1

Remington Pharmaceutical Industry

Origins and Evolution of Pharmaceutical Industry

The modern pharmaceutical industry is a highly competitive non-assembled1 global

industry. Its origins can be traced back to the nascent chemical industry of the late
nineteenth century in the Upper Rhine Valley near Basel, Switzerland when
dyestuffs were found to have antiseptic properties. A host of modern pharmaceutical
companies all started out as Rhine-based family dyestuff and chemical companies
e.g. Hoffman-La Roche, Sandoz, Ciba-Geigy (the product of a merger between Ciba
and Geiger), and Novartis2 etc. Most are still going strong today.

Over time many of these chemical companies moved into the production of
pharmaceuticals and other synthetic chemicals and they gradually evolved into
global players. The introduction and success of penicillin in the early forties and the
relative success of other innovative drugs, institutionalized research and
development (R&D) efforts in the industry 4. The industry expanded rapidly in the
sixties, benefiting from new discoveries and a lax regulatory environment. During
this period healthcare spending boomed as global economies prospered.

The industry witnessed major developments in the seventies with the introduction of
tighter regulatory controls, especially with the introduction of regulations governing
the manufacture of ‘generics’5. The new regulations revoked permanent patents and
established fixed periods on patent protection for branded products, a result of which
the market for ‘branded generics’6 emerged.
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Brief Introduction

For over 100 years, Remington has been the definitive textbook and reference on the
science and practice of pharmacy. This Twenty-First Edition keeps pace with recent
changes in the pharmacy curriculum and professional pharmacy practice.

More than 95 new contributors and 5 new section editors provide fresh perspectives
on the field. New chapters include pharmacogenomics, application of ethical
principles to practice dilemmas, technology and automation, professional
communication, medication errors, re-engineering pharmacy practice, management
of special risk medicines, specialization in pharmacy practice, disease state
management, emergency patient care, and wound care.

Purchasers of this textbook are entitled to a new, fully indexed Bonus CD-ROM,
affording instant access to the full content of Remington in a convenient and
portable format.

A must-have resource for all in the pharmaceutical industry!

With over two decades of serving your healthcare needs and a vision to enhance the
quality of life, Remington Pharmaceuticals is committed to providing you with best
healthcare solutions. We develop and manufacture pharmaceutical medicines
through our dedicated R&D team and state-of-the-art manufacturing facilities to
ensure not only a healthier today but also, a healthier tomorrow!

Keeping in mind the need for provision of better healthcare services, Remington
aims at providing high-class medicines with greater access for the benefit of
everyone. The company dedicatedly works towards improving the quality of human
life through continuous innovation and hard-work to bring forth a stream of
medicinal products that contribute to the betterment of the society. Remington offers
a broad portfolio of medicines seeking to give maximum benefit to patients.
 3
Among the medical professionals and other stakeholders, Remington is best known
for its dedicated people, passion for innovation through research and development
and quality healthcare solutions. Determined to always go beyond its reputation, the
recent development of its new state-of-the-art manufacturing facility is a testimony
of our continuous efforts to bring Remington to the global fore.

Company Information

With over two decades of serving your healthcare needs and a vision to enhance the
quality of life, Remington Pharmaceuticals is committed to providing you with best
healthcare solutions. We develop and manufacture pharmaceutical medicines
through our dedicated R&D team and state-of-the-art manufacturing facilities to
ensure not only a healthier today but also, a healthier tomorrow!

Keeping in mind the need for provision of better healthcare services, Remington
aims at providing high-class medicines with greater access for the benefit of
everyone. The company dedicatedly works towards improving the quality of human
life through continuous innovation and hard-work to bring forth a stream of
medicinal products that contribute to the betterment of the society. Remington offers
a broad portfolio of medicines seeking to give maximum benefit to patients.

Among the medical professionals and other stakeholders, Remington is best known
for its dedicated people, passion for innovation through research and development
and quality healthcare solutions. Determined to always go beyond its reputation, the
recent development of its new state-of-the-art manufacturing facility is a testimony
of our continuous efforts to bring Remington to the global fore.

With a diligent team and a cGMP compliant, 150,000 sq. ft. manufacturing facility
equipped with latest technology, Remington is devoted on ensuring that it delivers
and fulfils its commitments to the fullest. Strictly adhering to international
 4
maintenance and monitoring standards and stringent quality control checks, the
company has established an edge over its competitors enabling it to become the
industry benchmark. According to the IMS, Switzerland (Q1, 2008), Remington is
ranked among the top 30 companies from 681 pharmaceutical companies in Pakistan
in terms of unit-wise sales.

Here at Remington, we uphold strong moral values and instill them in our team. We
inculcate an environment that is based on ethical workings and integrity. The
company has also been working towards providing healthcare services to those who
are impoverished and in places where they are non-existent. We believe in giving
back to the society and for that purpose, the company helped establish Pakistan’s
first private pharmaceutical college and has also been funding a number of NGOs
and other non-profit organization such as Red Cross and Ameer Begum Welfare
Trust (ABWT).

In a world that is rapidly growing, Remington’s dynamic thinking and forward-

looking attitude has made it more adaptable to the changing needs of people. The
company envisions growth and partnerships that stretch across the globe. An
infrastructure of global standards, a concatenate R&D team, technological
advancements, long-lasting customer relationships and a mindset geared towards
growth are the key ingredients that are bound to make the company a success in the
future as well.

Company Values

• Creativity leads to innovation which lays the foundation for success.

• Innovative and updated technology to produce the best quality products.
• Utmost care for employees, customers and the society we live in.
• Respect the employees and their contributions at workplace.
 5
• Committed to the highest standards of ethics and integrity.
• Teamwork is the lifeblood of the organization.
• Trust in the relationships with clients.

Message from the C.E.O

I would like to thank everyone who has been directly or indirectly involved in
supporting our efforts to make Remington’s name synonymous to trust and quality.
It is with the untiring efforts of our Research & Development, Production, Quality
Assurance, Material Management, Engineering, Sales & Marketing, Regulatory
Affairs, Human Resource and Corporate Finance teams, that we have achieved
many valuable milestones in the short history of the Company.

Not only Remington, but the whole Pharmaceutical industry in Pakistan is at the
crossroads to be counted or to be neglected in the global arena. At Remington we
have committed all our energies towards making ourselves a recognized leader in
the global pharmaceutical industry by providing quality medicines at an affordable
price.

The new millennium represents the promise of a better future and the reality of rapid
and unpredictable change. To excel, those who will manage, must combine logic
with intuition and solid academic training with bold vision.

Dr. Khokhar is one of the leading figures in the pharmaceutical sector of the
country. He has represented the industry on various national and international
forums. He has been elected Chairman of Pakistan Pharmaceutical Manufacturer's
Association (PPMA) twice and has been the President of Pakistan Pharmacist
Association (PPA), Punjab. He represented PPMA on the Registration and Licensing
Boards, Ministry of Health - Pakistan.
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He has been a member of various national policy making bodies, including the
Committee for Monitoring Drugs Sector (CMDS), the Board of Governors of
Pakistan Medical Research Council (PMRC), the Central Pharmacy Council, the
Governing Council of Pakistan Council of Scientific and Industrial Research
(PCSIR). He has also been a member of the Pakistan Pharmacopoeia Committee, the
National Formulary Committee, the Good Manufacturing Practice Award
Committee and the Private Sector Advisory Council - constituted by the Prime
Minister of Pakistan. On behalf of the Government of Pakistan and the Company,
Dr. Khokhar has attended numerous conferences in North America, Europe and
Asia.

Over his illustrious career, Dr. Khokhar has also contributed significantly in the
education sector of Pakistan. He has been on the Board of Studies and the Board of
Faculty of Pharmacy at the University of Punjab. He was nominated a member of
the Study Group on Pharmacy Education, by the Higher Education Commission
(HEC), Pakistan. He was also instrumental in helping start the first ever private
sector pharmacy institution in Pakistan.

Dr. Khokhar's contributions are not only limited to the corporate and the education
sectors, but also stretch to the field of sports. He is the Life President of Pakistan
Gymnastic Federation (PGF) and has always strived to raise the profile of the sport
in Pakistan. He has also participated in the activities of the Pakistan Olympic
Association, the body which represents Pakistan on the International Olympic
Association.

Along with his accomplishments in the corporate sector, Dr. Khokhar is recognized
as one of the most eminent pharmacists in Pakistan. After completing his B.
Pharmacy from the University of Punjab, he completed his MPhil in Pharmacy from
the University of Wales. He pursued his doctorate at King's College London, where
 7
he joined the Research Group of Professor Arnold H. Beckett - an eminent scientist
of world repute. His outstanding contributions during and after his Ph.D. were
greatly appreciated by his co-researchers, he also authored several research papers in
international journals.

Vision and Mission

Remington Pharmaceuticals was established with a vision to enhance the quality of

health care services in Pakistan. Today, we have not only become the benchmark in
producing superior quality medicines while adhering to the international standards,
but we have also contributed significantly in upgrading the healthcare services in
many parts of rural and urban Pakistan.

Ophthalmology is an expertise area that Remington pharmaceutical now

successfully dominates. Our product brand portfolio covers a wide range of
therapeutic areas, the major ones being Ophthalmic medicines, Anti-infective,
Dermatology and Anti? Ulcerant products

According to the data released by IMS (Switzerland) for the first quarter of 2005,
Remington Pharmaceuticals is ranked 17th (Unit wise) among the 596
pharmaceutical companies in Pakistan.

Credit to Success

 We conduct ourselves with the utmost Integrity in all our dealings

 Good is the enemy of Great. We must strive for Excellence
 Innovative thinking leads to out-of-the-box solutions. Always add value!
 Perseverance should be a habit. Never ever give up!
 People are our guiding beacon. Promptly deliver to their needs
 8

Trust Regmination

We strive for excellence in every mile we run. Nothing takes our attention more than
delivering quality products to doctors, pharmacists and patients. That is why today,
Remington is taking care of millions of people trusting our medicines for their
wellbeing.

Our manufacturing facilities are designed to ensure our commitment to quality at

every step of the production process. Computerized building management systems
provide required environment round the clock and, in addition to that, extensive
equipment automation ensuring Quality by Design.

We work hard as a team so that you can be rest assured of getting the highest quality
medicine from Remington.

Structural Industry Analysis (Porter’s Five Forces)

This section provides a summary positional analysis of the pharmaceutical industry

using Porter’s Five Forces model (see diagram below)
 9

• Barrier to entry: High (Pharmaceuticals). Cost of R&D and patent limitations

• Industry Competition: High. Advantages gained by first mover advantage
(patents)
• Suppliers: supplier power is low
• Buyers: buyer power is low
• Substitutes: low (with patents) medium (after patent expiry)

Overall, the pharmaceutical industry shows an upward trend in its core markets. The
industry remains highly valued has a favorable market position with strong financial
make-up and strong earnings growth. Its future potential demand trend is positive
and despite increased competition the industry still shows a continuing upward
growth momentum. Datamonitor’s9 forecast of the leading 16 pharmaceutical
companies for 2001 to 2007 suggests that combined sales will grow at a minimum
rate of 5.2 percent based on the potential of their product pipeline.

Products
Remington manufactures and markets pharmaceutical drugs. A manufacturing
facility equipped with state-of-the-art technology and an extremely competent R&D
team ensures that the products provided by the company meet international
standards and are of the highest quality. The company’s product base covers a wide
range of therapeutic areas. We make sure that our medicinal products exactly fulfill
the requirements of both physicians and patients. Through continuous innovation,
we aim to keep broadening our product mix to serve an increasingly large number of
therapeutic areas. We focus on upholding and furthering our brand name and in
becoming a market-wide leader in the pharmaceutical industry.
 10

Products for International Market

Remington manufactures and markets pharmaceutical drugs. A manufacturing

facility equipped with state-of-the-art technology and an extremely competent R&D
team ensures that the products provided by the company meet international
standards and are of the highest quality. The company’s product base covers a wide
range of therapeutic areas. We make sure that our medicinal products exactly fulfill
the requirements of both physicians and patients. Through continuous innovation,
we aim to keep broadening our product mix to serve an increasingly large number of
therapeutic areas. We focus on upholding and furthering our brand name and in
becoming a market-wide leader in the pharmaceutical industry.

ANTHELMINITIC
PACK
GENERIC NAME BRAND NAME PRODUCT TYPE PACK TYPE
SIZE
Piperazine REMIPAR Syrup 30ml Glass Bottle
ELIXIR
ANTI-ANAEMIC
BRAND PRODUCT PACK PACK
GENERIC NAME
NAME TYPE SIZE TYPE
Iron (III) Hydroxide FEMTOL Syrup 60ml Glass
Polymaltose Complex Bottle
Iron (III) Hydroxide PolymaltoseFEMTOL Tablets 10’s Blister
Complex
Iron (III) Hydroxide PolymaltoseFEMTOL-F Tablets 10’s Blister
 11
Complex
ANTI-ASTHMATIC
PRODUCT PACK PACK
GENERIC NAME BRAND NAME
TYPE SIZE TYPE
Ketotifen ASFEN Syrup 60ml Glass
Bottle
Ketotifen ASFEN Tablets 30’s Blister
Montelukast REMIKAIR 4mg Sachet 28’s Aluminiu
m
Montelukast REMIKAIR 4mg / Tablets 14’s Blister
5mg / 10mg
ANTI-BACTERIAL QUINOLONE
PRODUCT PACK PACK
GENERIC NAME BRAND NAME
TYPE SIZE TYPE
Ciprofloxacin ROCIP 250mg /Tablets 10’s Blister
500mg
Levofloxacin KOBEXIN 250mg /Tablets 10’s Blister
500mg
Moxifloxacin OCUMOX Tablets 5’s Blister
Norfloxacin BACTINOR Tablets 14’s Blister
Ofloxacin CIOF Tablets 10’s Blister
Sparfloxacin Q-LOX 100mg /Tablets 10’s Blister
200mg
ANTI-BIOTIC / ANTI-INFECTIVE
PRODUCT PACK PACK
GENERIC NAME BRAND NAME
TYPE SIZE TYPE
 12
Amoxycillin WISEP Drops 10ml Glass
Bottle
Amoxycillin WISEP Suspension 60ml Glass
Bottle
Amoxycillin WISEP Tablets 100’s Blister
Amoxycillin WISEP-1000 Tablets 10’s Blister
Amoxycillin WISEP-DS Suspension 60ml Glass
Bottle
Amoxycillin WISEP-DS Tablets 20’s Blister
Amoxicillin-Clavulanic MAGNICILLIN Tablets 6’s Blister
Acid
Amoxicillin-Clavulanic MAGNICILLIN Suspension 60ml Glass
Acid Bottle
Amoxycillin- FLOMOXIN Capsules 20’s Plastic
Flucloxacillin Bottle
Amoxycillin- FLOMOXIN Suspension 45ml Glass
Flucloxacillin Bottle
Azithromycin MACRO-AZ Capsules 10’s Plastic
Bottle
Azithromycin MACRO-AZ Suspension 15ml Glass
Bottle
Cefadroxil DROXIL Capsules 12’s Plastic
Bottle
Cefadroxil DROXIL Suspension 60ml Glass
Bottle
Cefadroxil DROXIL-1000 Tablets 10’s Blister
 13
Cefadroxil DROXIL-DS Suspension 60ml Glass
Bottle
Cefixime ZYLOFIXIM Capsules 5’s Plastic
Bottle
Cefixime ZYLOFIXIM Suspension 30ml Glass
Bottle
Cefixime ZYLOFIXIM-DS Suspension 30ml Glass
Bottle
Cephradine ZEFLIN Capsules 12’s Plastic
Bottle
Cephradine ZEFLIN Suspension 60ml Glass
Bottle
Cephradine ZEFLIN-DS Capsules 12’s Plastic
Bottle
Cephradine ZEFLIN-DS Suspension 60ml Glass
Bottle
Doxycycline Hyclate VOXIN Tablets 20’s Blister
Fosfomycin MIFOS Capsules 10’s Blister
Fosfomycin MIFOS Suspension 60ml Blister
ANTI-CONVULSANT
PRODUCT PACK PACK
GENERIC NAME BRAND NAME
TYPE SIZE TYPE
Gabapentine NEUROGAB 200mg /Tablets 10’s Blister
400mg / 600mg
ANTI-DIABETIC
GENERIC NAME BRAND NAME PRODUCT PACK PACK
 14
TYPE SIZE TYPE
Glimepiride DIARID 1mg / 2mg /3mg /Tablets 20’s Blister
4mg
Glimepiride-Metformin DIARID-M 1mg-500mg Tablets 30’s Blister
Pioglitazone XOGLIT 15mg / 30mg /Tablets 14’s Blister
45mg
Pioglitazone-Metformin XOGLIT-M 15mg-500mg Tablets 28’s Blister
Pioglitazone-Metformin XOGLIT-M 15mg-850mg Tablets 14’s Blister
ANTI-EMETIC
PRODUCT PACK PACK
GENERIC NAME BRAND NAME
TYPE SIZE TYPE
Domperidone KOMETIC Suspension 120ml Glass Bottle
Domperidone KOMETIC Tablets 50’s Blister
ANTI-HISTAMINE
PRODUCT PACK PACK
GENERIC NAME BRAND NAME
TYPE SIZE TYPE
Cetrizine ZINOLUR Tablets 10’s Blister
Loratidine TILORA Syrup 60ml Glass Bottle
Loratidine TILORA Tablets 10’s Blister
ANTI-OBESITY
PRODUCT PACK PACK
GENERIC NAME BRAND NAME
TYPE SIZE TYPE
Sibutramine LOWBEST 10mg /Capsules 14’s Blister
15mg
ANTI-PEPTIC ULCERANT
GENERIC NAME BRAND NAME PRODUCT PACK PACK
 15
TYPE SIZE TYPE
Cimetidine SEMAG Tablets 10’s Blister
Famotidine TINOPEP 20mg Tablets 20’s Blister
Famotidine TINOPEP 40mg Tablets 10’s Blister
Omeprazole INGIS Capsules 14’s Plastic
Bottle
Pantoprazole PANTO Tablets 14’s Blister
Ranitidine RANIFUR Tablets 10’s Blister
Ranitidine RANIFUR-DS Tablets 10’s Blister
Lansoprazole ZOXILAN Capsules 14’s Plastic
Bottle
ANTI-RHEUMATIC
PRODUCT PACK PACK
GENERIC NAME BRAND NAME
TYPE SIZE TYPE
Diclofenac Potassium FLAMY 50mg Tablets 20’s Blister
Diclofenac Potassium FLAMY 100mg Tablets 10’s Blister
Diclofenac Sodium KONAC Tablets 20’s Blister
Flurbiprofen FLURIBEC Tablets 30’s Blister
Leflunomide RHEUMID 10mg /Tablets 30’s Blister
20mg
Meloxicam MELOX 7.5mg / 15mg Tablets 10’s Blister
Piroxicam KEMROX 10mg / 20mg Capsules 1’s Blister
ANTI-VIRAL
PRODUCT PACK PACK
GENERIC NAME BRAND NAME
TYPE SIZE TYPE
Ribavrin VIROFF 100mg / 200mg /Capsules 10’s Blister
 16
400mg
Ribavrin VIROFF 600mg Tablets 10’s Blister
Ribavrin VIROFF 50mg / 100mg Syrup 60ml Glass
Bottle
CARDIOVASCULAR
PRODUCT PACK
GENERIC NAME BRAND NAME
TYPE SIZE
Simvastatin-Ezetimibe TIMVAST PLUS 10mg-10mg /Tablets 7’s
20mg-10mg
Simvastatin-Ezetimibe TIMVAST PLUS 40mg-10mg Tablets 10’s
Rosuvastatin ROSULIP 5mg / 10mg / 20mg Tablets 10’s
Candesartan KANPRESS 8mg Tablets 14’s
Candesartan KANPRESS 16mg Tablets 28’s
Candesartan- KANPRESS PLUS Tablets 28’s
Hydrochlorothiazide
Clopidogrel-Aspirin CEGREL-A 75mg-75mg / 75mg-Tablets 10’s
150mg
Lisinopril- ZIDOPRIL Tablets 28’s
Hydrochlorothiazide
Ramipril RAPRIL 1.25mg / 2.5mg / 5mg /Tablets 28’s
10mg
Amlodipine-Atorvastatin MYODIP 5mg-10mg / 5mg-Tablets 7’s
20mg
Amlodipine-Atorvastatin MYODIP 10mg-10mg Tablets 10’s
Valsartan VALZAR 80mg / 160mg Tablets 14’s
Valsartan- VALZAR PLUS 80mg-12.5mg Tablets 28’s
 17
Hydrochlorothiazide
Valsartan- VALZAR PLUS 160mg-25mg Tablets 14’s
Hydrochlorothiazide
COUGH & COLD PREPARATIONS
PRODUCT PACK PACK
GENERIC NAME BRAND NAME
TYPE SIZE TYPE
Ammonium Chloride REMISOLE Syrup 60ml /Glass
EXPECTORANT 120ml Bottle
DERMATOLOGY
PRODUCT
GENERIC NAME BRAND NAME PACK SIZE PACK TYPE
TYPE
Benzyl Banzoate S.P. LOTION Lotion 60ml /Glass Bottle
120ml
Flucinolone Acetonide CINOL Cream 15gm Aluminium
Tube
Flucinolone Acetonide CINOL Ointment 15gm Aluminium
Tube
Flucinolone Acetonide-CINOL-N Cream 15gm Aluminium
Neomycin Tube
Flucinolone Acetonide-CINOL-N Ointment 15gm Aluminium
Neomycin Tube
Miconazole Nitrate MONITIN Cream 30gm Aluminium
Tube
Miconazole Nitrate GYNO MONITIN Cream 20gm Aluminium
Tube
Miconazole Nitrate-MONICORT Cream 10gm Aluminium
 18
Diflucortolone Tube
Polymyxin B. Sulfate-ZincZYLOSPORE Ointment 10gm/20gm Aluminium
Bacitracin Tube
Salicylic Acid-Sulphur SEPRODERM Ointment 20gm Glass Bottle
EAR, NOSE & THROAT
PRODUCT PACK
GENERIC NAME BRAND NAME
TYPE SIZE
Betamethasone BETADROP Ear Drops 7.5ml

Betamethasone-Neomycin BETADROP-N Ear Drops 7.5ml

Chloramphenicol REMICOL Ear Drops 10ml

Ciprofloxacin-Lignocaine LIGNOCIP Ear Drops 5ml

Ciprofloxacin OTOCIP Ear Drops 5ml

Dexamethasone-Ciprofloxacin DEXCIP Ear 5ml

Suspension
Fluticasone Propionate FLUTEX Nasal Spray 15ml

Gentamicin OPTAGEN Ear Drops 7.5ml

Gentamicin-Hydrocotisone OPTAGEN-HC Ear Drops 5ml

Levofloxacin- LEFODEX Ear 5ml

 19
Dexamethasone Suspension
Ofloxacin 0.3% KUNOXY Ear Drops 5ml

Ofloxacin 0.6% KUNOXY Plus Ear Drops 5ml

Polymyxin-Neomycin- POLYSPORE-HC Ear 5ml

Hydrocortisone Acetate Suspension
Polymyxin B-Lignocaine OTOCAINE Ear Drops 5ml

Sodium Cromoglycate NOSOCROM Nasal Spray 15ml

Sodium Cromoglycate-NOSOCROM -X Nasal Spray 13ml

Xylometazoline
Tobramycin TOBEC Ear Drops 5ml

Tobramycin-Dexamethasone TOBEC-D Ear Drops 5ml

Triamcinolone Acetonide NOSOLONE-AQ Nasal Spray 15ml

EYE DROPS
PRODUCT PACK
GENERIC NAME BRAND NAME
TYPE SIZE
Atropine Sulphate OPTA ATROPINE Solution 10ml

Betamethasone BETADROP Solution 7.5ml

 20
Betamethasone-Neomycin BETADROP-N Solution 7.5ml

Chloramphenicol OPTACHLOR Solution 10ml

Chloramphenicol-Dexamethasone METHACHLOR Solution 5ml

Ciprofloxacin ROCIP Solution 5ml

Dexamethasone OPTADEX Solution 5ml

Dexamethasone-Neomycin OPTADEX-N Solution 5ml

Dexamethasone-Neomycin- STERIBIOL Suspension 5ml

Polymyxin B.
Dexamethasone-Sulphacetamide METHASUL Solution 5ml

Dexamethasone-Polymyxin B.-POLYDEX Solution 5ml

Neomycin
Diclofenac Sodium KONAC Solution 5ml

Flourometholone- FEMICON Suspension 5ml

Tetrahydrozoline
Gentamicin OPTAGEN Solution 7.5ml

Gentamicin-Hydrocortisone OPTAGEN-HC Solution 5ml

 21
H.P.M.C. HICEL Solution 5ml

Latanoprost PROSTILET Solution 2.5ml

Latanoprost-Timolol PROSTILET-T Solution 2.5ml

Moxifloxacin OCUMOX Solution 5ml

Norfloxacin BACTINOR Solution 5ml

Ofloxacin CIOF Solution 5ml

Prednisolone-Neomycin- BIOPRED Suspension 5ml

Polymyxin B.
Prednisolone Acetate MILDOPRED Suspension 5ml

Prednisolone Acetate FORTIPRED Suspension 5ml

Prednisolone-Chloramphenicol PREDNICOL Suspension 10ml

Prednisolone-Sulphacetamide MYDOSONE Suspension 5ml

Pyrilamine Maleate-DECON-A Solution 15ml

Phenylephrine
Sodium Cromoglycate HISTALYN Solution 5ml
 22
Sodium Cromoglycate-HISTAZOLIN Solution 15ml
Tetrahydrozoline
Sulphacetamide Sodium OPTACID 10% / 20%Solution 10ml
30%
Timolol BLOTIM 0.25% / 0.5% Solution 5ml

Tobramycin NEBRA Solution 5ml

Tropicamide MYDROMIDE Solution 5ml

EYE OINTMENT
PRODUCT PACK
GENERIC NAME BRAND NAME PACK TYPE
TYPE SIZE
Acyclovir LOVIR Ointment 4.5gm Aluminium
Tube
Atropine Sulphate MYDRA Ointment 3gm Aluminium
Tube
Betamethasone-Neomycin BETA-N Ointment 3gm Aluminium
Tube
Chloramphenicol OPTACHLOR Ointment 5gm Aluminium
Tube
Chloramphenicol- METHACHLOR Ointment 3gm Aluminium
Dexamethasone Tube
Chlorobutanol T-WET Ointment 3.5gm Aluminium
Tube
Ciprofloxacin ROCIP Ointment 3.5gm Aluminium
 23
Tube
Dexamethasone- METHASUL Ointment 3.5gm Aluminium
Sulphacetamide Tube
Neomycin - Polymyxin B. STERIBIOL Ointment 3.5gm Aluminium
-Dexamethasone Tube
Oxytetracycline- XINOXY Ointment 3gm Aluminium
Polymyxin B. Tube
Polymyxin-Neomycin- TRIMIN Ointment 5gm Aluminium
Zinc Bacitracin Tube
Polymyxin B.-ZYLOSPORE Ointment 4gm Aluminium
Zinc Bacitracin Tube
Polymyxin B.-POLYSPORE-HC Ointment 3gm Aluminium
Zinc Bacitracin - Tube
Neomycin -
Hydrocortisone
Prednisolone-Neomycin- BIOPRED Ointment 3.5gm Aluminium
Polymyxin B Tube
Prednisolone- MYDOSONE Ointment 3.5gm Aluminium
Sulphacetamide Tube
Tobramycin NEBRA Ointment 5gm Aluminium
Tube
GASTROPROKINETICS
PRODUCT PACK PACK
GENERIC NAME BRAND NAME
TYPE SIZE TYPE
Itopride TOPRID Tablets 10’s Blister
MUSCLE RELAXANT
 24
PRODUCT PACK PACK
GENERIC NAME BRAND NAME
TYPE SIZE TYPE
Orphenadrine FLEXODIN Tablets 100’s Blister
Citrate-Paracetamol
NON NARCOTIC ANALGESIC
PRODUCT PACK PACK
GENERIC NAME BRAND NAME
TYPE SIZE TYPE
Mefenamic Acid FEBRIN Tablets 100’s Blister
Mefenamic Acid FEBRIN-DS Tablets 100’s Blister
VITAMINS
PRODUCT PACK PACK
GENERIC NAME BRAND NAME
TYPE SIZE TYPE
Alfacalcidol DOLBON 0.25mcg / 0.5mcg /Tablets 10’s Tablet
1mcg
Thiamine-Riboflavine- PLEXOVIT Syrup 60ml /Glass
Pyridoxine-Nicotinamide 120ml Bottle
B-Compound PLEXOVIT-L Syrup 60ml / Glass
Lysine Syrup 120ml Bottle
Antioxidant Vitamins VISAVIT Tablets 30’s Plastic
(Beta Carotene, C, E), Bottle
Mineral (Zn, Cu, Se),
Folic Acid and
Vitamin D
Antioxidant Vitamins VISAVIT PLUS Tablets 30’s Plastic
(Beta Carotene, C, E), Bottle
Mineral (Zn, Cu, Se),
 25
Folic Acid and
Vitamin D
Multi Vitamin VITONE Syrup 60ml /Glass
120ml Bottle
Multi Vitamin VITONE FORTE Syrup 120ml Glass
Bottle
Multi Vitamin VITONE FORTE Tablets 20’s Plastic
Bottle
International Business

Licensing & Alliances Various Coutries

We at Remington Pharmaceuticals understand the need for collaborative

development and marketing of drugs to achieve higher growth levels. Be that
through in-licensing or co-marketing, we seek to enhance our presence both
regionally and globally by partnering in areas where we can leverage on our
complementary expertise and exploit synergies.

Remington Pharmaceuticals is one of the leading pharmaceutical companies in

Pakistan and with the commencement of a cGMP compliant, 150,000 sq. ft., multi-
drug manufacturing facility we are augmenting our presence in the Asian, Middle
Eastern and African markets. Built on strong foundations of commitment to
excellence, today, Remington’s strong brand has become synonymous to highest
standards.

Our key strength areas include:

 Our team’s in-depth know-how and expertise right from rapid drug
registrations to generating substantial sales in short spans of time.
 26
 Our proven business model and strategic understanding of the markets assist
our partners gain forceful market entry across the region.
 Our successful track record of carrying out R&D, manufacturing quality drugs
and the marketing skills of our team puts us in a strong position to
successfully execute launches in multiple therapeutic areas.
 Our close working relationship with regulatory authorities, medical
professionals and other related associations & societies allows us to introduce
our partner products on a fast track.

Manufacturing Process

Recognition and Appreciation

Our manufacturing facility boasts enhanced production capacities for Eye and Ear
Drops, Ointments, Liquid (Oral) Medicines, Coated and Uncoated Tablets, Capsules
and External Preparations for various therapeutic categories.

The manufacturing facility is equipped with the latest technology including

automated and dedicated process control systems, computerized HVAC/dust control
mechanism, computerized Building Management System (BMS) and, process–water
and waste–water management systems providing with a ready compliance to cGMP,
ISO 9001:2000(E) and ISO 14001. Delegates from Europe and the US have visited
and admired the quality standards maintained at Remington’s production facilities.
This has led us to formalize transnational relationships and enhance our strategic
partnerships.

Contract Manufacturing

Remington’s dedicated and competent R&D team, a state-of-the-art manufacturing

plant that meets the highest international standards coupled with the company’s vast
 27
experience and expertise in Pharmaceutical Manufacturing and its strong ethical
values ensuring protection of intellectual property rights enable it to provide with a
complete outsourcing solution.

Using cGMP compliant and regulatory authorities’ approved manufacturing

processes, our production facility boasts enhanced production capacities for Eye and
Ear Drops, Ointments, Liquid (Oral) Medicines, Coated and Uncoated Tablets,
Capsules and External Preparations for various therapeutic categories.

At Remington, an ISO 9001:2000(E) certified company, a planned and systematic

pattern of all means and actions is designed to ensure that its products meet the
established standard specifications, legal requirements and the organization’s quality
objectives.

Contract manufacturing carries significant advantages some of which include:

Low Upfront Cost due to minimal capital requirement and a legal and tax presence not
 
being necessary
    
  Flexibility through being able to ramp up production volumes rapidly
   
  Fast-track Processing as a consequence of short lead-team for final production
    
  Access to External Expertise
    
Greater Adaptability to the ever changing demands of the market allowing for greater
 
revenue growth
   
The company provides tailored services to meet the clients’ needs by making
 28
available the requested information including the following reports:

  Inventory levels & movements

    
  Batch monitoring & reports
    
  Quality assurance reports
    
We strive to create a win-win situation by providing cost-effective and profitable
solutions for our partners.

Production Capacity

The annual production capacity of each section running on two 8 hour shifts, which
can be extended up to three shifts daily, is as follows:

  Capsules     30 million capsules

         
  Dry Syrups     12 million bottles
         
  Ear Drops     12 million bottles
         
  Eye Drops     60 million bottles
         
  Eye Ointments     12 million tubes
         
  Lotions     14 million bottles
         
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  Skin Ointments     12 million jars & tubes
         
  Syrups     60 million bottles
         
  Tablets     800 million tablets

Quality by Design

The manufacturing team is committed to produce highest quality products which can
meet the needs of both doctors and patients. The team strives to manufacture
products that are cost-effective through best utilization of their resources, reduced
down-time and by extensively applying planned-preventive maintenance program
with coordination of a highly skilled engineering team.

Our production facilities meet the regulatory requirements of cGMP and regulatory
authorities. All the manufacturing activities are performed according to the approved
procedures as required by cGMP and ISO 9001:2000(E) quality management
system.

In addition to quality assurance department's procedures at every stage of

production, in-process checks are also imposed, the results of which are
continuously monitored and recorded. Materials are procured from approved
suppliers through documented procedures, are quarantined until tested and released
for use by the manufacturing department. These materials are dispensed under
strictly controlled conditions supervised by our Quality Assurance team.

QUALITY ASSURANCE
 30
At Remington the core quality management groups cut across all functional
departments to coordinate and monitor the implementation of the quality policy and
quality management system. The quality assurance team effectively focuses on each
step starting from the raw material souring to packing and storing of the finished
products.

 Internal Quality Assurance

 External Quality Assurance
 Effectiveness and Suitability of Quality System

Being an ISO 9001:2000(E) certified company, we have extended our efforts to the
Total Quality Management Program for the benefit of the organization itself, its
members and of the society as a whole.

To run the quality system effectively and produce highest standard products, all the
required human, material, technical and financial resources are periodically and
thoroughly reviewed. The prime objective is the effective management of our
operations and substantiation of activities within the organization. These resources
include but are not limited to:

Human Resource Skills

 Design and Development Equipment

 Inspection, Testing and Examination Equipment
 Instrumentation and Computer Software

Here at Remington, a planned and systematic pattern of all means and actions is
designed to ensure that our products meet the established standard specifications,
legal requirements and the organization’s quality objectives.
 31
Collaboration Opportunities

Partnering with European / US Companies

For global and specialist pharmaceutical companies looking to enter the Asian,
Middle Eastern and African markets, Remington offers its unique platform to
partner in these regions.

With a vast knowledge of the region, Remington can streamline the difficulties
faced when launching a product in the aforementioned regions. Our team is well
versed in dealing with geographic areas where lack of information on market trends,
healthcare policies and reforms, and local doctors & patients are some of the main
challenges. Using our vast experience we successfully tackle these challenges hence
de-risking the market entry of our partners’ products and providing a perfect
platform to achieve high growth. We have a step-by-step market entry process that
involves initiating the process by carrying out comprehensive top-down market
analysis followed by formulating optimal strategies for entering a given market.

We appreciate that each partner is unique in its culture and business model; hence
we strive to provide customised solutions to contribute to our business partners'
success. To share the market entry risks, we also co-invest with our partners.

In summary, we are interested in sales and marketing partnerships and are keen to
explore licensing opportunities to create regional successes. We are not limited by
speciality areas and evaluate diverse opportunities to add to our portfolio of products
to expand our therapeutic and geographic coverage. Licensing innovative and ‘first
time’ products in the region across multiple therapeutic classes is of particular
interest to us.

We deal with our partners with highest level of integrity and strive to build long-
lasting, mutually beneficial relationships that add value for us and for our partners.
 32
Research and Development

Remington Pharmaceuticals has developed one of the most progressed and sensitive
R&D facility in the country. The core strength of our team is our foresightedness
that enables us to come up with the desired product at the apposite time. The in-
depth knowledge of the industry, science and the technology help us develop new
and effective products for the most pernicious diseases.

We have on our R&D team scientists with vast knowledgebase. To keep up with the
pace of today’s fast growing pharmaceutical industry, the R&D team regularly
participates in technical programs and seminars so that they are better able to tackle
new challenges and help develop better products. To facilitate the R&D team,
Remington’s laboratory is designed and equipped to meet international standards.
The R&D team is working on developing multi-therapeutic products pipeline.

At Remington Pharmaceutical we are committed to thrive and bring forth new

products which will help us in serving the humanity in a more effective way. With a
dedicated R&D team and facilities of international standards, we believe that
together we will be able to meet the challenges and continue our drive towards
progress.

COMPANY’S MARKETING & DISTRIBUTION

Laborate follows push strategy with robust distribution system as follows:
 33

The sale generated by company to distributor is termed as Primary sales. Laborate

doesn’t believe in advertisement. It has aggressive and vibrant field force to promote
their products in the market especially to stockiest, retailers as follows:
 34
Respnesibility

Valuing the community we live in and the environment has always been an integral
part of Remington’s policy. Remington considers itself a part of the community and
has always strived to make a difference for the betterment of the wider populace
through not only providing quality medicines at affordable prices but also, by giving
something back to the community. We have always made sure that our business
operations are carried out in a manner that protection of the environment remains
one of our top most priorities. Remington is moving towards becoming a carbon-
neutral company by offsetting its carbon emissions through the deployment of
renewable energies for power generation.

Community Support

Remington donates regularly to the NGOs and other foundations to help those who
are in dire need so that they can become responsible citizens and equally contribute
for the advancement of the country. The company continuously supports non-profit/
charitable organizations like Red Cross and ABWT.

The Indian Ocean Tsunami struck in the year 2004 killing millions of people in
areas including India, Sri Lanka, Indonesia and Thailand. Remington stepped up for
the support of all those affected by what was one of the deadliest natural disasters in
history. The company worked with international organizations like the Red Cross to
provide both financial aid and medical provisions to the aforementioned tsunami-
struck areas.

The year 2005, in a time of crisis when the whole country especially the Northern
areas were jolted by strong quakes, being a responsible part of the community,
Remington was among the first few to extend their full financial and emotional
support to the quake-affected people. The company made unrelenting efforts at
 35
making medical provisions available to those affected and helped in the
reconstruction of quake-torn houses.

We believe that education plays a vital role in better equipping the youth to make
positive contributions to the society as a whole and bringing about development.
One of Remington’s keys strengths have been its vast knowledge base and we are
committed on empowering our younger generation with that knowledge and more
and for that purpose, in the 90s the company helped establish Pakistan’s very first
private pharmaceutical college in Lahore. The college aims at providing quality
education and in departing invaluable knowledge to the budding youth of the
country. Our senior management team also regularly gives seminars and conducts
workshops at local public institutions.

We also promote healthy living and encourage people of all ages to engage in sports.
Recently Remington held a Polo Tournament for this very purpose. Special training
camps were held for younger people so that they make healthy activities a part of
their routines from an early age. The team at Remington also actively participated in
the tournament which served as an effective means for team-building. Remington
has also sponsored a polo team on a number of occasions.

Environment

The world is witnessing increasing globalization with the global markets evolving
continuously. Remington not only strives to adapt itself to the changing needs of the
world but also, in upholding strong values that inculcate in the team an
understanding of the need to protect the environment through clean and efficient
means of manufacturing and production. We believe that through a cleaner
environment we can better ensure a healthier tomorrow.
 36
Analysis of Key Industry Participants and Strategy

This section provides a descriptive overview on the top three pharmaceutical firms
worldwide.

Pfizer\Pharmacia:

After its merger with Warner-Lambert in July 2000, Pfizer became the world’s
largest pharmaceutical company. The strong commercial potential of Pfizer’s
product portfolio and its strong products pipeline, has caused Pfizer to invest heavily
in product support, global sales force expansion and increased R&D spend. In April
2003 the merger of Pfizer Inc. and Pharmacia Corporation was announced. The
estimated $60 billion merger consolidates Pfizer’s position as the world's largest
pharmaceutical company. The merged entity will control 11% of the global
pharmaceutical market, from 8%, with annual revenue estimated to increase from
$32 billion to $46 billion. The new Pfizer will also control 50% more of the market
than its closest rival, the world's second largest drug company, GlaxoSmithKline10.
The European Commission approved the merger but demanded that the firm divest
pharmaceuticals in nine different areas in response anti-competitive charges.

GlaxoSmithKline:

The December 2000 merger of GlaxoWellcome and SmithKline Beecham created

the GlaxoSmithKline, the world's second largest pharmaceutical company with a
global market share of 7%. GSK has global pharmaceutical sales of over $22bn and
also the largest share in several therapeutic areas, including the vaccine and over-
the-counter products (OTC).

However, GSK is still arguably a more global company (in terms of spread) than
Pfizer, given that GSK generates a far higher proportion of its sales outside the
North American market. GSK is ahead of Pfizer in every other region outside North
 37
America. GSK generated a relatively high $6.0bn, or 26.6% of its sales, in the
European market in the year to September 2002 compared to Pfizer's $3.8bn
(16.9%). The region in which Pfizer's market share is closest to GSK's is Africa,
Asia and Australasia; this is due mainly to GSK’s strong position in the large
Japanese market, which has been targeted by Pfizer for future growth.

Merck & Co:

Merck is the third-largest global pharmaceutical company. Excluding organic

growth, for Merck to rival the top two it will have to acquire at least one of the 15
leading pharmaceutical firms in the world - a smaller acquisition would not gain it
sufficient market share to overtake either Pfizer or GSK. While it has not gone for a
full-blown merger, Merck, like other drug companies, has increased the number of
collaborations with external and biotech firms. It has so far signed close to 50 deals
with research partners in the past 5 years. Merck has also teamed with Schering-
Plough to develop respiratory drugs. Merck's strategy is to focus on breakthrough
drugs, rather than go the consolidation route or imitate competitors with so-called
"me-too" products. Unfortunately its current product pipeline is rather weak and
Merck may come under increased pressure to merge as a means of gaining market
share and growth. Analysts believe Merck’s ideal merger candidate would be
Johnson & Johnson due to the little overlap with Merck’s pharmaceutical portfolio.

SWOT Analysis and Strategy Review

Since inception in 1849, Pfizer has grown from a small family firm with two
employees into a global enterprise with 95,000 employees on six continents. Pfizer
has increasingly focused its efforts on R&D and this remains its core business
strategy. Pfizer’s strengths lie in its strong pipeline of innovative pharmaceutical
compounds and strong marketing capabilities. Pfizer's performance is characterized
 38
not only by size, but also by growth. In 1999, Pfizer achieved 20% revenue growth.
Pfizer has also set records in each of the past three years to 2003 with the most
successful product launches in pharmaceutical history Lipitor, Viagra and Celebrex.

Pfizer’s strength in R&D, marketing, and sales has made them a partner of choice
for many companies in the pharmaceutical industry and they are involved in a wide
variety of research collaborations and a large number of licensing agreements with
universities, institutes and organizations.

An outline SWOT analysis of the world’s largest pharmaceutical firm follows next.

Strengths

• R&D innovation with a broad therapeutic coverage

• Marketing strength in major geographical and therapeutic areas
• Existing Patent protection for a number of years on key products

Opportunities

• Decreasing development time through favorable R&D collaborations and

internal efforts
• Emergence of integrated global markets and globalization for new products
• Co-marketing agreements with companies wishing to capitalize on Pfizer's
marketing strengths, providing Pfizer with strong products and therefore
revenue growth

Weaknesses

• Discontinuation of products in the latter stages of development

• Co-marketing agreements can limit Pfizer's global presence
• Increased size and operational complexity makes Pfizer a less agile company
 39
Threats

• Increased competition for core products like Viagra as its high cost
encourages use of cheap alternative treatments
• An increase in the number of safety issues surrounding Viagra
• Competition from products similar to Pfizer's in R&D that reach the market
close to or before Pfizer's products
• The new economic potential of emergent China, India and competition in
diverse regional markets.

Constraints
1. Found a little bit difficulty initially in meeting with the company guide to get
the assignments due to his busy schedule.
2. Company didn’t want to involve trainees in their business directly.
3. Most of the chemist doesn’t provide their Sales information easily.
Strategy adopted:
1. Strictly follow work-timings from 9:00 a. m to 6:00 p.m.
2. Zeal to learn from existing employees.
3. Passion & Dedication towards work to prove myself.
4. Cooperation and assistance to other employees in their work.
5. Effective Communication and presentation skills.
6. Started sending professional-mails to get the assignments and submission of
reports of the tasks thus making them (Company guide, Chemists and
Retailers) aware the significance of this project in our professional life.
 40

Critique and Analytical Review

of Pfizer’s Strategy
Pfizer has done quite well historically and analysis has revealed that they are
looking to position Themselves strategically for the future. But as we enter a new
era in the pharmaceutical industry With increased patent risks and lower marginal
product returns, pharmaceutical firms like Pfizer Must restructure their huge
organizational mass to reduce structural inefficiencies, cut costs Which is required to
enable them compete better in the changing global environment. Due to it Massive
R&D push, Pfizer suffers a relatively high rate of discontinuation in pre-approval
Products and more focus are required to reduce resource wastage. Pfizer’s lack of
promising
Products in its early stage pipeline have left its combined pipeline relatively weaker.
This pipeline Deficit will not manifest for a number of years yet, and Pfizer is
perhaps well positioned than Most to ensure that it balances its R&D pipeline before
it becomes a cause for concern in future.
Pfizer’s imbalanced geographical presence (the US accounts for over 60% of
Pfizer’s market Area) may cause potential geographic limitations and can limit
revenue growth should US Demand weakens.
While the numbers of co-marketing and collaborative agreements, which Pfizer has
established, Are currently proving very favorable, agreements that geographically
limit Pfizer’s activities will Ultimately reduce its long term potential and must be
guarded against.
Finally, the economic emergence of mass production economies like India and
China into the Pharmaceutical fray will require new containment strategies. While
this is not an immediate Threat, over time the nature of competition will change and
 41
the big pharmaceutical firms must Develop strategies to enable them reduce threats
and seize the opportunities that are created in Increasingly integrated global markets.
Going forwards, I recommend that Pfizer actions a resource\competence based
analysis of it’s Innate capabilities, those characteristics that offer Pfizer distinct
competitive advantage over its Industry rivals. There may be a role for using
‘McKinsey’s 7S Framework’ to determine the firm’s Core advantages.
On the period of internship I observed Job Descriptions and Responsibilities of the
Employees were Multi-tasking. The environment of the workplace is entirely
different From the concepts which I studied in books. So I found that to survive in
the cut-throat Competitive era we need to develop multi-tasking skills along with
dynamic personality And strong communication skills.

Conclusion
The Pharmaceutical industry has a lot of yet untapped potential and it will be
interesting to see How the industry matures over the long term. Undoubtedly, the
long history and global expertise Of firms like Pfizer, GSK and Merck will stand
them in good stated to create and benefit from Emerging global opportunities.
Notwithstanding its strengths, complacency must be guarded Against because
smaller, agile and innovative firms are on the prowl and all it takes for the small
Upstarts are a Superdrug that can change the entire face of the industry. We’ve seen
it in happen In the Information & Communications industry, for all we know
pharmaceuticals may just be Next.
 42

Recommendations
There are few recommendations from my side which can be beneficial for the
company
 Employees should be trained according to the changing standards of the
Organization.
 Company should conduct survey from time to time according to which
changes can
 Be introduced in the organization to stay updated in the market.
 They should introduce creativity into the work, so that the employees can do
their Work passionately.
 Employees should be more involved in decision making to become more
Differentiated.
Leanings from IP:
 Learning beyond classroom
 Platform for implementing theoretical concepts
 Exposure to corporate culture
 Experience under belt
 Insight of actual strengths and weaknesses
 Developing a network
 Refinement of Career goals
 Soft skill development
 Impart Winning Edge
 Feather in the cap as PPO