,*
Division of Bioengineering, College of Life Sciences and Bioengineering, Incheon National University [email protected]
1

PO-33 Development of folate decorated multifunctional polymer-gold nanoconjugates as potential

anticancer drug carrier
Mani Gajendiran1,2, Heejung Jo,1 Sengotteuvelan Balasubramanian2,* Kyobum Kim1,*
1
Departement of Bioengineering, School of Life Sciences and Bioengineering, Incheon National University, Incheon-22012,
Korea. 2Department of Inorganic Chemistry, University of Madras, Guindy Campus, Chennai-600025, India.
[email protected]
PO-34 Gold nanoparticle with cyclodextrin cap for photodynamic and photothermal tumor therapy
Mi Jin Koo1, Eun Seong Lee1,*
Department of Biotechnology, The Catholic University of Korea [email protected]
1

PO-35 Photo-responsive nanoparticle incorporated anticancer drug to accomplish synergistic therapeutic

effect at localized tumor site
Da Hye Kim1, HeeSook Hwang1, Kun Na1*
Department of Biotechnology, The Catholic University of Korea, [email protected]
1

PO-36 Reactive oxygen species-responsive polymer nanoparticles for chemo-photodynamic cancer therapy
Yugyeong Kim1, Saji Uthaman1, In-Kyu Park2,*, Kang Moo Huh1,*
1
Department of Polymer Science and Engineering, Chungnam National University, 99 Daehak-ro, Yuseong-gu, Daejeon,
34134, Republic of Korea, [email protected] 2Department of Biomedical Science, Chonnam National University Medical School,
160 Baekseo-ro, Gwangju, 61469, Republic of Korea, [email protected]

PO-37 Urethral catheter abled with continuous delivery of lidocaine for local pain relief
Cho Rim Kim1+, Beom Kang Huh1+, Young Eun Yoon4, Hong Sang moon4,* and Young Bin Choy1,2,3,*
1
Interdisciplinary Program in Bioengineering, College of Engineering, Seoul National University 2Department of Biomedical
Engineering, College of Medicine, Seoul National University 3Institute of Medical & Biological Engineering, Medical Research
Center, Seoul National University 4Department of Urology, College of Medicine, Hanyang University [email protected]
[email protected] + These authors contributed equally to this work

PO-38 Anti-cancer gene therapy by delivering of bacterial tRNase genes using polymer nanoparticles
Sungjin Min1, Yoonhee Jin1, Chen Yuan Hou2, Jayoung Kim3, Jordan J. Green3, Taek Jin Kang2
and Seung-Woo Cho1,*
Department of Biotechnology, Yonsei University [email protected], 2Department of Chemical and Biochemical
1

Engineering, Dongguk University 3Department of Biomedical Engineering, Johns Hopkins University School of Medicine
*[email protected]
PO-39 Thermodynamic injectable hydrogels for long-term treatment of musculoskeletal
Sanghee Lee1, Young-seok Jung1, Kun Na1*
Department of Biotechnology, The Catholic University of Korea [email protected]
1

PO-40 Fabrication of stimuli-responsive multicompartmental drug carriers for cancer therapy

Dae Gun Choi1, Hyeon Ung Kim2, Yoon Ho Roh2, Hyunjee Lee2, Ki wan Bong2* and Min Suk Shim1*
Department of Chemical and Biological Engineering, Korea University, Seoul 02841, Republic of Korea. *Corresponding
1

author: [email protected] 2Division of Bioengineering, Incheon National University, Incheon 22012, Republic of Korea.
*Corresponding author: [email protected]
PO-41 Light-responsive micelle generating ROS for cancer treatment
Jangsu Lee1 Kihong kim1 Kun Na*
Department of Biotechnology, The Catholic University of Korea *[email protected]
1

PO-42 Application of β-glucan microparticles for doxorubicin treatment

Kyungwoo Lee1, Jangsun Hwang1, Muhammad Saad Khan1, Sachin Ganpat Chavan1, Chanhwi Park1,
Yonghyun Choi1, Dasom Kim1, Jaehee Jang1, Yejin Kwon1 and Jonghoon Choi1*, Hojeong Jeon1*
School of Integrative Engineering, Chung-Ang University, Seoul 06974, Republic of Korea E-mail: [email protected]
1

PO-43 Synthesis of doxorubicin derivatives and its cytotoxicity

Jong-soo Choi1,2, Jae-won Park1, Young-Bae Seu2,*, Kyung-Oh Doh1,*
Departments of Physiology, College of Medicine, Yeungnam University, Daegu, Republic of Korea, 42415 2School of Life
1

Sciences and Biotechnology, Kyungpook National University, Daegu, Republic of Korea, 41566 *Corresponding author. Tel.:
+82-53-640-6920 Fax: +82-53-651-3651 [email protected] (K.Doh), [email protected] (Y.Seu)

PO-44 Targeted cellular delivery of robust enzyme nanoparticles for the treatment of drug-induced
hepatotoxicity and liver injury
Min Sang Lee, Ji Hoon Jeong*
School of Pharmacy, Sungkyunkwan University [email protected]

PO-45 Fabrication of polymeric micelles containing pheophorbide a for cervical cancer targeting
Ji-Hui Ha1 and Young-Jin Kim1,*
Department of Biomedical Engineering, Daegu Catholic University [email protected]
1
PO-46 Mussel adhesive protein-based microneedle patch loading silk fibroin-based nanoparticles for
sequential transdermal drug delivery
Junghwan Heo1, Eun Young Jeon1, Hyung Joon Cha1*
1
Department of Chemical Engineering, Pohang University of Science and Technology, Pohang 790-784, Korea
E-mail address: [email protected]

PO-47 The preparation of gene delivery system based on cellulose nanocrystal

Jihyeon Lee1, Hanjin Yu1 and Kwang Suk Lim1,2,*
Department of Biotechnology and Bioengineering, Kangwon National University, 2The Institute of Forest Science, Kangwon
1

National University [email protected]

PO-48 Low molecular weight polyethylenimine (PEI2k) cross-linked by oxidized lactose for efficient gene
delivery systems
Kyusik Kim1, Jaehong Park1 and Tae-il Kim1*
1
Department of Biosystems & Biomaterials Science and Engineering College of Agriculture and Life Sciences Seoul National
University [email protected]

PO-49 Endothelial adrenoceptor-targeted eNOS gene delivery using redox-sensitive polymer bearing L-
arginine to ameliorate atherosclerotic inflammation and plaques
Jee Young Chung1,2, Seok Beom Yong1, Yoonsung Song1, Seong Su Kim1, Hyung Seok Choi1, Yong-Hee Kim1,2,*
Department of Bioengineering, Hanyang University, Seoul, Korea 2Institute for Bioengineering and Biopharmaceutical
1

Research, Hanyang University, Seoul, Korea *[email protected]

PO-50 Co-delivery of antigen and immune-modulator via dissolving microneedle array for enhanced
cancer vaccine
Su Yeon Lim, E Seul Kim, Da Hwun Kim, Jae Baek Jung and Ji Hoon Jeong*
School of Pharmacy, Sungkyunkwan University *[email protected]

PO-51 GO nanoflakes functionalized with catechol-derivatized cationic polymer for efficient siRNA delivery
Jung Eun Lee, Da Hwun Kim, Jae Baek Jung, Ji Hoon Jeong*
School of Pharmacy, Sungkyunkwan University *[email protected]

PO-52 I-motif coated exosomes for pH-sensitive delivery of small molecules

Jun Yeong Kim, Jihyeon Song, Heejung Jung, and Hyejung Mok*
Department of Bioscience and Biotechnology, Konkuk University, Seoul 05029, Republic of Korea *[email protected]

PO-53 Hypoxia-triggered transforming immunomodulator for cancer immunotherapy via photodynamically

enhanced antigen presentation of dendritic cell
Sooseok Im1, Wonjong Kim1,2,*
1
School of Interdisciplinary Bioscience and Bioengineering, Pohang University of Science and Technology (POSTECH),
Pohang 37673, Republic of Korea, 2Department of Chemistry, POSTECH, Pohang 37673, Republic of Korea
*[email protected]
PO-54 Anticancer therapy using natural product via dual-sensitive self-assembly nanoconstruct
Jinhwan Kim1, Yeoul Kang1, Won Jong Kim1,*
Department of Chemistry, Pohang University of Science and Technology (POSTECH), Pohang 37673, Republic of Korea
1

*[email protected]
PO-55 Synthesis of alginate-based stimuli-responsive, non-cytotoxic hydrogel as a carrier of bovine
albumin serum and 5-amino salicylic acid
Dipankar Das1,2, Kang Cheol1, Eunchong Cha1 and Insup Noh1,2,*
Department of Chemical and Biomolecular Engineering, 2Convergence Institute of Biomedical Engineering and Biomaterials,
1

Seoul National University of Science and Technology, Seoul 01811 Korea (Republic of); *[email protected]

PO-56 Titanium-tethered cell-derived lipid bilayer with selenium catalyst to achieve a permanent NO
releasing system
Mahmoud A. Elnaggar1, Chung-Man Lim1 & Yoon Ki Joung1,2*
1
Center for Biomaterials, Biomedical Research Institute, Korea Institute of Science and Technology 2Department of Biomedical
Engineering, University of Science and Technology TEL: 02)958-5282, FAX: 02)958-5308, Email: [email protected]
PO-57 Delivery of multiple growth factors using gelatin/hydroxyapatite composite nanofibers for
enhancement of bone regeneration
Nopphadol Udomluck1, Haram Lee1, Hansoo Park1*
School of Integrative Engineering, Chung-Ang University, Seoul, Korea E-mail: [email protected]
1

PO-58 A local drug delivery system based on visible light-cured glycol chitosan and doxorubicin
hydrochloride for thyroid cancer treatment in vitro and in vivo
Dae Hyeok Yang, Young Jin Yun and Heung Jae Chun*
Institute of Cell & Tissue Engineering, Department of Biomedical Sciences, College of Medicine, The Catholic University
of Korea Email: [email protected]

분야 III : Tissue engineering

PO-59 Physico-chemical and biological properties of in situ forming gelatin hydrogels from different
sources for tissue engineering
Phuong Le Thi, Ki Dong Park*
Department of Molecular Science and Technology, Ajou University [email protected]
1

PO-60 Three-dimensional electrospun nanofibrous demineralized bone matrix scaffold for bone regeneration
Sung Won Ko1, Joshua Lee1, Hak Su Jang2, Jeong-Hwi Cho4, Hyun-Jin Tae4, Young Min Oh3,
Chan Hee Park1,*, and Cheol Sang Kim1,*
1
Department of Bionanosystem Engineering, Graduate School, Chonbuk National University, Jeonju, Korea 2CGBio, Seoul,
Korea 3Department of Neurosurgery, Research Institute of Clinical Medicine, Chonbuk National University Medical School
and Hospital, Jeonju, Korea 4College of Veterinary Medicine and Bio-safety Research Institute, Chonbuk National University,
Iksan, Korea [email protected], [email protected]
PO-61 The efficacy of coacervate with dual growth factor delivery using biodegradable electrospun
nanofiber on mouse skin flap
Min Suk Lee1, Taufiq Ahmad2, Hassan K. Awada3, Yadong Wang3, Kyobum Kim4*, Heungsoo Shin2*,
Hee Seok Yang1*
1
Department of Nanobiomedical Science & BK21 PLUS NBM Global Research Center for Regenerative Medicine, Dankook
University, Korea 2Department of Bioengineering & BK21 PLUS Future Biopharmaceutical Human Resources Training and
Research Team, Hanyang University, Korea 3Department of Bioengineering, University of Pittsburgh, USA 4Division of
Bioengineering, College of Life Sciences and Bioengineering, Incheon National University, Korea [email protected]
PO-62 PCL scaffold with a gradient structure and growth factors for bladder regeneration
Bo Mi Kim1, Eun Hye Lee2, Bo Hyun Yoon3, Yun-Sok Ha4, Bum Soo Kim5,6, Jun Nyung Lee5,6,
Jae-Wook Chung4, So Young Chun3, Se Heang Oh7, Tae Gyun Kwon4,6,*
Department of Urology, Kyungpook National University 2Department of Pathology, Kyungpook National University
1

3
BioMedical Research Institute, Kyungpook National University Hospital 4Department of Urology, Kyungpook National
University Chilgok Hospital 5Department of Urology, Kyungpook National University Hospital 6Department of Urology, School
of Medicine, Kyungpook National University 7Department of Nanobiomedical Science & BK21 PLUS NBM Global Research
Center for Regenerative Medicine, Dankook University *corresponding author's e-mail address: [email protected]
PO-63 Effect of increasing stem cell passage on directional migration by direct electric current
Seung Hee Hong1,2, Mi Hee Lee1, Min-Ah Koo1,2, Gyeung Mi Seon1,2, Ye Jin Park1,3, and Jong-Chul Park1,2,3,*
Cellbiocontrol Laboratory, Department of Medical Engineering, Yonsei University College of Medicine 2Brain Korea 21 PLUS
1

Project for Medical Science, Yonsei University College of Medicine 3Department of Medical Device Industry, Yonsei University
College of Medicine [email protected]
PO-64 Liver targeted delivery of hepatic cells using detachable heparin hydrogel micropatches
Youngmin Hwang1, Meeichyn Goh1, Mihye Kim1, Giyoong Tae1,*
School of Material Science and Engineering, Gwangju Institute of Science and Technology [email protected]
1

PO-65 Fabrication of 3d hierarchical celllulose scaffolds using an electrohydrodynamic jet process for bone
regeneration
YoungEun Choe1, Minseong Kim1, GeunHyung Kim1*
Department of Biomechatronic Engineering, College of Biotechnology and Bioengineering Sungkyunkwan University (SKKU)
1

*[email protected]
PO-66 Engineered celery structured electrospun aligned nanofibers enhance nerve tissue regeneration
Serim Jang1, Dohee Lee1, Seo Yeon Lee1, Chan Hee Park1,2,* and Cheol Sang Kim1,2,*
1
Department of Bionanosystem Engineering, Graduate School, Chonbuk National University, Jeonju 561-756, Republic of
Korea. 2Division of Mechanical Design Engineering, Chonbuk National University, Jeonju 561-756, Republic of Korea.
[email protected], [email protected]
PO-67 Rapid cartilage regeneration by human nasal septum derived chondrocytes in rat articular cartilage
defect model
Jung Ho Jeon1, Sun Hwa Park1, Jung Yeon Lim, Byeong Gon Yun1, Sung Won Kim1,2,*
1
Postech-Catholic Biomedical Engineering Institute, College of Medicine, The Catholic University. 2Department of
Otolaryngology-Head and Neck Surgery, College of Medicine, The Catholic University.

PO-68 Coccoliths-based bone graft substitutes for bone tissue reconstruction

Jin Young Yun1, So Yeong Bahn1, Hyo Jeong Kim1, Yun Kee Jo1, Onyou Nam2, EonSeon Jin2,
and Hyung Joon Cha1,*
1
Department of Cheminal Enginnering, Pohang University of Science and Technology, 2Department of Life Science, Hanyang
University, *[email protected]

PO-69 Cellulose monolith containing protoporphyrin IX for nerve regeneration

Ji-Hye Lee1, Hiroshi Uyama2 and Young-Jin Kim1,*
Department of Biomedical Engineering, Daegu Catholic University, 2Department of Applied Chemistry, Osaka University
1

*[email protected]
PO-70 Highly hydrated PEDOT:PSS conductive hydrogel with micropattern for a myogenic differentiation
HyeYeon Gong1, Seungmin Kang and Wongun Koh*
Department of Chemical & Biomolecular Engineering Yonsei University [email protected]
1

PO-71 Effective immobilization of lactoferrin on electrospun nanofibers for bone tissue engineering
Jinki Lee1,2, Jinkyu Lee1,2 and Heungsoo shin1,2,*
Department of Bioengineering, Hanyang University, Seoul, Korea 2Brain Korea 21 Plus Future Biopharmaceutical Human
1

Resources Training and Research Team, Seoul, Korea *[email protected]

PO-72 Scaffold with conductive line pattern using polyaniline for peripheral nerve regeneration
Soyoung Noh1, Ji Hong Min1,2 and Won-Gun Koh1,*
1
Department of Chemical and biomolecular Engineering, Yonsei University, Korea 2Active Polymer Center for Pattern
Integration (APCPI), Yonsei-ro 50, Seoul, Republic of Korea *[email protected]

PO-73 Synthetic peptides from copine7 in combination with collagen gel accelerate osteogenic
differentiation of dental pulp stem cells and bone regeneration
Dong Woo Lee1, Kwang-Sook Park2, Beom Soo Jo1, Jue Yeon Lee1, Chong Pyoung Chung1, and Yoon Jeong
Park1,2*
Central Research Institute, Nano Intelligent Biomedical Engineering Corporation (NIBEC), 2Dental Regenerative Biotechnology,
1

Dental Research Institute, School of Dentistry, Seoul National University [email protected]

PO-74 Development of stabilized dual growth factor-loaded hyaluronate- collagen dressing (Dual-HCD)
matrix for diabetic wound healing
Jihyun Kim1,2, Kyoung-Mi Lee1,3, Hyun Jung Kim4, Ik Kyu Park4, Eun Ae Ko1, Eun Ju Park1, Dawoon Baek1,2,
Kwang Hwan Park1, Jin Woo Lee1, 2, 3, Sung-Hwan Kim5*
Department of Orthopaedic Surgery, Yonsei University College of Medicine 2Brain Korea 21 PLUS Project for Medical
1

Science, Yonsei University 3Severance Biomedical Science Institute, Yonsei University College of Medicine 4R&D center,
Genewel co., Itd, Sungnam 5Department of Orthopaedic Surgery, Gangnam severance hospital, Yonsei University College
of Medicine *Corresponding Author: [email protected]

PO-75 Evaluation of double network hydrogel of poloxamer-heparin/gellan gum for bone marrow stem cells
delivery carrier
Joo Hee Choi, Ok Kyun Choi, Jeonghun Lee, Joungyoun Noh, Sumi Lee, Ain Park, Min Joung Choi,
Jeong Eun Song, Muthukumar Thangavelu, and Gilson Khang*
Department of BIN Convergence Technology, Department of PolymerNano Science & Technology and Polymer Materials
Fusion Research Center, Chonbuk National University, 567 Baekje-daero, Deokjin-gu, Jeonju-si, Jeollabuk-do, 54896
Republic of Korea *[email protected]

PO-76 Study on characteristics of resveratrol/agarose hydrogels for retinal pigment epithelial cells
regeneration
Myeong Eun Shin, Eun Yeong Shin, Jong Ho Park, Won Kyung Kim, Jeong Eun Song,
Muthukumar Thangavelu and Gilson Khang*
Department of BIN Convergence Technology, Department of PolymerNano Science & Technology and Polymer Materials
Fusion Research Center, Chonbuk National University, 567 Baekje-daero, Deokjin-gu, Jeonju-si, Jeollabuk-do, 54896
Republic of Korea
PO-77 Directly decellularized extracellular matrix on polymeric scaffold incorporate with magnesium
hydroxide nanoparticle for renal tissue regeneration
Yun Ah Kim1, So Young Chun2, Seung Kwon You3, Tae Gyun Kwon2, Yoon Ki Joung1,4*
Center for Biomaterials, Korea Institute of Science and Technology, 2Department of Urology, Kyungpook National University,
1

3
Department of Biotechnology, Korea University, 4Dept. of Biomed. Eng., Korea University of Science and Technology
*[email protected]
PO-78 Collagen hydrogel contained chitosan nanofiber for bone tissue engineering
Wheemoon Cho1,2, Sang Jun Park1, Youngsook Son2 and Chun-Ho Kim1,*
Laboratory of Tissue Engineering, Korea Institute of Radiological and Medical Science, 2Department of Genetic Engineering,
1

College of Life Science and Graduate School of Biotechnology, Kyung Hee University *[email protected]

PO-79 Physicochemically tuned myofibroblasts for healing strategy in severe wound

Ung Hyun Ko1, Jongjin Choi2, Jinseung Choung1, Sunghwan Moon2* and Jennifer H. Shin1*
Department of Mechanical Engineering, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea,
1

School of Medicine, Konkuk University, Seoul, Republic of Korea, [email protected]

2

PO-80 Decellularized heart ECM hydrogel using supercritical carbon dioxide for improved angiogenesis
Yoojin Seo1,2, Soo Hyun Kim1,2,3*, 3Youngmee Jung2,3*
KU-KIST Graduate School of Converging Science and Technology, Korea University, Republic of Korea 2Biomaterials
1

Research Center, Korea Institute of Science and Technology, Republic of Korea 3Department of Biomedical Engineering,
Korea University of Science and Technology, Republic of Korea [email protected], [email protected]

PO-81 Enhanced modified gellan gum hydrogel with hyaluronic acid for cartilage regeneration
Won Kyung Kim1, Joo Hee Choi1, Myung Eun Sin1, Jin Su Kim1, Jeong Eun Song1, Muthukumar Thangavelu1,
Alessio Bucciarelli2, Claudio Migliaresi2, Antonella Motta2 and Gilson Khang1,*
1
Department of BIN Convergence Technology, Department of PolymerNano Science & Technology and Polymer Materials
Fusion Research Center, Chonbuk National University, 567 Baekje-daero, Deokjin-gu, Jeonju-si, Jeollabuk-do, 54896
Republic of Korea. 2Department of Industrial Engineering, University of Trento, via Sommarive 9, Trento, Italy BIOTech
Research Center, University of Trento, via delle Regole 101, Trento, Italy and European Institute of Excellence on Tissue
Engineering and Regenerative Medicine, Trento, Italy.

PO-82 BMSCs were differentiated into cartilage cells using blood-derived exosomes loaded with miRNA140
Yong Woon Jeong1, Giwon Lee1, Han Sol Kim1, Jeong Eun Song1, Muthukumar Thangavelu1, Rui L. Reis2,
Gilson Khang1,*
1
Department of BIN Convergence Technology, Department of PolymerNano Science & Technology and Polymer Materials
Fusion Research Center, Chonbuk National University, 567 Baekje-daero, Deokjin-gu, Jeonju-si, Jeollabuk-do, 54896
Republic of Korea 23B's Research Group - Biomaterials, Biodegradable and Biomimetics, Headquarters of the European
Institute of Excellence on Tissue Engineering and Regenerative Medicine, AvePark, 4805-17, Barco, Guimares, Portugal

PO-83 Evaluation of sodium hyaluronate loaded agar hydrogel for cartilage regeneration: in vitro test
Jin Su Kim1, Jong Seon Baek1, Won Kyung Kim1, Jeong Eun Song1, Muthukumar Thangavelu1,
Alessio Bucciarelli2, Claudio Migliaresi2, Antonella Motta2 and Gilson Khang1,*
1
Department of BIN Convergence Technology, Department of PolymerNano Science & Technology and Polymer Materials
Fusion Research Center, Chonbuk National University, 567 Baekje-daero, Deokjin-gu, Jeonju-si, Jeollabuk-do, 54896
Republic of Korea. 2Department of Industrial Engineering, University of Trento, via Sommarive 9, Trento, Italy BIOTech
Research Center, University of Trento, via delle Regole 101, Trento, Italy and European Institute of Excellence on Tissue
Engineering and Regenerative Medicine, Trento, Italy

분야 IV : Nanomedicine

PO-84 Combinational therapy of photosensitizer and antibiotics for propionbacterium acnes via enzyme-
reactive liposomes
Byeong Nam Im1, Kun Na*
Biotechnology, Catholic university of korea [email protected]
1

PO-85 Engineering PNIPAM grafted gold nanoparticles for the triggered release of anti-tumor drug
molecules
Yejin Kwon1, Jangsun Hwang1, Yonghyun Choi1, Muhammad Saad Khan1, Sachin Ganpat Chavan1, Kyungwoo
Lee1, Chanhwi Park1, Dasom Kim1, Jaehee Jang1, Joohye Hong1, Nayeong Kim1, Taemu Lee1 and Jonghoon Choi1*
School of Integrative Engineering, Chung-Ang University, Seoul 06974, Republic of Korea [email protected]
1
PO-86 Development of silver and/or copper nanoparticles synthesized on graphene oxide nanosheets for
the antibacterial and antibiofilm applications
Jaehee Jang1, Jangsun Hwang1, Yonghyun Choi1, Muhammad Saad Khan1, Sachin Ganpat Chavan1, Kyungwoo
Lee1, Chanhwi Park1, Dasom Kim1, Yejin Kwon1, Joohye Hong1, Nayeong Kim1, Taemu Lee1 and Jonghoon Choi1*
School of Integrative Engineering, Chung-Ang University, Seoul 06974, Republic of Korea *[email protected]
1

PO-87 Polydopamine nanoparticle-based fluorescence sensing of isothermally amplified bacterial nucleic acids
Ha Neul Lee1, Hyun Jung Chung1,2,*
Graduate School of Nanoscience and Technology, 2Department of Biological Sciences, Korea Advanced Institute of Science
1

and Technology, Daejeon, Republic of Korea *[email protected]

PO-88 Dual function of anti-cancer peptide via inhibition of two biomarkers for the cancer stem cells target
Gook Jin Yoon1, Kwang-Sook Park1, Jue Yeon Lee2, Yoon Shin Park3, Chong Pyoung Chung2,
and Yoon Jeong Park1,2*
Dental Regenerative Biotechnology, Dental Research Institute, School of Dentistry, Seoul National University, 2Central
1

Research Institute, Nano Intelligent Biomedical Engineering Corporation (NIBEC), 3Major in Microbiology, School of Biological
Science, College of Natural Science, Chungbuk National University [email protected]
PO-89 Magnetic field-inducible drug-eluting nanoparticles for image-guided thermo-chemotherapy
Shameer Pillarisetti1, Kondareddy Cherukula1, In-Kyu Park1,*
1
Department of Biomedical Science and BK21 PLUS Centre for Creative Biomedical Scientists, Chonnam National University
Medical School, Gwangju 61469, Republic of Korea
PO-90 Elastin-like peptide-bearing liposomes for non-thermal ultrasound-triggered doxorubicin delivery
Gyeongtaek Lim1, Wooram Um2 and Jae Hyung Park1,2*
1
School of Chemical Engineering, College of Engineering, Sungkyunkwan University, 2Department of Health Sciences and
Technology, SAIHST, Sungkyunkwan University. [email protected]
PO-91 Versatile and stable affibody protein corona shield nanoparticle (PCSN) as the delivery platform
Jun Yong Oh1,†, Han Sol Kim2,†, L Palanikumar1,†, Eun Min Go3, Batakrishna Jana1, Soo Ah Park4, Ho Young Kim3,
Kibeom Kim1, Jeong Kon Seo2, Sang Kyu Kwak3, Chaekyu Kim1*, Sebyung Kang2*, Ja-Hyoung Ryu1*
Department of Chemistry, Ulsan National Institute of Science and Technology (UNIST), Ulsan 44919, Republic of Korea.
1

2
Department of Biological Sciences, Ulsan National Institute of Science and Technology (UNIST), Ulsan 44919, Republic
of Korea. 3Department of Energy Engineering, School of Energy and Chemical Engineering, Ulsan National Institute of
Science and Technology (UNIST), Ulsan 44919, Republic of Korea. 4In Vivo Research Center, UNIST, Central Research
Facilities, Ulsan National Institute of Science and Technology (UNIST), Ulsan 44919, Korea [email protected],
[email protected], [email protected]

PO-92 Graphene oxide-immobilized PCL nanofibrils for culture and electrical stimulation of neural cells
Wei Mao, Young Ju Son, Sol Lee, Jiun Shin, Juwon Lee, Hyuk Sang Yoo*
Kangwon National University, South Korea *[email protected]

분야 V : Nano-micro-biotechnology

PO-93 Single molecular force across integrin determines cell migration

Seong-Beom Han1, GeonHui Lee1, Jeong-Ki Kim1, and Dong-Hwee Kim1,*
KU-KIST Graduate School of Converging Science and Technology, Korea University *[email protected]
1

PO-94 Highly selective plasmonic fibrinogen sensor with red blood cell membrane-coated gold
nanoparticles
Insu Kim1, Gyudo Lee1 and Dae Sung Yoon1,*
Department of Bio-convergence Engineering, Korea University *[email protected]
1

PO-95 Development of microfluidic-mediated fungi separation

Byeong Seon Park, Jong Min Lee, and Bong Geun Chung*
Department of Mechanical Engineering Sogang University *[email protected]

PO-96 Detection pathogens by apoferritin nanoporobe

Dasom Kim1, Jangsun Hwang1, Sachin Ganpat Chavan1, Yonghyun Choi1, Muhammad Saad Khan1,
Kyungwoo Lee1, Chanhwi Park1, Jaehee Jang1, Yejin Kwon1, Joohye Hong1, Nayeong Kim1, Taemu Lee1
and Jonghoon Choi1*
School of Integrative Engineering, Chung-Ang University, Seoul 06974, Republic of Korea *[email protected]
1
PO-97 A microneedle-based sensing platform for highly sensitive detection of biomarkers
Ye-Eun Kang1, Keum-Yong Seong1, Sang-Gu Yim1, Yechan Lee1 and Seung Yun Yang1,*
Department of Biomaterials Science, Pusan National University *[email protected]
1

PO-98 Core-shell structured nanoparticles for improved tumor treatment efficacy of irreversible
electroporation (IRE)
Jun-Hyeok Han1,2, Ik Hwan Kim2, Wooram Park1*, and Dong Keun Han1*
1
Department of Biomedical Science, CHA University, Republic of Korea 2Department of Biotechnology, Korea University,
Republic of Korea *[email protected] and *[email protected]

분야 VI : Bio-imaging

PO-99 Development of pathological stimulus-activatable nanoplatforms with theranostic functions

Seri Hong1, Semee Seon1, Dongwon Lee1,*
Department of BIN Convergence Technology, Chonbuk National University *[email protected]
1

PO-100 Fabrication of blue-fluorescent nanodiamonds modified with alkylisocyanate for cellular bioimaging
Guk-Young Ahn1 and Sung-Wook Choi1,*
Department of Biotechnology, The Catholic University of Korea [email protected]
1

PO-101 Biomedical aplication of carbon nano onions: A versatile fluorescence nanomaterial for multi-channel
glutathione sensing
Vishnu Revuri1, Jeongman An2, Woo-Jung Kang3,* and Yong-kyu Lee1,2,*
1
Department of Green Bio Engineering, Korea National University of Transportation, Daehak-ro 50, Chungju 27469, Republic
of Korea 2Department of Chemical and Biological Engineering, Korea National University of Transportation, Daehak-ro 50,
Chungju 27469, Republic of Korea 3Department of Aeronautical Science & Flight Operation, Korea National University of
Transportation, Daehak-ro 50, Chungju 27469, Republic of Korea

PO-102 Application of fluorescent carbon layer-coated Gd2O3 nanoparticles to T1-weighted MRI and cell
imaging
Moon Sung Kang1, Yong Cheol Shin2, Anara Molkenova3, Tomiris Mulikova3, Su-Jin Song1, Yu Bin Lee1,
Heejung Seo1, Timur Sh. Atabaev3* and Dong-Wook Han1,*
Department of Cogno-Mechatronics Engineering, Pusan National University, Busan 46241, Republic of Korea 2Department
1

of Medical Engineering, Yonsei University College of Medicine, Seoul 03722, Republic of Korea 3Department of Chemistry,
School of Science and Technology, Nazarbayev University, Astana 010000, Kazakhstan *[email protected] &
[email protected]

PO-103 Surface charge modification of polyethyleneimine for improved renal excretion in vivo
Hoon Hyun1,*
Department of Biomedical Sciences, Chonnam National University Medical School *[email protected]
1

분야 VII : Regenerative medicine

PO-104 Endothelial ER71/ETV2 activation in injury induced vascular regeneration

Changwon Park1,2,3,†, Tae-Jin Lee4,†, Suk Ho Bhang4,*, Fang Liu5, Rei Nakamura6, Sunday S. Oladipupo7,
Ian Pitha-Rowe6, Benjamin Capoccia8, Hong Seo Choi1, Tae Min Kim9, Norifumi Urao9, Masuko Ushio-Fukai9,
Dong Jun Lee10, Hiroyuki Miyoshi11, Byung-Soo Kim12, Dae-Sik Lim10, Rajendra S. Apte6,13, David M. Ornitz7,13
Kyunghee Choi5,13,*
1
Department of Pediatrics, 2Children's Heart Research and Outcomes Center, 3Molecular and Systems Pharmacology
Program Emory University School of Medicine, Atlanta; 4School of Chemical Engineering, Sungkyunkwan University,
5
Departments of Pathology and Immunology, 6Ophthalmology and Visual Sciences, 7Developmental Biology, 8Biochemistry
and Molecular Biophysics, Washington University School of Medicine, MO, 9Department of Pharmacology, College of
Medicine, University of Illinois at Chicago, IL, 10Korea Advanced Institute of Science and Technology, Korea, 11RIKEN
BioResource Center, Japan, 12School of Chemical and Biological Engineering, Seoul National University, Seoul, Korea,
13
Developmental, Regenerative, and Stem cell Biology Program. *Suk Ho Bhang, PhD [email protected] Kyunghee
Choi, PhD, [email protected] †These authors contributed equally

PO-105 Characterization of novel AAV based gene-cell therapy products for hypoxic ischemic
encephalopathy treatment
Mira Cho1, Kwangsoo Jung2, Seung-Hyun Kim1, Il-Sun Kim2, Kook In Park2 and Jae-Hyung Jang1,*
Department of Chemical and Biomolecular Engineering, Yonsei University, 2Department of Pediatrics, College of Medicine,
1

Yonsei University [email protected]

PO-106 Enhancement of graft survival and osteogenic differentiation of bone marrow stromal cells based
on microenvironmental control
Eugene Lee1, Juyoung Kim2, Songhee Lee2, Ji-yun Ko2, Gun-Il Im1,2,*
Department of Orthopedics, Dongguk University Ilsan Hospital, Goyang, Republic of Korea, 2Research Institute for Integrative
1

Regenerative Biomedical Engineering, Dongguk University, Goyang, Republic of Korea [email protected]*

PO-107 Osteogenic peptide with bone targeting ability for the treatment of osteoporosis
Jue Yeon Lee1, Dong Woo Lee1, Beom Soo Jo1, Kwang-Sook Park2, Yoon Shin Park3, Chong Pyoung Chung1,
and Yoon Jeong Park1,2*
Central Research Institute, Nano Intelligent Biomedical Engineering Corporation (NIBEC), 2Dental Regenerative Biotechnology,
1

Dental Research Institute, School of Dentistry, Seoul National University, 3Major in Microbiology, School of Biological Science,
College of Natural Science, Chungbuk National University *[email protected]

PO-108 Need for a biocompatible delivery system in use of natural product: expanding applications of
soyasaponin
Eun-Ji Choi1, Han-Jun Kim1, Hyo Sung Kim2 and Sun Hee Do1*
1
Department of Veterinary Clinical Pathology, College of Veterinary Medicine, Konkuk University, Seoul 05029, Republic
of Korea, 콯 enter for Minimally Invasive Therapeutics, California NanoSystems Institute, UCLA, Los Angeles, California 90095,
United States *[email protected]

PO-109 Different Homeobox Gene Expression in Hypertrophic Scars and Keloids

Minwoo Kang1, Ung Hyun Ko1, Ho Yun Chung2 and Jennifer H. Shin1*
Korea Advanced Institute of Science and Technology 2Kyungpook National University *[email protected]
1

분야 VIII : Medical devices

PO-110 Carrier free everolimus-eluting stent for cardiovascular medical device applications
Jun-Kyu Park1,2, Jae-Woon Nah2,*
1
CGBio Co. Ltd, 2Department of Polymer Science and Engineering, College of Engineering, Sunchon National University
[email protected]

PO-111 Gold nanoparticle-based wireless non-invasive sensor for glucose level monitoring in body fluid
Seong Hwi Cho,† Su-Kyoung Kim† and Sei Kwang Hahn†,*
†
Department of Materials Science and Engineering, Pohang University of Science and Technology (POSTECH), 77
Cheongam-ro, Nam-gu, Pohang, Gyeongbuk 790-784, Korea. *[email protected]

PO-112 Preparation of a pH sensor microdevice with microstructured PEG hydrogel composites for
biomedical applications
Young Ho Kim1,*, Sang Hyun An1, Jaesung Kong1, Byung-Hoon Lee1, Jiyoung Yoon1, Suwon Seo1
Daegu-Gyeongbuk Medical Innovation Foundation [email protected]
1

PO-113 Fabrication of a PU dressing including anti-microbial carbon composites for functional and effective
wound healing
Gwijae Kim1, Young-Gwang Ko1, Dongjin Kim1, Donghwan Cho1, Won Ho Park2, Oh Hyeong Kwon1,*
Department of Polymer Science and Engineering, Kumoh National Institute of Technology, Gumi, Gyengbuk 39177, Korea
1

2
Department of Advanced Organic Materials and Textile System Engineering, Chungnam National University, Daejeon 34134,
Korea *[email protected]

PO-114 A study of tensile strength of suture depending on the type of grip, load cell capacity, and method
of knot
S.I.Lee*, Y.J.Ha, H.Y.Han, C.I.Lim, M.J.Kim
Medical Device Research Division, National Institute of Food and Drug Safety Evaluation *[email protected]

PO-115 Design of a dermal filler containing ceramic nanoparticles -incorporated polymeric microspheres
for long-lasting with low inflammatory responses
Yeon-Do Jang1,2, Young-Jae Heo1, Yong-In Yoo1, Tae-Il Son2, Wooram Park1*, and Dong Keun Han1*
Department of Biomedical Science, CHA University 2Department of Systems Biotechnology, Chung-Ang University
1

*[email protected] and *[email protected]

PO-116 Synthesis of zwitterionic and tetra-fluorinated polyurethanes additives for enhancing blood
compatibility
Su-yeon Choi1,2, Jong Hee Kang1, Won-Gun Koh2, Yoon Ki Joung1,3,*
Center for Biomaterials, Biomedical Research Institute, Korea Institute of Science and Technology, 2Department of Chemical
1

and Biomolecular Engineering, Yonsei University, 3Division of Bio-Medical Science and Technology, University of Science
and Technology, *[email protected]
PO-117 Therapeutic effect of atmospheric cold plasma on biofilm-forming bacteria
Jae Gon Lee1, Jin Hee Na2, Seul Chan Hong1, Jae Min Seo1, Yong-Su Na1, Sangmin Lee3, Ji-Ung Park4,*
1
Department of Nuclear Engineering, Seoul National University, Seoul, Korea 2Department of Pharmaceutical Science College
of Pharmacy, Kyung Hee University, Seoul, Korea 3Department of Pharmacy, College of Pharmacy, Wonkwang University,
Iksan, Jeonbuk, Korea 4Department of Plastic and Reconstructive Surgery, Seoul National University Boramae Hospital,
Seoul, Korea *[email protected]

분야 IX : 3D printing

PO-118 Low temperature processing of fast setting 3d printed calcium phosphate scaffolds for bone tissue
engineering
Naren Raja1,2, Honghyun Park1, Hui-suk Yun1,2,*
Engineering Ceramic Department, Powder and Ceramics Division, Korea Institute of Materials Science (KIMS), Changwon.
1

Korea University of Science and Technology (UST), Daejeon. [email protected]

2

PO-119 Fabrication and strength evaluation of BCP scaffold on sintering temperature

Seung-Hyeok Choi1, Chang-Hee Lee1, Min-Woo Sa2 and Jong Young Kim1,*
Department of Mechanical Engineering, Andong National University 2Research Institute, SJ TOOLS [email protected]
1

*[email protected]
PO-120 Fabrication of tetrapod interlocking DIP/PLA scaffold and its osteoinductivity
Daeryong Jun1 and Sungwook Choi1,*
Department of biotechnology, Catholic University of Korea [email protected]
1

PO-121 Regeneration of bone defect using GBR/GTR hybrid scaffolds fabricated by electrospinning and 3D
printing techniques
Taegyun Yeo, Gyeongwoo Lee, Dongmin Kwak, Ji Young Lee, Oh Hyeong Kwon*
Department of Polymer Science and Engineering, Kumoh National Institute of Technology, Gumi, Gyeongbuk 39177, Korea
*[email protected]
PO-122 The influence of cross-linking methods on cell proliferation rate in three-dimensional bioprinting
Dong Jin Choi1,2, Sang Jun Park1, Seok Chung2 and Chun-Ho Kim1,*
Laboratory of Tissue Engineering, Korea Institute of Radiological and Medical Sciences, Seoul, Korea, 2Department of
1

Mechanical Engineering, Korea University, Seoul, Korea *[email protected]

분야 X : Stem cells

PO-123 Resveratrol improves MSC therapy for bone and cartilage regeneration
Dawoon Baek1,2, Yoorim Choi1,2, Seong Mi Choi1,2, Kyoung-Mi Lee1, Kwang Hwan Park1, Jin Woo Lee1,2,3,*
Department of Orthopaedic Surgery, Yonsei University College of Medicine 2Brain Korea 21 PLUS Project for Medical
1

Science, Yonsei University 3Severance Biomedical Science Institute, Yonsei University College of Medicine *Corresponding
Author: [email protected]
PO-124 Study on adult stem cell cultivation & differentiation on various 3D membrane structures
Keun Jae Kim1, Ji Hye Won2, Hee Sung Park2, Seong Eui Lee1,*
Department of Convergence IT Device and Material Engineering, Korea Polytechnic University, Si-hung 15073, Korea
1

2
56, Naruteo-ro, Seocho-gu, Seoul, 06527, Korea *Address correspondence to Seong Eui Lee, Tel: 82-31-8041-0588,
E-mail: [email protected]
PO-125 Three- dimensional graphene/RGD peptide nano-composites for osteogenesis of human
mesenchymal stem cells
Ee-Seul Kang1, Da-Seul Kim1, Yoojoong Han1, Hyungbin Son1, KunHee Lee2, Hyewon Kim2, Junhong Min1
and Tae-Hyung Kim1,3*
School of Integrative Engineering, Chung-Ang University, 2Department of Chemical Engineering, Hoseo University
1

3
Integrative Research Center for Two-Dimensional Functional Materials, Institute of Interdisciplinary Convergence Research
*[email protected]
PO-126 Guiding differentiation of human mesenchymal stem cell by modified substrates of two-dimensional
material
Intan Rosalina Suhito1, Novi Angeline1, Yoojoong Han1, Da-Seul Kim1, Hyungbin Son1, Tae-Hyung Kim1,2*
1
School of Integrative Engineering, Chung-Ang University, Seoul 06974, Republic of Korea 2Integrative Research Center
for Two-Dimensional Functional Materials, Institute of Interdisciplinary Convergence Research, Chung-Ang University, Seoul
06974, Republic of Korea *[email protected]

PO-127 The enhancing effect of synthetic peptide on the efficient generation of human induced pluripotent
stem cells
Kwang-Sook Park1, Dong Woo Lee2, Jue Yeon Lee2, Chong Pyoung Chung2, and Yoon Jeong Park1,2*
Dental Regenerative Biotechnology, Dental Research Institute, School of Dentistry, Seoul National University
1

Central Research Institute, Nano Intelligent Biomedical Engineering Corporation (NIBEC), *[email protected]
2

PO-128 Adipose-derived stem cells attenuate atopic dermatitis-like skin lesions in NC/Nga mice
Min-ha Choi1, Hyun-Sun Park, MD2, Youngsook Son, PhD3, Sundong Kim, PhD4, Hyun-Sook Hong, PhD5
and Ji-Ung Park, MD1,*
1
Department of Plastic and Reconstructive Surgery, Seoul National University Boramae Medical Center, 2Department of
Dermatology, Seoul National University Boramae Medical Center, 3Department of Genetic Engineering, Graduate School of
Biotechnology, Kyung Hee University, 4Senior Science Life Corporation, 5Kyung Hee Institute for Regenerative Medicine,
College of Medicine, Kyung Hee University [email protected]

PO-129 Control of migration of mesenchymal stem cell using neighboring endothelial cells without chemical
factor
Ji Eun Kim1, Yun Gyeong Kang1, Yanru Wu2, Eun Jin Lee1, Min Ju Kim1, Chan Mi Kim1, and Jung-Woog Shin1,2,3*
Department of Biomedical Engineering, Inje University 2Department of Health Science and Technology, Inje University
1

CMDC/Institute of Aged Life Redesign/UHARC *[email protected]

3

분야 XI : Other areas

PO-130 Room temperature based synthetic method for reducing cytotoxicity of silver nanoplates
Gwang-Bum Im1,#, Aasim Shahzad2,#, Jiyong Chung2, Tae-Jin Lee1, Yeong Hwan Kim1, Woo-Sik Kim2, Taekyung
Yu2, Suk Ho Bhang1,*
1
School of Chemical Engineering, Sungkyunkwan University, Suwon 16419, Republic of Korea 2Department of Chemical
Engineering, College of Engineering, Kyung Hee University, Yongin 17104, Republic of Korea *Author to whom
correspondence should be addressed [email protected] # Both authors contributed equally to this work

PO-131 Verification of long-term genetic stability of hMSCs during subculture after internalization of quantum
dot based nanogels
Se Won Yi, Ji Sun Park, Hye Jin Kim, Hyun Jyung Oh, Jung Sun Lee, Keun-Hong Park*
Department of Biomedical Science, CHA University [email protected]

PO-132 ECM stiffness may modulate macrophage phenotype

Cininta Savitri1,2, Jong Ho Lee1, Sang Su Ha1,2, Kwideok Park1,2,*
Center for Biomaterials, Korea Institute of Science and Technology, Seoul 02792, Korea 2Division of Bio-Medical Science
1

and Technology, KIST School, UST, Seoul 02792, Korea [email protected]

PO-133 Controlling the morphology of polyvinylidene-co-hexafluoropropylene (PVDF-co-HFP) membranes

via phase inversion method
Yye Jin Song, Jong Hoo Kim, Ye Som Kim, Sang Deuk Kim, Young Hoon Cho, Ho Sik Park,
Seung Eun Nam, You In Park, Eun Ho Son*, and Jeong F. Kim†
Membrane Research Center, Advanced Materials Division, Korea Research Institute of Chemical Technology (KRICT),
*Interface Materials and Chemical Engineering Research Center, Advanced Materials Division, Korea Research Institute of
Chemical Technology (KRICT), ([email protected])

PO-134 Preparation and properties of PVA hydrogel containing chitooligosaccharides conjugated with gallic
acid for wound dressing application
Hyeon-Ho Park1,2, Gun-Woo Oh1,2, Seok-Chun Ko2 and Won-Kyo Jung1,2,*
1
Department of Biomedical Engineering, and Center for Marine-Integrated Biomedical Technology (BK21 Plus) Pukyong
National University, Busan 48513, Republic of Korea, 2Marine-Integrated Bionics Research Center, Pukyong National
University, Busan, Republic of Korea *[email protected]
PO-135 Fabrication and antibacterial effects of poly (vinyl alcohol) hydrogels containing
diphlorethohydroxycarmalol (DPHC)
Min-sung Kim1,2, Gun-Woo Oh1,2, Seok-Chun Ko2, Young-Mog Kim3, and Won-Kyo Jung1,2,*
1
Department of Biomedical Engineering, and Center for Marine-Integrated Biomedical Technology (BK21 Plus) Pukyong
National University, Busan 48513, Republic of Korea 2Marine-Integrated Bionics Research Center, Pukyong National
University, Busan 48513, Republic of Korea 3Division of Food Science and Biotechnology, Pukyong National University,
Busan 48513, Republic of Korea *[email protected]

PO-136 Development of a colorimetric sensor using an environmental microfluidic chip and app-mediated
analysis
Yooyeol Yang1 and Myoung-Hwan Park1,*
Department of Chemistry, Sahmyook University, Seoul, Korea, [email protected]
1

PO-137 Preparation of organic-soluble gold nanoparticles using a ctab nanobubble solution

Jungmin Lee1, Chan-Hyun Cho1, Myoung-Hwan Park1,*
Department of Chemistry, Sahmyook University, Seoul, South Korea *[email protected]
1
Plenary Lecture

-1-
-2-
  

          ! $#"% $'&( )"







 








! "#

 
 
   ! 
"$$#%&  % " 
(%*'%  "')#'
  +, 







*% %* *  -% .%*, /   ,  ./% *  % 
 %%%  ,   0  %%   /%%  ., 0,  %    ,
..%  '  %      * ,     % /    0 
 % %% 1 /  0. ./%
 0  ,  % ..  .%* %% $    .%*2*% %*%3
4 "5-, %,*% ,%%%., % 6 0%%. 
%%  . %*   ..%  /   %. %%* *  %%%  ,   %
  ..    /  ,    ,  , %%-     
6 0% ,  %   %* %   .,    ,   .  
..%  /   %. * *%   .. ,. .   %  ,
 % 7      0 ,% ( ,  %  ,  . ,,,% *
.    % % %   %%    . %-, .    (
 0%0 %*% .,.% ,0  0,  %
 %%%* ,  . 

-3-
  

          ! $#"% $'&( )"







 

 





 
    
      

%  (   
  (     '   )  !#$&" 
  
      *#    
 (        (  '  
(       ( 
 (+,   
$(-,$0./   ,    $2143   '  
      

   (  #$& 
  +(   (     '   5  
       

 
   (      
 

 '  


#6 ( '     
(  #$& 
  +(    
    '   -     ( ' 
 ( (    
' 

 ( '  

 (  +(
(#,3( #$&

 
    

   '       7       (    

'  #$& 
   

, (  8         
      




-    +   9  ( #$&    '   +  '  (    
     
  :  '  #$&    (     
 ,  ) !;,."
      

 '    ( 
  

  
(  , '  #$& ) 
   (     

(   ;,.      
    
     (     

 (      
 
< ,# .
   


  =  6 /
!<  .  '  
.  .   $  (
  " #
 6 =(
#
 ? > 6  #
 - 
=- (!" +  
(  '

-4-
Keynote Lecture

-5-
-6-
  

          ! $#"% $'&( )"



  
 
   

     
" !#
 
  





 







!
"#
!$!
%
 !
$
%
!$$&
!!%!'"$
!
"


 
  !!   
' 

     ( 
 $

!"% 
" 
 %
 "
  !
  
  
)   
 '
!!
 ! * "
  
 +%
 ""
 " 
 
 
%

$


'

"
$ 
#


!

,!
  !

!""!$
!
#!! %%!

 -012/.( 


'"


 %

2

 $ 33 

4 
 
 
   !   
 % (
# "" !
4 ! 

  
   
 5 ! 
4 5 ' " 
!" 
!
    $ "!
 012/   $
!&
 
  
   !
!%!( 


"$$

 
!
&


!



$ %
!5"


%!!!
%
 
 $  
) % %   ! "$

 
 !

%%
 



-7-
  

          ! $#"% $'&( )"





 






 


     "!!# 


  
$%"#  $!&
 (')*"%
"""#  $! 
,+'*




 %*'(% 
%**-'

     *   
%  .*  *   %  /%    '
#%  *     %      * 
' **   * *    *
***'0**
%1***
,22**'






-8-
Oral Presentation 1

-9-
-10-
Company Session I

-11-
-12-
  

          ! $#"% $'&( )"




 


 
   


  










   #$!"# "
 #%#" #" & '      " !  #"  $" 
(*)  #!"" $   (')  "&      "       !
""   ""   +$ ! !  $"&   ! !$ # 
"  " & !!% ##$#"!
 "     * ! "   ! !$  & #  $"# "
"$!#",!""" "
""$  ! ""  ! "$# 

-13-
  

          ! $#"% $'&( )"







 

 


 







 

 








"# " $"#
"#% ! 
"# " '#%&#

( $  0 -. #   %  * # )+ #   %  , /# " $ # 
 "  5!#" #
   2  413   "  #
 !$#  0
0$#   "# "  #
 5!"   " 0   $" ## 
 "# " 
  '#
0 "#   %  # " " "#  # # & -6.( 0 #
 ##  "# "  '#  "
"#  ##&#  % , "# "  #""
$&!0  $"
"# "   # 
 #
" %#
  "#   # " "
$ & !
" $# $"#"$"# %#
 # $#%27& $# #
&  '#
8#" 
#0% # 0"# "  "0%"
 3 #$ 9  3
  
 4# &  : # 00$#    #  "  #  
;1 !"$ # & =9<#
) ? " &>  !"$ #  
; !"$> 
*   "#  
;<:7 # 7 ? $$
# 7 
+ &"#$#$ $!# 

-14-
  

          ! $#"% $'&( )"




  


      


 
 










         $ " !   #      
%& &  '$' &'% #'
&&&$(% & %&  %
    % & *$   %%$ & )    ' ) 
&  &$
+ #' &&&&$(  #' 
  $, & # +'%$% 
  &) #'%# %*$ %%$&
   #$ &&   #   & (   '-  ) 
%&'& $$ )
 1.02  1/((3542('-%  $6
%
7   &0%$4# !8) #&#   )
# &  ) .     94   &  + $  & 3
#   '&'')# 94 )
$


-15-
-16-





 




 

-17-
-18-
  

          ! $#"% $'&( )"










 


 

 !
 
&$#%""% 




+,-' *)(.+++/!01+1&
+,!,,,!!,"2+
+ *)   3   ,+  ! 44 '5( ! !
, 3 ! 4! -3 !  ! 6, 6 ')*(" +, + *)
,, , +   ,7, +&+ - +8! 4& -! 6!-
 !& ! 9 -6   8& ! + , ! +  
!+," +,$+!&
++,&+"  - + !4 4 ! 4& + *)
,! ! ,  ++  , ! )* ! 9 ! ++
6!-   + . ,! + ! !-&  !  + *) 4!  -
6&  ';:(- " + ;:- ! . !! !
!-! 4& $, *) !  !,& ;:- 4,4 
'; ("2+&+8++ *)!6-+-,
+,!,.4!+4,!;:+ *)!!,
, 6  , & + -  !"
 + %
 . 
+ *)-; !+&"




-19-
  

          ! $#"% $'&( )"





    
 
    


 

! ! #"!$%$ *&"!')&"( !'$ +! #!  "

 
      
  
   !!"





 


 % % % $%  $  !# & 
' 

 % 
%   $  
   (    & %  $
    %% ! #$  $  ($
#)"&  * %  
' 
$&  "!+
#)
  %$ %  $
' 
&&!# & $

#) % % 
    (   % & ! &
     & %   '% 
 + 
 ) ($  ,
 -  , &  +)-),
 / ! . +)-),  /     $       %  %    
*(    (  %    $ 
' 
  &&  $%$    %  & 
% #)  ! 0      
 #)    %  % 
   ($
  (       %  % ! 1    $    % 
 ' 
%  '&  ($ $ ($
%   %   $
' 
!2 
  $  %
  % $ % 3!2 
  & %  

  /  (  
'  % %    ( 
%   $
' 
&&!2   $   ($'     
  

'  % % &&4! 

!   -$ 7 ! #   65  '% 
  ($ 
   %  %  
$ '(% &&&389 

 38:;4'88!

3! -$7"<)""7!#7#6$65 '
% 
=)'+> > #
'-
?&384 

 :83;'
339!

4!     @ + &%% $( ?! #!  >  6 ,  - 5
0    ( (      (  

 
 (    38: 
 

 3:A;'43

-20-
  

          ! $#"% $'&( )"





  
 

 !  

 
  
 "
! #
 


 $&%%& 







*)  '(  +      , -   *)
   --   %-++
,  -&    ,,,    -   --   
-,-+, -- % /. ,-*) 
  +  ,  . -   % 0 )
.&  .-.- ,+--
. ,  1 *) '1 (  -  .   1  . , -   -& .
    + ,-+   *)   %   -  , 
              % 2  --  
--  1        ,     /+  '/(  - 3 4,
')
53(/ ,+ , -  -%6 7 





89,+)%%
 !"60:% 
89 , % ;%%

 !"<< 
839 , % ;%%!"67% 
809 , % ;%%
!"#633% 
869 , % ;%%
 !"$% 
879 , % ;%%
 !"% %



-21-
-22-







 


-23-
-24-
  

          ! $#"% $'&( )"




  
 
    
# "!$' &)% '($# *+' # *,$! *'$!!"!(,$% .-! 
! *'($,/

  



!  !      
&$%#
""%



 !*      *  *&  
 !*   ')(   !
   +
   *! ! +!+!, -
++
  -  
  !  - 0    '/(" .       +    
  !-!   )   + +  !!      / *  !    !
*! ! *!
),!
+
% +  ),!  
+  !-  -*!   + 
"    ,! +!  % &   *
++! 
+!- 
     '/(  *    ,
1+! "&-!*+ 
 ! +!   -  !
 !
-
- *! +*!*!! "
  & !  -+),! *   +  !- 
!,   

* 

+" .     *!   +  *!  - 

!+*! &, !+*! +!+  
!')2( ++ '3/(    
!  + 0+* '4(". 
 !* '),2(&   



! !'! 
( *   +        !!& *
!   !

 +  *  !'
 !*  ( ')(" ) *! !,+    + &
+! * ! 0    !   +  !+  
+
 
     
 !*  
*&  )    
 ! 5,!   
 + " 
 !+*!  

* +! +
')2   3/( &

! -         +" 
 !  !   +  &
!+
, -*! 
 !* ")0+  
*!     + &          -  *
 /     +
 -       
     +! )" +*6+ !      +    
 !0&*-*
    -   &
 + " 
%  
+!  
1)0
*  ! -+!  !+ 
+ !-!!*
      +&
!,   

*+ "7
*!-
)&+!+  &  ! ,*!! ! *!! "

-25-
  

          ! $#"% $'&( )"

 
 
%" %'"%% " #!  $$ #" # "&
!# ) ( !" $(#%
 *+

 
  

! "#$%##
     #% "$&'% (  ) %  *# +  
.$#,-10/$%##
%#,-2 /#)#$$-10%$$
  %$3$  .   4 4    -2  
3$-2 %%#5$-104$3%
%3#%$.##':968;877
5$  $# $#33## $$-10  %
 * % $   -2   $ $%     8 .  
 -105$4%#-10
#-2 .%%.#$ 

-26-
  

          ! $#"% $'&( )"



 
   
 "#$ ! 
" %&" $ ' (& )$)
$(&)  &* $  &
+ *  (&+ ,+  ) .&/&- 

 
 



!" $$&%(%'#
)
 
 *"

"

+
 ,
   
"

"

  -
 
.( % 

/

+


0+
1

'

23+
+  (,56,3444478

, 

"/'%/'%#
"
8
8
 ,
 "

 "6


9
6  3
" 
"
,/'%
:8
4!3

/'%6

8





,     88  ,  
   8 6 6  
,," , 
86  

;,
,8   
     3
  

 
  
 ;4  
,
 


6

"

 
6


6,8 ,

6



/'%4*8 "/'%
8
6

6
88,8

6 
 "
  /'%  6   
,   
 
  
 ;  /'% 3


6 6 4'





 ,,,8
,

8 ,

"6

 

 " 
"
 

      88
   6

8   /'%  


:
  , 
  3
6
8,8


 3
"8
 8 ,
"

4
<
 8," 88   6  8  ,8
: (+1# ,

 3 
 
8

    
 6 "  
 )$. 0 ==#4 !3

   ,

 
 

 
:   
  
 " 


"4% 


,
 
", 
8
/'%


,
9
4
>
6
,8
6


,
 
"
 
8
,/'%



,         )$) 0 $0#4 
 (+1 ,

  ;
  8
 6
  
3,

6


,3)  
6
"

 /'% (+1
,


6
6


:
  4'6 
6


6

:"
6

,8
" 6,

 " )    8 "  ,
  6  )  
8

/'%


4+

3

,


88
%(#3 )  ,

""

 
 

8

 


  /'%
8 
  
 (+1 ,

 8
8
 ,
8 


 "  # 8 ? 
# (*(?# 6
" .6: 8
 6   @( %#
,

(?
4
% " @( %, 
 (+1 ,

 @( % ,

# 8

  
3 

  , 
 


/'%,8
 
8 ,


8
6

 


 4 +  
6  ,
  
 @( % ,  
 , 6
 
  
  6 
 

6    
 %(
8  
 ,

4  3
 
 


8
 
 @( % ,

 
,8
 
 "


" 86    
 6   
 ,

 
    4 )$= $$0#4
>


 
,

@( %, 
(*(? 
%(
8 
  6 4
@( %, 
)$A0B3



3
6
8
,
6

6 
,",


:
 
%( 

6 ;

/'% 


  
 
 

  %(
 "  
 " /'% 4 /

  3
 


 

8
 
 8
 6
6
 %(
8
 (+1 ,

  "

   ,

"
 /'%



,     )$=D=0C#4 

 
,


 %(
8

3
8 ,
4


9
,8

,E77""8
 6  ,

8 ,

"6


  


6,
 88 4+

3

 
 
,




/'%
-'%   ,/'%

 3  
"4 >
 "  6


  
 8
 6  6
 %(

8

,8
,8


3 
6,
 
4

-27-
  

          ! $#"% $'&( )"




 
 

  

 


 
 !"&$%#  '"(# )" # %*'"+


      !  
"#      $!   
    %  '! & &(

)  !  * *    +      * * * *!  
   +    ,!! * !! +(!   
 !& -  *   *     *     ! 
      +  *   +     *  + *  & .
!    ! *  *     *  /*! *  +    ,
!       *!!!& !**    
    !  /  +     *   *  +   & 0  
** *  ! ** * !4*13)2 *** !
4* 13)2  +   !! * !     +     !  & . 
!* /*!  *+ *  !!   !    
 * +  ! *   * +*  *  /   !    *
 & - !! *  !   !    "+ *  * * 3)" *  
+  3)"! *   * 3)"+*5*  +  *   5* 
!   *      !!& . **   * !   ! 
 **      * / 4!*& )  *  *     !
   "+ * *   *+ ! + *  + !*   / 
+ *  !! &3)" * + *!     */
+*   !**  **&3)"! *  *! 
 * *        *  !** +  3)"! *  & ) 
 *3)"+*5* + *!*   +  /*
  4   4"  (   /   +*5* 3)& #  3)"+*5*
 +  *   *     !   *   + 
/ **    &    *     !    "+ *
 *   !  * *   + & .      *    
 !    "+ *  !  *    !  !!   *!
+ ! + *+  *&

-28-
  

          ! $#"% $'&( )"




    

 

   

   

  ! 

"!
 #%$ 

 
  
   #"!!

$&'%%&(
 !     % &   ) ' ' %%  &   
%%'%&&%!
*(+%#&&&&
&%,&& %!-,./%&&,
& & && ,)  ' '  '    '
&   %    &     % !-
0  '   '    &   %   
&  #&      &  '     %
   & &! /    &   %
     , & &&  %   % && 
% )%! 


     ( &   %  )   %!
*& &&%& &&1/,/032'% 
 %#%% !40/
 & &&   ,&  ' )    &  & &&
%)%  &  ! *  /,/03    ) &    )
%&# &&&&!5
    ) 
  
  ' (    '   '
  && ' &7  #6  !8  & && '
&&% #   &  &7   % '   &  
!               #%
&% 
  ,!

5  ' & % && & & && ,)   
  % '    &  %%   %   
   %   %! 9 ' &   &&
%& &&1/,/032' )%&7/,
/03)&%%! %,&%%
& '&%& %!


:0!$ %'& & 
   -;4=>?<.,=<!
-
:0!,&0
 /%$  
-;--4?<=8,<>;!
.
:0!@&,3  &,@ 
BA,$C$$ 
 -;-.4?4.88,4.<-!
4
: 0  ! 7 /% 3 && '  /&&       
-;8-?.88,.<;!
8
: 0  !   D 7% &  ' &7,& 7#, 
%/%3 &&! -;=4?-<=8E-<>;!



-29-
  

          ! $#"% $'&( )"

 


  
    
   

  
 
 "!#! )% $(%&'%"!*% $% %"! '), $+%)% "! %,-  % 
&("! %*%,%  %)% (%"!.

 
   
 

      
    
   
   
! "! #
!& & $%!)((' *

 !+
,
,- .
!

+
,
,-
%
# 
 / 0   
1
#   5  6 
 63"24 
%! 7
9
 8
&!


 :(!$;) *

,

49

  
 

 
99
&    ,  !

  
  1 
  1
 
       
 1 , <   
  1
1
 

  



1  
 
9
 , 
    1
 
 =   >  9  &9
 

  
  , 79    
   
         1
 
    
   
 ,     



  ? !&  1 

 @23 <A
  
  
 
 @5#6A

 

 1      
,   
  

 
  1
 

1     
     B  
 
  B 

   
 &9     ,A
   
 
  


     

    1
 
  , 3


 

   
   1 
    
 
  
  
 

 

   
1   

 
 ,3
 


 
  C  
 9C


1 

 , 
7   9      
   1

!     

 

  @
!
7##D 45  0D 45A  C  1
 

   1
        
 


 
 1
 

 @,
A, < 9   
     
 1 9 

 1
 


!7##D 450D 45
 C,%A

!7##9
 ? 1


 
 
 !C
!:!

1C
,    
 

  
  E6@1A:F @ 45A 9
  ? 
   ,:A
  
!7##  '!
1C 1
 9
      
    45
 1
  
!
7##D 450D 45 C,8  

   #!
!7##D 45 C

  
  @
  
  
  <5A 1     

 
 
  
,<   
 1
 
@ 


 A9
1  1  ,0
!7##D 45
0D 45 C
1
 

  1 
 
  9 $ ,      
  
 #!
!7##D 45
 0D 45
 C  
 

 
1
 

 ,39   
1
 
1
 
 
,
A#,!G,8 *,7H,!,H
H,!J,
I,!5,KG,!,
G,,L H,!G, 
,!8,5

#/"0)(%%:!%:$,
%AG,"

7,"1

G,,7
4,"
?
9
,7


#/"'( ';!
(,
:AL,*,H
,6,7
 ,*,  G,8
6,5,0
9  ,*8,7,
 

#//1$($% !($:%,

-30-
  

          ! $#"% $'&( )"




 
    
 
 !" $#! &%'

  



 


 


 
 
 !
""# 

$% 
 

     
     

 
 
& 
  &
  
         
  & & " '
 &  
     
       

"$  
   
       
(     & 
& &    

  %
 &&"
)  
( 

 

 
 
*&    

   % 
  " +     
  &&  
(   ,   


 
 
&& 
 & 
*
  
- 
". 
% &-
& 
 %

&/)210
& 
& 
/310 
  % % -

*&  
 & &  4%& 

&
  
  
& 
 4 
 &    
" +      % &
 
    & 
 & 
 4  
 
 
    &  4%& 


 &   %&  
 
&   #%    & & " +   & 
 %
 
&  %             
  

   
  "

)$+ *( +  #   & %  6
 '  $
&
  5  /6'$0  


&&%5 

/:+0/78,39)7,80"

-31-
  

          ! $#"% $'&( )"

%%)")"#,".%#(-#,$(""
 * (+/10 2 $-&&3 4

=$ 9#5<21!#!$
$+$1-5$ $-#$+$7?>77 $ 
0# 
6
=$ 9#5<21!#!$
$+$1-5$ $-#$+$7?>77 $
@
=$ 9#5<21!#!$
$+$1-5$ $-#$+$7?>77 $
A
2%#<$%5#5$ 9: 
6='#9: $

5$ # @2 3% $* $   %  $ %#  3  
%#%%#+%+3%+$%
 -$$%$3#$#%
$ 3  @23%   $ $ # .$$   $ @23%   + $
       #%  # . 1 $  #  
#$%%#
$3@23%3%%.$%#
3$$$#5$3#.$$33$
 $ . 3 *#  ,/ 4 %% C 3 $  @23%B ,6/
3 C $ %  $  % 3   B ,@/ 
3#%3  % C $$  3  % .$ %#   $ *
    4    %    $ $ #B ,A/
%%% #$ %%B  ,7/   %3  %#    .
 #  $  # 9  3 #% $  3 
%$,'0D2-/&%E
D, /&$#,9-/3
 . % 3  .$ $# 3% ,@23%/ #$ 5$ 
333-#%'0D #%$.
@23%  3 $    4    .  9- .$
%%#3,=<!/.%%3!.$.#%3
3 #  %  5$  '0D     %
3.$#$G7F3$$#34$343$
#$3,##"6HAH/.$$
$3##%#$$4=<!3$
  5$ @23% #$ $ #$ %#  3    #  
###


6*5
5$$.$%%$.#$:=I2'# $
L#36>JK( >7>>>6>?K(!>78>@M$( $LD
 @JJ>AM $ $+$ ' 1 5# LD >?>>@7?8@@M  .  $ K$
5D5$1LD6>75;>E>J8M

(7
5 
LM D ( E N
 ;
 !
 9 ) K N$ K
 N ) " = 
 ) 2 @2
'9$$!$3D90=%<$2 
-("6>?J>88AA
L6M N$ E =  " K $ 2 ) "
 ) N$ E ' 9
 ) ) @23%
<3#%9 .$1"#'# O3
2<3$1O1O-6>?@ 6>J>>77>

-32-
  

          ! $#"% $'&( )"

 


 
 

    

 


 


 
 
  
   "#!$  




 
  
  


 
 !"
#


 $ "
 
#
%
%)'&() 

*   
$ #  
+ 
 ,)  

 
))
 
# 
&*  
 
$ 

)


#)
# 
1 
  #-0/.

+
 
+ 
 ) $ 
 
 #  #

 ) 
     

 &

))
  ,   +   
+
"    2  
+  )    ) )

     #
)

   
    
  
  
    
 
   )
 &  
 )) 
+
))


 %
 ) )

0/ %
1
 &3 
 $
  
      )   
   #  ) #

 # 4#
 #  #
     
#, ) 
  
#  
# 

#%+   
 
 
+   )

  )

 
  
 ,+  )
 #)
 
   0/    
 
 &   

 
 
 %
  ) )

  #)
# 
1  0/ -76555 0/.& 3 

+
 
 # 

    $   , %) #
+    -:89.
  #
  

,  ))    +#       $  
 
    )
  #
  0/
-&;%<.&  0/     
 
 



 

 
)
 
  +
"    #  -&8.&      
  
  
     
     


 # 
 # &=) #
  
)
   )


0/
#
+ 
 $ + #
" 
 
#
 #
)
)
  )& 
#) 0/) )


))
#
)$ 
)#
 
$

   
$ #  &

&  >
 %
  ) )

  0/& -;.  #
  )
  #
  0/
  


 
)

&-?.
+
 , %) #
+ :89 #

)&-<.)
 
# 0/
@
  &-8.0

  
 #
)
 0/&

-33-
  

          ! $#"% $'&( )"

 



 



 



 ! 
 
!$%  #" 


$#'
$&
()*+*
)&,.--.-/-/.
0
1&,.--.2-/2
3
&
3'4
*
*5


 )$##' "
$' 
"""$ 
 " $'  
# ##$$
' ' '%
##
$*
6#'$' 
"""$ #' $3# ##

 7 $
"% "3#
"%
' 8
%1%*$
'
8
#$
 
$$
$1%
'1'3
5$
"""$
 ' 
$* 9  
:' #'$' 
"""$
 '$
"  
$#  '
'%

#%* 
 $ $'% 8 
 $%$:' +1" ;+1< =
' #'$' 1% 
""""$
;+1>A@?$<* +1>A@?$
 $3#% $%$:' "% 
$ 3"
   + ) + ))B - 


'    ' '% 3
$3  C+C?-D2 "
$ 
 $  -+
' D+ 3'$*
9 
"""$ 8 1%
'
' =
' 8 +1 
$  
"%
' '
$ 
 
8* E 8 '$$$  

:
  %  
%
' 3
$3   +1>A@?$* 0


:
 +1>A@?$ 8 

' $ #

' $ 3$#% C 9C @9
F
#

'+6 *9 $ %
' 
%
$ 8
' 8 +1>A@? 8
"* 9  3  3
$3   +1"G 
' )3
"%
'  ;) <  
+1>A@?$
' 
 A1% #$ ; A < > $ 8 

'* A $$ $$ 

+1>A@?$ #'$ 8 +1 '$ $
   $$ $ +1>A@?$
 #3$   
''%

3
3'$*


-34-




 





 
  

-35-
-36-
  

          ! $#"% $'&( )"


  


#  !"!! !
 
 % $ &$(' )  * 
+ 



    

 
 
 


$
 # "#
! $
# %
 

&
' )+ *+ #((+

,#
#
'# 4

,
$
# 
#-1#.3 2 

#0/'0/32 2
   %
 #      
 # $ 67( 5 +
 2
 
#
,#
# 
 #
   2#2    %

  $ # 

##2#
#  #8 8#(#
 % 8#- 8#.
% +
%
# 2%#  
##
# 2
 2 %67(

%'
 $

,#
#

 +
#
% 9  #%'  % $# $



 6:7(
# 


#
 
    # % 
,#
#
, #  
2 # 
,#
 #        
 # 
+  
2
## 4
(;
%2
#3
%#

2  #
  32 2 #2 2%
' 
# $
 
'# 3 23%
 67(  4

,#
## #  +
#
2 #

,#
 #  
2 9
# 
 
9 
(

 3

$

 2
 # 
  
 
 
'
 2

2 
,#
# #  %2
  

#  #
  


,#  8   9   #%
#
( 2
 %2
   

# 2$
   
# %  
2      #
32 2$
# 

 2
# $


#6<7(=#%#
 #
#2

#
#).%2
'



,#
 
  .  
'#

,#
 #    :. 
 
'#


   


,#  8( 8'# 4


,#
# 
 

#  
# % 
  
 % 3 
  
-:/// .( 2
  #
 
,#
 

# 3# $ # 4
 % #  >'?   '?(
22 2


%' #
# $
 @'%# #
#% -. 2
    3
  
  2#2#

  2
 2#2    %
( 2
 $

 

 
,#
 

# 3# 
#
  
A0/%
 3 2%2
(B


 
2

 
%
2 

 + #
-;#.(;
 
'
  

,#
#3

$ # 4
 2
#    
#
 
  

,#
#
3# 
%%4 
,#
#
+
#;C ;A:(8
,2

,#


# 


 
% #
 % 2  
##
  
 ( > 


,#
# 3

 % #
$
  %2
'


(B
#
2

 
%$
 
 

2   
'#

2 (8
,
3
 #

,#
#    #  E; 
 -D:. ;; 
 -D:.   2
2%  -D0.
#  
'#

2 (F  '  'G 
#
 

#


 2
2% ( = 2
 2
 2 # F     ':G0

#
  
 
#( ;# $
% 
2 $
#  
#
'

  
#%''#
 
2  
 
 #   

  
,#
 8   #
# 
#
#
 # 
 
'#

#
 $

,#
'#


# #( 


!  
67 (2
(;2

$-/H.
67@(5 
(;
5
$(:C:(HA'C:-/G.
6:7(5(B2 
#
 $; ;2
$(G<-/A.
6<7"(!
+#?( 2 (8+%I > ;2
$(00(CCHA'CCC-//G.


-37-
  

          ! $#"% $'&( )"


  


 
 

!  "%#$ %!  #&($$'!  )


        

 !!!
! ! !   "   
 $  ##% 

&    !    '  ! 
""!
 # (    !  "   ') (  '   ' *  " ! " 
    +  !

  " !  " ! #    "        !  "

 !    !# ( "(! ""'!+  " ! ( 
  !# " 
"(! "  !"' " ( 
,! !    
"# -  
"  ! "  !  +     % 
 !       "     .-0  # /  ""    
"  '  ,! !"
(  "      '    ! *" ,!# 1 !   "  ' 
" 
" ,! !
"  !" ,! !'!  !"+! !   
"
  "   ( '
'      
" !         
 

*  "   " ((  ( # 
     ( " 
"      !

 
"      
(%( ,!#2 '",
 ",
 " ! , 

    3! !  !   

"  !   !       "  ( ( '   '
""  " ' "   
"  
 (  "  ( +
 "" ' 
!  # 2
  "" (,
     4  6!  !'      "    5   "  !  
% "        
"#2!"   "" !' 
! "  ( 
"       
"# 2 ""      "  !  ! 
"  " " " "   "!! '!
#2",! ! 

"  "  "   4* '  "  !!  " ! * 
  5#
   ( '" ! *" ,! !  ,! ! 
"  "  "   (%
!! ,!# 

#+#,#*#( 
78@##>.#0##! ##- = A#0#1 9#?   #<;
:;,
:4:B5

-38-
  

          ! $#"% $'&( )"


  


 

 !" #$$
%&"' 

 
  

#!" !$$!
()*#
'&&&%&""""
    %    &' &  "$ (   "
&        &     
   $ (  %    " 
"""#%$)&"
& # ""*
 %#   "" " $ + #   " % 
"$
$,!#+-
) %  &"  #    &   
"  ""!    "$  " & 
"""%%,+-./# %"
" 0  10  $ .  "    "& " & 
&& ,+ 2/ 3 # &&$      " (4    ""% &
"&#""%
" 65#"")3"%'&"
 "  #  "& %   "  & & !
3"3&"#&"%"'9( 8(7$
*%(%. +%#%/
   " "" &&
     $  "  % "&  
 %  &$ 9&   & &&  * ""
":%'&$&89;("
   " (4  &        " $
9 *&  " &   '  &  
&*&&:$ ""-;(""!
"*"&##$ 
(+/% #%%0%( ($
<&%"%$ 
"!%&"!&#"
#"&%#""$<
 % ""  #  "    
"$ ) *&   & %#    " % 
" : %    $      #  
&"   &&      &' " 
&$

$0$*$($/ 
=>($?$+-$)'-$"  
&&%,05@/
=0> ?$ " ($ 8"
$ 8 7$  -$ )' -$ "    $ @ &$ 00A
,05B/
=A>
$8?$8
$8)$?$"$8?$2!-$"$5$&$5655
,05@/

-39-
  

          ! $#"% $'&( )"


  


 
$%$&
""!"!#


   
 "  "!
#
%$&
)("' ')







      *   + ) *- -"  ,   -  
  *--" )  *-./
   * " ' 0 "         * - * 
  -  "   "  "- -' 1- -   * - 
  **  -    )   "  -' 0 - 
*- -    .  -20--" 
- +0
1 ,2'0-* "*-.43"  
    "   "    -  . / -  ' 
-"    .      - 3"   -  * " 5-  *
"    ' 0 -       *   *  -" -- -  * 
*- - '0- " - * -
* * *    *  - -' 0 5   -    -" 
+-"- - ,-).-*--"-'0- -
-" -*"-.*--- "-' 

-40-
  

          ! $#"% $'&( )"


  

 

! ! #" 

  
        
 
!
!"









#  $%  
 $ &
   

!
'$( 
 

&  
  

 $  $!
) * 
 -",+ $  &$
 
 $    -    
  &$  $   $ %  
  '$
, .  / $ 3+,2  1 !  1,0 
$  $   3+,2    

  (&   

 


!2 "($

&
 (

 $  $ $(( 

 
$  
!

-41-
-42-



)

% 
 



-43-
-44-
  

          ! $#"% $'&( )"




   

  

 
 


 
   








"


 "#! 
$

%% %&
'
$

& 

()


   &  
)$   %*  &) 
 )
 
 

' %
%
)
$"#!
$


  


 )
)


 %$
%
&&
 

%


)
) $
%
)

%
&$)
%
+
& ) ,
 
%
 & +

 
 & )
 )

 

 
)
%&,






$ +$
%

  

&$

$



$-$)
  
$
  
& $ 
 "#!  

 
'$
) $ +    ) 

&
) $

   &  
% 
   % 

% 
% 
   





& %
 
$"#!
$

+





&
)



%* & 

% 

 )
"#!
$




&%.
,
%
) 

%

& "#!
$

+

)
 )
&
-)
)$%+*


 

 
$

 
$"#!
$

 


-45-
  

          ! $#"% $'&( )"




 
 
 
 

  
 
  


 

 
!!  "

   
"!"  ! " #$"
%
                          "!&"'




  " " " ( *") +!    $ "  "
" "," !- ", $ " "(! ")
"" !",+" !'
" " "! "   -+$ ! "  $ ! "   " "! "
 " " ( ")     +   " " !$ !$    
! ""-+ $ !! " ,'
"( "),'"(") /.,'"(/")! "$ *,  
!  *  " +!       "    !
 "! "0!"  " !
"   /" 1!  !" "  "      +'"  $
* "" !   !  "   /"  +  "+! +    
2!!"" "$    "" 
 "" /"! "+!!!$  ""!!" $ 
,!"" " "


-46-
  

          ! $#"% $'&( )"



  
  


 
    
   
  !#"$ %& %'(#"$ ! & !#$  &
&*)+$ )! %,!+$ ! !$ !!-!  '#$
(' %&.$ &)/ %'(.$ /! !!  '#$ ')
$ ,& !!0 &1 /)'  &+0



  
  

  
 
  
  

 !%(' 

 ' $

  
 #   &
 "

  

 %(' )  
 
 
   

*
+ '
 $


 

 ' $

 
 

 ' +
 
# 

 . #
' , +##- 
/
 * 
   




&
. 
 '&
. 
 22

0!1
  
 0 '
3'  
4

66!5'/ '1*87 72


9'
 


  .
  
:.
. ' 
  

 ,'%$-   
 


  '
    7 )'  
  '%$ ('  
  
 (
 

. ' 
  '%$  
 
  
 ( '' 
  
 .
'    ' 
;&00'
.

.
< 

<  .
:

. 7 =   
   ;&00:

 ,;&00- . ;&00:
 ,;&00-
'%$ .

. '  ( ''
<

.  '
 

7 #  ' '
 

 
 
;&00'%$(''
$
9'

 

3,$93-.
#>* 
 (


. 
.
 


 
 '


7 +.

. ': 

 

 ('  :  .
  #>* 
 
.
.'

.
';&00;&00'%$.'
  '.



7;&00'%$

.
(#>* 
 

79'


'

#>*

  

 
 
'%$('


.
7





-47-
  

          ! $#"% $'&( )"





 


 


 
"!#! $"!%
 #!&
 '!
(&#!)("!* 

 
    


   
    
  
! "   

$ $!% # #&




'              
 (     
)* # +     
( 
*         )


) #
)
 *

 
               
)    ,    
   #-, &(         

   
             
# - ,

   
*
(
   
  ./  *   2/- 10 ( ,   

  3 ) (   
   *

       
(*          #'(

    (  
 

 
,
 
 
        

  )
 *    
 #
4   (      ,   *    ) ( 
  
 *, 

        
,
 
      #5   

  *     6 
            
      

 
  
   

  )
 *#

1/- ( ,   (.  "2877,,,#  # 0#

&%-,+ )8    (*    

-48-
  

          ! $#"% $'&( )"





    

    
 
  "! $#%# 


    
 !$#"  
     
%# %&  ' '% 






+#$ % ##$$# (*)
$$$$ %   # ' 
   $,     #$   $  #  +   $$ '
-# $#+#$#%   

"*
./#0+$   +$$ % 
  '""1  $$ % 
% # $,  $ '


-49-
-50-
 
*




*

#&

 


-51-
-52-
  

          ! $#"% $'&( )"




      
   

   
 
! " "








%#%&'$* ) *) ( 
+    ()    )    *        ) * ()
 *) (  ,%&' ) (
    )( )*() -  
( +))  . )   ( 
     ) .( ( / * +) . ..
     *  )  , * (+)        )
) ( *   #0&$ , (. )  *  !) )  " )
 )       1 ))  ( * )    +   )
 0&.())  )  " )) )    ) *)   " 
 )*0&, )) " ) *) )
       ")     ()      32 )  
   56 4      7)   (   ) .
  ( * %&'  )        )    . ( )
.() )(*) ( 
.7 !" 

 ; 8   '(   , :" ,
*  ) ' , " 9.    
)(0? 4 )''4@2=<<>>.<32<A2
A  '(   ; 8  , :" ;     ,
*  ) ' , " 1! ( )
( ).( )0? 4 )''4@2B
B=>3.B=>=A227 (( 


-53-
  

          ! $#"% $'&( )"




 
   


  
  
      

 
 ! !#" 


  ! 
%$"#&&$ 






#!#!'!!
! !& ,!  (,+*) %# #' '  #   #
-! #!&  ! ## #.! #   #!'#
 ''#'#,+*&#!%
'#,+*  '-'!#.!%##!
  !     '  #'& ,# '-'!
 # %#     ! !  ! # ,+* 
'  #      %  !   # !& ,# %
!!#' #'!&

-54-
  

          ! $#"% $'&( )"



 

   


  "!

 
   

     

    










!   $   "# 
   
    #

     $     "
 %  # &
 ' 
"##  #    %$      

 
 $
 % $ ( )%


"  %  
   #


*-,+  .  $

"##  #%   #
 $
 &
$
 "

"        $
   #     ##      $ 
# 
 
/   ##/  $        
  $   
/    $     0   %

  #      

  
  #   
    
          
$     &" 
    "
 "  
/  111 *"
&"  "  +&&&   %

    #   

"

$ % 
/ 

 
   





-55-
  

          ! $#"% $'&( )"





 

 
 

 

 
    
 
  !#"$ "% ('&
#" )'   #" '& (', *+-#"
%. *( & +, /+#

    
 
 !  "$!# 
'%&( ) 




*    , #+)* 
 + #   )-.$ $/
 / /)*$##  $   
   $)0    1$#   +
#.   .     2+) 3 +#. 
 . )  # #.$  .)
/    .   . $ ) *         
     # .    1$ #       
 ) 4  .         2   ) "
   5   1$#  .)*  
/ $ 1#  )


-56-
  

          ! $#"% $'&( )"




    
  
!
 



 


 
 
 !!" 








#
%$
$
 


%

%$
(

& )!'
)
*
 $
+



%% 
(

& )
.  
$   %   (

  (
 ,((- ! 
 )
 

%$ 

 $
 
  
 
 * 
 
  
 
 

%% 
  
 %
 $
   
%$ $ 
    ! /$
 
%% 
% $"$ %% 

$
 
%!0

 *

  %   

 1$%  
 
     ! 2
  % %
 ) 
  
 
%
,034-%

 
% 


$
 


%%%
$!7$
655$

% 
*


034+ 
%
$59$
$
*
 * ,8
4-*%%   5"':)%"+
+%"
,<%%-
;5<%%!#


%  )   
  ) *  

! 7  
 $
  034 

 
%


$0/,>=5"*%-
$59$$
*
 * ,84-)


0/



!

 
  *


 *
%  * 1 


$  $

 
 %



    $$
 $
 
 * 
$*  
$
 $ % * 0/!
7)
$ $) 
$* 
)
$% !



0/
$)

)1%$ $
0/
+
 $$
,<(-
$ *
     *:
 ,32'-! # $  
 0/ <( $ * 32'  
*).  *%
*$$
:

  

)6?0/
$$
 ! / 
 ) $
  
 32'    %$   
$
 $ 32'
+ $$
,23(-!2 
$ +*0/<($
$
 *  *. % $! 

 
 0/  *   %


% % 

 *
  
$

$* !1%) ** 

)+
$
 %
 0/
 

$:!  

%

*  :

%

(( ! 2
 
 %


%   +$*  
*
 ) $
  0/

* +) %
   < 
 %  .    0/ ) $  ) %
  )

*
*:)

$% $0/. !#%
. 

$


0/*$ 
)%
$$0/ +$*  <
%   < 1%
  
+1%
 ! ( +  0/ % ) *:



  *  
$% $ 0/ .  *
 %
*@
 % 
$% 1 
0/%)=55$ )) $
!

#  " )    *


 %% 
 
 $
 
   1%
  

###


%$
 

*


!

-57-
-58-
 
+




+

 
,
  
%

-59-
-60-
  

          ! $#"% $'&( )"

SOC-1 SOC-2
Nanofilm Coating on Mesenchymal Stem Cell to Effect of Functional Additives on Mechanical
Maintain Sustained Effect of Promoting Properties and Inflammation Suppression in
Chondrogenesis Poly(L-lactic acid) Composites for Biomedical
Uiyoung Han and Jinkee Hong* Applications
Department of Chemical & Biomolecular Engineering, College of Eun Young Kang1,2, Wooram Park1, Ik Hwan Kim2,
Engineering, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul and Dong Keun Han1,*
03722, Republic of Korea 1
Department of Biomedical Science, CHA University
[email protected] (Jinkee Hong) 2
Department of Biotechnology, Korea University
Regulating cell differentiation through physical stimuli is having *[email protected]
tremendous interest to many researchers due to their relatively safe Poly(L-lactic acid) (PLLA) has some attractive properties including
to the several issues in cell treatments. Especially cell surface biodegradability and biocompatibility that is applicable for medical
modification involves minor challenges because extrinsic factors in devices. However, due to the decrease in the molecular weight of the
the coating process can exert unexpected effects on cell functions. polymer in the thermal processing, the mechanical properties of the
Here, we decorated the surface of mesenchymal stem cells (MSCs) PLLA composite could be weakened. Additionally, inflammatory
with multilayered nanofilm to promote chondrogenesis by using response of polymer degradation products after in vivo transplantation
fibronectin (FN) and chondroitin sulfate (CS). We found that of PLLA composite is a limitation in their bioapplications. To
chondrocyte marker expression and cell proliferation depend on the overcome these limitations, functional additives were added into the
number of nanoshell layers. We regarded that the thickness of the PLLA composites with a melt extrusion processing. Mechanical and
nanofilm that is adsorbed on the cell surface is related to the biological properties of the functionalized PLLA composites were
duration time of the effect occurred by the binding of cell membrane characterized by using gel permeation chromatography (GPC),
and FN, CS. At the same time, the nanofilm also showed a negative thermogravimetric analyzer (TGA), differential scanning calorimetry
effect of inhibiting growth by isolating cells from the outside. Thus, (DSC), universal testing machine (UTM), pH-measurements, and in
precisely controlling the structure of the nanofilms deposited on the vitro cell experiments. Such PLLA composites exhibited superior
cell surface is essential for promoting cartilage differentiation. So, mechanical performance with low inflammation. These results
we also analyzed the effect of nanofilms on the cell surface on the suggest that the functional additives play a role as plasticizers,
physical and biochemical aspects and we investigated changes in thermal stabilizers, and anti-inflammatory effect in PLLA composites.
chondrocyte marker expression over time to found the mechanism of We believe that the PLLA composites containing functional
the nanofilm effect. Our results provide a foundation for stem cell additives have great potential as a platform material for a variety of
engineering based on biofunctional cell coating. biomedical devices including stents.

SOC-3 SOC-4
Studies on cytotoxicity and in vivo biosafety of Water Soluble Ceria Nanoparticle-Embedded
PEEK composite for spine cage Contact Lens for the Treatment of Dry Eye
Joonwoo Chon1, Ji Eun Jung2, Young Jun Kim2, Syndrome
In Sung Jun3, Jae Young Cho3, Da Hyun Jung4, Seung Woo Choi1, Bong Geun Cha2,
Jin Ho Kim4, and Dong June Chung1,* and Jaeyun Kim1,2,3,*
1
Department of Polymer Science & Engineering, Sungkyunkwan 1
Department of Health Sciences and Technology, Samsung
University, [email protected], Advanced Institute for Health Sciences & Technology (SAIHST),
2
School of Chemical Engineering, Sungkyunkwan University, Sungkyunkwan University (SKKU)
3
School of Chemical and Biological Engineering, Seoul National 2
School of Chemical Engineering, Sungkyunkwan University
University, (SKKU)
4
Department of Chemistry, Incheon National University 3
Biomedical Institute for Convergence at SKKU (BICS),
To overcome several concerns which were caused by using metallic
Sungkyunkwan University (SKKU)
materials, polyaryletherketones (PAEKs) which include poly- [email protected]
etheretherketone (PEEK) for family group have been employed as Oxidative stress can be a potential therapeutic strategy using certain
biomaterials for spine cage. Polyaromatic polymers were growing substances to reduce reactive oxygen species (ROS) in dry eye
interest in the fracture fixation plate due to its stiffness and similar disease (DED).1 Because the efficacy of the eye drop is low, contact
Young’s modulus comparable to human bone. This polymeric lens can be an excellent alternative to increase bioavailability. Ceria
material (PEEK) has an elastic modulus similar to human bone, so nanoparticles (CeNPs) have effective ROS scavenging property,
that eliciting maximum bone growth into the cage. The Young’s
modulus can be fitted to closely match human bone (3-20 GPa) by and, to incorporate this property into contact lens, we propose water
preparing composite type with various reinforcement or modifying soluble CeNP-embedded contact lens (CeNP-CL). Excellent
chemical structure to increasing molecular weight. transparency and ROS scavenging properties have been confirmed
In this research, we aimed to verify potential in vitro and in vivo in contact lens form. Cell viability was increased by about 30% with
biocompatibility of various reinforced PEEK composite which will be CeNP-CL in high H2O2-containing media, and intracellular ROS
applicable for spinal surgery. To confirm cytotoxicity of PEEK level decreased without release of CeNPs from CeNP-CL. These
composites, in vitro analysis was carried out by MTT assay. And cell results demonstrate CeNP-CL’s therapeutic potential for DED.
activity which showed charge of phosphatase derived from living cell
membrane was also detected by ALP assay. For confirming in vivo Reference
biocompatibility, short term inflammation analysis and skin
sensitization test were conducted by animal test using SD-rat model. 1. Seen, S. & Tong, L. Acta Ophthalmol (2017).
After H&E staining and immune staining of biopsy tissue of SD-rat,
histochemical evaluating was carried out for confirming biosafety
through macrophages manifestation.

-61-
  

          ! $#"% $'&( )"

SOC-5 SOC-6
Tumor Targeting PLGA Nanoparticles for Rylene dyes encapsulated polymeric
Chemotherapy nanoparticles for cellular detection and imaging
Wheemoon Cho1,2, Eunsun Lee1, Sang Jun Park1, Mingyeong KANG1,2 and Minseok KWAK1,*
Youngsook Son2, and Chun-Ho Kim1,* 1
Department of Chemistry, Pukyong National University
1 2
Laboratory of Tissue Engineering, Korea Institute of Radiological Interdisciplinary Program of Marine Convergence Design,
and Medical Science, 2Department of Genetic Engineering, College Pukyong National University
of Life Science and Graduate School of Biotechnology, Kyung Hee [email protected]
University
[email protected] Rylene fluorescent dyes have great light stability as well as high
fluorescence quantum yields. Despite the excellent photophysical
Chemotherapy are combined with surgery or radiotherapy for cancer properties of dyes, the highly hydrophobic structure in common
treatment. However, the efficacy of drug delivery is low and there makes the compounds difficult to function as biological
are various disadvantages such as damage of normal tissue. To fluorescence probes. To generally utilize a family of organic
enhance chemotherapeutics efficacy, poly(lactic-co-glycolic acid) fluorescent dyes such as Lumogen® Orange, Violet and KM18 as a
(PLGA) nanoparticles (NPs) containing paclitaxel (PTX) were biomarker for cellular imaging in flow cytometry and fluorescence
prepared for drug delivery. For active targeting, targeting antibody microscopy, we used an encapsulation method using amphiphilic
was conjugated to PLGA NPs. For cancer imaging, fluorescence block copolymer namely Pluronic® F127. Cell uptake of the probe
dye, Cy5, was encapsulated into PLGA NPs. Size of PLGA NPs nanoparticles by HeLa cells was analyzed by flow cytometry and
were measured using dynamic light scattering. Morphologies of confocal laser scanning microscopy.
PLGA NPs were observed using scanning electron microscope and
transmission electron microscopy. Encapsulation of PTX into PLGA
NPs were confirmed using spectrophotometer. Conjugation of
targeting antibody was confirmed by bicinchoninic acid assay.
Expression of target protein was confirmed on A549 cell line.
Cellular uptake of PLGA NPs were confirmed using FACS.
Cytotoxicity according to nanoparticle concentration was analyzed
by FACS after annexin V and PI staining. In this study, PLGA NPs
with paclitaxel and conjugated targeting antibody of about 200 nm
in diameter were prepared. We confirmed that expression of target
protein on A549 cells. Cytotoxicity of PLGA NPs was shown at a
concentration of 100 μg/ml or more.

SOC-7 SOC-8
3D Human Blood-Brain Barrier in vitro model In Situ Hydrogelation in a Deep Tissue Using
for testing BBB-opening agents Alternating Magnetic Field and Magnetic
Suyeong Seo1,2, Seung-Yeol Nah3, Hyewhon Rhim4,5, Nanoparticles
Kangwon Lee2, Nakwon Choi1,5, Hwangjae Lee1, Guru Karthikeyan Thirunavukkarasu1,
and Hong-Nam Kim1,5,* Semin Kim1, and Jae Young Lee1,2,*
1 1
Center for BioMicrosystems, Brain Science Institute, Korea Institute School of Materials Science and Engineering, Gwangju Institute of
of Science and Technology (KIST), 2Program in Nano Science and Science and Technology
Technology, Graduate School of Convergence Science and 2
Department of Biomedical Science and Engineering, Gwangju
Technology, Seoul National University, 3Department of Physiology, Institute of Science and Technology
College of Veterinary Medicine, Konkuk University, 4Center for [email protected]
Neuroscience, Brain Science Institute, Korea Institute of Science and
Technology (KIST), 5Division of Bio-Medical Science & Technology, Injectable hydrogels are widely used in biomedical applications such
KIST School, Korea University of Science and Technology (UST), as drug / cell delivery due to their ability to non-invasively form
*[email protected] hydrogels. Recently, a novel system consisting of near-infrared
Blood-brain barrier strictly regulates the molecular transport between the (NIR) light and plasmonic nanomaterials was demonstrated to
brain and blood vessels to keep cerebral homeostasis. The interaction achieve controllable in vivo gelation. However, NIR light is not
between BBB-composing cells and microenvironment such as ECM sufficient to form hydrogels in deep tissues because of its limited
maintain and enhance the barrier function. The unique property of the brain tissue-penetrating ability. To overcome these problems, we
vessel induces to the high drug resistance in CNS. As a result, the BBB in developed an alternating magnetic field (AMF)-inducible hydrogelation
vitro model is regarded as a valuable tool in Neurotherapeutic to verify the system with superparamagnetic iron oxide nanoparticles (SPIONs).
entry of the drugs into the brain. Although several in vitro BBB models Taking advantage of a deep-tissue-penetrating ability of AMF,
were developed, replicating the native BBB properties remains SPIONs can generate heat in deep sites, leading to thermal
challenging. Here, we fabricated 3D human BBB model by co-culturing
human brain microvascular endothelial cells (hBMEC) with human polymerization. The feasibility of hydrogelation in deep tissues was
astrocyte (HA) and human brain vascular pericyte (HBVP) within 3D successfully demonstrated using porcine muscle tissues (> 2 cm),
collagen space. Endothelium formation is verified by immunostaining of whereas the NIR light-based hydrogelation system could form
adherens/tight junction. For proving physical barrier property, the 4 kDa hydrogels only in tissues of thinner thickness (< 3 mm).
FITC-dextran is infused into the endothelium and the vascular permeability Cytocompatibility of our system was verified by successful cell
is analyzed. Tri-culture lead to the lowest vascular permeability, suggesting encapsulation with high cell viability (> 80%). Further, in situ
that HBVP and HA are indispensable for BBB formation. Moreover, our hydrogelation in deep muscle tissues of living rats demonstrated the
models are used as a platform to test the BBB opening agents (gintonin and feasibility of in situ hydrogelation in deep sites. This AMF-inducible
mannitol). The barrier is temporarily disrupted and restored after removal hydrogelation system may overcome the problems of depth
of agents. Our BBB model is expected to be a robust and reliable platform limitation of hydrogelation and extend the applicable area of on-
to study the vascular function and monitor biochemical response and drug
efficacy. demand injectable hydrogel systems for biomedical applications.

-62-
  

          ! $#"% $'&( )"

SOC-9 SOC-10
Silicone implants capable of the local, controlled Characteristics of human nasal septal cartilage-
delivery of triamcinolone for the prevention of derived progenitors encapsulated in collagen as
fibrosis with minimized drug side effects injectable therapeutic agent for cartilage defect
Byung Ho Shin1, Chan Yeong Heo2,3,4,5,*, repair
and Young Bin Choy1,3,6,* Mi hyun Lim1, Jung Ho Jeon1, Byeong Gon Yun1,
1
Department of Biomedical Engineering, College of Medicine, Seoul Sun Hwa Park1, Jung Yeon Lim1,*,
National University, Seoul, Republic of Korea, 2Institute of Human- and Sung Won Kim1,2,*
Enviornment Interace Biology, Seoul National University Medical Research 1
Center, Seoul, Republic of Korea, 3Interdisciplinary Program for Postech-Catholic Biomedical Engineering Institute, College of Medicine,
Bioengineering, College of Engineering, Seoul National University, Seoul, The Catholic University of Korea, Seoul, South Korea
2
Republic of Korea, 4Department of Plastic and Reconstructive Surgery, Department of Otolaryngology head and Neck Surgery, the Catholic
College of Medicine, Seoul National University, Seoul, Republic of Korea, University of Korea, College of Medicine, Seoul, South Korea
5
Department of Plastic and Reconstructive Surgery, Seoul National *[email protected], *[email protected]
University Bundang Hospital, Seongnam, Republic of Korea, 6Institute of Implantation of chondrocytes is a promising therapeutic strategy for the
Medical & Biological Engineering, Medical Research Center, Seoul treatment of cartilage repair. However, articular cartilage injury has poor
National University, Seoul, Repulic of Korea repair ability and has limited regeneration capacity by therapy based on
[email protected] implantation of articular chondrocytes. Human nasal septal cartilage-derived
progenitor cells (hNSPs) are an excellent alternative source of chondrocytes
We propose silicone implants capable of the local, controlled release of a for cartilage tissue regeneration because hNSPs can be obtained easily by
glucocorticoid drug, triamcinolone acetonide (TA), for the prevention of minimally invasive collection procedures and have sufficient cell expansion
fibrosis. The shells of these silicone implants were coated with two different and chondrogenic potential, which are demonstrated by immunostaining and
loading amounts of TA, which could release the drug in a sustained manner expression of cartilage-specific protein. Moreover, those characters are not
for 12 weeks. The drug-loaded implants were inserted into the subcutaneous influenced by prolonged cultivation. In this study, we fabricated hNSPs by
space in living rats, and the tissues were biopsied at scheduled times during encapsulating them in hydrogel, type I collagen, to transplant into injured
12 weeks. For the drug-coated implants, the capsule thickness and collagen articular cartilage tissue, and we evaluated the characteristics. The hNSPs
density decreased compared with those of the non-coated implant. Because encapsulated by the hydrogel (hNSPs-collagen) showed a viability about 80%
of the effect of TA, inflammation and the expression of pro-inflammatory when they were incubated at 4oC for 9 hr. Moreover, most of hNSPs in
cytokines were downregulated, thereby decreasing the number of monocytes hNSPs-collagen showed expression levels of chondrocyte-specific protein, type
during acute inflammation. This effect in turn decreased the number of II collagen, sox9 and aggrecan, which are evaluated by immunofluorescence
macrophages at the later stage of inflammation, leading to the expression of staining. Notably, in osteochondral defect model, implantation of hNSPs-
less TGF-β and consequently fewer fibroblasts and myofibroblasts. Our collagen showed greater cell survival and led to greater chondrogenic repair
findings also revealed that with an appropriate dose control, skin and muscle into an articular cartilage defect in rats. At 8 weeks after implantation, many
atrophy, major side effects of TA, could be avoided while still effectively of human cells was shown in defect, which is expected to potential and
reducing fibrosis. Therefore, we conclude that the local, sustained release of benefits for cartilage regeneration. hNSPs-collagen are valuable therapeutic
an appropriate dose of a glucocorticoid drug can be a promising strategy for agent for implantation into injured cartilage tissue and can be used clinically
safely preventing fibrosis around silicone implants. for repair of articular cartilage defect in the knee.

SOC-11
Antitumor effects of intra-arterial delivery of
ultrasound activated microbubble-doxorubicin
loaded albumin nanoparticle for trans-arterial
chemoembolization on VX2 rabbit liver tumors
Doyeon Kim1, Minkyu Seo1, Jiwon Kim1,
and Hyuncheol Kim1,2,*
1
Department of Chemical and Biomolecular Engineering, Sogang
University, 2Department of Biomedical Engineering, Sogang
University, *[email protected]
Hepatocellular carcinoma (HCC) is one of the most common and deadly
cancer in the world. The majority of patients diagnosed with HCC are
suffering from unresectable hepatocellular carcinoma, and primary
therapeutic option for those patients is transarterial chemobolization
(TACE). However, significant amount of the infused anticancer drug
passes into systemic circulation, which cause systemic side effects. To
reduce systemic adverse issues and enhance local drug delivery, we have
developed doxorubicin loaded human serum albumin nanoparticles-
microbubble complex, and emulsified in lipiodol. This complex enables
ultrasound-triggered local delivery by sonoporation effects and enhance
therapeutic efficiency to the target site. This transarterial chemobolization
demonstrated a size distribution of 17.6 ± 6.8 μm which is similar to
conventional transrterial chemobolization. Also in in vitro experiments,
nanoparticle-microbubble for transarterial chemobolization showed
higher stability in both phosphate-buffered saline and lipiodol. The
intra-arterial administration and ultrasound irradiated of nanoparticle-
microbubble for transarterial chemobolization sufficiently reduced
tumor growth compared to the control group in the VX2 rabbit tumor
model. Pathological analysis showed that nanoparticle-microbubble for
transarterial chemobolization group demonstrated a higher necrotic
fraction and lower viable tumor volume. In conclusion, this study shows
that liver tumor suppression can be maximized by combining ultrasound
exposure with intra-arterial administration in transarterial chemobolization.

-63-
-64-
 
-




-

./

/


$ 
%   
/

% 
'
0$%'1

-65-
-66-
  

          ! $#"% $'&( )"




         
        
!   "#" & $ %" ' %( %"
 ) 

  
         
   







  
         
          
      ! 
 " #     
  
   $ (  
%'& 
  
    
    )       '      
    *    

  +, -   *,  
 
   
      ,   
   ,  #        ! 
 

.  +(       / 
 *
    #        * 
 0
   %,1/+ !   & # *  
           

, 
     ' 
    $ 





2    -   

(-  +-  79433365433666433344
  8

, 1: 

-67-
  

          ! $#"% $'&( )"





 
  


 
  
 
 


 
  
 



! " 

  
&%$#&%"('))*&%*&%$##)&%*&%+"%$)
#,%*&+,%-)%&%$.#,%/)."#,&%$.0,/)#&%$,,'
##1)23%"%$1),&%$.&%341),&%0&5341).,,%6,,
0,%1) ,%$.&%#0&%$1)"%7,*&%0&%$8).3%,348 
 
  
      "! #  
                          $%&#&'  "! #(    "! #
1
# %& *&&)
      +, *&  ) 


#-! ! & . -
//.    0!#  +  1 + 1 #! '   %  
1! 1!#+  1 +  #!!  +  #)
//+ 1!   % !   
!1  ! 1  1!&-.) 
2  % !33 !3 ! 3! % 4 3 !
// ! 1  3 !  
11   '  + 1!)  1 #! ,   4   , %  # !       ! 
+ 1 # 3 !
// 1!1!      "! "% "!   "    
1 #! ,  4! "# !1 #! ,  #' !&011! !+#
 " %-.)  1 !1 31 #! ,  !33 !3 !" 1 % 0   
 1 #! ,  1!    , %  5!! '  +  ) 6 !  1!1!  3  1  
#! 5#1 -72.+  "! +  !# + +3 ! 
"!     +  %  ! 3
//) 7 '"! ' 72   "!  !    
%% ! !  ! %  !% 3   1  ) !3 ! !+  3 +! -6. '   
1! "    !%)    #
//  1   ' 3+!  '    3 ! 3 6 
72  % 1  + %   3   33    1! 1!   +  1 +  #) 8 
 1'!'  "! ) "! 3#+  %  1 +  # 3! 3 !
//
 1    " !   #  5  # #       '! !!  ) 6!    #
!"!#
// 1  ' '+ ";:9 3" +  #)2"!#
// 1  ' '
33 !+ 1! 1!  
// 1  !3) 

9'%,+5#7$4#%;:<   ' !& ' 11 ! +#    %#  " 
! %! - ! +!<
::((= ?>" 1 %     3! %  4 3 ! !   1 #&    ! ! 3 !
 1  - 1! "!%@A:
.3 ! 11  B.3+#  !# 3!
!#C/!%# 3 !)

#<#(#%9#:
) " ) )= D  ) >)
// + !   ! ! 1   1  1)
E ! ::;F )AA$GA(H:):(I8)+ ! )::;):;):)
)  J% 7)= K )= L% J)= ' & >) ) )= D % D)= J L)= 
) )   
+  % !!   3  0 &!+  1 #!#0!0!0& )E ! ::F )
AA0AA;:):(I8)+ ! )::):;):$)
)  !  !3)=7 M)=>  )'
#!#))
#-! & . ' 2! %
4 32 1 1!2!  /!0 E &)!  HAHF )$;0$
:):I::H::)
)  !  !3)= 7 M)= E ! ) ' 1 #! #< )
!1!  3 !   1 #-!
& .3!  #+ 1 )
#!HAF )$$0$(:):(I::0A(-A.H:$$0:)

-68-
  

          ! $#"% $'&( )"






    


    
  
! #"$%  # $ %&'"
 $(  ) $(  $ *

 
 
 

   
 
  
! " 
#
$  
 
$%
%  ! "
                         & ($  '

 
$%
%  ! "
                      )$  '*
 
 

$%% " 


*+++ ,-     "+ 
     
%" 
" %     "
%  
     %  ,
   (     .(10/ 
     .(20/   
  +
          
 ++   + +
"       "         
    
3%,+
   %
 -  4       5   
.
 ,+, / .(20,(10/ %+      "   +++
" 6%+   5 , 7
(20,+,(10,+,(20 +     5 " 
, 
 5  
  %

 ,-(10
   $ .8 /# +  -  
+    -     . 4/   % %  % 
 
+" 
          +    -  +  ,9:
%++ "  $ 6       " -      "   + 
   + + 01( .  /   66 ..&,.);,5,#,/,#;,
 ,5% +//   4 ,""    5     +,
  +"
       + +   +      + 
  -. 0/   " %  + 
  6     
   0 %         "


-69-
  

          ! $#"% $'&( )"




    

 



   !!  " "  ! !"  $#
 %!  !! !
  
 
 

 



 
! 
&#$

""% 







'( + ('
 , +   ,)*&

 + 

'  
 &
 
  ( (   (  
& %   

 )--* 
" . 

+
+  
++ ( 
  
 
(' '

 
&+ (
 + & + '
(
 

(
/ " & 

+

'   (, +   ,)*( (  + 
+" (
   (
+
('  ('
+ "0++
( &'(

( '
( 
   1+
 & 
  % '   
 +   
 +
" +
+
& 


((   +
( ((+
 (
(  
  + 

 
 (" .  & , ( ' +    
( 
/ 
  
  + 
 ( +" +   

 
+(

+ ( &    (
&+

( +
    ++ "


,  
+
 
(+ /( ,'(( '+ +
(
+".(& ' (
( 
    +  +
( ( 1+  & +' 
( '(" .   

 
 +  ++  & 
 ( '   /
   +  &  (  
   /    /

  + ( ("2  ++(+ /(


'
( 
+ 
 + 
  +( ' 
 ( (     + 

 
" . ( '( 

+ 
  + (        
 
 
 
 
  (
  +  


 1+ 
+ 
 
"


-70-
  

          ! $#"% $'&( )"




      
   
" !#$$ % & '!($ %+ )*, 
&+ &- 


         
!
&#% $'&" 
(
)%  '*
'" )&)% 
*+
  % 





  % ,0/.- &   ,
1 
'  / - 2  %  & 33 3
 654 ' &3% % 3   '32%%3% 
&%   3 3       %&1  

 
% &&%.$7
. '%83% % 3  %
  % ,09.- 088%1  ,00
:- 088   ,0 9- 0  3 
,0*# - %   3   ,0/- .  % &  %   %  
2 &2;  %.  & 2'%%&&
<  %/#0&  
2 %&& 3  3 & 3'%  
 3=%   &  % %% 3&   3' 3%*
  ' %  % &     %1  31 %    3
=%'& =%3% % 3&%  
* & - = &7
. '%3% % 32% 
 %&  %!-&   '&  %&
= %


)  % '    2% 88  % ,099.- %   %  8
 2,)>  ?4#2 444
-2 3 =% %&%3'1 
' ' 2 %   %    4@ 099. 2   % 3  %   
%&2A% %'   2   %&& 
2  '  % 2   % .%   &  32  %    2
&%'    %3 3&*%'& 33 3
% %'&& % %%&2 &7
. ; ' 
&%  % 
* %    %   & % %1 &    +8%1 8!8 2 
%'%  && =%   
'%/#0 %3% % 3 %& =%
2%'% % 3 3 % 33 3 %' % = 
3   1%

-71-
-72-



 









 

 










-73-
-74-
  

          ! $#"% $'&( )"

PO-1 PO-2
The Development of Rapid Diagnosis kit for Development of Acute Myocardial Infarction
Dengue fever and Dengue Hemorrhagic fever Diagnostic technology with Time-Resolved
Sang-Jin Park1,*, Tae Yong Kim1, Dong Hoon Shin2, Fluorescence Detection
Jeeyong Kim3 and Min Soo Kim1 Hanshin Kim1, Jong-Myeon Park1, Heejun Kim1,
1
Diagnosis Headquarters, ImmuneMed, Inc., Sungjoon Kim1* and Kyujeong Song1
2
Department of Laboratory Medicine, Hallym University, 1
R&D Center, Precision Biosensor Inc.,
3
Department of Laboratory Medicine, Korea University [email protected]
*[email protected] [email protected]
Dengue virus is a major threat to public health worldwide. Two- Membrane-based immunoassay technology, which is widely used in
thirds of the world's population is now at risk of infection with the point-of-care testing(POCT) that has advantages of low cost and
mosquito-borne viruses. Most people infected with Dengue virus high efficiency, has limitations in improvement of diagnostic
cause only mild dengue fever, but some cause serious dengue sensitivity and precision. We have developed a technology that can
hemorrhagic fever, dengue shock syndrome and organ damage. increase the reaction efficiency and lower the coefficient of
Infection of one of the four viral serotypes leads to the development variance(CV) by directly controlling the liquid without using
of homozygous immunity to its serotype. However, subsequent membrane. Combined with time-resolved fluorescence detection
infections of other serotypes increase the risk of serious illness, for technology, it succeeded in lowering diagnosis time and CV
example, dengue hemorrhagic fever. Therefore, it is very important compared to membrane-based immunoassay technology. Early and
to diagnose a secondary heterotypic infection to care dengue virus accurate diagnosis of diseases is expected by this research.
infectious disease. In this project, we have developed recombinant
antigens that can specifically bind to serotype specific antibody
against infectious dengue viruses by processing the envelope
proteins. Using those recombinant antigens we have developed not
only a rapid diagnosis kit that can detect dengue fever caused by the
primary infection of dengue virus but also a rapid diagnostic kit that
can detect dengue hemorrhagic fever caused by secondary
heterotypic infection of dengue virus. Therefore, we are able to
predict whether the dengue virus disease would progress to dengue
fever or dengue hemorrhagic fever.

PO-3 PO-4
Development of natural product for improving K⼮ ↫⺏ ᚪᩃ ‪⺂ ⼮ẇ ᚪᩃ ⃋ᝪ῏ ⼻‫ط‬,
menopausal symptoms, such as hot flash, ῏⼮, をᩃ, ᩞ℻ ᔵ ؆℻ ᰂả Ղᕂ
arthralgia, sleep disorder, depression and fatigue Development of fluorescence, hematolysis,
Yongwook Lee *, Chulyung Choi , Jaeyong Kim ,
1, 2 2 dilution, cleaning and attaching agents in
Huwon Kang2, Doolri Oh2, Gyuok Lee2, hematology analysers for the comprehensive
Chansung Park1, Junkee Hong1, Joohyun Oh1, analysis of whole blood
Sukkyung Lee1, Suhyon Kim1, Jimin Kim1, Jin Woo Park1,* Seong Jong Park2, Yong Goo Kim3,
Inae Kwak1, Haneul Jo1 Tae Gyu Nam4
1
Herbal Hormone Research Institute, Naturalendo Tech Co., Ltd 1
BioActs, Inc., New Optics, Inc., 3Seoul St Mary's Hospital, College
2
2
Jeonnam Institute of Natural Resources Research of Medicine, The Catholic University of Korea, 4Department of
*[email protected] Pharmacy and Institute of Pharmaceutical Science and Technology,
NET-161 was a candidate of health functional food ingredient that
Hanyang University *[email protected]
has been tested to improve menopausal symptoms, such as hot flash, The objective of this project is to develop various consumable reagents
arthralgia, sleep disorder, depression and fatigue, through in vitro that are essential to analyze blood components such as red blood cell
and in vivo. NET-161 was confirmed to improve hot flash through (RBC), white blood cell (WBC) and platelet (PLT) in newly developing
ovariectomized (OVX) rat model and is to improve arthralgia (joint blood analyzer by New Optics Ltd. New Optics is in charge of the
pain) through osteoarthritis model using monosodium iodoacetate. development of new automatic blood analyzer that performs better than
This finding confirms that exercise capability is improved by existing analyzers and is also focusing on the preparation of analysis
ameliorated inflammation and cartilage strengthening due to modules for each hemocyte. BioActs is responsible for the development
reduction of catabolic factors (MMP-3&7, COX-2, TNFα, ILβ, NF- of analysis reagents for integrated blood analyzer along with each
κB) and increase of anabolic factors (aggrecan, Collagen I&X, modules. A number of blood cell analysis reagents (five WBCs such as
TIMP-1). NET-161 was confirmed to improvement sleep disorder neutrophil, eosinophil, basophil, lymphocyte monocyte; three RBCs
and insomnia through pentobarbital-induced mouse model and to such as reticulocyte, nucleated RBC and HGB), and other diluting,
improvement depression through long-term restraint stress mouse lysing, washing agents are being developed. Additional goal for this
model by antagonistic effects on 5-HT6 receptor, too. Finally NET- project is to provide a QC standard material for quality control of blood
analyzer and to develop and commercialize fluorescent dyes for DNA
161 was confirmed to improve fatigue through forced swimming test and RNA staining. Currently, the development of HGB and WBC
rat model, and this result was assumed from reduced LDH activation analysis reagent have been completed by co-work of BioActs, New
within muscle, increased level of genetic factors (PPARγ, USP-3) Optics, Catholic and Hanyang University, and the development for
for recovery from physical exertion, and better antioxidant effect remaining analysis and other reagents is in progress. Acknowledgment:
from liver leading to more favorable environment for the muscle This research is supported by the venture type professional material
cells. technology development project (Project No: 10067255) of Korea
Industrial Technology Evaluation and Management Institute.

-75-
  

          ! $#"% $'&( )"

PO-5 PO-6
ACCEL ELISA for Highly Sensitive Rapid Development of an Injectable Tissue Adhesive
Simple and Convenient Detection of Aflatoxin B1 for Surgical Applications
in Maize Kyung-Hee Hwangbo1, Jin Woo Bae1,*,
Yoon Jae Lee, Haeyoung Eo, Yeonsu Park and Ki Dong Park2 and Sung-Min Jung1
Sun Hee Lim* 1
GENOSS Co.,
2
Plexense, Inc., Yongin-si, Gyeonggi-do 17015, Republic of Korea Dept. of Molecular Science & Tech., Ajou University
*E-mail: [email protected] *[email protected]
Aflatoxin B (AFB ) is a carcinogenic mycotoxin. AFB
1 1 1
Conventional surgical procedures commonly employ sutures or
contamination has been the most common cause of acute and staples to seal and repair elastic tissues. Although these techniques
chronic mycotoxicosis in animals and humans. Its concentration in have been regarded as standard tools since early times, they are
foods and food materials is globally strictly regulated. Unfortunately, inherently traumatic to surrounding tissue, time-consuming to large
current mass spectrometry coupled with chromatography-based wound closure and are difficult to use in inaccessible body regions.
methods are inefficient and impractical for the AFB assay because
1
Accordingly, injectable tissue adhesives for sutureless tissue repair
they require complicated processes, long analysis time and high or minimized suture has received great attention due to their
cost. In this study, we report a novel biosensor allowing highly versatile and enhanced usability. In consideration of limited
sensitive rapid simple and convenient assay of AFB in maize. This
1
techniques available on chemistry and commercialization, we have
sensor, based on our proprietary ACCEL ELISA platform adopted an enzymatic crosslinking technique that enables fine
technology, takes advantages of both homogeneous immunoassay control of clinically relevant features such as gelation rate and
and increased surface area. The biosensor detects AFB in maize
1
mechanical properties. Herein we present a new injectable tissue
with a detection range of 0.08~5 ng/mL. Its limit of detection (0.08 adhesive based on chitosan derivatives with phenol groups. Our
ng/mL) is better than that of typical ELISA. The biosensor enables tissue adhesive showed exceptional tissue adhesion strength over
to complete the assay within 30 minutes, 8 times faster than typical 100kPa even under wet conditions, exhibiting good elasticity. The
ELISA. In addition, an assay using the biosensor requires only two gelation rate was controllable from 5 seconds to 1 minute by
steps for results, making the assay much simpler and more adjusting the enzyme concentration. In vitro and in vivo tests also
convenient than conventional ELISA requiring more than 4 steps. demonstrated that the tissue adhesive was highly biocompatible.
Our novel biosensor can be useful for highly sensitive rapid simple Therefore, we expect that our tissue adhesive can be useful in
and convenient assay of AFB in maize as well as in other foods and
1
sealing and gluing various tissues during surgical applications.
their materials.
Acknowledgement: This work was supported by Grants No.
Key words: Aflatoxin B , Mycotoxin, ELISA, Maize, Immunoassay
1
10062079 from the Ministry of Trade, Industry & Energy (MOTIE).

PO-7 PO-8
Development of next generation implant: Զἢᩗ⋮⽾⁾ ఊ∷ ᰊᰂԪ ⋪ఎ ‪⺂
high strength, durability and low elastic ₶ᩗ⺓◚⁛⺏⃒᪲ ‫ݖ‬ᭆՂᕂ
modulus Ti alloy applied biomedical implant Development of magnetic-antibody fusion
and growth factor added functional implant technology for multiplex real-time diagnosis of
Jong Hwan Lee1, Pan Gyu Kim1, Yoon Ho Cho1,* infectious diseases
1
Department of research and development, Dentium. Co. Ltd. JinWoo Park1*, JaeHo Choi1, Euiyul Choi2,
*[email protected] Jae-Seok Kim3
1
Conventional titanium implants have some problems such as stress BioActs Co. Ltd., Boditech Med Inc., 3Department of Laboratory
2

shielding due to high elastic modulus, fatigue fracture of long term Medicine, Hallym University College of Medicine,
usage and difficulty of inducing new bone. *[email protected]
New biomedical titanium alloy was developed having high strength,
high durability and low elastic modulus. The mechanical property of The goal of this project is the development and commercialization of
new alloy is 1,139 MPa in strength, 75 GPa in elastic modulus for multiplex technology for real-time diagnosis of infectious diseases such
dental implant fixture. as food poisoning, sexually transmitted diseases (STD) and others. In
Functional orthopedic implant is also developed for solving detail, monoclonal antibodies against those diseases are being
inducing new bone problem. A titanium based porous lumbar cage developed, infected samples are collected, and functionalized linkers
was developed which can load growth factor(BMP-2, bone and magnetic nanoparticles are being developed. Finally, achieved
morphogenetic protein-2). The additive manufacturing technology results will be consolidated into multiplex cartridge and high sensitive
was adapted to make porous titanium body. analyzer that enables efficient quantative analysis. Close cooperation
among project partners, BioActs, Boditech Med and Hallym University,
Acknowledgments: This work was supported by grants No. resulted in the development two prototype cartridges for the detection of
10037915, (WPM Biomedical Materials-Implant Materials) from the five species of STD and one infectious bowel disease (Neisseria
Ministry of Trade, Industry and Energy. gonorrhoeae, Chlamydia trachomatis, Trichomonas vaginalis, Mycoplasma
genitalium, Ureaplasma urealyticum, Clostridium difficile). Additionally,
mass production processes for magnetic silica nanoparticles and 10
functional linkers are also established. At present stage, the standardized
protocols for the conjugation between magnetic nanoparticle and
antibody are being developed for the commercialization, and the clinical
evaluation of prototype cartridges is in progress.
Acknowledgment: This study was supported by Strategic Core Material
Technology Development Project (Project Number: 10047748) by
Korea Industrial Technology Evaluation and Management Service.

-76-
  

          ! $#"% $'&( )"

PO-9 PO-10
Development of innovative technology for high Wound Healing Effect of a Novel Extracellular
sensitive in vitro diagnostics based on Matrix Sheet Dressing Derived from Human
multifunctional magnetic beads Adipose Tissue in Rat Skin Defect Model
SungIl Kim, Young-Seon Joo, Jae-Wan Jung, Yoonjae Lee2, Sujin Lee1, Kijoo Kim2, Suko Moon2,
Saem Mun, Myoung-Ho Kim, Soonil Kwon, Jongwon Rhie2,*
Myung Ryul Lee* 1
Department of Biomedicine and Health Sciences, College of
AMOLIFESCIENCE Co., Ltd., Gangneung, 25451, Republic of Medicine, The Catholic University of Korea
2
Korea *[email protected] Department of Plastic and Reconstructive Surgery, College of
Medicine, The Catholic University of Korea
We developed the multifunctional magnetic beads (AMO-MagTM) *[email protected]
for high sensitive in vitro diagnostics. The AMO-MagTM beads are
core-shell structure by superparamagnetic nanoparticles and silica Background: Extracellular matrix (ECM) is an intricate network of
with uniform size. Magnetic particles have had a significant impact various combinations of elastin, collagens, proteoglycans that plays
on a wide range of advanced applications in the industrial fields. For key roles in stimulating cell proliferation and differentiation. This
such biomedical applications, the nanoparticles require specific study was conducted to evaluate the efficacy of ECM sheet derived
properties, including hydrophilic behavior, uniform and tunable from human adipose tissue as a dressing material to enhance the
dimensions, and good magnetic properties. In this study, we wound healing.
developed the AMO-MagTM beads for in vitro diagnostics. The Methodology: we prepared a novel ECM sheet dressing which is
AMO-MagTM has larger surface area and will lead high magnetic porous scaffolds prepared from human adipose tissue. Full-thickness
content and excellent dispersion. The surface chemistry of the excisional wounds were created on the dorsal skin of rat and were
AMO-MagTM can provide rich and various functional groups splinted with silicone rings which inhibit wound contraction and
(Hydroxyl, Amine, Carboxyl and Tosyl). Using in vitro studies, we rather heal by granulation and re-epithelization.
successfully measured the level of biomarkers, such as CRP, AFP, Principal Findings: The splinted rat full thickness wound model
PSA, Troponin I and DNA using the AMO-MagTM. Thus, the AMO- revealed that application of an ECM sheet dressing enhanced
MagTM is expected to be highly suitable for widespread use in macroscopic wound healing rate on day 4, day 7 and day 10
biomedical fields. compared to control group. ECM sheet also showed the highest
microvessel density compared to Healoderm and control group.
Conclusion: we suggest that bioactive ECM sheet dressing derived
from human adipose can fulfill its function as it provides therapeutic
proteins for wound healing.
Significance: The ECM sheet dressing should be further refined in
more complex wound models to provide further evidence for
establishing a clinically beneficial dressing material.

PO-11 PO-12
Development of FGF7 with Collagen Pad for Whole process the up & down stream and
improvement mature protein stability analysis of Recombinant Human Bone
Young Sik Kim1,2, You Lim Bang1, In Keun Kim1, Morphogenetic Protein-2 activity Produced by
Jung Soo Lee1 and Ju Woong Jang1,* CHO Cell Expression System
1
The Institute of Biomaterial and Medical Engineering, Cellumed Young Sik Kim1,2, Eun-Lee1, You-Lim Bang1,
CO., Ltd, Korea In Keun Kim1 and Ju Woong Jang1,*
2
Department of Molecular Science and Technology, School of 1
Medicine, Ajou University, Suwon, Republic of Korea The Institute of Biomaterial and Medical Engineering, Cellumed
Tel(02)2104-0475/Fax(02)2104-0479; e-mail: [email protected] CO., Ltd, Korea
2
Department of Molecular Science and Technology, School of
Keratinocyte growth factor is a protein that in humans is encoded Medicine, Ajou University, Suwon, Republic of Korea
by the FGF7 gene. The protein encoded by this gene is a member Tel(02)2104-0475/Fax(02)2104-0479; e-mail: [email protected]
of the fibroblast growth factor(FGF) family. This protein is a potent
epithelial cell-specific growth factor, whose mitogenic activity is Purpose: Bone morphogenetic protein-2 (BMP-2) has considerable
predominantly exhibited in keratinocytes but not in fibroblasts and osteoinductive potential, but it shows the limits of BMP-2 protein mass
endothelial cells. Studies of mouse and rat homologs of this gene production and economic efficiency. The aim of this poster was to
implicated roles in morphogenesis of epithelium, reepithelialization produce recombinant human BMP-2(rhBMP-2) from CHO cell in a
of wounds, hair development and early lung organogenesis. In our large scale and evaluate its biological activity. Materials and Methods:
product, for produce an effective wound healing dressing, FGF7 The CHO cell was used as a host for rhBMP-2 production. Dimerized
rhBMP-2 was purified by affinity and IC chromatography. We examined
was loaded on a collagen pad. To identify materials of wound
the HPLC profile and performed Western blot analysis. The effect of the
healing, we tested collagen pads with FGF7 using a rat excision
purified rhBMP-2 dimer on osteoblast differentiation was examined by
wound model. Each group was composed with NC, PC and ALP activity and representing morphological change using ATDC5 cell.
FGF7+CP group. Wound healing effects were evaluated by wound Results: We have established a purifying system of rhBMP-2 dimer.
closure rate, number of RBC/WBC, Western blot, Hydroxyproline After the whole process (cell culture and protein purification), total yield
and histopathological FGF7+CP showed more new capillary vessel, is about 15~20%. The purified rhBMP-2 homodimer was characterized
proliferation of fibroblast and collagen contents than NC. As a by SDS-PAGE and Western blot as molecular weight of about 30kDa
result, FGF7+CP were considered to help wound healing by and eluted at 10% acetonitrile, 21 min(retention time) in the HPLC
increasing FGF, TGF-β1, VEGF contents and collagen accumulation profile detected. The purified rhBMP-2 dimer stimulated ALP activity
by proliferation of fibroblast. Based on the above results, FGF7- and induced the transformation from myogenic differentiation to
mediated wound cloning on collagen pads is currently in clinical osteogenic differentiation. Conclusion: rhBMP-2 was produced in CHO
trial. cell using genetic engineering. The purified rhBMP-2 dimer stimulated
ALP activity and induced the osteogenic differentiation of ATDC5 cells.
Significance: CHO cell, BMP-2, Purification, Efficiency

-77-
  

          ! $#"% $'&( )"

PO-13 PO-14
Hydrophilic treated silk fiber reinforced Medium optimization of lactobionic acid
hydrogel with non-invasive, high modulus and production of Pseudomonas taetrolens by
toughness response surface methodology
Sungsoo Lim1, Jinwoo MA1, Ramesh Subbiah2, Bo-Young Jeong, Young-Ah Jang, Jang-Ho Kim,
Kwideok Park2,*, Jeong-Yun Sun1,* Si-Beom Seong and Gyeong Tae Eom*
1 1
Department of Materials Science and Engineering, Seoul National Bio-based Chemistry Research Center, Korea Research Institute of
University 2Center for Biomaterials, Biomedical Research Institute, Chemical Technology (KRICT), 406-30, Jongga-ro, Ulsan, Republic
Korea Institute of Science Technology of Korea
*[email protected], *[email protected] E-mail : [email protected]
The degeneration of intervertebral disc(IVD), which is composed The major focus of this research was to optimize statistically LBA
of elastic annulus and soft absorbable Nucleus pulposus, is one of production by P. taetrolens. In this work, a two-step medium
the major health issue. Current treatments attempt to reduce the optimization for improvement on LBA production was conducted
pain by administering medicine and intervention therapy and using firstly one-factor-at-a-time (OFAT) method. The following the
surgical treatment. Many biomaterials for repairing of IVD have most significant contributing factors selected through OFAT method
not been conservative with removing annulus fibrosus. So we were optimized using Box-Behnken design (BBD) of response
targeted to replace only nucleus pulposus maintaining annulus, surface methodology (RSM). Results demonstrated a mathematical
which compensates high durability, biocompatibility, stiff ness and model with high fitness was constructed. LBA production from
toughness for IVD treatment [1]. RSM optimized medium such as 1 g/L yeast extract, 7.5 g/L peptone
Here, we fabricated biocompatible non-invasive, fiber reinforced and 5 g/L NaCl was increased by 152.35 ± 0.81 g/L when compared
hydrogel, Using surface treated silk fiber for enhancing to LBA production (135 ± 4.37 g/L) in the NB medium. The
hydrophilicity as the reinforcement and poly(vinyl alcohol)(PVA) experimental design and ANOVA of measured variables indicated
as the matrix via physical crosslinking. The mechanical properties the significance of the model. The experimental values of response
of composites increased on PVA concentration dependent manner variables exhibited in concordance with the predicted values. In
and by addition of the fraction of silk fiber. As a result, The fiber conclusion, the present study revealed the first report on the
reinforced hydrogel shows high elastic moduli(~13MPa) and high optimization of LBA production of P. taetrolens through OFAT
fracture toughness(~5,300 J/m2). In vitro cell viability test shows method and BBD, thus the statistically optimized medium would be
over 90% of cell alive. industrially used for the higher and cheaper production of LBA by P.
taetrolens in future.

-78-
Oral Presentation 2

-79-
-80-
From Research to
Commercialization

-81-
-82-
  

          ! $#"% $'&( )"



 

    
  

  !    
"  
#! $  %&'&


  


  
    
 
 
! " $%&#$



% ! ((&  )  ' $)&$ (  
 & (   * $)&  ($ +$   ( '$$' $
'&'   * $ )$   (  && ,./-
&  ) 0$ ( & $  &( $ $ 1 &&  &
'(  &) )+ (  & + )$ &  $ & +  ./
 + &($  $& $  $  + 2$ . (( +
2$ ' '  3&)
 ,3
- 4  (   $ ( $
&(  (  ./  + ')$  & $ 
2 ( '& & (  &
"!(* $ $$   ./  +  5    '  ( &
   (( $ '&' 6(   & 987 +$  &&) ( '$
  & '  $  & + ')$     (( 3
&  ') (  &: & 4  (  & +$  $% 
(   & (  ./  & ( +  $   & (  &$
./  ')     $  +  $  ./  +  
 5 &$ ./  $   $  ($    & '''' (($,; 4-

! ( *  $ &$ & ./  + ($  ' (  (
) & $ &      '&' $    $ &' (
  ) $ ( )    & (($
)  $ )' + $$  ( $ 2& '&' $
 ( (  ./   & )  ( ( &$ ( $ &
2 ( +     )'

)* <  $,5- & && ,./- '''' (($ & 



-83-
-84-
Company Session II

-85-
-86-
  

          ! $#"% $'&( )"



   
 

 



 
! "#$%

  
   "!
 $# "%( ""  '")&#"&)







&
' 
 #" "*  % . $ +#%  -%# -.."#"$, $ -%+"$$ #, #-"%". 
#  # # &  ",%% ,".+ -   #"%.  %#  "*  #%""  -  / +     * + "*
  % .  $ +#%  " + . ", %%"."% % , -"%0 + --  %% %  -  +  ,,#  %
#%#- %-& -, - %"%%"+# - , - %%+* "*",%%- + , & 

)
 (
+*   
 
$# %1 - .-# %"$ - #%#   $ % %+ $*%#"%% "%- "* % %.".  "-- "*
--   +"%  #"+    -" + "%  " -# %-*  "* % -- - *"$   +"%"2-&
"3 .  +.%# $ %- % ++.  $%*#% ""- #"$% + 3     %+ -%+% "*
"#"$, $ -# -"3*#"-%+-#**"+- -,,"% $"%"*",%%-
""*"+%-- %+"%-# -& 
++*
 
  
4& 

 
  
 
 
   4*# + $- #  + "  ,%% "* - $ # - %+
"+ + $ - 3 %*"$+ %- %+-, #*# #".  "*  3"%++ ,%+ ,".+ -%
 %.  + $ $,% -""%  , . %- -# *"$"% %+ ,"$" -   , 0"% #" %
- % --%+% ".-#0"%   **# %# & 
&
 
 
 



,%%"*- $# -3, %" + 
,""--#**"+ $+ "*"""-"$ -- 5, # +"-". # % -"* %- # + -"%%+
% . %+-"%"*%-,% +# -"%"# + %# % , & 

&
 

 

6,%%"*-",-# +-#**"+- "+ + #"%+#. %+
-**% --% -#"$% +3"%)-%+#+"$ "#  -" %  ,"+# ,"+#"%"**%#"%
#+"$ "#  ,# -& 
+++*,   
  
.  -+ #+  %"%"",%%-- %,+ - -,"%- "%$ % +-% - #%+
 # &4+.%# -%",%%#"$$% -%+ #%""  * #",+$-*-*"$%. -"
#-"$0 +  ,  "% %-,%"% " "%   % "% %+ *"$ %$  -% " ,+  $"+  +
$%-- -&


 - 


.  -+ #+  %"%"",%%-- %,+ - -,"%- "%$ % +-% - #%+
 # &4+.%# -%",%%#"$$% -%+ #%""  * #",+$-*-*"$%. -"
#-"$0 +  ,  "% %-,%"% " "%   % "% %+ *"$ %$  -% " ",
 -% 3 %%  + $% -- -&    
 2- *  3") 3 # %  "% %" "%  + . ",%
#%#  ,%% )-  -" "% ++ --% # % - %  "  **- %+ + -% "* ,",  #%#
%*-# "##    %-"%"*",%%%"#%#*"$,". +, %"#"$ -&

-87-
  

          ! $#"% $'&( )"



 
  

   !
 


  
   
  









         !  "   
 $     #$      
        $          $
 $           $ %  "    
$) (- $&+'$ *%,%$
$/.% 

0 $  % %    "      $   
  
"1
 


-88-
 
2




2

.

!
 
3
!

. /
/
'

$

-89-
-90-
  

          ! $#"% $'&( )"




         
 
   ! 
  
 


 
 
  
   







%' !    ' ( ' &

  $#"
     
  ) !  

  '& ( '
*


  &  '
(
 ( ' &  &  , ' +  
 ''    ' -   
(  (
,    
  &
  -  
  

  ' -   
 
  


    !'   

''  
.' '  
& 

 
  
 
/ '  /0 
   !   ' 
 &   (  (
  (/ 
-    (     

!  
&   

 
  
 1'-   
    
  
  
      '2   &  ' '  ' 
3 
  ' 4 ' &5  
    .' 

 ' ( '
  
'       
  
     
 '(  !  
     ) ' '  &
( .' '  
 
 (  '
 
    

   ' .. !    '2   '    

  . &

   ( &
  ' ..   ' 
 '
 6 (  '   
(    &

(-   

-91-
  

          ! $#"% $'&( )"




     
        
! !"# $& %"# ' () # * *
%# ( +# !  *,# * -)"#
! "# 

 









 
 
$ &
% !'# " 
 
(
 
$ %)% !'# " 
 
*
 
,
"
-)+ 

 
# 
&*.)!!


/
 )


  0
  


  ) )
 )!/ 
 1) ) 2 
   )  
  
   )! ( 

 
 
  
) )
  -
     ) ) 


 
        
2  

  
3)  0 )
 
!4
)   

( ) ))
-  -
--  -
 )!/
 
  )
)2

) 
 )-
  ) 
!# 
   
 
 )-)2
)
 )


 
 )

! /
   )    -        
   
  
  )
  )
 ) )


 
 
!5
  
-

 
) !6 7)
 

 
7  

- 
 
 
2 )
-
 
2 

-
 
!

) 

2 
)
--   


3 2 
)
%3 
 
  -

 

)
 
  !
6
-    
 
))
( 
  
 -- 
!6  
) ,":8 
9)

( 
  !
5)  - - 
 
    
    
3
 ) 
 --  
)   ! 6)   
  )   
)   

-  - 23       
 )  
3   -
 
   )

 
)
(

 
! 

-92-
  

          ! $#"% $'&( )"



    

  
!" #%$&


    
 

 !   # $"$
 !
 !   # % !#&" 
!)'  (!" *!+'(  !"



!   ,.-  !  
* !  0 ! 
 ! /  /
 

1
!0
/  1," "
 !    
      2-    !    !"  . ! 
!3! 
4



4 1!/
 

   /   ! ! ! 
 / 
    ! /
  " $ !


!!
 ./! /

  "%!.
 / / /
 
/ 
 ///" %! !      
  
/4
 
! ! 
 !  /

3 

4"%!04/ 
!
 
 !6/4! !.
5  /
/
  / 7     / 
   
 
 
"  %! /

 !
  4! !  / 
  ! 
  
    
 !!  4 /

 
!" 

8! 
 8 4
 !4 / 40  
  !"
%!
 
//4!! 40
!/
! !
  
  
    !/ 
      
 
   /
4
 
  
! ! !3
"8

!  ! 

/
5  
/333 !"%!
! 5  
  
 
 
     
  ! 
 4 / /


"   

& 04
9%! !404



!: ; !& . 
 
  <<<,=3 <=3<<5-
!>; !:

,>;:-, <=5&???7'75
 <'5&??<+''-" 

-93-
  

          ! $#"% $'&( )"



 

      

 
 

    
 

!!"# $ $% 









%!       &     (')('' " *" $
+     & , "  %!      -
    " "   "&    " $
    " 
 . " ,-  " 
&   "& &$
%," %!
    %!  $ /-&  , , ,     !    01
11  , "        2  .   " "$ 3& ,
 .%!," & " . %
"000 $

-94-
  

          ! $#"% $'&( )"




    
   ! 

  

 

 
!
  "    &  $&#& % '  
(
) *&  







$&      +-,  
 & 
 &' .   ' &  )    
    
   
 

 
  '  $&
  -
/  
       
 '    -  
 & 
 $&  - /  

& .0 &
 - /  &   '
 & & 
    &  '
  
   $    
  

 
 - /  
 &
 &      &             
  / - /  
 &  
' 
         1       & &
   - /  
     
 //  )& &         
       

        
  '    $&     &  - /  
 & 
  

 
  
 '
  /
'2 &   2)  &   &
  &-/  
 &  
  '  


-95-
-96-
 
4




4

&
 

%

-97-
-98-
  

          ! $#"% $'&( )"




  
 

 



 


 
 





"!
 # 








$"

 
""
 
"
%
&
'

 
 "
" "
 (    #  "  % 
   " %
 "


"
 
#
"
%")
# #   *"
 
 % " "  " 
+ 
   &

 (""
 
)


"

   ,
 "
(#%%&

 
 %" #

 


 ("" 
 %  % 

  -    
 
%
 
 .%/201 

 -3 
4

%

.653)798;:)/201
)

) 

4<
* =" ><*=?  
 @    
  "
 "

.*A47#"

<*="

%& "
 "
"
 "
    A"  %" 

 " "
  "    B
""C("%
 (
"







%% %
 
 .""4 (" 
 +  "    

%
 

 "  "
 "


    (
 ( 
 % "


"
   <

#
 


 #
D " # " % # 

 ( E
 "  " %

  

-99-
  

          ! $#"% $'&( )"




   
 
   
  
  
 

 

  










$%

 " *!$
& )*( 
 
((++* '#
,
 -   *  *   (         /
  .

  
  
  
  
  
  (    0   
  )           

 ) 


 

  
   )     

  * *   


  )    
 
 (
 ( *    * 

  0  , $
 & ) 
   
 
+     


 )
 0   
  ) 
   

   12 3  1
 12 3
$  10 $


0  4$05
$  6(7 4$05

$  
 (7  
( 
 (7 *(    

 

        
 ( 




     8     
   
 

      $
 ( *      
 
  
  )  
  7

- 2* ) 
 
 
 

  *

 )
)  ( 

  
 )$
 

   $ ) *   
 



$ *
 $* 9  
 !$
& )




    
  
 $  
 -  
  
 

 


  
&
3 )
 (
 


 )  ) 

  **

3   
      8 

 ,

   
           

 
( 
 


- 
 (
   )   )

(
   )


-100-
  

          ! $#"% $'&( )"



 
    
 
 
 
  

  











  
 !"  $
  
 #
#

 
   #
# 
 %

&
#
' 
(# #&
#
"

"
  
 
 
) #  
  #
 " #
   #  
   # #
 
#
 ## 
  *#

 #)##
#
#
#
   ' ( ##)# # 
 (#
 
 '# "+'
 (# 


   &
##
 "
# 
)  

'#   

%#  ,
*  *#

'
 )#


# 
#  )) 

)
  ##
 # 

 - # '

'
   (#
#

 #
# # ''#
# (#

' )0!/#
# " ##
.'
)#  "

 #
'1
 

' 
"#

)#  #"
 #
"
'



   

"

.' ' ) #  
  
  # "
  ' # 

  '#  ' 
# 
  


   '
(#
#$
 

' #
'''#

''

#
'# #
 
   
" 
 

-101-
  

          ! $#"% $'&( )"




     
    
 
  
 
  










"   " !    
                
# 
 
$ 


'    "  $&   
  " "    
!% 

%  
 

%  

 "    $& 

(!
  $& 
   )"  

 +

"   !*  +
%
      
 '  " "    
"   

'    


  +
'   !


 
 
 ' 

 
!! 

 " "   
' 


 
 

  !     
 ' "


 
 
 "  "

" !
 "   "  


 "  " "    

 
 
   "          
 !
 
)  


-102-
 
5




5

 
,
  
%%

-103-
-104-
  

          ! $#"% $'&( )"

SOC-12 SOC-13
ROS-Induced Cell Sheet Detachment and Inkjet-Spray Lamination Printing for Freeform
Transfer Based on Photosensitive Polymer Film Fabrication of Gelatine Methacryloyl-based
Min-Ah Koo1,2, Mi Hee Lee1, Gyeung Mi Seon1,2, Hydrogel Structure
Seung Hee Hong1,2, and Jong-Chul Park1,2,* Sejeong Yoon1, Ju An Park2, Hwa-Rim Lee2,
1
Department of Medical Engineering, 2Brain Korea 21 PLUS Project Woong Hee Yoon3, and Sungjune Jung1,2,3,*
for Medical Science, Yonsei University College of Medicine, 1
Division of Interdisciplinary Bioscience and Bioengineering,
[email protected] Pohang University of Science and Technology, 2Department of
Cell sheet engineering was recently proposed as a new approach Creative IT Engineering, Pohang University of Science and
towards transplanting cell sheets to lesions without the use of Technology, 3Division of Integrative Bioscience and Biotechnology,
scaffolds. To date, most of invasive cell sheet harvesting methods Pohang University of Science and Technology
have used culture surface property variations, such as wettability, *[email protected], *[email protected]
pH, electricity, and magnetism, to induce cell detachment. These Here, we report a new bioprinting process by combining drop-on-
methods that rely on surface property changes are effective when demand inkjet printing with a spray-coating technique, which enabled
cell detachment prior to application is necessary, but of limited use the high-resolution, high-speed and freeform fabrication of large-scale
when used for cell sheet transfer to target regions. The study reports cell-laden hydrogel structures. Hydrogel structures with various shapes
a new reactive oxygen species (ROS)-induced strategy based on and composed of different materials, including alginate, cellulose
hematoporphyrin-incorporated polyketone film (Hp-PK film) that nanofiber and fibrinogen, were fabricated using the inkjet-spray
facilitates transfer of the cell sheet directly at the target area without printing. To manufacture cell-friendly hydrogel structures with
an intermediate harvesting process. After green LED (510 nm) controllable stiffness, gelatine methacryloyl was saponified to stabilise
irradiation, production of exogenous ROS from the Hp-PK films jet formation and was subsequently mixed with sodium alginate to
induces cell sheet detachment and transfer without damage of focal prepare blend inks. The blend hydrogels were generated by the blend
adhesion molecules and extracellular matrix (ECM)-related proteins. inks with different compositions. The hydrogels were characterized by
This study suggests that ROS-induced cell detachment property of assessing physical properties including the microstructure and
the Hp-PK film is closely related to conformational changes of ECM mechanical stiffness and cellular responses including the cell viability,
proteins. When a multi-layered cell sheet laminated by this method metabolic activity and functionality of human dermal fibroblasts
was transplanted into a mouse wound site, it has an effect of within the hydrogel. We generated cell-laden hydrogel structures on a
accelerating angiogenesis and skin regeneration. Furthermore, ROS- large scale and assessed collagen type I secretion and spreading of
induced strategy to easily and quickly transplant cell sheets can be cells within the hydrogels. Our results demonstrate that the inkjet-
applied to 3-dimensional (3D) tissue reconstruction, including spray printing system will ensure the formation of a cell-laden
cardiac, cartilage, corneal damage as well as skin regeneration in hydrogel structure with high shape fidelity in a rapid and reliable
tissue engineering. manner. Ultimately, we expect the proposed printing technique and the
blend bioink to be used to fabricate 3D laminated large-scale tissue
equivalents that potentially mimic the function of native tissues.

SOC-14 SOC-15
Microfluidics-assisted fabrication of Adhesive Hemostatic Patch using Marine
macrophage microtissues with tunable physical Biomaterials
properties for developing in vitro multiplex Jaeyun Lee1, Hyo Jeong Kim1, Eun Young Jeon1,
tissue model Tae Yoon Park1, Geunho Choi1, Eun Jin Kim3,
Dongjin Lee1, Kangseok Lee1, and Chaenyung Cha1,* Ki Joo Kim3, Kye Il Joo1, Bong-Hyuk Choi1,2,
1
Jong Won Rhie3, and Hyung Joon Cha1,2,*
School of Materials Science and Engineering, Ulsan National 1
Institute of Science and Technology, Department of Chemical Engineering, Pohang University of
[email protected] Science and Technology, 2Nature Gluetech Co., ltd., 3Department of
Plastic Surgery, College of Medicine, The Catholic University of
Microfluidic flow-focusing devices (FFD) are increasingly adopted Korea
*
to develop micron-scale emulsion particles (‘droplets’) with variable [email protected]
size and shape for biomedical applications. Specifically, droplets
consisting of gel-forming precursors can be crosslinked to form The use of effective hemostatic agents in surgery can increase the
microgels for tissue engineering and drug delivery. In this study, efficiency of operation, help patients recover faster, and reduce
cell-laden microgels fabricated by photocrosslinking droplets blood transfusions. In case of excessive bleeding, however, few
containing methacrylic gelatin (MGel). The mechanical properties commercial hemostatic agents are able to maintain their contact with
of the microgels could be controlled by the MGel concentrations, the bleeding site and perform hemostatic functions. We developed a
while their size could be controlled by varying the flow rates during novel adhesive hemostatic patch composed of marine biomaterials
droplet generation. The viability of macrophages encapsulated in the with proven biocompatibility and biodegradability. Mussel adhesive
microgels was well maintained regardless of the physical properties, protein (MAP) derived from the mussel byssus utilizes DOPA
while their proliferation was dependent on the mechanical residues to strong underwater binding which can attach hemocytes
properties. More significantly, lipopolysaccharide (LPS) induced or plasma proteins on surface of the patch. Aneroin, a silk-like
M1/M2 differentiation of macrophages was also heavily influenced protein derived from nematocyst of starlet sea anemone imparts the
by the mechanical properties of the microgels. Eventually, these mechanical strength and elasticity of the patch. Alginate from the
macrophage microtissues were embedded into larger tissue cell wall of brown algae can absorb blood plasma and extrude, and
constructs to develop in vitro multiplex tissue model to study the slowly releases calcium ion to aid in hemostasis. These biomaterials
effects of macrophage in different stages of differentiation and were mixed and irradiated with light to crosslink, then lyophilized as
mechanical environment on the surrounding cells. hygroscopic patch. In vitro tests proved good tissue adhesion,
platelet activation, and blood coagulation ability of the patch. In vivo
animal tests confirmed superior hemostatic ability of the patch,
which also showed minimal inflammation and toxicity when left in
body. From these results, we successfully demonstrated this
developed patch as novel adhesive hemostatic agent.

-105-
  

          ! $#"% $'&( )"

SOC-16 SOC-17
Dual Delivery of Insulin-like Growth Factor and 3D Printed Microfibrous PCL/Bioceramics
Adipose-derived Stem Cells using Coacervate- Bundles with Aligned Topological Cue for Bone
Embedded Interpenetrating Composite Tissue Regeneration
Hydrogels for Cartilage Repair JuYeon Kim1, WonJin Kim1, Minseong Kim1,
1 2
Hyeran Cho , Junhyung Kim , Byung-Jae Kang , 2 Ji Un Lee1, and GeunHyung Kim1,*
and Kyobum Kim1,* 1
Department of Biomechatronic Engineering, College of Bio-
1
Division of Bioengineering, College of Life Sciences and technology and Bioengineering, Sungkyunkwan University, Suwon
Bioengineering, Incheon National University, Incheon, 22012 Korea [email protected]
2
Department of Veterinary Surgery, College of Veterinary Medicine To regenerate various tissues, it is necessary that topological cue of
and Institute of Veterinary Science, Kangwon National University, scaffolds has been one of successful tissue regeneration. In case of
Chuncheon 24341, Korea bone, the structure is highly anisotropic with microstructures aligned
Current osteoarthritis (OA) treatments are limited to pain in the direction of the long axis of the bone. Specifically, orthotropic
management, but regeneration of neo-cartilage tissues is still structure that is similar to natural expression (lamellae) is beneficial
challenging. For engineered OA treatments, we have developed for alignment of osteoblasts to realize the microstructure of bone.
implantable interpenetrating (IPN) composite hydrogels containing Aligned microscale bundle made of mixture of various fabricating
adipose-derived stem cells (ADSC) and insulin-like growth factor-1 techniques can provide an environment like the formation of bone
(IGF-1). It is hypothesized that exogenous IGF-1 delivery via tissue and transmitting interaction between cells. In this study,
polycation-based coacervates in IPN hydrogels could enhance aligned structure obtained by leaching PVA from 3D printed PCL/
chondrogesis of ADSCs and subsequent cartilage repair. Loading PVA scaffold mimics microfibrils found in several types of tissue,
efficiency of IGF-1 in coacervates was 86 % and a sustained release such as muscle, nerves, blood vessel, and bone, etc. Aligned
of IGF-1 was obtained during 21 days. IPN composite gels including structure of scaffold might induce orientation of osteoblast that is
thiolated gelatin and poly(ethylene glycol)-diacrylate exhibited no crucial for mechanical property of bone. To improve low
cytotoxicity on encapsulated ADSCs. Coacervate-mediated IGF-1 biocompatibility and osteogenic differentiation of the pure PCL
delivery effectively facilitated glycosaminoglycan deposition, indicating scaffold, aligned microfibrous struts were supplemented with type-1
enhanced in vitro chondrogenic differentiation of ADSCs. Moreover, collagen and bio ceramics. Then, preosteoblasts (MC3T3-E1) are
to evaluate in vivo efficacy of this platform, IPN composite gels were used to observe the cellular responses on the fabricated scaffold. It
implanted into the medial femoral condyle of rabbits for a dual can be confirmed that aligned microfibrillated structure has a
delivery of both IGF-1 and ADSCs. The histological results indicated possibility to regenerate bone tissue effectively by comparing a
that a dual delivery group enhanced normal-like cartilage regeneration control, normally 3D-printed PCL scaffold.
as compared with any single delivery group. Therefore, our IPN
composite hydrogels could be utilized as implantable delivery tissue
engineered platform for chondgrogenesis and cartilage repair.

SOC-18 SOC-19
Antibody-targeted leukemia siRNA delivery for High-throughput Single-cell Analysis on the
enhanced chemotherapy Mechanosensation of Macrophage
Seok-Beom Yong1, Jee Young Chung1, Jeong-Ki Kim1 and Dong-Hwee Kim1,*
and Yong-Hee Kim1,* 1
KU-KIST Graduate School of Converging Science and Technology,
1
Institute for Bioengineering, Hanyang University Korea University
*[email protected] [email protected]
Acute myeloid leukemia (AML), shows myelodysplastic and Macrophages play an important role in inflammation and immune
myeloproliferative characters. Genetic mutation-induced over- responses, and their malfunctions are associated with various
sensitization of GM-CSF and epigenetic reprogramming transforms chronic human diseases. Although macrophages are located in
myeloid cells to be cancerous and organ-accumulation of leukemic various tissues exposed to different physical environments, however,
cells induce organomegaly and organ impairment, consequently the role of mechanical signals on their activation associated
patient death. Heme oxygenase-1 (HO1) is cytoprotective gene and phenotypic alteration remains unclear. Here, we have developed a
involved with anti-oxidant stress in cells. In previous study, SA high throughput cell phenotyping (HtCP) technique that allows us to
Heasman et al. demonstrated over-expression of HO1 gene in obtain essential cellular information in a single cell resolution, such
response to daunorubicin and cytarabine treatment and lentiviral as morphology, cell cycle, and specific protein expression. Using
HO1 silencing sensitizes AML cells to chemotherapy. In this study, this approach, we quantitatively demonstrate that the morphology
we develop antibody-targeted HO1 siRNA delivery system for and activation level of bone marrow-derived macrophage (BMDM)
enhanced myeloid leukemia chemotherapy. Single chain antibody- are precisely controlled by modulating substrate compliance.
conjugated carrier delivers target siRNA specifically to AML cell BMDMs poorly spread as the substrate stiffness decreases, leading
lines and suppresses HO1 gene, which enhance responsiveness to to structural deformation of cell nucleus. In addition, BMDMs
chemotherapy. With leukemia xenograft model, antibody-carrier- exposed to the activators reduces both iNOS and arg-1 expression,
mediated siRNA delivery for bone marrow enriched leukemia cells the molecular marker of M1 and M2 macrophages, respectively. We
was shown. Collectively our data suggest promising strategy for also note that myosin inhibitor affects only the expression of iNOS
AML-targeted therapy. of BMDM on soft substrate and did not affect for arg-1 expression.
These results reveals that the mechanosensation of immune cells via
actomyosin contractility is selectively associated with the M1
activation of macrophages, providing a new perspective on the
relationship between physical environment and inflammatory
response.

-106-
  

          ! $#"% $'&( )"

SOC-20 SOC-21
Therapeutic Efficacy-potentiated and Diseased Stimulating Angiogenesis In Ischemic Tissue Via
Organ-targeting Nanovesicles Derived from Solar Cell
Mesenchymal Stem Cells for Spinal Cord Injury Gun-Jae Jeong1, Jin Young Oh2, Yeon-Ju Kim3, Suk
Treatment Ho Bhang4, Byung-Soo Kim5, and Dong-ik Kim1,*
Han Young Kim1, Hemant Kumar2, In-Bo Han2,*, 1
Division of Vascular Surgery, Samsung Medical Center,
and Byung-Soo Kim1,* Sungkyunkwan University School of Medicine, 2Department of
1 Materials Science and Engineering, Yonsei University, 3Department
School of Chemical and Biological Engineering, Seoul National of Physiology, School of Medicine, Pusan National University,
University, Seoul, 2Department of Neurosurgery, CHA University, 4
School of Chemical Engineering, Sungkyunkwan University,
CHA Bundang Medical Center, *[email protected] 5
School of Chemical and Biological Engineering, Seoul National
Human mesenchymal stem cell (hMSC)-derived exosomes have been University, [email protected].
spotlighted as a promising therapeutic agent for cell-free regenerative
medicine. However, poor organ-targeting ability and insufficient Cell therapy has been suggested as a treatment modality for
therapeutic efficacy of systemically injected hMSC-exosomes were ischemic diseases, but the poor survival and engraftment of
identified as critical limitations for their further applications. implanted cells limit its therapeutic efficacy. To overcome such
Therefore, in this study we fabricated iron oxide nanoparticle (IONP)- limitation, we used electrical stimulation (ES) derived from a
incorporated exosome-mimetic nanovesicles (NV-IONP) from IONP- wearable solar cell for inducing angiogenesis in ischemic tissue. ES
treated hMSCs, and evaluated their therapeutic efficacy in a clinically enhanced the secretion of angiogenic growth factors and the
relevant model for spinal cord injury. Compared to exosome-mimetic migration of mesenchymal stem cells (MSCs), myoblasts,
nanovesicles (NV) prepared from untreated hMSCs, NV-IONP not endothelial progenitor cells, and endothelial cells in vitro. In a
only contained IONPs which act as a magnet-guided navigation tool mouse ischemic hindlimb model, ES generated by a solar cell and
but also carried greater amounts of therapeutic growth factors that can applied to the ischemic region promoted migration of MSCs toward
be delivered to the target cells. The increased amounts of therapeutic the ischemic site and upregulated expression of angiogenic paracrine
growth factors inside NV-IONP were attributed to IONPs that are factors (vascular endothelial, basic fibroblast, and hepatocyte growth
slowly ionized to iron ions which activate the JNK and c-Jun factors; and stromal cell-derived factor-1α). Importantly, solar cell-
signaling cascades in hMSCs. In vivo systemic injection of NV-IONP generated ES promoted the formation of capillaries and arterioles at
with magnetic guidance significantly increased the amount of NV- the ischemic region, attenuated muscle necrosis and fibrosis, and
IONP accumulating in the injured spinal cord. Accumulated NV- eventually prevented loss of the ischemic limb. Solar cell ES therapy
IONP enhanced blood vessel formation, attenuated inflammation and showed higher angiogenic efficacy than conventional MSC therapy.
apoptosis in the injured spinal cord, and consequently improved spinal This study shows the feasibility of using solar cell ES as a novel
cord function. Taken together, these findings highlight the development treatment for therapeutic angiogenesis.
of therapeutic efficacy-potentiated extracellular nanovesicles and
demonstrate their feasibility for repairing injured spinal cord.

-107-
-108-
 






# "6
7

'

-109-
-110-
  

          ! $#"% $'&( )"



 
  
 
  
! "#"$

      
  


  

 
 ##!"$ 






   
            
     
  
            
           
 

               

 
  
           "      !  
               
      
          
  
#  
  
  
    $  
         $          
   !          
 
    
 %
 %  %         %
   %   '&'    (   ) 
                      $      
  *        % +(  '&'          
  ,-         
  
533.    1420'/&   %    
       56300'/7  %  
 
    
        410. (             
   
)  %                    8       
                            

  
   
  

-111-
  

          ! $#"% $'&( )"

S11-IL-2
NANOELECTRONICES MEDIATED IN VIVO
REPROGRAMMING FOR
NEURODEGENERATIVE DISEASES
JongPil Kim1,*
1
Dept. of chemisty, Dongguk University,
[email protected]

The discovery of reprogramming by ectopic expression of a defined set of transcription factors, known as
direct reprogramming, provided a tractable platform to uncover molecular characteristics of cellular specification,
differentiation, and pluripotency. We discuss the controlling cellular identity by cell reprogramming, with an
emphasis on nanotechnological approach. Recently, we report that nanoelectronices based in vivo
reprogramming efficiently and non-invasively alleviated symptoms in mouse Parkinson's disease models. This
study provides a proof of principle for in vivo lineage conversion as a potentially viable and safe therapeutic
strategy for the treatment of neurodegenerative disorders. We also discuss the strategies used to generate such
disease models using either patient-specific reprogrammed cells, creating new possibilities for the establishment
of neurological models for their use in drug screening.

-112-
  

          ! $#"% $'&( )"




 
 

 


    

 
  
      
 " !
 "#$
'
 & %  








  



'   " 
  ' 
" '
  
 
 ( 
 



  "  *
' 
 %)  


'
  ' "'
' 
 
"%+' *  
 ' 
" '  
$

" 
 
 
   '   " 
     - ,$      


  
  *"   

 "
 "-
 .$   
       
    
 "/ 
 


' # %%' ' 
"

' 
"$%' ' 
  /
 ' 
"
*      '    
     '

'  
 

"
 ' 
' 
"   
  "  /" ! 
 


% +
  '     !   

 *
 
0*
     "

'      
"  


 
"   
        '  
"
 
 "  
    

" 

% 


-113-
  

          ! $#"% $'&( )"




  


 
 
 
 
 

  
 "&%$# !  
 
 




 
 







  
 ! 

    
  

 # "   
 

 "$ %#


   &# 
 " #
  "

 "
 "# ' 
 "

 

  
   
   "#      "#   "#   
     ) 
) ! (

 "

 &


 
*
"%#
&
 )"

&

  


)
!
  
      
 +
&

  ,
 
 "!
  #!
  "#!" # "!   
"!   -  
    #
 
  )
  "!
  
!


&


. "  /

 
  &
    !    0'$.'/'0 $/,+#'*+ -, ()

11  "!"
 
 #
    
   
$"

! 

 2
 

&
 " $
54 !  3( "
 "  ! $!  ")  # #
 &
 

&
 "!
 

!  #
) 
#
 "
) 
 
3($

 "

 !
# " 
 

 #

 
" &
 )$
 #))
. 
/
 /
&
  0+2..3)+)+ '40'* (

11  
 ) $54
6 ! # 
#   
)

 " 
  4   ! !

  ) /" "  
  

 
  


!


&


"
 

"


)
"!
7

, '#5 22'*'$/ *,/%- ,-2-3$*/

 "
&
)#!
/)
$54
3(
"
 " ! $! ") # #

- $4-./$4'$# 2 6 $$)' '$/-2* 45.'$ / 
 

   *

!  
 # "

"
$54
3 0+,3$/ 2 

 $4 '4$/'2'*/'$ 2 ,/5#$. /


*
)  #$
&

  !!

 ) 






, :)#!8;

!8"

#!.: 
)5")#<)#!5
="5#!8. 5#!9
"!
9
;

 ":&   05 

)/";)
$
)$;)
4

=&
 &
. !
1
78>,,?$>,-A-@,A5


 
&
 
 4#"
2 

"!))4#5 


- :/!5
;

"24529
!C#5
!5! B
5
B!
! 8 "      :)#! 8 ;

 0D     

6
  

E=) 1
  :9,F-$,FG-@,G5


 
&
 

3 C < 4 5# C#! ;  5 2 9
! C# 5
! 5!   B 
 5
  B!
!8"   :)#!8;

0
6
$


 "
 

!

 

 
"!
1
;(1,H-@,G

-114-
  

          ! $#"% $'&( )"




  
  

   






    
  

  


! "
! 







# $%$
 &#'   
    (        "( #

)
%(    "   "
    
    
  
"
+%
  " *"* 
 %( % ,   
%,
( &/.-! ' *#%(
 $+ 
 
 
"0 " 
$ +  %
 " 1
* , 
 %(  %  
  
    
%( $
    
!
  " #, "" 423
 %+ 
 , 
 
    ,$
 " 
      &5- ! ' 
%     
" 3
#
" , *"

 "( 
   
%
, "  +
  %
  *
      , * %
  
+ +,  %(% % 
"   
,
, "  
   " $      "

 %   %( 6"  *(
 " $ 
  
"  &87#8'"%#
( ,  *+
 
%( "
""
 " 

" ((,
    
      3
#$
   
 %  , , %  
 
(
"    
%   "
!%" ,% 


""  
          
   "
 
    
"
 ,%
"  



-115-
-116-
 







&
 

%%

-117-
-118-
  

          ! $#"% $'&( )"




     
     
     ! 

   










#  $!  " !  #  #%   !  
"!
&##"!$!!!

!! "$"!#%
!   #  ! ! !$  $  "! % $
!!"'"#"##  #"#$"!
!!!"#"!#!#"'"'!'!
!$"'#"" !"! #!'
!$#!
#  $!   $$'   #  # ! !$   
$#' #$'!!#$#%
!$'##


-119-
  

          ! $#"% $'&( )"

S12-IL-2
Ceramide-based Biocompatible Skin Vesicles
Jun Bae Lee*
Innovation Lab, Cosmax R&I Center, [email protected]

The pathway of skin penetration has been studied for a long time in the field of cosmetic research.
There are three different skin penetration pathways; intercellular, intracellular and follicular pathway. From
many recent studies, the intercellular pathway is the main route for active delivery. However, barrier property
of the skin makes difficult skin penetration.

To improve skin penetration of cosmetics, there are two different of skin enhancer technology. First,
physical skin enhancers that use electric field, magnetic field, ion force, ultrasound, laser, or microneedles are
the best for skin delivery. However, these treatments are somewhat expensive or inconvenient. And, chemical
skin enhancers; pyrrolidone, DMSO, azone, ethanol or menthol damage or elute human skin lipids in the
process of skin penetration. Therefore chemical enhancers are not also desirable for sensitive skin.

In this talk, we are going to introduce ceramide-based biocompatible skin vesicle. We use computer
simulation modeling method to confirm the possibility of good interaction between our skin vesicle and skin
surface. Our skin vesicles were composed of ceramide, hydrogenated lecithin and cholesterol derivative. DSC
results show the molecular interaction among ceramide, hydrogenated lecithin and cholesterol. For the analysis
of long-term stability, particle size distribution of skin vesicles was measured with Dynamic Light Scattering
(DLS). Biocompatible property of our skin vesicle was confirmed using small angle X-ray scattering (SAXS)
analysis on 3D human skin equivalent model. The skin penetration profiles was confirmed with in vitro Franz
diffusion cell study and in vivo confocal Raman spectroscopy method using retinol as a model drug. As a result,
new ceramide vesicles could be effective for skin penetration and biocompatible vesicles for skin. Also they
could be applied as a new skin enhancer for cosmetic formulation.

-120-
  

          ! $#"% $'&( )"






 


  







 
 !

    


 

 !"
"#








$   
' % %& &&& &' (
     %
 '     ')&   

 "    % &&
&
        &* '%&      &
 
 '%&
  '%&      

 &     &     



 +  "  && & 
 &&' &,
   &  " -(     
 '  % 
 % '      
' &'(&' 
 
% &  && &"
.'&'   & '  %      && &  (  ' & 

' 

 &

% 

 &"
/ '  
  (       && & '   
  
 
 ( % 
" /  ( ( 
 '  

      & 
&'&'0"

-121-
  

          ! $#"% $'&( )"

















$#"
#"
 !
%
%%"
 !

#"
%"&

'"(
#"
)#*
)%& 

 
   
   
  !"$ #! % &!''( 





+! # $ )  , #$ !+# *# #+-  (   #* +# #
# *+# #!) +#  !  $ !# +)*!.#(#!  #'/  
*!# # +! #+#) +# *$+##$*  0 #*+#+# #'
1# 0  0  #    *  #! #- !+ *  # )! +# 0 22 +#
! -  *#'      #  $ ! + #0  )! ( +   0    !* 
 #$*  +3+  # #    +!*   #* *# ) 
   *   #( ! ' 4  0 *#+##   +# + ##   #  # #'  * 0  0
 #  * !#-+! +*'5 +*!##++ #+
)* 0 *$  #' 5  !#  + !   #   $ !  $   ++   2
!*  #  #+ #' 5    # #+  #   * *+   #      #)- 
+#) $  * #0) *#+## * * +#('


-122-
  

          ! $#"% $'&( )"











!"
"

#
$ 

 
 




 


#
"#!  
$ %%&








 '(      
( 
 
 
) 
  *    

  
     
  ( 
   % + ( 
,( 
(
  

 
 
 
  - 
  )
 (  
(    
 ( 
   ( *   - 
  ( (  ) 


.  
      (  ( 
 
    
% /
  *& *
 
   ( 
   
)  
  ( 0 * 
  

 ( 0 (
* 
0 (
)- 
   
%
#  (
 
   
 (      (   ( *  *0

 ( ( 
   
% +  
     
   ( ) ((

( 
 
   *(  * )  

% 1
    
 
  &
  

 

( 
 

 ((
  

% +      
 ) 
(
 
*       )
 )(& 
 (
 ( 
2 )
0
0* 13+  (
    )(& ( 


 * 
  ( ( ( 
%+
   
*  (
* 
(  
* 

  ( ( 

   
( 
 
  )  (  
 
   (%
# 
)  
      )   ( ) *(   


( 
  
   
   
( 
 
  *   
 

     ((%

-123-
-124-
 
!




!

 
/
# 
/

&


8

'

-125-
-126-
  

          ! $#"% $'&( )"




 

  




  

     

 
"" #$!  '& %








         !( )'   $   !  ' '  % 
 !    *    * '!#  '  '     '
 +  '  "*  '$* !!$'$ '
!  % ! ! ' #'*
 ) '+ ! '#$!!!   )
    *  '  " ,    ' %!  " # !
,'  ! ,*  '#'#'!  $# 
  ' ' %



-127-
  

          ! $#"% $'&( )"




   

 




 
 

 
!" 




  


 
 
 

 !" 





#

 $  !



 !
%



 &)(*'%   

%




 %

%
%


  
"+,



 






%
 


   %
 
%
 % 
 " -
  
.!
 !
 

  , 

%    

 /
 % 
 %
  
 &((0' ,    
 ! $$ 

% %%%
 
 
%
1   %    !
 

 
     
   



 
"
0 

%
!% !

%

!
 )(*
!
%



%




%  %  
 !   
 ! 

! ,



% 
 %   %  



2,%
"((0%

,
 !


  %  
  
 ! 
 % 
  ,   $    
!
     
  !
%
 ! 
    
 
  !
 ! /   %
 


 " #  
 
 
3


  

 / ! 3

 % 
 


 

,

 
 %
!% !
&4(4',    
 
  !%


!


   
  " 
( %%%


%

%


  
%

%
!
 

%
!
 
!
"5 


%
 
  ,
3

%  %  
 

    "-

% % ,%

%

! 


  !%
.!
 %
 


  
  
 !%

 
   !

!" #  
  


 


  
  

%
%

!
%
 
,! 
 

 

 
%

3!
" #    % %%%
 
%
    
  
   
$
 



 ,

!


 


 
 
%



  
  
  ! !  
 
  %
  %
 


 " 6  
   

  
 
  
  
 
%
  
3
  
 
   
 



 %
     

   $   
%

 
 
"+,



!

 
  ! 
   

  !
!
   "
#,



  

 
 %
%



 

 
%  
,



4(4 $ 


%

 $  !



 ! 
  

)(*"



-128-
  

          ! $#"% $'&( )"



     

      
 
  ! 

  
      
  








   
 
     
       !

 %%      %  $       %       "#       
 
       &       

   %    !'

    
  %    %     !  %%          (

 
 
   %  $
 
    
   % 
 
 %%!      !   (   !
 
 
   %  
%% %      
  %%  
)%
   %  ! %%   
 !
   ! 
    

 % 
#%  
    %

!  

   ! %      

     !     %    %    %  ! 
 %    
 

 % !
  &       
   %
%  !
   %!
     (
 
!
 %      %        (
%    %% %             !
 %       ! 

  % "#      )  (      

 

*&$$+ %   ! (    %%        *,1 -.1 /,1+   %
0
  
           
  %         2  
!  (

 





-129-
  

          ! $#"% $'&( )"

 










 
!
 

$#"%
 
&!

 

'

'
(
)! &
) 

 


  

    








!
! ! ! 
 !
 
  "
 ! ' 

  #&%'$   (

"(  )    

 !  )


 !"& !&"*
)  ( ))  &"*
 !#-%+,$ 
 .-%+,
   
  !) 
-%+,
)  (      ) ))    )  

 
0   ! (  (   )! /  
 )!  

   #    $
 -%+,"!!
! 
&%'
)  (  1!  
( .  !2 
    
))
  
' 
2!   ) " ! )#,"434$ 
!! )!/  

 
    )    ) 
 
!   )! / )


!(
    -%+,    
!    .      )  
)!/"7 !   !!!56)!/ ) 4 
 )! / ! ) ) )   8   !
  
!"!! ) 



  ! !  !! 
  )! /  
    !
) )!/
! (   ) 

-130-
  

          ! $#"% $'&( )"




 







!

"#
$ 

  
  










!   # # $ #    #  #   $ "%# # $ #$ # 
#" #   # $ &   # $ #   #  $  " '  #'
*+ (# ')$# , $# '     +-#"
#   # #  $   #    .    ' # "'  #
$ $   '# #%# $  $ #  #"
  %$  $ . "  # # $"   #
+ $# ,  '   ## / #  '# *  $# 
#  "    /   "  # "      $' #  * +  $#  " # 
  / "  #  #  " %   #  $$ $ #  1,0 '   
# ##"#  #$ #$# 2%  /$"
#   # %# $  $ ,   ''   #" ''
$        # "  $ " #  '    #    $  $   
#"%
!#'''      #   $%#  # 
     $$$   #" #" #   # #  $ ,   

 #"  #     $ #  ## %$ 3

-131-
-132-
 소속
성명
연락처

절취 후 추첨함에 제출 요망

소속
성명
경 품 추 첨 연락처

<등록데스크> : 도장 날인 시간에 등록데스크에서 날인 해 드립니다.

1차 18일 08 : 30 ~ 09 : 30 2차 18일 12 : 40 ~ 16 : 00
<필수>
3차 19일 09 : 00 ~ 10 : 00 4차 19일 12 : 40 ~ 16 : 00
<필수>

<부스> : 6개이상 필수
애니테이프 BioActs

Collagen Solutions plc H&A파마켐

ROKIT Healthcare 노아닉스

머크코리아 에이치앤엘바이오

제노스
 경품 추첨 방법
u 경품 : 8개 도장 이상(1차, 3차, 부스6개 반드시 포함)을 받은 사람에 한해서 응모 가
능합니다.

u 소속과 성함을 먼저 기재하여 주시고 명찰 확인하여 도장을 찍어드립니다.

u 절취하여 추첨함에 넣어주시면 추첨 대상이 됩니다. (19일 16시 30분 까지)

경품 종류

u 1등 경품(1명) : 백화점 상품권 20만원

u 2등 경품(3명) : 백화점 상품권 10만원

u 3등 경품(10명) : 문화상품권 5만원

u 4등 경품(20명) : 문화상품권 3만원

u 기타 경품(10명) : 마스크팩

경품추첨은 19일 폐회식에 진행될 예정입니다.

메 모