Microbiology: Dr. Murad Ibrahim Miss Jumana Wadi
Microbiology: Dr. Murad Ibrahim Miss Jumana Wadi
Microbiology: Dr. Murad Ibrahim Miss Jumana Wadi
Faculty of Medicine
Microbiology
Prepared By:
Diaa M. Srahin
April, 2016
Case Study
A 50-year-old advertising executive consulted his primary health-care
provider because of tiredness, lethargy, and an abdominal pain centered
around the lower end of his sternum, which woke him in the early hours of
the morning. The pain was relieved by food and antacids. His uncle had
died of stomach cancer and he was worried that he had the same illness.
On examination his doctor noted that he seemed a bit pale and that he had
a tachycardia. His blood pressure was low. He was slightly tender in his
upper abdomen but there was no guarding or rebound tenderness.
The doctor took blood and feces samples and organized for an upper
gastrointestinal endoscopy. The full blood count showed a hypochromic
normocytic anemia with a hemoglobin of 8.9 consistent with iron
deficiency anemia. The gastroscopy showed a 3 cm ulcer in the prepyloric
region of the stomach (Figure 1). .The fecal antigen test for Helicobacter
pylori was positive. The patient was started on routine treatment for a
duodenal ulcer.
Clinical Case Summary
A 50- year-old male.
Chief Complain
Abdominal pain centered around the lower end of his sternum.
Onset of the Pain
On fasting.
Relieving Factors
Food and Antacids.
Associated Symptoms
Tiredness, Lethargy .
Family History
His uncle had died of stomach cancer.
Clinical Case Summary
Physical Examination
Tachycardia , Low BP , Tender in his Upper Abdomen and he
seemed a bit pale.
LAB. Investigations
Blood Test
Iron deficiency anemia & hypochromic normocytic anemia.
Endoscopy
3 cm ulcer in the prepyloric region of the stomach.
Anemia (due to blood loss from the ulcer) and weight loss may also
occur
Signs and symptoms of perforation (acute abdominal pain,
abdominal rigidity and guarding, rebound tenderness and shock).
Clinical Presentation and Complications
H. pylori has a role in inflammatory bowel disease.
Endoscopy and biopsy: the biopsy can then be cultured under micro-
aerobic conditions for H. pylori, which takes 5 days.
Rapid urease test (which involves putting one of the biopsies into a urea
solution with a pH indicator).
Recommended tests are urea breath test and the fecal antigen tests.
H2N(13/14CO)NH2 + H20 →
urease → 2NH3 + 13/14CO2
3. 14CO2 is transported in
the blood to the lungs.
4.Patient exhales. 14CO2 is
captured for analysis.
Treatment
The concept that underlies the choice of drugs is to use antibiotics to
eliminate Helicobacter plus a drug to reduce gastric acidity.