RUH Vol 9 10 Issue 1
RUH Vol 9 10 Issue 1
RUH Vol 9 10 Issue 1
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Contents
Editorial 1
Studies to Read
Fundamental Research
The Effect of Iodium 30c on Experimental Visceral Leishmaniasis 2
Preparation and Standardization of Escherichia coli Nosodes Sourced from Select E. coli Strains 3
A green method for determination of ethanol in homeopathic medicines using thermal infrared
Enthalpimetry 4
In Vitro Assessment of Homeopathic Potencies of Hydrastis canadensis on
Hormone-Dependent and Independent Breast Cancer 5
Silicea terra and Zincum metallicum Modulate the Activity of Macrophages Challenged
with BCG In Vitro 6
Verification of Nuclear Magnetic Resonance Characterization of Traditional Homeopathically
Manufactured Metal (Cuprum metallicum) and Plant (Gelsemium sempervirens)
Medicines and Controls 7
Daily consumption of a homeopathic product decreases intestinal damage and stool
bacterial counts in mice challenged with Escherichia coli 8
Characterization of Nanoparticles in 2X, 4X and 6X Potencies of Ferrum Phosphoricum 9
Homeopathic Rhus toxicodendron Induces Cell Adhesions in the Mouse Pre-osteoblast
Cell Line MC3T3-e1 10
Anti-Tumoral and Anti-Angiogenic Effects of Low-Diluted Phenacetinum on Melanoma 11
Low-dose Drosera rotundifolia induces gene expression changes in 16HBE human
bronchial epithelial cells 12
Preparation of Coronavirus nosodes sourced from a clinical sample of SARS-Cov-2
positive patient, inactivated strain, and spike glycoprotein 13
Nanoparticle characterization of HOMOEO AGROCARE (Agro Homeopathic Drug)
by HRTEM and EDS analysis 14
Homoeopathic Viscum album (10-3) is More Cytotoxic to in vitro Culture of Human
Breast Cancer Cell Line than to Human Mesenchymal Stem Cells 15
Clinical Research
Homeopathic Treatment as an Add-On Therapy May Improve Quality of Life and Prolong
Survival in Patients with Non-Small Cell Lung Cancer: A Prospective, Randomized,
Placebo-Controlled, Double-Blind, Three-Arm, Multicenter Study 16
Counting Polar Symptoms: How to Represent Results? 17
Individualized Homeopathic Medicines in Chronic Rhinosinusitis: Randomized, Double-Blind,
Placebo-Controlled Trial 18
Individualized homeopathic medicines and Urtica urens mother tincture in treatment of
hyperuricemia: an open, randomized, pragmatic, pilot trial 19
Development of a Prognostic Factor Prediction Model in Patients with Musculoskeletal
Pain Treated with Homeopathy: An Individual Patient Data Meta-Analysis of Three
Randomized Clinical Trials 20
A Randomized, Double-Blind, Placebo-Controlled, Pilot Trial of Individualized Homeopathic
Medicines for Cutaneous Warts 21
Comparative Effectiveness of the Homeopathic Preparation Traumeel S in Third Molar
Extraction Surgery: A Preliminary Triple-Blind Clinical Trial 22
Individualized Homeopathic Medicines in the Treatment of Generalized Anxiety Disorder:
A Double-Blind, Randomized, Placebo-Controlled, Pilot Trial 23
Contents
Evaluation of Individualized Homeopathic Treatment in Patients With Irritable Bowel Syndrome:
A Pilot Study 24
Impact of Homeopathic Treatment on the Quality of Life of Women with Chronic Diseases:
A Randomized Controlled Pragmatic Trial 25
Individualized Homeopathic Medicines in Stage I Essential Hypertension:
A Double-Blind, Randomized, Placebo-Controlled Pilot Trial 26
Review
Experimental Evidence Supports New Perspectives in Homeopathy 27
The Human Microbiome, Conventional Medicine, and Homeopathy 28
Homeopathy in Experimental Cancer Models: A Systematic Review 29
Homeopathic Preparations for Preventing and Treating Acute Upper Respiratory Tract
Infections in Children: A Systematic Review and Meta-Analysis 30
[Evidence-based homeopathy and veterinary homeopathy, and its potential to
help overcome the anti-microbial resistance problem - an overview] 31
Physicochemical Investigations of Homeopathic Preparations: A Systematic Review and
Bibliometric Analysis-Part 3 32
A Homeopathic View of the Influence of Chronic Diseases in the Manifestation of COVID-19 33
Homeopathy Assessment-Contribution of the Human Sciences 34
Effects of Highly Diluted Drugs on Experimental Infection with Trypanosoma cruzi
In Vivo: Systematic Review 35
Case Reports
Pituitary Microadenoma Treated with Individualized Homeopathic Medicine: A Case Report 36
Multimorbidity After Surgical Menopause Treated with Individualized Classical
Homeopathy: A Case Report 37
Evaluation of the Modified Naranjo Criteria for Assessing Causal Attribution of Clinical
Outcome to Homeopathic Intervention as Presented in Case Reports 38
Antimonium crudum in pediatric skin conditions: A classical homeopathic case series 39
Fibromyalgia: A Report of 2 Cases Treated With Homeopathy 39
Severe Acute Thromboinflammation: Case Report of Individualized Homeopathic Treatment 40
Appearance of Acute Inflammatory State Indicates Improvement in Atopic Dermatitis
Cases Under Classical Homeopathic Treatment: A Case Series 41
Veterinary
Homeopathic Treatment of Pododermatitis in Magellanic Penguins (Spheniscus magellanicus) 42
Evaluation of the Efficacy of Crataegus oxyacantha in Dogs with Early-Stage Heart Failure 43
Experimental infection with Escherichia coli in broilers: Impacts of the disease and
benefits of preventive consumption of a stimulator of homeopathic immunity 44
The effects of road transportation with or without homeopathic remedy supplementation
on growth performance, apparent nutrient digestibility, fecal microbiota, and serum
cortisol and superoxide dismutase levels in growing pigs 45
Agrohomeopathy
Effect of Homeopathic Preparations on Lettuce, Parasitized or Not by Meloidogyne enterolobii 46
Effects of Homeopathic Preparations of Mercurius corrosivus on the Growth Rate of Moderately
Mercury-Stressed Duckweed Lemna gibba L 47
Contents
Dentistry
Systematic Review on the Use of Homeopathy in Dentistry: Critical Analysis of Clinical Trials 48
Drug Proving
Five Years of Practical Experience Using the Revised Proving Guidelines of the
Homœopathic Pharmacopœia Convention of the United States 49
Survey
International Patent Survey of Products and Processes Concerning Homeopathy 50
Data Collection during the COVID-19 Pandemic: Learning from Experience, Resulting
in a Bayesian Repertory 51
Prevalence and Likelihood Ratio of Six Objective Signs among Good Responders to
Natrum muriaticum: Multi-centre Observational Assessment 52
Trajectory of Patients Treated With Classical Homeopathy: A Retrospective Analysis 53
Use of Homeopathy in Integrative Oncology in Strasbourg, France: Multi-center
Cross-Sectional Descriptive Study of Patients Undergoing Cancer Treatment 54
Conference Proceeding
International Journal of High Dilution Research 55
Be a Research Voice
IPRH Sitemap
Research Updates – Homeopathy by IPRH. Creating Avenues | Spreading Truth
We often come across tall claims but not supporting valid evidences. Such situations are tricky –
whether to believe them because we have “faith” or to follow the “scientificity” and subject their claims
to “methodology”. Amidst this we sometime lose our connect. At times majority of us “accepts” the
things “as it is” rather than establish the true “evidence-based medicine”.
If this would have been the scenario, Hahnemann would not have established Homeopathy as a system
of medicine. Observations are one aspect of scientific methods; the other aspect is to formulate the
right “research question” and follow the methodology of scientific methods. If we retrospectively
analyze Hahnemann’s work, we know that his methodology, scientific methods, understanding, analysis
of data and presentation of facts (for future research) was ahead of the time. We still have lot to learn,
understand and experiment in homeopathy. And this is the right time now when we should understand
our science as true practitioners of the healing art, rather than believers of something we never tried to
understand. Choice is ours!
Research has never been parted from science and cannot be. Knowingly or unknowingly, we do
research but seldom pen down or report it logically. We talk of research, but where to start a research
becomes difficult for us. Challenges, issues and learnings, would be our companion in this journey of
homeopathy learning. We must start accepting them to make ourselves equipped with latest knowledge,
to sharpen our logic and apply our intellectual abilities for betterment. We must be an active part of the
evolution so as to upgrade the system and ourselves.
Let us pledge on this world homeopathy day to keep moving forward – with scientific methods, better
clinical understanding and aim to strengthen homeopathy from the roots.
Dr Saurav Arora
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Studies to be Read
Abstracts of peer-reviewed studies published during Oct 2020 – March 2021. The original links are
provided with each article. For citations, original links, authors and journals should be referred.
Fundamental Research
Abstract
Background: Leishmaniasis is one of several neglected tropical diseases that warrant
serious attention. A disease of socio-economically poor people, it demands safer and
cheaper drugs that help to overcome the limitations faced by the existing anti-
leishmanials. Complementary or traditional medicines might be a good option, with an
added advantage that resistance may not develop against these drugs. Thus, the present
investigation was performed to evaluate the anti-leishmanial efficacy of an ultra-diluted
homeopathic medicine (Iodium 30c) in experimental visceral leishmaniasis (VL).
Methods: Compliant with strict ethical standards in animal experimentation, the study was
performed in-vivo in inbred BALB/c mice which were injected intravenously with 1 × 107
promastigotes of Leishmania donovani before (therapeutic) or after (prophylactic)
treatment with Iodium 30c for 30 days. In other groups of mice (n = 6 per group),
amphotericin B served as positive control, infected animals as the disease control, while
the naïve controls included normal animals; animals receiving only Iodium 30c or Alcohol
30c served as sham controls. The anti-leishmanial efficacy was assessed by determining the
hepatic parasite load and analysing percentages of CD4+ and CD8+ T cells. Biochemical
analysis and histological studies were performed to check any toxicities.
Results: Iodium-treated animals showed a significantly reduced parasite load (to 1503 ± 39
Leishman Donovan Units, LDU) as compared with the infected controls (4489 ± 256 LDU) (p
< 0.05): thus, the mean therapeutic efficacy of Iodium 30c was 66.5%. In addition, the
population of CD4+ and CD8+ T cells was significantly increased (p < 0.05) after treatment.
No toxicity was observed, as evidenced from biochemical and histopathological studies of
the liver and kidneys. Efficacy of Iodium 30c prophylaxis was 58.3%, while the therapeutic
efficacy of amphotericin B was 85.9%.
Conclusion: This original study has shown that Iodium 30c had significant impact in
controlling parasite replication in experimental VL, though the effect was less than that
using standard pharmaceutical treatment.
Abstract
Background: The nosodes are well-known preparations in homeopathy that are
sourced from organisms and diseased materials. More than 40 known nosodes have
been used in homeopathic practice for over a century. Having identified the need
for scientifically developed new nosodes sourced from organisms that are currently
prevalent, the preparation of Escherichia coli nosodes from different strains of the
bacterium is presented in this article.
Materials and methods: Escherichia coli strains (E. coli ATCC 11775E, ATCC 25922,
and ATCC 8739) were identified, cultured, and tested for purity, and 20 billion cells
were processed following the nosode preparation method given in the
Homoeopathic Pharmacopoeia of India, group N1. Serial dilution and potentization
for liquid potency were done up to 30c potency. Nosodes were prepared by two
methods: from cell-free extract (endotoxin) and from entire-cell extract.
Result: Six nosodes were developed in total. Three univalent nosodes were prepared
using individual endotoxins, one from each of the three E. coli strains; those three
univalent nosodes were also combined as "Trivalent nosode-I". "Trivalent nosode-II"
was prepared by mixing entire cells of the three E. coli strains. A mix of both Trivalent
nosode-I and Trivalent nosode-II was labeled "EC-Polynosode". The safety profile of
the potentized nosodes was documented by the non-detectability of traces of
source material (absence of contamination, live organisms, or DNA material)
through a culture test, sterility test, and molecular testing (polymerase chain
reaction).
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Abstract
In this work, a simple and fast method is proposed for the determination of
ethanol in homeopathic medicines using thermal infrared enthalpimetry (TIE).
Samples containing alcohol in a wide concentration range (from 5% to 95% v/v)
were used. Purified water or absolute ethanol was added directly into
homeopathic medicine and increase of temperature was monitored using an
infrared camera. Total volume, stirring speed and dispensing rate of solutions
were the most significant parameters studied for method optimization. A
response surface methodology (RSM) was used for optimization of the
experimental conditions. The method was validated in the following parameters:
selectivity, linearity, linear range, precision (repeatability and intermediate
precision), limit of detection and quantification, accuracy and robustness. Linear
range was obtained from 4% to 55% (ethanol, v/v). The proposed method
showed accuracy in agreement with the conventional one. The proposed
method it was demonstrated a good alternative for determination of ethanol in
homeopathic medicines, presenting low cost, fast analysis and agreement with
the principles of green analytical chemistry.
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Abstract
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Abstract
Methods: RAW 264.7 macrophages were infected with BCG, treated with
different potencies of Sil and Zinc (6cH, 30cH and 200cH) or vehicle, and
assessed 24 and 48 h later for bacilli internalization, hydrogen peroxide (H2O2)
and cytokine production, and lysosomal activity.
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Abstract
Background: Nuclear magnetic resonance (NMR) proton relaxation is sensitive to
the dynamics of the water molecule, H2O, through the interaction of the spin of the
proton (1H) with external magnetic and electromagnetic fields. NMR relaxation
times describe how quickly the spin of 1H, forced in a direction by an external
electromagnetic field, returns to a normal resting position. As a result, such
measurements allow us potentially to describe higher structuring of water in
homeopathic medicines.
Objective: The purpose of the present study was to verify whether specific NMR
relaxation times could be measured in full lines of cH dynamizations of a metal
(copper) and of a plant substance (Gelsemium sempervirens), compared with a
solvent control, a potentized lactose control and a control prepared by simple
dilution, in three production lines. It is aimed at verification of a previous publication
(2017) on two new manufacturing lines of the same starting material and controls.
Results: When the values of the three production lines were pooled, a statistically
significant discrimination of NMR relaxation times between the medicines and their
controls was confirmed. We found for copper cH and Gelsemium sempervirens cH a
highly significant influence of the starting material (p = 0.008), a highly significant
influence of level of dilution (p < 0.001), and a significant influence of the O2
concentration (p = 0.04).
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Abstract
Introduction Nosodes, the homeopathic preparations sourced from biological
materials including clinical samples, cultures of organisms, and diseased tissues
have been in use against the source-specific infections as well as other diseases.
The nosodes have demonstrated some efficacy in managing epidemics, such as
influenza, dengue, and leptospirosis. This article presents the need and process
of development of nosodes from the SARS-CoV-2 to explore its prophylactic and
therapeutic potentials against certain related viral diseases. MATERIALS AND
METHODS A clinical sample of SARS-Cov-2 positive patient, based on the cycle
threshold (CT) value of the qRT-PCR, heat-inactivated SARS-CoV-2, and spike
glycoprotein all were processed for making nosodes as per the method
described in Homoeopathy Pharmacopoeia of India. Molecular tests, such as
qRT- PCR and sterility tests were performed to establish the live organisms, RNA
material, and the absence of contamination. RESULT Three variants of
Coronavirus Nosode were developed using a clinical sample, heat-inactivated
SARS-CoV-2, and spike glycoprotein. In potencies 3c and above, no detectable
SARS-CoV-2 RNA material was found by PCR. The analytical results for nosodes
were reported as compliant for sterility testing as per the IP. CONCLUSION Three
variants of Coronavirus nosodes were prepared which need to be evaluated
further through pre-clinical and clinical studies.
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Abstract
Background: Use of Homeopathy as a therapeutic tool is still very nascent in
plant science and agriculture. Therapies used for plant growth and diseases are
not relevant for plants alone, but they also drastically influence the ecosystem of
the organic world too. Use of pesticides and chemical fertilizers was a boon
during the initial phase of green revolution around the world. Unfortunately, later
they became the major reason of chronic illnesses like cancers and a cause for
soil degradation all over. Current scenario demands the use of alternative
models in agricultural practices in-order to prevent diseases and to maintain the
health status of the population. This is also very important to get rid of the
damages done to the soil. Aims: Present study aimed at analyzing the material
content of the agro homeopathic drug, ‘Homeo agrocare’. Methdology: High
resolution transmission electron microscope (HRTEM) and Energy dispersion
spectroscopy (EDS) was used to evaluate the material content of the drug.
Results: (1) the drug solution contains plenty of nanoparticles (NPs). (2) the size of
NPs ranges between 4.99nm - 120nm. (3) Twenty elements were identified in the
fields studied. Conclusion: Study conclusively proved the presence of NPs of the
original drug materials used in the ‘Homoeo agrocare’ drug solution. The
presence of NPs of the original drug substances suggest that the drug action of
‘Homoeo agrocare’ in plants is due to the epigenetic modifications initiated by
the NPs in the plant genetics.
Article Link: https://highdilution.org/index.php/ijhdr/article/view/1025
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Abstract
BACKGROUND Adenocarcinomas can be of several types, and MCF-7 is an
adenocarcinoma of human breast cell line useful as preclinical model to screen
therapeutic agents such as ultra-diluted Viscum album, an European plant
whose extract is commonly used in cancer therapy. AIMS MCF-7 and
mesenchymal stem cells were used to evaluate the in vitro cytotoxicity of
homoeopathic Viscum album 1x10-3 (VAD3). METHODS cells were cultured for 24
hours in controlled environment (37.5oC and 5% CO2) in 96-well plates. After this
time, VAD3 was added to the culture medium in concentrations varying from 10
to 100 ?L/mL for MTT assay (evaluation of viability of cells). A control group was
maintained with culture medium only. After 48 hours, the procedures of analysis
of cells viability were performed. RESULTS MTT assay showed that the
concentrations of 42 ?L/mL and 62 ?L/mL were able to reduce cell viability to
50% in MCF-7 and mesenchymal stem cells, respectively, which means that half
of the cells cultured were dead after 48 hours in contact with VAD3.
CONCLUSION Viscum album presented higher cytotoxic action on human breast
cancer cell line culture than on mesenchymal stem cells. This medicine is
extensively used against cancer, and the use of the homoeopathic form of it
brings new possibilities as no or fewer adverse effects would be present.
Article Link: https://highdilution.org/index.php/ijhdr/article/view/1036
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Clinical Research
Homeopathic Treatment as an Add-On Therapy May Improve Quality
of Life and Prolong Survival in Patients with Non-Small Cell Lung
Cancer: A Prospective, Randomized, Placebo-Controlled, Double-
Blind, Three-Arm, Multicenter Study
Oncologist. 2020 Dec;25(12):e1930-e1955.
Abstract
Lessons learned: Conventional medicine and homeopathy work well together. Quality
of life improves with additive homeopathy in patients with non-small cell lung cancer
(NSCLC). Survival improves with additive homeopathy in patients with NSCLC.
Background: Patients with advanced non-small cell lung cancer (NSCLC) have limited
treatment options. Alongside conventional anticancer treatment, additive
homeopathy might help to alleviate side effects of conventional therapy. The aim of
the present study was to investigate whether additive homeopathy might influence
quality of life (QoL) and survival in patients with NSCLC.
Methods: In this prospective, randomized, placebo-controlled, double-blind, three-arm,
multicenter, phase III study, we evaluated the possible effects of additive homeopathic
treatment compared with placebo in patients with stage IV NSCLC, with respect to QoL
in the two randomized groups and survival time in all three groups. Treated patients
visited the outpatients' centers every 9 weeks: 150 patients with stage IV NSCLC were
included in the study; 98 received either individualized homeopathic remedies (n = 51)
or placebo (n = 47) in a double-blinded fashion; and 52 control patients without any
homeopathic treatment were observed for survival only. The constituents of the different
homeopathic remedies were mainly of plant, mineral, or animal origin. The remedies
were manufactured by stepwise dilution and succussion, thereby preparing stable
Good Manufacturing Practice grade formulations.
Results: QoL as well as functional and symptom scales showed significant improvement
in the homeopathy group when compared with placebo after 9 and 18 weeks of
homeopathic treatment (p < .001). Median survival time was significantly longer in the
homeopathy group (435 days) versus placebo (257 days; p = .010) as well as versus
control (228 days; p < .001). Survival rate in the homeopathy group differed significantly
from placebo (p = .020) and from control (p < .001).
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Review
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CASE REPORTS
Pituitary Microadenoma Treated with Individualized Homeopathic
Medicine: A Case Report
Homeopathy. 2020 Nov;109(4):243-247.
Abstract
Background: Pituitary adenomas are common benign tumors of the pituitary
gland with an overall estimated prevalence of 16.7%. As per the revised World
Health Organization (WHO) classification, these tumors are identified by their
histological subtypes and are designated by their pituitary cell lineage instead of
the hormone they produce. The lactotroph adenoma is the most common
subtype of hormone-producing pituitary adenoma. Surgery is the mainstay of
treatment, but complications are encountered. So far, there is no reported study
evaluating individualized homeopathic intervention in pituitary adenoma in peer-
reviewed journals.
Methods: This case study describes a case of functional lactotroph
microadenoma with history of failed surgical treatment and heavy intrasellar
hemorrhage occurring during the surgery. Phosphorus was prescribed as an
individualized homeopathic medicine on the basis of symptoms-hemorrhagic
complication during surgical procedure and aggravation of headache
thereafter.
Results: There was a marked subjective improvement along with complete tumor
regression, as evidenced by repeat magnetic resonance imaging scans. The
Modified Naranjo Criteria total score was +10 out of a possible +13, providing
some evidence to attribute the clinical outcome with the homeopathic
intervention.
Conclusion: This case study reconfirms the association between increased
frequency of headaches and pituitary hemorrhage among cases of lactotroph
adenoma. It also suggests that individualized homeopathic treatment may be
helpful in pituitary adenomas with increased risk of complications such as
intrasellar hemorrhage.
Article Link: https://pubmed.ncbi.nlm.nih.gov/32862414/
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Veterinary
Homeopathic Treatment of Pododermatitis in Magellanic Penguins
(Spheniscus magellanicus)
Homeopathy. 2021 Feb;110(1):62-66.
Abstract
Background: Problems with the feet are common in penguins, with a particular
predisposition to pododermatitis. This condition usually occurs due to the
changes in normal activity that result from being held captive, but its precise
pathogenesis is still undetermined.
Methods/patients: This veterinary case study reports the use of oral homeopathic
treatment on acute and chronic pododermatitis in five Magellanic penguins in a
zoological park setting. During treatment, the patients remained in the penguins'
living area, and the effect of the treatment on the progression of their lesions
was assessed visually once weekly. The treatment consisted of a combination
of Arnica montana and Calcarea carbonica.
Results: After treatment, the appearance of the lesions had noticeably
improved: in the majority of penguins there was no longer evidence of infection
or edema in the feet. The rate of recovery depended on the initial severity of the
lesion. Those penguins that still showed signs of infection nevertheless exhibited a
clear diminution of the size and thickness of the lesions. Homeopathic treatment
did not cause any side effects.
Conclusion: Homeopathy offers a useful treatment option for pododermatitis in
captive penguins, with easy administration and without side effects.
Article Link: https://pubmed.ncbi.nlm.nih.gov/33316832/
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AGROHOMEOPATHY
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AGROHOMEOPATHY
Effects of Homeopathic Preparations of Mercurius corrosivus on the
Growth Rate of Moderately Mercury-Stressed Duckweed Lemna
gibba L
Homeopathy. 2021 Mar 10.
Abstract
Background: A bioassay with severely mercury-stressed duckweed (Lemna
gibba L.) had revealed growth-inhibiting effects of homeopathically
potentised mercury(II) chloride (Mercurius corrosivus, Merc-c.). We
hypothesised that effects of potentised preparations are dependent on the
stress level of the organisms used in the bioassay. The aim of the present
investigation was to examine the response of duckweed to potentised Merc-
c. at a lower stress level.
Methods: Duckweed was moderately stressed with 2.5 mg/L mercury(II)
chloride for 48 hours. Afterwards plants grew in either Merc-c. (seven different
potency levels, 24x-30x) or water controls (unsuccussed or succussed water)
for 7 days. Growth rates of the frond (leaf) area were determined using a
computerised image-analysis system for day 0-3 and 3-7. Three independent
experiments with potentised Merc-c. and three systematic negative control
experiments were performed. All experiments were randomised and blinded.
Results: Unsuccussed and succussed water did not significantly differ in their
effects on duckweed growth rate. The systematic negative control
experiments did not yield any significant effects, thus providing evidence for
the stability of the experimental system. Data from the two control groups
and the seven treatment groups (Merc-c. 24x-30x) were each pooled to
increase statistical power. Duckweed growth rates for day 3-7 were
enhanced (p < 0.05) after application of Merc-c. compared with the controls.
Growth rates for day 0-3 were not influenced by the homeopathic
preparations.
Conclusions: Moderately mercury-stressed Lemna gibba L. yielded evidence
of growth-enhancing specific effects of Merc-c. 24x-30x in the second
observation period (day 3-7). This observation is complementary to previous
experiments with severely mercury-stressed duckweed, in which a decrease
in growth was observed in the first observation period (day 0-3). We
hypothesise that the differing results are associated with the level of stress
intensity (moderate vs. severe).
Article Link: https://pubmed.ncbi.nlm.nih.gov/33694141/
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DENTISTRY
Systematic Review on the Use of Homeopathy in Dentistry: Critical
Analysis of Clinical Trials
J Altern Complement Med. 2021 Mar;27(3):214-224.
Abstract
Objectives: The objective of this research was to systematically map the
literature on homeopathy and dentistry studies and to evaluate the
effectiveness of using homeopathy in dental practice through the critical
analysis of clinical studies.
Design: The search for scientific articles in any language, year, and place of
publication was made in the databases of Public Medline (PUBMED), Web of
Science, Cochrane, and Virtual Health Library; the articles selected were later
classified according to the type of study. Gray literature was accessed
through Google Scholar. Clinical trials were analyzed for methodological
quality. Two previously trained reviewers accomplished the entire process
independently.
Results: Of the 281 studies retrieved by means of the search, 44 met the
eligibility criteria, with prevalence of literature reviews (56.8%), followed by
clinical trials (34.1%), cross-sectional studies (6.8%), laboratory research (6.8%),
and longitudinal observational studies (4.5%). The clinical trials identified were
published from 1965 to 2019, using homeopathy in several dental specialties:
in Endodontics, Periodontics, Orofacial Pain, Surgery, Pediatric Dentistry, and
Stomatology, as well as in cases of dental anxiety. Qualitative failures, in all
criteria investigated, and positive influences of the individual prescriptions on
the results of treatments reported were observed.
Conclusions: There is still a scarcity of studies about homeopathy and
dentistry. The clinical trials selected showed positive effects on oral health;
however, when they were critically evaluated, it was possible to recognize
qualitative failures, mainly relative to double-blinding. It is necessary to
encourage research on the subject, using standardized methodological
procedures, to obtain better evaluation of the clinical applicability.
Article Link: https://pubmed.ncbi.nlm.nih.gov/33170020/
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DRUG
PROVING
Five Years of Practical Experience Using the Revised Proving
Guidelines of the Homœopathic Pharmacopœia Convention of
the United States
Homeopathy. 2020 Nov;109(4):230-237.
Abstract
The Homœopathic Pharmacopœia of the United States (HPUS) is one of the
three officially recognized compendia of medical drugs in the United States.
A well-conducted homeopathic proving is one pathway to entry into the
HPUS. In 2013, guidelines for homeopathic drug provings were updated to
better assess the methodology of provings and improve the confidence in
the outcomes generated. In addition, the team who developed the revised
guidelines included a pragmatic approach to assess the quality of proving
outcomes in terms of their usefulness in determining the therapeutic profile.
The monograph review team, composed of homeopathic clinicians and
researchers, has evaluated 25 new homeopathic medicines for monograph
purposes. The team has noted that the guidelines have helped frame and
standardize the monograph review process. The revised structure for
monograph reporting has enhanced the reviewer's ability to ascertain the
therapeutic profile for a new substance. Sponsors have stated that the new
guidelines have helped increase their conformance with Good Clinical
Practices, helped improve the reporting and transparency of their provings,
and may help safeguard provings as a valid research method. Similar
harmonized guidelines have been adopted by the European Committee for
Homeopathy and the Liga Medicorum Homœopathica Internationalis.
Article Link: https://pubmed.ncbi.nlm.nih.gov/32172528/
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SURVEY
International Patent Survey of Products and Processes Concerning
Homeopathy
Homeopathy. 2021 Feb;110(1):2-12.
Abstract
Background: Homeopathy is a complementary medicine characterized by the
use of diluted and potentized medicines. Innovations in this area are
constantly being proposed in the relevant literature, such as scientific articles
and patents. The objective of this study was to carry out a patent survey of
homeopathic products and processes.
Methods: A free and international patent database, Espacenet, was used. The
search was carried out using the keyword homeop*, with two approaches: (1)
no date restrictions for the search and (2) a date limit for the publication years
2008 to 2018. The patents from the limited period were organized as depositor
countries, ownerships and groups, including homeopathic formulations,
equipment, packaging, production procedures, and analytical methods.
Results: Without date restriction, 601 patents were identified in the survey. Of
these, 174 were related to homeopathy and published in the period 2008 to
2018. Technologies come mainly from the following countries: United States (55
patents), Russia (24), Germany (15), France (13), India (12), Ukraine (11), Brazil
(6), and China (6). Among the ownerships, 69% of patent applications were by
independent depositors, 23% by companies, 7.5% by universities, and 0.5% by
company/university partnerships. New formulations represented 75.9% of
technologies, whilst the others comprised 14.3% for equipment, 3.8% for drugs
packaging, 3.8% for production procedures, and 2.2% for analytical methods.
Conclusions: The present review helps visualize the homeopathy-related
patents published in recent years, as well as the main countries and
researchers investing in the field of homeopathy.
Article Link: https://pubmed.ncbi.nlm.nih.gov/33063310/
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CONFERENCE PROCEEDINGS
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